Introducing laparoscopic total gastrectomy for gastric cancer in general practice: a retrospective cohort study based on a nationwide registry database in Japan
AbstractBackground Although laparoscopic total gastrectomy (LTG) is considered a technically demanding procedure with safety issues, it has been performed in several hospitals in Japan. Data from a nationwide web-based data entry system for surgical procedures (NCD) that started enrollment in 2011 are now available for analysis.MethodsA retrospective cohort study was conducted using data from 32,144 patients who underwent total gastrectomy and were registered in the NCD database between January 2012 and December 2013. Mortality and morbidities were compared between patients who received LTG and those who underwent open t...
Source: Gastric Cancer - February 9, 2018 Category: Gastroenterology Source Type: research

Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer –GIRCG)
AbstractBackgroundThe aim of this study is to compare surgical outcomes including postoperative complications and prognosis between total gastrectomy (TG) and proximal gastrectomy (PG) for proximal gastric cancer (GC). Propensity-score-matching analysis was performed to overcome patient selection bias between the two surgical techniques.MethodsAmong 457 patients who were diagnosed with GC between January 1990 and December 2010 from four Italian institutions, 91 underwent PG and 366 underwent TG. Clinicopathologic features, postoperative complications, and survivals were reviewed and compared between these two groups retros...
Source: Gastric Cancer - February 8, 2018 Category: Gastroenterology Source Type: research

HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells
ConclusionsThese results uncovered the novel interaction between HOTAIR and Runx3, and provided potential therapeutic targets on the metastasis of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - February 7, 2018 Category: Gastroenterology Source Type: research

Ramucirumab for the treatment of patients with gastric or gastroesophageal junction cancer in community oncology practices
This study was designed to describe ramucirumab monotherapy or combination therapy use in a community oncology practice setting.MethodsThis was a retrospective observational cohort study to describe the treatment of adult patients with gastric or GEJ cancer who initiated ramucirumab treatment between 4/21/14 and 6/30/16 within the US Oncology Network. Kaplan –Meier method and Cox proportional hazards regression analyses were used to assess clinical outcomes. Multivariable logistic regression models were used to assess patient-level predictors of ramucirumab monotherapy or combination therapy.ResultsA total of 505 pat...
Source: Gastric Cancer - February 3, 2018 Category: Gastroenterology Source Type: research

Predictors of heterogeneity in the first-line treatment of patients with advanced/metastatic gastric cancer in the U.S.
This study was designed to describe the treatment patterns of patients with gastric cancer and to understand the factors associated with treatment choices to inform evidence-based care.MethodsA retrospective observational study was conducted using two real-world databases to describe treatment trends and to quantify variability in treatment patterns of patients diagnosed with advanced/metastatic gastric cancer between 1/1/2007 and 9/30/2014 in the U.S. Heterogeneity was measured by the Herfindahl –Hirschman Index (HHI). Predictors (baseline clinical, treatment, and demographic variables) of treatment regimen choice w...
Source: Gastric Cancer - February 1, 2018 Category: Gastroenterology Source Type: research

Which method is more suitable for advanced gastric cancer with enlarged lymph nodes, laparoscopic radical gastrectomy or open gastrectomy?
ConclusionsFor advanced gastric cancer with an ESLN diameter from 1.0 to 1.9  cm, LG could be chosen preferentially; nevertheless, LG is not safe if ESLN are >  2.5 cm. (Source: Gastric Cancer)
Source: Gastric Cancer - January 30, 2018 Category: Gastroenterology Source Type: research

Reporting of health-related quality of life in randomized controlled trials involving palliative systemic therapy for esophagogastric cancer: a systematic review
ConclusionsHRQoL reporting in RCTs concerning palliative systemic therapy for advanced esophagogastric cancer is limited and has not improved over time. This systematic review provides specific recommendations for authors to improve HRQoL reporting: formulate hypotheses a priori, clearly describe instrument administration, and handle missing data and interpret findings appropriately. (Source: Gastric Cancer)
Source: Gastric Cancer - January 29, 2018 Category: Gastroenterology Source Type: research

Preliminary opinion on assessment categories of stomach ultrasound report and data system (Su-RADS)
ConclusionThe Su-RADS system could inform the physicians about key findings, indicating the risk for malignancy and necessity of additional gastroscopy examination. Prospectively randomly controlled study design with larger clinical trial is needed for further investigations. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2018 Category: Gastroenterology Source Type: research

Phase II study of oxaliplatin, irinotecan and S-1 therapy in patients with advanced gastric cancer: the Korean Cancer Study Group ST14-11
ConclusionThese data suggest that the OIS regimen is effective and relatively well tolerated in patients with advanced gastric cancer. Given that all the patients treated, but one, had a good performance status, these results must be confirmed in a patient population more representative of regular clinical practice.Trial RegistrationClinicalTrials.gov Identifier: NCT02527785. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2018 Category: Gastroenterology Source Type: research

Validation of the prognostic impact of the new tumor-node-metastasis clinical staging in patients with gastric cancer
This study validated the prognostic value of cStage in the 8th edition of the TNM classification and the significance of N classification for pretreatment staging in gastric cancer.MethodsA total of 4374 patients with primary gastric cancer who underwent surgery at the Shizuoka Cancer Center were included. Survival analysis was conducted based on the newly proposed cStage criteria of the TNM 8th edition. Prognostic accuracy was evaluated using Harrell ’s concordance index (C-index).ResultsThe five-year survival rates according to cStage were as follows: cStageI, 91.2%, cStageIIA: 75.1%, cStageIIB: 57.7%, cStageIII: 4...
Source: Gastric Cancer - January 22, 2018 Category: Gastroenterology Source Type: research

Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents
ConclusionsThe covering method using PGA sheets and fibrin glue has the potential to reduce post-ESD bleeding in patients receiving continued antithrombotic agents. (Source: Gastric Cancer)
Source: Gastric Cancer - January 22, 2018 Category: Gastroenterology Source Type: research

First-line chemotherapy with S-1 alone or S-1 plus cisplatin for elderly patients with advanced gastric cancer: a multicenter propensity score matched study
AbstractBackgroundFluoropyrimidine and platinum combination is the standard treatment for advanced or recurrent gastric cancer (AGC). However, fluoropyrimidine monotherapy is commonly used for elderly patients with AGC because of its good tolerability.MethodsIn this multicenter retrospective study, we collected clinical data of AGC patients aged 70  years or older, treated with S-1 alone or S-1 plus cisplatin (SP) as the first-line treatment between January 2009 and December 2011. Propensity score matched cohorts (PSMC) were used for reducing the confounding effects to compare efficacy and safety between the two treat...
Source: Gastric Cancer - January 20, 2018 Category: Gastroenterology Source Type: research

Application of artificial intelligence using a convolutional neural network for detecting gastric cancer in endoscopic images
ConclusionThe constructed CNN system for detecting gastric cancer could process numerous stored endoscopic images in a very short time with a clinically relevant diagnostic ability. It may be well applicable to daily clinical practice to reduce the burden of endoscopists. (Source: Gastric Cancer)
Source: Gastric Cancer - January 15, 2018 Category: Gastroenterology Source Type: research

Higher risk of gastric cancer among immigrants to Ontario: a population-based matched cohort study with over 2 million individuals
ConclusionThe risk of GC among immigrants is elevated. Although high-risk immigrant populations in Ontario have been identified, further knowledge is required before a program of GC prevention that is targeted to them can be planned. (Source: Gastric Cancer)
Source: Gastric Cancer - December 28, 2017 Category: Gastroenterology Source Type: research

Lymphovascular invasion and lymph node metastasis rates in papillary adenocarcinoma of the stomach: implications for endoscopic resection
ConclusionsEndoscopic resection can be indicated for papillary EGC according to current guidelines. Given a considerable lymphovascular invasion rate, careful histological evaluation is required after endoscopic resection for papillary EGC. (Source: Gastric Cancer)
Source: Gastric Cancer - December 26, 2017 Category: Gastroenterology Source Type: research

Safety, pharmacokinetic, and clinical activity profiles of ramucirumab in combination with three platinum/fluoropyrimidine doublets in Japanese patients with chemotherapy-na ïve metastatic gastric/gastroesophageal junction cancer
ConclusionRamucirumab 8  mg/kg on days 1 and 8 every 3 weeks in combination with XP, SP, or SOX was generally well tolerated and demonstrated preliminary anti-tumor activity in chemotherapy-naïve Japanese metastatic gastric/gastroesophageal junction cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - December 22, 2017 Category: Gastroenterology Source Type: research

Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion
ConclusionsThese findings demonstrated that kallistatin functions as an endogenous lymphangiogenesis inhibitor and has an important part in the lymphatic metastasis of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - December 14, 2017 Category: Gastroenterology Source Type: research

Indication for endoscopic treatment based on the risk of lymph node metastasis in patients with Siewert type II/III early gastric cancer
ConclusionsTumor size and LVI were associated with LNM in patients with early Siewert type II/III gastric cancer, and the expanded indication for endoscopic resection may be used. (Source: Gastric Cancer)
Source: Gastric Cancer - December 14, 2017 Category: Gastroenterology Source Type: research

Establishment of pathological quantitative method for determining undifferentiated component ratio in patients with differentiated/undifferentiated mixed-type early gastric cancer and clinical significance of this ratio
AbstractPurposesThe purpose of this study was to establish a pathological quantitative method for determining the undifferentiated components ratio (UCR) in patients with differentiated/undifferentiated mixed-type (Mixed-type) early gastric cancer (EGC) and to examine the clinical significance.MethodsThe subjects were 410 patients who underwent surgical resection for EGC with the invasion limited to m or sm1. Analysis 1: In 12 randomly selected patients with Mixed-type cancer, we calculated the area ratio and the ratio of the length ratio using ImageJ and analyzed the correlation between them. Analysis 2: We generated ROC ...
Source: Gastric Cancer - December 13, 2017 Category: Gastroenterology Source Type: research

Mixed poorly differentiated adenocarcinoma in undifferentiated-type early gastric cancer predicts endoscopic noncurative resection
ConclusionAdvanced age and mixed poorly differentiated adenocarcinoma predicted endoscopic noncurative resection. (Source: Gastric Cancer)
Source: Gastric Cancer - December 13, 2017 Category: Gastroenterology Source Type: research

Correction to: Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC ‑06)
The correct name of the twelfth author should be ‘‘Yasuhiro Yuasa”, and not ‘‘Yasuhiko Yuasa’’ as given in the original publication of the article. (Source: Gastric Cancer)
Source: Gastric Cancer - December 12, 2017 Category: Gastroenterology Source Type: research

The impact of advanced age on short-term outcomes following gastric cancer resection: an ACS-NSQIP analysis
ConclusionsAdvanced age, defined as more than 75 years, was independently associated with increased morbidity after GC resection. The magnitude of this impact is further modulated by clinical scenarios. Increased risk in elderly GC patient should be recognized and considered in indications for resection. (Source: Gastric Cancer)
Source: Gastric Cancer - December 11, 2017 Category: Gastroenterology Source Type: research

Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study
ConclusionsThis is the first prospective study demonstrating a higher risk of gastric cancer to be associated with either extremely short or extremely long telomere length. Short and long telomere length may function differently in the early and late stages of gastric carcinogenesis. (Source: Gastric Cancer)
Source: Gastric Cancer - December 7, 2017 Category: Gastroenterology Source Type: research

DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression
ConclusionsDEC1 acts as an anti-apoptotic regulator in GC cells under hypoxia by promoting Survivin expression. Our study demonstrates the critical role of the DEC1 in oncogenesis and highlights a novel role for DEC1 in the regulation of cell apoptosis in GC. (Source: Gastric Cancer)
Source: Gastric Cancer - December 4, 2017 Category: Gastroenterology Source Type: research

Prophylactic effect of neoadjuvant chemotherapy in gastric cancer patients with postoperative complications
ConclusionOur study is the first to demonstrate the potential of NAC to abolish the poor prognosis induced by postoperative complications after curative resection for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - November 29, 2017 Category: Gastroenterology Source Type: research

Clinical and biological significance of a − 73A  & gt;  C variation in the CDH1 promoter of patients with sporadic gastric carcinoma
ConclusionThe − 73A >  C variation may lead to differences in the overall survival of SGC patients and allele-specific repressions ofCDH1. (Source: Gastric Cancer)
Source: Gastric Cancer - November 22, 2017 Category: Gastroenterology Source Type: research

The 8th edition of the American Joint Committee on Cancer tumor-node-metastasis staging system for gastric cancer is superior to the 7th edition: results from a Chinese mono-institutional study of 1663 patients
AbstractBackgroundWe investigated the superiority of the 8th edition of the tumor-node-metastasis (TNM) system for patients in China with gastric cancer.MethodsThe survival outcomes of 1663 patients with gastric cancer undergoing radical resection were analyzed.ResultsIn the 8th edition system, homogeneous 5-year survival rates among different pathological TNM (pTNM) categories belonging to the same stage were observed. However, in the 7th edition system, the differences of 5-year survival rate among pTNM categories belonging to the same stage were observed in stages IIB (P = 0.010), IIIB (P = 0.004), and IIIC (P 
Source: Gastric Cancer - November 22, 2017 Category: Gastroenterology Source Type: research

Risk of osteoporosis after gastrectomy in long-term gastric cancer survivors
AbstractIntroductionAlthough early detection and successful gastrectomy have improved the survival of patients with gastric cancer, long-term health problems remain troubling. We evaluated the prevalence of osteoporosis and its risk factors in long-term survivors of gastric cancer after gastrectomy.MethodsWe reviewed the medical records of a tertiary hospital between 2007 and 2014 to identify survivors of gastric cancer who had visited our center at around 5  years after gastrectomy. We evaluated their health status, including bone mineral density (BMD). Dual-energy X-ray absorptiometry was used to measure the BMD of ...
Source: Gastric Cancer - November 21, 2017 Category: Gastroenterology Source Type: research

High adherence to the Western, Prudent, and Mediterranean dietary patterns and risk of gastric adenocarcinoma: MCC-Spain study
ConclusionDecreasing the consumption of fatty and sugary products and of red and processed meat in favor of an increase in the intake of fruits, vegetables, legumes, olive oil, nuts, and fish might prevent gastric adenocarcinoma. (Source: Gastric Cancer)
Source: Gastric Cancer - November 14, 2017 Category: Gastroenterology Source Type: research

Preservation of the celiac branch of the vagal nerve for pylorus-preserving gastrectomy: is it meaningful?
ConclusionsPreserving CBVN in LPPG for early gastric cancer is a feasible procedure. However, no clinical benefits of the preservation of the CBVN after LPPG are identified. (Source: Gastric Cancer)
Source: Gastric Cancer - November 10, 2017 Category: Gastroenterology Source Type: research

Priority of lymph node dissection for proximal gastric cancer invading the greater curvature
ConclusionsThe metastatic rate of #10 was relatively high at 13%, and the therapeutic value index was as high as those of other suprapancreatic nodes. D2 dissection for proximal cancer located in the greater curvature should include removal of node #10. (Source: Gastric Cancer)
Source: Gastric Cancer - November 8, 2017 Category: Gastroenterology Source Type: research

Factors influencing health-related quality of life after gastrectomy for cancer
This study aimed to evaluate and identify factors associated with HRQoL after gastrectomy.MethodsThis cross-sectional study used prospective databases from seven Dutch centers (2001 –2015) including patients who underwent gastrectomy for cancer. Between July 2015 and November 2016, European Organization for Research and Treatment of Cancer HRQoL questionnaires QLQ-C30 and QLQ-STO22 were sent to all surviving patients without recurrence. The QLQ-C30 scores were compared to a D utch reference population using a one-samplet test. Spearman ’s rank test was used to correlate time after surgery to HRQoL, and multivar...
Source: Gastric Cancer - October 24, 2017 Category: Gastroenterology Source Type: research

Regional differences in advanced gastric cancer: exploratory analyses of the AVAGAST placebo arm
ConclusionsRegional differences in the healthcare environment may have contributed to the differences in overall survival observed in the AVAGAST study. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2017 Category: Gastroenterology Source Type: research

Validation of the American Joint Committee on Cancer (AJCC) 8th edition stage system for gastric cancer patients: a population-based analysis
ConclusionThe AJCC 8th stage system for gastric cancer performs as well as the AJCC 7th edition in the United States (USA). Importantly, when more than 15 lymph nodes are examined, the discriminatory performance of the new edition is improved. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2017 Category: Gastroenterology Source Type: research

Long-term outcomes of endoscopic submucosal dissection versus surgery in early gastric cancer meeting expanded indication including undifferentiated-type tumors: a criteria-based analysis
This study included 1823 consecutive EGC patients meeting expanded indication conditions and treated at a tertiary referral center: 916 and 907 patients underwent surgery or ESD, respectively. The expanded indication included four discrete criteria: (I) intramucosal differentiated tumor, without ulcers, size  >2  cm; (II) intramucosal differentiated tumor, with ulcers, size ≤3 cm; (III) intramucosal undifferentiated tumor, without ulcers, size ≤2 cm; and (IV) submucosal invasion 
Source: Gastric Cancer - October 19, 2017 Category: Gastroenterology Source Type: research

Development and validation of a risk assessment tool for gastric cancer in a general Japanese population
AbstractBackgroundThere have been very few reports of risk score models for the development of gastric cancer. The aim of this study was to develop and validate a risk assessment tool for discerning future gastric cancer risk in Japanese.MethodsA total of 2444 subjects aged 40  years or over were followed up for 14 years from 1988 (derivation cohort), and 3204 subjects of the same age group were followed up for 5 years from 2002 (validation cohort). The weighting (risk score) of each risk factor for predicting future gastric cancer in the risk assessment tool was deter mined based on the coefficients of a Co...
Source: Gastric Cancer - October 17, 2017 Category: Gastroenterology Source Type: research

Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study
ConclusionsThe eCura system is a useful aid for selecting the appropriate treatment strategy after noncurative ESD for EGC. However, caution is needed when applying this system to patients with undifferentiated-type EGC. (Source: Gastric Cancer)
Source: Gastric Cancer - October 5, 2017 Category: Gastroenterology Source Type: research

Time to initiation or duration of S-1 adjuvant chemotherapy; which really impacts on survival in stage II and III gastric cancer?
AbstractBackgroundSurgical resection with S-1 adjuvant chemotherapy (AC) is the standard of care for stage II –III gastric cancer (GC). However, it is unclear if time to initiation and duration of S-1 AC impact on survival.MethodsA multi-institutional GC database identified 498 patients who were treated with S-1 AC after D2 or more extended radical surgery for stage II –III gastric cancer. Patients were divided into four groups according to the interval between surgery and initiation of AC and the duration of AC as follows: group A (n = 226), who received AC earlier (≤6 weeks) and for longer (...
Source: Gastric Cancer - September 30, 2017 Category: Gastroenterology Source Type: research

The newly proposed clinical and post-neoadjuvant treatment staging classifications for gastric adenocarcinoma for the American Joint Committee on Cancer (AJCC) staging
This article summarizes the analysis for these stages.MethodsGastric adenocarcinoma patients diagnosed in 2004 –2009 were identified from the National Cancer Database (NCDB). The cStage cohort included both surgical and nonsurgical cases, and the ypStage cohort included only patients who had chemotherapy or radiation therapy before surgery. Survival differences between the stage groups were determined by t he log-rank test and prognostic accuracy was assessed by concordance index. Analysis was performed using SAS 9.4 (SAS, Cary, NC, USA).ResultsFive strata for cStage and four strata for ypStage were developed. The 5-...
Source: Gastric Cancer - September 25, 2017 Category: Gastroenterology Source Type: research

Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06)
ConclusionsTrastuzumab in combination with S-1 alone demonstrated promising antitumor activity and manageable toxic effects as well as promising survival results in elderly patients with HER2-positive AGC.Clinical trials registrationUMIN000007368. (Source: Gastric Cancer)
Source: Gastric Cancer - September 21, 2017 Category: Gastroenterology Source Type: research

Higher incidence of pancreatic fistula in laparoscopic gastrectomy. Real-world evidence from a nationwide prospective cohort study
ConclusionThe safety and minimal invasiveness of LDG were confirmed in the present Japanese nationwide survey. However, care must be taken to prevent the formation of pancreatic fistulas with LDG, and further improvements in surgical quality are warranted in this regard. (Source: Gastric Cancer)
Source: Gastric Cancer - September 8, 2017 Category: Gastroenterology Source Type: research

How to adjust endoscopic findings to histopathological findings of the stomach: a “histopathology-oriented” correspondence method helps to understand endoscopic findings
ConclusionsThe histological structure of gastric cancers of the same histological subtype may not be similar. One-to-one correspondence between endoscopic images and gastric mucosal histology (histopathology-oriented correspondence) will improve endoscopic diagnosis and provide more useful information for pathological diagnosis. (Source: Gastric Cancer)
Source: Gastric Cancer - September 5, 2017 Category: Gastroenterology Source Type: research

An application study of low-dose computed tomography perfusion imaging for evaluation of the efficacy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma
This study used low-dose computed tomography (CT) perfusion imaging technology to evaluate the efficacy of neoadjuvant chemotherapy in patients with advanced gastric adenocarcinoma and to determine whether any of the perfusion parameters could predict tumor response to chemotherapy.MethodsForty patients with gastric adenocarcinoma (T3-4NxM0) received three cycles of neoadjuvant chemotherapy and low-dose spiral CT perfusion imaging prior to and after the first and third series of chemotherapy. We calculated tissue blood flow (BF) and blood volume (BV) using commercial software. One-way analysis of variance (ANOVA) was used ...
Source: Gastric Cancer - September 4, 2017 Category: Gastroenterology Source Type: research

In situ analysis of FGFR2 mRNA and comparison with FGFR2 gene copy number by dual-color in situ hybridization in a large cohort of gastric cancer patients
ConclusionRNAscope and DISH are suitable methods to evaluate FGFR2 status in gastric cancer. Formalin-fixed paraffin-embedded (FFPE) tissue slides allowed evaluation of the intratumor heterogeneity of these FGFR2 biomarkers. (Source: Gastric Cancer)
Source: Gastric Cancer - August 29, 2017 Category: Gastroenterology Source Type: research

Health-related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma
ConclusionsExtended total gastrectomy, subtotal esophagectomy, and combined esophagogastrectomy seemed to yield similar 6-month postoperative HRQOL outcomes for patients with GEJ adenocarcinoma. (Source: Gastric Cancer)
Source: Gastric Cancer - August 29, 2017 Category: Gastroenterology Source Type: research

DNA diagnosis of peritoneal fluid cytology test by CDO1 promoter DNA hypermethylation in gastric cancer
ConclusionsDNA CY1 detected by Q-MSP forCDO1 gene promoter DNA methylation has a great potential to detect minimal residual disease of the peritoneum in GC clinics as a novel DNA marker. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2017 Category: Gastroenterology Source Type: research

Clinical significance of altering epithelial –mesenchymal transition in metastatic lymph nodes of gastric cancer
ConclusionsThe expression of N-cadherin in metastatic lymph nodes is useful for predicting the prognosis of patients with gastric cancer. The Snail switch —namely, the positive-to-negative conversion of the Snail status—between primary tumors and lymph node metastasis may be important for confirming EMT and mesenchymal–epithelial transition. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2017 Category: Gastroenterology Source Type: research

Nomograms predicting survival of patients with unresectable or metastatic gastric cancer who receive combination cytotoxic chemotherapy as first-line treatment
AbstractBackgroundSome clinicopathological variables are known to influence the survival of patients with advanced gastric cancer. A comprehensive model based on these factors is needed for prediction of an individual ’s survival and appropriate patient counseling.MethodsA nomogram for predicting 1-year survival in patients with advanced gastric cancer in the palliative chemotherapy setting was developed using clinicopathological data from 949 patients with unresectable or metastatic gastric cancer who had received first-line doublet cytotoxic chemotherapy from 2001 to 2006 at the National Cancer Center, Korea (Basel...
Source: Gastric Cancer - August 21, 2017 Category: Gastroenterology Source Type: research

Short-term outcomes and nutritional status after laparoscopic subtotal gastrectomy with a very small remnant stomach for cStage I proximal gastric carcinoma
ConclusionsLsTG with a very small remnant stomach had favorable short-term outcomes and nutritional status compared with LTG and LPG, so it may be a better treatment option for cStage I proximal gastric carcinoma. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2017 Category: Gastroenterology Source Type: research

Health-related quality of life associated with regorafenib treatment in refractory advanced gastric adenocarcinoma
ConclusionsRegorafenib improved DFS without an excessively negative effect on QoL. Progressing development to the phase III setting is warranted. (Source: Gastric Cancer)
Source: Gastric Cancer - August 16, 2017 Category: Gastroenterology Source Type: research