Recurrence of gastric cancer caused by implantation of tumor cells after percutaneous transesophageal gastrostomy
(Source: Gastric Cancer)
Source: Gastric Cancer - August 25, 2022 Category: Gastroenterology Source Type: research
SPK1/S1P axis confers gastrointestinal stromal tumors (GISTs) resistance of imatinib
ConclusionsOur findings suggest that IM secondary resistance is associated with the elevation of S1P, and blockage the signaling pathway of SPK1/S1P warrants evaluation as a potential therapeutic strategy in IM-resistant GISTs.Graphical abstractThe design of this study from blood management, group information collection, IM plasma concentration with different elements, identification of sphingolipid metabolism and lastly verification the function of SPK1/S1P in the IM-resistance GISTs cells. (Source: Gastric Cancer)
Source: Gastric Cancer - August 24, 2022 Category: Gastroenterology Source Type: research
Survival trends in gastric cancer patients between 1987 and 2016: a population-based cohort study in Finland
ConclusionsGastric non-cardia adenocarcinoma survival declined, limited to advanced stage patients not receiving any treatment. Gastric cardia cancer survival seems to have improved over time in Finland.Mini abstractThis study evaluated survival trends of gastric cancer in Finland during 1987 –2016 and established that the 5-year survival is declining in non-cardia adenocarcinoma but improving in all gastric cancers. (Source: Gastric Cancer)
Source: Gastric Cancer - August 7, 2022 Category: Gastroenterology Source Type: research
Deep learning predicts resistance to neoadjuvant chemotherapy for locally advanced gastric cancer: a multicenter study
ConclusionsA CT-based model using DL showed promising performance for predicting NACT resistance in LAGC patients, which could provide valuable information in terms of individualized treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - August 6, 2022 Category: Gastroenterology Source Type: research
ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer
ConclusionsThese results suggest that ADAMTS10 targets TXNIP and ROS via the JAK/STAT/c-MYC pathway and that may play important roles in GC progression and macrophage polarization which indicates that ADAMTS10 can be a potential survival marker for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - August 4, 2022 Category: Gastroenterology Source Type: research
Comment on: “Internal hernia after gastrectomy for gastric cancer in minimally invasive surgery era,” Gastric Cancer, 2019 Feb 13, by Kang et al
(Source: Gastric Cancer)
Source: Gastric Cancer - August 4, 2022 Category: Gastroenterology Source Type: research
ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer
ConclusionsThese results suggest that ADAMTS10 targets TXNIP and ROS via the JAK/STAT/c-MYC pathway and that may play important roles in GC progression and macrophage polarization which indicates that ADAMTS10 can be a potential survival marker for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - August 4, 2022 Category: Gastroenterology Source Type: research
Comment on: “Internal hernia after gastrectomy for gastric cancer in minimally invasive surgery era,” Gastric Cancer, 2019 Feb 13, by Kang et al
(Source: Gastric Cancer)
Source: Gastric Cancer - August 4, 2022 Category: Gastroenterology Source Type: research
Determinants of clinical outcomes of gastric cancer patients treated with neoadjuvant chemotherapy: a sub-analysis of the PRODIGY study
ConclusionsBoth initial cStage and ypStage were independent factors for survival outcomes of gastric cancer patients treated with neoadjuvant chemotherapy. Efforts should be made to develop optimal peri-operative treatment strategies for patients at different risks according to cStage and ypStage. (Source: Gastric Cancer)
Source: Gastric Cancer - August 3, 2022 Category: Gastroenterology Source Type: research
