A prospective multi-institutional validity study to evaluate the accuracy of clinical diagnosis of pathological stage III gastric cancer (JCOG1302A)
ConclusionClinical diagnosis of T3/T4 tumors was not an optimal criterion to select patients for intensive NAC trials because more than 10% of patients with pathological stage  I disease were included. We propose the criterion “cT3/T4 and cN1/N2/N3” instead. (Source: Gastric Cancer)
Source: Gastric Cancer - February 13, 2017 Category: Gastroenterology Source Type: research

Safety and feasibility of minimally invasive gastrectomy during the early introduction in the Netherlands: short-term oncological outcomes comparable to open gastrectomy
AbstractBackgroundMinimally invasive techniques for gastric cancer surgery have recently been introduced in the Netherlands, based on a proctoring program. The aim of this population-based cohort study was to evaluate the short-term oncological outcomes of minimally invasive gastrectomy (MIG) during its introduction in the Netherlands.MethodsThe Netherlands Cancer Registry identified all patients with gastric adenocarcinoma who underwent gastrectomy with curative intent between 2010 and 2014. Multivariable analysis was performed to compare MIG and open gastrectomy (OG) on lymph node yield ( ≥15), R0 resection rate, and ...
Source: Gastric Cancer - February 9, 2017 Category: Gastroenterology Source Type: research

Nishi Memorial Award in Gastric Cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - February 6, 2017 Category: Gastroenterology Source Type: research

Analysis of gallstone disease after gastric cancer surgery
ConclusionsAlthough few patients required further gallbladder removal after gastrectomy for gastric malignancy, the increased mortality rate for subsequent cholecystectomy was worth noting. The decision to undergo prophylactic cholecystectomy might be individualized based upon patient characteristics and the surgeon ’s discretion. (Source: Gastric Cancer)
Source: Gastric Cancer - February 2, 2017 Category: Gastroenterology Source Type: research

Current management of liver metastases from gastric cancer: what is common practice? New challenge of EORTC and JCOG
AbstractThe role of multidisciplinary treatment including surgery for liver metastases from gastric cancer (LMGC) is controversial. Studies to answer this clinical question are increasing in number, but all published data thus far are based on retrospective analyses with limited sample sizes. Thus, the European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) and the Japan Clinical Oncology Group (JCOG) Stomach Cancer Study Group (SCSG) initiated a collaboration to develop an optimal treatment strategy for LMGC. Before planning a prospective study, a questionnaire was se...
Source: Gastric Cancer - February 1, 2017 Category: Gastroenterology Source Type: research

Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells
ConclusionCollectively, our data demonstrated that the interaction between GKN2 and TFF1 can have synergistic antiproliferative and pro-apoptotic effects on gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - February 1, 2017 Category: Gastroenterology Source Type: research

Gastric cancer: Asia and the world
(Source: Gastric Cancer)
Source: Gastric Cancer - January 31, 2017 Category: Gastroenterology Source Type: research

Pattern of extragastric recurrence and the role of abdominal computed tomography in surveillance after endoscopic resection of early gastric cancer: Korean experiences
ConclusionsAfter endoscopic resection of early gastric cancer, regional lymph node recurrence is the predominant extragastric recurrence pattern, which can be detected via abdominal computed tomography and cured by rescue surgery. Abdominal computed tomography should be considered as a surveillance method, especially in patients with an expanded indication. (Source: Gastric Cancer)
Source: Gastric Cancer - January 27, 2017 Category: Gastroenterology Source Type: research

Incidence of and risk factors for preoperative deep venous thrombosis in patients undergoing gastric cancer surgery
Conclusion Preoperative gastric cancer patients receiving neoadjuvant chemotherapy seem to be at higher risk for the development of DVT. (Source: Gastric Cancer)
Source: Gastric Cancer - January 24, 2017 Category: Gastroenterology Source Type: research

Long-term outcomes of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG0703)
ConclusionsThe long-term outcomes of stage I gastric cancer patients undergoing LADG seem comparable to those of patients undergoing an open procedure, although this result should be confirmed by a randomized control trial. We have already completed accrual of 921 patients for a multicenter randomized phase III trial (JCOG0912) to confirm the noninferiority of LADG compared with open gastrectomy in terms of relapse-free survival. (Source: Gastric Cancer)
Source: Gastric Cancer - January 16, 2017 Category: Gastroenterology Source Type: research

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer
ConclusionsThe current prevalence ofH. pylori infection among students was low even in an area of Japan with a high incidence of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 16, 2017 Category: Gastroenterology Source Type: research

Protocol for enhanced recovery after surgery improves short-term outcomes for patients with gastric cancer: a randomized clinical trial
ConclusionsThe ERAS protocol is safe and efficient, and seems to improve the postoperative course of patients with gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 6, 2017 Category: Gastroenterology Source Type: research

Associations between CYP2A6 polymorphisms and outcomes of adjuvant S-1 chemotherapy in patients with curatively resected gastric cancer
ConclusionsCYP2A6 polymorphisms are not associated with toxicity of S-1 chemotherapy, but correlate with the efficacy of S-1 in the adjuvant setting for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2017 Category: Gastroenterology Source Type: research

Site-specific fibroblasts regulate site-specific inflammatory niche formation in gastric cancer
ConclusionThe dynamic states of immune cells differ between the submucosal and subserosal layers in cancer tissues. Site-specific fibroblasts regulate site-specific inflammatory niche formation according to the depth of cancer cell invasion. (Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2017 Category: Gastroenterology Source Type: research

Japanese gastric cancer treatment guidelines 2014 (ver. 4)
(Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2017 Category: Gastroenterology Source Type: research

Western strategy for EGJ carcinoma
AbstractIn this paper, the epidemiological and clinicobiological behavior of esophagogastric junction (EGJ) adenocarcinoma in the West is compared and contrasted to that in the East, and an overview is provided of current therapeutic strategies employed for this type of tumor in Western countries. It is well known that multimodal treatment is the therapeutic standard in locally advanced EGJ adenocarcinoma, but whether neoadjuvant/perioperative chemotherapy (CT) or neoadjuvant chemoradiotherapy (CRT) is the optimal approach is still debated. Neoadjuvant CRT improves local control in locally advanced Siewert type I and II tu...
Source: Gastric Cancer - December 30, 2016 Category: Gastroenterology Source Type: research

Effectiveness of a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer
AbstractWe established a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer. Twenty-two gastric cancer patients aged 65 years or older with a diagnosis of sarcopenia according to the algorithm proposed by the European Working Group on Sarcopenia in Older People received our preoperative program. The median duration of the program participation was 16  days. Total calorie and protein intakes were significantly higher after the program than before [29.4 ± 6.9 kcal/kg ideal body weight (IBW) vs 27.3 ± 5.6 kcal/kg IBW,p ...
Source: Gastric Cancer - December 28, 2016 Category: Gastroenterology Source Type: research

Development of an e-learning system for teaching endoscopists how to diagnose early gastric cancer: basic principles for improving early detection
AbstractWe developed an internet e-learning system in order to improve the ability of endoscopists to diagnose gastric cancer at an early stage. The efficacy of this system at expanding knowledge and providing invaluable experience regarding the endoscopic detection of early gastric cancer was demonstrated through an international multicenter randomized controlled trial. However, the contents of the system have not yet been fully described in the literature. Accordingly, we herein introduce the contents and their principles, which comprise three main subjects: technique, knowledge, and experience. Since all the e-learning ...
Source: Gastric Cancer - December 28, 2016 Category: Gastroenterology Source Type: research

Surgery after intraperitoneal and systemic chemotherapy for gastric cancer with peritoneal metastasis or positive peritoneal cytology findings
ConclusionsSurgery after response to intraperitoneal and systemic chemotherapy is safe and may prolong the survival of P1 and CY1 gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - December 27, 2016 Category: Gastroenterology Source Type: research

Prognostic factors in 868 advanced gastric cancer patients treated with second-line chemotherapy in the real world
AbstractBackgroundAlthough second-line therapy is often considered for advanced gastric cancer patients, the optimal candidates are not well defined.MethodsWe retrospectively collected baseline parameters, tumour features, and treatment data for 868 advanced gastric cancer patients exposed to multiple treatment lines at 19 Italian centres. Cross-tables and chi-square tests were used to describe categorical features. To predict the impact of clinical variables on progression-free survival and overall survival, Kaplan –Meier and Cox regression analyses were performed.ResultsAt the start of second-line therapy, median a...
Source: Gastric Cancer - December 27, 2016 Category: Gastroenterology Source Type: research

Characteristics of gastric cancer in negative test of serum anti- Helicobacter pylori antibody and pepsinogen test: a multicenter study
ConclusionPatients in group AP had CAG, and their gastric cancers were similar to those ofH. pylori-eradicated patients. Concerning the recent ABC classification system, advanced decision criteria should be proposed to decrease the false-negative evaluation of gastric cancer risk. (Source: Gastric Cancer)
Source: Gastric Cancer - December 26, 2016 Category: Gastroenterology Source Type: research

Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging
AbstractBackgroundMost metastatic gastrointestinal stromal tumors (GISTs) develop resistance to the first-line imatinib treatment. Recently, increased vessel density and angiogenic markers were reported in GISTs with a poor prognosis, suggesting that angiogenesis is implicated in GIST tumor progression and resistance. The purpose of this study was to investigate the relationship between tumor vasculature and imatinib resistance in different GIST mouse models using a noninvasive magnetic resonance imaging (MRI) functional approach.MethodsImmunodeficient mice (n = 8 for each cell line) were grafted with imatinib-se...
Source: Gastric Cancer - December 19, 2016 Category: Gastroenterology Source Type: research

Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for esophagogastric junction adenocarcinoma
ConclusionsESD may be an effective alternative to surgery for the treatment of early gastric cancer in the EGJ based on the comparable long-term outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - December 19, 2016 Category: Gastroenterology Source Type: research

Prevalence of deep venous thrombosis detected by ultrasonography before surgery in patients with gastric cancer: a retrospective study of 1140 consecutive patients
ConclusionsFemale sex, older age, worse PS, the presence of CVC, and a history of preoperative chemotherapy were the independent risk factors for DVT. Routine lower-extremity venous ultrasonographic screening is useful for prevention of PTE because it can identify patients at high or low risk for PTE. (Source: Gastric Cancer)
Source: Gastric Cancer - December 16, 2016 Category: Gastroenterology Source Type: research

Comparison of long-term survival and immediate postoperative liver function after laparoscopic and open distal gastrectomy for early gastric cancer patients with liver cirrhosis
ConclusionsFor EGC patients with liver cirrhosis, especially Child A cirrhosis, laparoscopic or laparoscopy-assisted distal gastrectomy can be a safe surgical procedure in comparison to open distal gastrectomy in terms of the long-term survival rate and immediate postoperative liver function. (Source: Gastric Cancer)
Source: Gastric Cancer - December 10, 2016 Category: Gastroenterology Source Type: research

Side overlap esophagogastrostomy to prevent reflux after proximal gastrectomy
ConclusionsSOFY can be easily performed laparoscopically and may overcome the problems of postoperative reflux and stenosis. (Source: Gastric Cancer)
Source: Gastric Cancer - December 10, 2016 Category: Gastroenterology Source Type: research

Reply to “How should we define the no. 3b lesser curvature lymph node?”
(Source: Gastric Cancer)
Source: Gastric Cancer - December 8, 2016 Category: Gastroenterology Source Type: research

Interobserver agreement in detection of “white globe appearance” and the ability of educational lectures to improve the diagnosis of gastric lesions
AbstractBackgroundWhite globe appearance (WGA) refers to a small white lesion of globular shape underneath cancerous gastric epithelium that can be clearly visualized by magnifying endoscopy with narrowband imaging (M-NBI). WGA has been reported to be a novel endoscopic marker that is highly specific in differentiating early gastric cancer (GC) from low-grade adenoma, and has a significantly higher prevalence in early GCs than in noncancerous lesions. However, interobserver agreement in detecting WGA and whether training intervention can improve diagnostic accuracy are unknown.MethodsTwenty sets of M-NBI images were examin...
Source: Gastric Cancer - December 3, 2016 Category: Gastroenterology Source Type: research

Risk factors and management for gastric stenosis after endoscopic submucosal dissection for gastric epithelial neoplasm
ConclusionsA wide resection of more than three fourths of the circumferential extent was the significant risk factor for post-ESD stenosis in both cardia and antrum, and prophylactic EBD could be a promising procedure for the management of post-ESD stenosis. (Source: Gastric Cancer)
Source: Gastric Cancer - November 30, 2016 Category: Gastroenterology Source Type: research

Multi-institutional prospective feasibility study to explore tolerability and efficacy of oral nutritional supplements for patients with gastric cancer undergoing gastrectomy (CCOG1301)
AbstractBackgroundPostoperative malnutrition after gastrectomy is deemed inevitable, which could have prejudicial influence on survival for gastric cancer patients. A prospective feasibility study was conducted to evaluate the efficacy of postoperative oral nutritional supplements.MethodsStage I –III gastric cancer patients who underwent distal or total gastrectomy received oral administration of Racol® NF (Otsuka Pharmaceutical Factory, Japan), a liquid enteral nutritional formula, as a supplement to regular meals. Racol® NF administration at a recommended dosage of 400 kcal/400 ml per da...
Source: Gastric Cancer - November 24, 2016 Category: Gastroenterology Source Type: research

Examining the gastric cancer survival gap between Asians and whites in the United States
ConclusionsThis study characterizes distinctive gastric cancer survival patterns among the six major Asian groups and NHWs in the US. The favorable survival for Koreans is largely attributable to specific clinical factors, particularly stage at diagnosis. The causes of the survival disadvantage for NHWs remain elusive. (Source: Gastric Cancer)
Source: Gastric Cancer - November 19, 2016 Category: Gastroenterology Source Type: research

Intratumor stromal proportion predicts aggressive phenotype of gastric signet ring cell carcinomas
AbstractObjectiveThe aim of this study was to evaluate the prognostic significance of the intratumor stromal proportion in gastric signet ring cell (SRC) carcinomas.BackgroundCancer stroma, as exemplified by cancer-associated fibroblasts (CAFs), plays critical roles in cancer proliferation, invasion, and metastasis.MethodsOne hundred seventy-five SRC carcinoma cases were classified according to the intratumor desmoplastic stromal proportion to then analyze the clinicopathologic characteristics of stroma-rich cases. We also investigated the impact of CAFs on the migration as well as on the phenotypic changes of gastric SRC ...
Source: Gastric Cancer - November 17, 2016 Category: Gastroenterology Source Type: research

Irinotecan monotherapy as third-line treatment for advanced gastric cancer refractory to fluoropyrimidines, platinum, and taxanes
ConclusionIrinotecan monotherapy appears to be tolerated but was shown to have modest activity as third-line chemotherapy for advanced gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - November 17, 2016 Category: Gastroenterology Source Type: research

The contribution of Helicobacter pylori to excess gastric cancer in Indigenous and Pacific men: a birth cohort estimate
ConclusionsPolicy should focus on reducing the acquisition and prevalence ofH.  pylori infection in these populations. (Source: Gastric Cancer)
Source: Gastric Cancer - November 16, 2016 Category: Gastroenterology Source Type: research

Impact of progression type on overall survival in patients with advanced gastric cancer based on randomized phase III study of S-1 plus oxaliplatin versus S-1 plus cisplatin
ConclusionsProgression accompanied by new lesions had a strong negative impact on OS in patients treated with S-1 and platinum for AGC. (Source: Gastric Cancer)
Source: Gastric Cancer - November 7, 2016 Category: Gastroenterology Source Type: research

Clinical outcomes of endoscopic submucosa dissection for high-grade dysplasia from endoscopic forceps biopsy
ConclusionsCentral depression, nodular surface, surface redness, lesion location, large tumor size, and submucosal fibrosis were associated with EGC or submucosal cancer. Caution must be used in treating lesions with these features with ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - November 7, 2016 Category: Gastroenterology Source Type: research

Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a multicenter collaborative study
AbstractObjectiveThe indications for endoscopic submucosal dissection (ESD) in patients with early gastric cancer (EGC) have been expanded. However, the long-term outcomes of ESD remain unclear. We retrospectively investigated the long-term outcomes of ESD in patients with EGC.MethodsWe retrospectively studied patients with EGC who underwent ESD at 11 institutions between January 2003 and December 2010. A total of 6456 patients (7979 lesions) who met the absolute indications for ESD and 4202 patients (5781 lesions) who met the expanded indications for ESD were studied. Clinicopathological features, clinical course, and out...
Source: Gastric Cancer - November 2, 2016 Category: Gastroenterology Source Type: research

Intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis
AbstractPeritoneal metastasis is the most frequent pattern of gastric cancer recurrence or metastasis and is a definitive determinant of prognosis. However, an effective means of treating peritoneal disease has not yet been established. Systemic chemotherapy has only a limited effect on peritoneal metastasis, although some progress has been shown in terms of median survival time, especially among patients with a minimal or moderate disease burden. Clinical research related to intraperitoneal administration of anticancer drugs is currently underway. An advantage of intraperitoneal chemotherapy is the ability to achieve high...
Source: Gastric Cancer - November 1, 2016 Category: Gastroenterology Source Type: research

Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma
ConclusionsComplete nodal clearance along the distal portion of the stomach offers marginal survival benefits for patients with EGJ cancers less than 4  cm in diameter. The optimal extent of esophageal resection and the benefits of mediastinal node dissection remain issues to be addressed in managing patients with esophagus-predominant EGJ cancers. (Source: Gastric Cancer)
Source: Gastric Cancer - October 28, 2016 Category: Gastroenterology Source Type: research

Clinicopathological features of Siewert type II adenocarcinoma: comparison of gastric cardia adenocarcinoma and Barrett ’s esophageal adenocarcinoma following endoscopic submucosal dissection
AbstractObjectivesSiewert type II esophagogastric junction adenocarcinoma encompasses both gastric cardia adenocarcinoma (GCA) and Barrett ’s esophageal adenocarcinoma (BEA) due to short-segment Barrett’s esophagus. We compared these two types of Siewert type II esophagogastric junction adenocarcinoma in terms of background factors and clinical outcomes of endoscopic submucosal dissection (ESD).MethodsWe enrolled 139 patients (142 lesions) who underwent ESD from 2006 to 2014 at our institution. Background factors evaluated were age, sex, body mass index, hypertension, hyperlipidemia, hyperuricemia, diabetes mel...
Source: Gastric Cancer - October 25, 2016 Category: Gastroenterology Source Type: research

Early detection of nonperitoneal recurrence may contribute to survival benefit after curative gastrectomy for gastric cancer
AbstractBackgroundThere is no evidence that strict follow-up using cross-sectional imaging after curative gastrectomy benefits survival; however, nonperitoneal recurrence detected early might be treated with additional surgery. The present study examined whether early detection of recurrence by imaging modalities could increase survival, particularly in patients with nonperitoneal recurrence.MethodsWe retrospectively analyzed 218 patients with recurrent gastric cancer after curative gastrectomy performed from 2002 to 2014. The patients were divided into an asymptomatic group (n = 117) and a symptomatic group (n&n...
Source: Gastric Cancer - October 24, 2016 Category: Gastroenterology Source Type: research

Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan
AbstractAmong advanced gastric cancer cases, peritoneal dissemination is a life-threatening mode of metastasis, and any strategy to control peritoneal metastasis will significantly improve treatment outcomes. Since intraperitoneal administration of anticancer drugs can induce an extremely high concentration of drugs in the peritoneal cavity, intraperitoneal chemotherapy would appear to be a reasonable and promising strategy to control the peritoneal dissemination. However, it has been reported in the past that intraperitoneal administration of mitomycin C or cisplatin resulted in no significant clinical effects against per...
Source: Gastric Cancer - October 20, 2016 Category: Gastroenterology Source Type: research

Changing epidemiology of Helicobacter pylori in Japan
AbstractHelicobacter pylori (H. Pylori) is known as the most important cause of gastric cancer. The prevalence ofH. pylori infection varies widely by geographic area, age, and socioeconomic status. In Japan,H. pylori infection has been highly correlated with the incidence rate of gastric cancer, and a reduction inH. pylori infection is therefore crucial for decreasing the incidence of gastric cancer, especially at the population level. Infection occurs during childhood, commonly before 5  years of age. In Japan, where gastric cancer has ranked as the most common cancer by incidence and mortality for the last several d...
Source: Gastric Cancer - October 18, 2016 Category: Gastroenterology Source Type: research

Distinct expression profile of key molecules in crawling-type early gastric carcinoma
AbstractBackgroundGastric “crawling-type” adenocarcinoma (CRA) is a tumor histologically characterized by irregularly fused glands with low-grade cellular atypia that tends to spread laterally in the mucosa. To date, the expression characteristics of the key molecules involved in CRA, including receptor tyrosine kinases (RTKs), mismatch repair (MMR) proteins, phosphatase and tensin homolog (PTEN), as well as the Epstein–Barr virus (EBV) status, have yet to be uncovered.MethodsWe constructed tissue microarrays of 94 CRAs, 72 conventional-type differentiated adenocarcinomas (CDAs), and 71 intramucosal poorl...
Source: Gastric Cancer - October 12, 2016 Category: Gastroenterology Source Type: research

Usefulness of preoperative estimated glomerular filtration rate to predict complications after curative gastrectomy in patients with clinical T2 –4 gastric cancer
AbstractBackgroundGastrectomy with systemic lymphadenectomy is the standard of care for resectable gastric cancer (GC), but it is sometimes associated with postoperative morbidity. Predicting complications is therefore an essential part of risk management in clinical practice. The renal function is routinely evaluated before surgery by blood examinations to determine dose of medication and infusion. However, the value of various parameters of renal function in prediction of postoperative complications remain unclear.MethodsWe included 315 patients who underwent curative D2 gastrectomy for clinical T2 –T4 GC without p...
Source: Gastric Cancer - October 12, 2016 Category: Gastroenterology Source Type: research

Past and current trends in endoscopic diagnosis for early stage gastric cancer in Japan
AbstractMethodology for the diagnosis and staging of early gastric cancer (EGC) has improved in Japan since the development of the gastro-camera and determination of a definition of EGC. Imaging technology has been steadily evolving in the endoscopy field. Improvements in the resolution of standard endoscopy images used in screening and surveillance provide greater opportunities to find gastric cancer earlier. Image enhancement endoscopy (IEE), such as narrow band imaging (NBI), highlights mucosal structures and vascularity. In particular, when NBI is used with magnifying endoscopy, it reveals fine details of subtle superf...
Source: Gastric Cancer - October 12, 2016 Category: Gastroenterology Source Type: research

Clinical outcomes of early gastric cancer patients after noncurative endoscopic submucosal dissection in a large consecutive patient series
ConclusionsAdditional gastrectomy should be performed particularly in noncurative gastric ESD patients with lymphovascular invasion or a positive vertical margin with submucosal invasion. (Source: Gastric Cancer)
Source: Gastric Cancer - October 8, 2016 Category: Gastroenterology Source Type: research

A Bayesian network meta-analysis on second-line systemic therapy in advanced gastric cancer
ConclusionsThis is the first network meta-analysis to compare all second-line regimens reported in phase III gastric cancer trials. The results suggest the paclitaxel plus ramucirumab combination is the most effective therapy and should be the reference regimen for future comparative trials. (Source: Gastric Cancer)
Source: Gastric Cancer - October 8, 2016 Category: Gastroenterology Source Type: research

Short-term surgical outcomes from a phase III study of laparoscopy-assisted versus open distal gastrectomy with nodal dissection for clinical stage IA/IB gastric cancer: Japan Clinical Oncology Group Study JCOG0912
This study is now in the follow-up stage. The primary endpoint is relapse-free survival (RFS) and the primary analysis is planned in 2018. Here, we compared the surgical outcomes of the two groups. This trial was registered at the UMIN Clinical Trials Registry as UMIN000003319.ResultsBetween March 2010 and November 2013, 921 patients (LADG 462, ODG 459) were enrolled from 33 institutions. Operative time was longer in LADG than in ODG (median 278 vs. 194  min,p 
Source: Gastric Cancer - October 7, 2016 Category: Gastroenterology Source Type: research

Global chemotherapy development for gastric cancer
AbstractTo combat the dismal mortality rates from metastatic gastric adenocarcinoma (GAC), new drugs and treatment strategies are needed. Today, metastatic GAC is predominantly treated by empiric chemotherapy. Combination of two cytotoxic agents has become commonplace in North America, Europe, and Asia. Human epidermal growth factor  2 (HER2) overexpression (protein or gene copy numbers) has resulted in the addition of trastuzumab in the first-line chemotherapy combination in patients whose tumor is HER2 positive. The addition of trastuzumab in this select population has provided a modest survival advantage. In this r...
Source: Gastric Cancer - October 7, 2016 Category: Gastroenterology Source Type: research