Chemotherapy treatment patterns, costs, and outcomes of patients with gastric cancer in the United States: a retrospective analysis of electronic medical record (EMR) and administrative claims data
Conclusions Costs and duration of care received vary among gastric cancer patients in the U.S. There is a need to understand which regimens may be associated with better health outcomes and to standardize treatment as appropriate. (Source: Gastric Cancer)
Source: Gastric Cancer - March 19, 2015 Category: Gastroenterology Source Type: research

An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence
Abstract The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature a...
Source: Gastric Cancer - March 17, 2015 Category: Gastroenterology Source Type: research

Second primary malignancy risk among patients with gastric cancer: a nationwide population-based study in Taiwan
Conclusions Patients with gastric cancer are at increased risk of developing SPM. Close surveillance of patients with risk factors over a longer period should be considered. (Source: Gastric Cancer)
Source: Gastric Cancer - March 13, 2015 Category: Gastroenterology Source Type: research

Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance
Conclusions Our study implies that detection of Bmi-1 and RKIP is valuable in predicting patient survival and therapeutic response in gastric cancer, and the inverse association between Bmi-1 and RKIP reveals the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance. (Source: Gastric Cancer)
Source: Gastric Cancer - March 12, 2015 Category: Gastroenterology Source Type: research

The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors
Conclusions These results suggest that differences in background factors are unable to fully explain the survival difference of GC patients between UK and Japan. Comprehensive studies into the biology of GC and/or host factors are needed to fully understand the survival difference. (Source: Gastric Cancer)
Source: Gastric Cancer - March 12, 2015 Category: Gastroenterology Source Type: research

Clinicopathological features of gastric cancer in young patients
Conclusion Early-onset gastric cancer is likely to present lymph node metastases. The survival rate of gastric cancer in young patients was equivalent to that in patients in their 60s, which is the typical age at onset. (Source: Gastric Cancer)
Source: Gastric Cancer - March 10, 2015 Category: Gastroenterology Source Type: research

Endoscopic and histological features of gastric cancers after successful Helicobacter pylori eradication therapy
Abstract Background Gastric cancer after successful Helicobacter pylori eradication therapy is often difficult to diagnose by endoscopy because of its indistinct borderline or lack of obviously cancerous characteristics. Furthermore, it has become evident that non-neoplastic epithelium covers cancerous areas in gastric cancer after eradication. Here, we investigated these endoscopic features and their relationship to histological findings. Methods We studied 24 and 47 gastric cancers in patients who had (eradication group) and had not (control group)...
Source: Gastric Cancer - March 10, 2015 Category: Gastroenterology Source Type: research

Gastrokine 1 inhibits gastrin-induced cell proliferation
Conclusion These data suggest that GKN1 may contribute to the maintenance of gastric epithelial homeostasis and inhibit gastric carcinogenesis by downregulating the gastrin-CCKBR signaling pathway. (Source: Gastric Cancer)
Source: Gastric Cancer - March 10, 2015 Category: Gastroenterology Source Type: research

Weight loss at the first month of palliative chemotherapy predicts survival outcomes in patients with advanced gastric cancer
In this study, we evaluated whether weight loss during the first month of chemotherapy could predict survival outcomes in patients with AGC. Methods We analyzed 719 patients with metastatic or recurrent AGC who were receiving palliative chemotherapy. We calculated the initial body mass index (BMIi), percent weight loss after 1 month of chemotherapy (ΔW 1m), percent weight loss after last administration of chemotherapy (ΔW end), and average weight loss per month during chemotherapy (ΔW/m). We correlated these data with overall survival (OS)...
Source: Gastric Cancer - March 8, 2015 Category: Gastroenterology Source Type: research

Accuracy of diagnostic demarcation of undifferentiated-type early gastric cancers for magnifying endoscopy with narrow-band imaging: endoscopic submucosal dissection cases
Abstract Background The usefulness of magnifying endoscopy with narrow-band imaging (ME-NBI) for undifferentiated-type early gastric cancers (UD-type EGCs) is unclear. The present study examined the accuracy of the diagnostic demarcation of lesions using ME-NBI. Methods The study population consisted of 76 patients with UD-type EGC lesions measuring ≤20 mm in diameter using white-light imaging (WLI) and endoscopic ultrasonography and diagnosed as intramucosa and UL(−); all the lesions were confirmed as early gastric cancer based on postoper...
Source: Gastric Cancer - March 5, 2015 Category: Gastroenterology Source Type: research

Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPβ-associated mechanism
Abstract Background Polymorphisms in inflammation-related genes have been associated with a risk of gastric carcinoma (GC). However, the biological mechanisms underlying these associations are still elusive. Our objective was to determine whether chronic inflammation-associated IL1Β signalling, as seen in the context of Helicobacter pylori infection, could be linked to gastric carcinogenesis by modulating the behaviour of gastric epithelial cells. Methods The effect of IL1B was assessed by studying the expression and activation status of the IL1&Bet...
Source: Gastric Cancer - March 5, 2015 Category: Gastroenterology Source Type: research

Learning curve for gastric cancer surgery based on actual survival
Conclusion As a surgeon’s experience increases, survival after gastric cancer surgery improves. Special attention needs to be paid to the second period of surgeon experience because survival of patients in this period was the lowest. (Source: Gastric Cancer)
Source: Gastric Cancer - February 25, 2015 Category: Gastroenterology Source Type: research

TSPAN8 , identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer
Conclusion These results suggest that tetraspanin 8 is involved in tumor progression and is an independent prognostic classifier in patients with GC. (Source: Gastric Cancer)
Source: Gastric Cancer - February 25, 2015 Category: Gastroenterology Source Type: research

Skip lymph node metastasis in gastric cancer: is it skipping or skipped?
Abstract Background Skip metastasis is the presence of a metastatic lymph node (LN) in an extraperigastric (EP) area without perigastric (PG) involvement. The mechanism and prognosis of skip metastasis are still unknown. The purpose of this study was to scrutinize the clinical significance of skip metastasis in gastric cancer. Methods Data were reviewed from 6,025 patients who had undergone gastrectomy for primary gastric cancer. Patients were categorized as a PG-only group when the metastatic LNs were limited to only the PG area, as a PG + EP ...
Source: Gastric Cancer - February 24, 2015 Category: Gastroenterology Source Type: research

Nishi Memorial Award in Gastric Cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - February 17, 2015 Category: Gastroenterology Source Type: research

Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients
Conclusions The study suggested that c-MET-positive status had poor prognostic value. These data could be used as the basis for future clinical trials for targeting agents for advanced gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - February 15, 2015 Category: Gastroenterology Source Type: research

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer
Conclusions A DNA methylation marker—namely, the panel of the three genes—is useful to estimate the cancer cell fraction in GCs. (Source: Gastric Cancer)
Source: Gastric Cancer - February 13, 2015 Category: Gastroenterology Source Type: research

A systematic review of laparoscopic total gastrectomy for gastric cancer
Conclusions During LTG, the method used for esophagojejunostomy is important for surgical reliability and to reduce postoperative complications. There has been rapid development of new techniques from the level of esophagojejunostomy through a small skin incision to the high level of intracorporeal esophagojejunostomy using various techniques. A nationwide prospective phase II study is urgently needed to establish the value of LTG. (Source: Gastric Cancer)
Source: Gastric Cancer - February 11, 2015 Category: Gastroenterology Source Type: research

Erratum to: Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?
(Source: Gastric Cancer)
Source: Gastric Cancer - February 11, 2015 Category: Gastroenterology Source Type: research

The new modified ABCD method for gastric neoplasm screening
Abstract Background The ABCD screening method was developed for risk stratification of gastric cancer. It is unclear whether the ABCD method can predict the risk of gastric neoplasms, including gastric adenomas, as observed for gastric cancer. We aimed to devise a modified ABCD method for predicting gastric neoplasms. Methods We reviewed 562 patients who had undergone upper gastrointestinal tract endoscopy and whose serum IgG anti-Helicobacter pylori antibody, gastrin, and pepsinogen (PG) I and PG II data were available. Patients were classifie...
Source: Gastric Cancer - February 7, 2015 Category: Gastroenterology Source Type: research

Incidence of lymphatic involvement in differentiated-type intramucosal gastric cancers as examined by endoscopic resection
Conclusions We determined that the incidence of lymphatic involvement in differentiated-type intramucosal cancer was 2.0 %. To clarify the clinical significance of such lymphatic involvement, it is necessary to detect it with this incidence in mind and to gather and follow up the clinical courses of such cases. (Source: Gastric Cancer)
Source: Gastric Cancer - February 1, 2015 Category: Gastroenterology Source Type: research

Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study
In this study we analyzed 313 PPG patients and 909 DGBI patients. Results Body weight loss was −6.9 % in the PPG group and −7.9 % in the DGBI group (P = 0.052). The PPG group scored better on the diarrhea subscale (PPG; 1.8 vs. DGBI; 2.1, P 
Source: Gastric Cancer - January 31, 2015 Category: Gastroenterology Source Type: research

Long-term quality of life after surgery for adenocarcinoma of the esophagogastric junction: extended gastrectomy or transthoracic esophagectomy?
Conclusions After mid- and long-term follow-up, HRQL after extended gastrectomy with Roux-en-Y reconstruction is superior to that after esophagectomy and gastric tube reconstruction. Improved HRQL after gastrectomy is mainly due to less pulmonary and reflux-related symptoms. Our findings may influence the choice of the surgical strategy for patients with AEG. (Source: Gastric Cancer)
Source: Gastric Cancer - January 28, 2015 Category: Gastroenterology Source Type: research

Pituitary tumor-transforming gene-1 serves as an independent prognostic biomarker for gastric cancer
We examined PTTG1 mRNA and protein expression in gastric cancer (GC) cell lines and tissues to determine its value as a biomarker for GC diagnosis and therapy. Methods PTTG1 mRNA expression from 78 GC cases and paired adjacent normal mucosa (PCR cohort) as well as from five gastric cell lines was assessed using qRT-PCR. Nuclear and cytoplasmic RNA were extracted from two gastric cell lines to determine PTTG1 mRNA localization. PTTG1 protein expression from 98 GC cases, their paired adjacent normal mucosa, and 23 gastric intraepithelial neoplasia (GIN) cases was examined using immunoh...
Source: Gastric Cancer - January 28, 2015 Category: Gastroenterology Source Type: research

Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer
Conclusions Our results revealed that copy number gains in MYC and TNFRSF11B located at 8q24 are associated with survival in GC, particularly noncardia GC. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2015 Category: Gastroenterology Source Type: research

High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection
Conclusions Based on the high rate of 5-year survival among EGC patients undergoing curative ESD for absolute indications or for expanded indications in the largest patient series with a median follow-up period of over 5 years, ESD could be employed as a standard treatment for EGC lesions. (Source: Gastric Cancer)
Source: Gastric Cancer - January 24, 2015 Category: Gastroenterology Source Type: research

Preoperative locoregional staging of gastric cancer: is there a place for magnetic resonance imaging? Prospective comparison with EUS and multidetector computed tomography
Conclusions Our prospective study confirmed the leading role of EUS and MDCT in the staging of gastric cancer and did not prove, at present, the value of the clinical use of MRI. (Source: Gastric Cancer)
Source: Gastric Cancer - January 23, 2015 Category: Gastroenterology Source Type: research

Risk factors for selection of patients at high risk of recurrence or death after complete surgical resection in stage I gastric cancer
Abstract Background The therapeutic benefit of adjuvant chemotherapy has not been proven in stage I gastric cancer (GC). The aim of this study was to identify stage I GC patients at high risk of recurrence or death. Methods We retrospectively reviewed the medical records of 2,783 patients with pathologically confirmed stage I GC who underwent curative surgical resection alone at Asan Medical Center between 2003 and 2007. The clinicopathologic parameters explored included age, sex, histologic differentiation, Lauren classification, size, location, multipl...
Source: Gastric Cancer - January 23, 2015 Category: Gastroenterology Source Type: research

Methylation status of long interspersed element-1 in advanced gastric cancer and its prognostic implication
Conclusion Our findings indicate that the discrepancy in the methylation level of L1 between fresh tissue and formalin-fixed paraffin-embedded tissue samples depends on the CpG sites considered, and that the methylation status of L1 at CpG sites 1 and 4 combined could be utilized as a prognostic parameter for advanced gastric cancers. (Source: Gastric Cancer)
Source: Gastric Cancer - January 22, 2015 Category: Gastroenterology Source Type: research

Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis
Abstract Background The effect of Helicobacter pylori (H. pylori) eradication on gastric cancer (GC) prevention is controversial. Intestinal metaplasia (IM) seems to be a “point of no return” in the precancerous cascade. We performed a meta-analysis of randomized controlled trials (RCTs) to illustrate this issue. Materials and Methods The MEDLINE, EMBASE, Cochrane Library were searched for relevant RCTs that were published in any language up to March 2014. By dividing participants into subgroups based on their baseline diagnoses as group
Source: Gastric Cancer - January 22, 2015 Category: Gastroenterology Source Type: research

A phase II trial of concurrent 3D-CRT/IMRT and oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) in gastric cancer patients with R0 gastrectomy and D2 lymph node dissection
Conclusions Adjuvant 3D-CRT/IMRT to a dose of 50.4 Gy/28f with concurrent FOLFOX is safe and effective in patients following radical gastrectomy with D2 lymph node dissection. (Source: Gastric Cancer)
Source: Gastric Cancer - January 22, 2015 Category: Gastroenterology Source Type: research

Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer
Abstract Background The V325 study showed that docetaxel, cisplatin, and fluorouracil (DCF) prolonged overall survival (OS) of patients with advanced gastric cancer, but with a high incidence of dose-limiting toxicities. We investigated the efficacy and safety of a modified DCF (mDCF) regimen for Chinese patients with advanced gastric cancer. Methods Untreated advanced gastric cancer patients randomly received docetaxel and cisplatin at 60 mg/m2 (day 1) followed by fluorouracil at 600 mg/m2/day (days 1–5; mDCF regimen) or cisplatin at 75&...
Source: Gastric Cancer - January 21, 2015 Category: Gastroenterology Source Type: research

Predicting the survival probability of gastric cancer patients developing metastatic epidural spinal cord compression (MESCC)
Abstract To create a tool for estimating the survival of gastric cancer patients developing MESCC, clinical factors were evaluated in 29 patients. Factors were age, gender, performance status, affected vertebrae, ambulatory status, further bone metastases, visceral metastases, time from gastric cancer diagnosis until MESCC and rapidity of developing weakness of legs. On multivariate analyses, visceral metastases (risk ratio: 6.80; p = 0.003) and rapidity of weakening of legs (risk ratio: 2.73; p = 0.023) had a significant effect on survival and were included in the tool. Scoring points for each...
Source: Gastric Cancer - January 15, 2015 Category: Gastroenterology Source Type: research

Adverse prognostic impact of perioperative allogeneic transfusion on patients with stage II/III gastric cancer
Conclusions BTF was an independent prognostic factor in patients with stage II/III GC after curative gastrectomy. To improve prognosis, BTF should be avoided when possible, particularly during surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - January 7, 2015 Category: Gastroenterology Source Type: research

C-reactive protein on postoperative day 3 as a predictor of infectious complications following gastric cancer resection
Conclusions Elevated CRP levels on POD 3 will help physicians predict the postoperative course and facilitate decision-making regarding prompt, comprehensive clinical searches and therapeutic approaches for PICs. (Source: Gastric Cancer)
Source: Gastric Cancer - January 6, 2015 Category: Gastroenterology Source Type: research

Obesity and related risk factors in gastric cardia adenocarcinoma
Abstract Over recent decades, the incidence of cancers of the gastroesophageal junction, including gastric cardia tumors, has increased markedly. This is a trend that has been well documented, especially in studies from the USA and northern Europe that have also demonstrated a concomitant rise in the ratio of cardia to distal gastric cancers. The rise in the prevalence of gastric cardia adenocarcinoma has been paralleled by the worldwide obesity epidemic, with almost all epidemiological studies reporting increased body mass index and obesity increase the risk of cardia cancer development. However, the strength of...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Trends in the management of gastric cancer over a 32-year period: a French population-based study
Abstract Background Gastric cancer is still generating interest because of its poor prognosis. The aim of this study was to investigate time trends in diagnostic assessment, patterns of care, and survival of gastric cancers. Methods We considered 5,010 gastric cancers diagnosed between 1976 and 2007 in a well-defined French population. Logistic regressions were used to identify factors associated with R0 resection and operative mortality. A multivariate relative survival analysis was performed. Results D...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

A systematic review and meta-analysis of gastric cancer treatment in patients with positive peritoneal cytology
Abstract Gastric cancer patients with positive peritoneal cytology as the only marker of metastatic disease have poor prognoses. There is no universal consensus on the most appropriate treatment regimen for this particular patient group. We reviewed and analyzed published data to determine the optimal treatment regimen for patients with peritoneal cytology-positive gastric adenocarcinomas. Six electronic databases were explored [PubMed, Cochrane (Systematic Reviews and Controlled Trials), PROSPERO, DARE, and EMBASE]. The primary outcome was overall survival with secondary outcomes including patterns of recurrence...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients
Conclusion PGSAS-45 provides a valid and reliable integrated index for evaluation of symptoms, living status, and QOL in gastrectomized patients. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Adjuvant or neoadjuvant therapy for operable esophagogastric cancer?
Abstract Esophagogastric cancer encompasses proximal squamous cell carcinoma of the esophagus, distal esophageal/junctional adenocarcinoma of the esophagus and gastric adenocarcinoma. These diseases have different etiologies, geographic incidences and biologies. This review mainly focuses on the treatment of operable esophagogastric adenocarcinoma. In Asia, adjuvant chemotherapy is commonly used for patients with gastric cancer following the landmark ACTS-GC trial. In contrast, perioperative chemotherapy is a standard of care in many Western countries based on the results of the MAGIC trial. Neoadjuvant chemother...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Totally laparoscopic pylorus-preserving gastrectomy for early gastric cancer in the middle stomach: technical report and surgical outcomes
Conclusion TLPPG with an intracorporeal delta-shaped anastomosis was found to be a safe procedure, although it tended to require a longer operating time than the well-established LAPPG with a hand-sewn gastrogastrostomy. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

A case of local recurrence and distant metastasis following curative endoscopic submucosal dissection of early gastric cancer
Abstract Currently in Japan, differentiated-type gastric submucosal invasive cancers
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Is a clear benefit in survival enough to modify patient access to the surgery service? A retrospective analysis in a cohort of gastric cancer patients
Conclusions A positive association between hospital volume and survival was evident for long-term outcome after adjusting for patient and tumor confounding. Moreover, the patient’s choice of hospital was not guided by specific care pathways or screening programs, and prognosis was not poorer for patients in high-volume hospitals. These findings suggest that there is leeway for improving access to surgery for gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Micropapillary component in gastric adenocarcinoma: an aggressive variant associated with poor prognosis
Conclusion Gastric adenocarcinomas with MPC appear to be an aggressive variant associated with a poor prognosis. MPCs occurring in gastric adenocarcinomas should be included in surgical pathology reports, even if the proportion of MPC in the lesions is very low in the lesion. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Laparoscopic completion total gastrectomy for remnant gastric cancer: a single-institution experience
Abstract Background The aim of the present study was to evaluate the feasibility of laparoscopic completion total gastrectomy (LCTG) in patients with remnant gastric cancer. Methods Patients who underwent completion total gastrectomy for remnant gastric cancer between May 2003 and December 2012 were divided into two groups: an open completion total gastrectomy (OCTG) group and an LCTG group. Clinicopathological data, operative data, and patient survival rates were analyzed. Results Thirty-four remnant ga...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Preliminary study of surgical audit for overall survival following gastric cancer resection
Conclusions The current study suggests the possibility of surgical audit for postoperative OS in gastric cancer. Further studies including high-volume centers will be necessary to validate this idea. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Clinical significance of RacGAP1 expression at the invasive front of gastric cancer
Abstract Background Rac GTPase activating protein 1 (RacGAP1) plays a regulatory role in cell growth, transformation and metastasis. The aim of this study was to clarify the association between RacGAP1 expression and clinical outcome in patients with gastric cancer. Methods A total of 232 gastric cancer patients in our institute who underwent surgery without preoperative treatments were enrolled in this study. We investigated RacGAP1 expression using immunohistochemistry (IHC) and evaluated IHC scores calculated by the percentage of positive cells...
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

In vivo optical pathology of paclitaxel efficacy on the peritoneal metastatic xenograft model of gastric cancer using two-photon laser scanning microscopy
Conclusions Our method may become a powerful tool for evaluating the efficacy of novel anti-gastric cancer drugs in a preclinical murine model with minimum interindividual variation. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Gastric carcinoma: stage migration by immunohistochemically detected lymph node micrometastases
Conclusion Immunohistostaining of regional lymph nodes in node-negative gastric carcinoma patients leads to an increased detection of micrometastases with significant implications for the staging system. Although no impact on survival time was shown, the higher recurrence rate for node-positive patients younger than 70 years indicates a prognostic value of immunohistochemically detectable micrometastases. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee
Conclusions G-factor based on the expression of p53 and MMP-7 was found to be a promising factor to predict outcome of Stage II/III gastric cancer, and possibly to help select the treatment for Stage II cancer, thus supplementing the conventional TNM system. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research