Oncological safety of proximal gastrectomy for T2/T3 proximal gastric cancer
ConclusionsConsidering the nodal stations that need to be dissected, proximal gastrectomy would be the choice and oncologically safe for patients with T2/T3 proximal gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - February 18, 2019 Category: Gastroenterology Source Type: research

Digital image analysis-based scoring system for endoscopic ultrasonography is useful in predicting gastrointestinal stromal tumors
ConclusionsThe scoring system based on the information of digital image analysis is useful in predicting GISTs in case of GMTs that are 2 –5 cm in size. (Source: Gastric Cancer)
Source: Gastric Cancer - February 18, 2019 Category: Gastroenterology Source Type: research

Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF- κB-mediated expression of CEACAM1-3S in human gastric cancer
ConclusionsMUC17 was epigenetically downregulated in GC withH. pylori infection. MUC17 inhibitedH. pylori CagA translocation via attenuation of NF- κB-mediated expression of CEACAM1-3S in GC cells. Thus, MUC17 may serve as a valuable prognostic biomarker forH. pylori-associated GC. (Source: Gastric Cancer)
Source: Gastric Cancer - February 18, 2019 Category: Gastroenterology Source Type: research

Mediterranean diet adherence and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study
ConclusionsHigher MD adherence was associated with reduced risks of ESCC, GCA, and GNCA in the NLCS. However, the decreased ESCC risk might be limited to men. (Source: Gastric Cancer)
Source: Gastric Cancer - February 15, 2019 Category: Gastroenterology Source Type: research

Internal hernia after gastrectomy for gastric cancer in minimally invasive surgery era
This study aimed to analyze the clinical features and risk factors for internal hernia after gastrectomy for gastric cancer.MethodsWe retrospectively analyzed internal hernia after gastrectomy for gastric cancer in 6474 patients between January 2003 and December 2016 at Seoul National University Bundang Hospital. Multivariable logistic regression was performed to evaluate risk factors.ResultsInternal hernias identified by computed tomography or surgical exploration were 111/6474 (1.7%) and the median interval time was 450 days after gastrectomy. Fourteen (0.9%) of the 1510 patients who underwent open gastrectomy and 97 (2....
Source: Gastric Cancer - February 13, 2019 Category: Gastroenterology Source Type: research

Identification of early genetic changes in well-differentiated intramucosal gastric carcinoma by target deep sequencing
ConclusionsUsing LCM and NGS, mutations inTP53 and theWnt-signaling pathway were frequently found and were mutually exclusive in the earliest stage of gastric carcinogenesis. (Source: Gastric Cancer)
Source: Gastric Cancer - February 11, 2019 Category: Gastroenterology Source Type: research

The predictive value of the preoperative C-reactive protein –albumin ratio for early recurrence and chemotherapy benefit in patients with gastric cancer after radical gastrectomy: using randomized phase III trial data
ConclusionsA recurrence-free interval of 12 months was found to be the optimal threshold for differentiating between ER and LR. Preoperative CAR was a promising predictor of ER and PAC response. PAC with 1 –3 cycles may not exert a protective effect against ER for stage III GC patients with CAR ≥ 0.131. (Source: Gastric Cancer)
Source: Gastric Cancer - February 9, 2019 Category: Gastroenterology Source Type: research

Identification of different gene expressions between diffuse- and intestinal-type spheroid-forming gastric cancer cells
ConclusionsOur results suggest that diffuse- and intestinal-type spheroid-forming cells express genes differently. Our data suggest that these candidate genes from spheroid-forming cells can be used in applications in targeted therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - February 6, 2019 Category: Gastroenterology Source Type: research

Biomarker analysis of the GATSBY study of trastuzumab emtansine versus a taxane in previously treated HER2-positive advanced gastric/gastroesophageal junction cancer
ConclusionsPatients with previously treated HER2-positive AGC with higher HER2 expression experienced a better treatment effect from T-DM1 than those with lower HER2 expression and may derive comparable survival benefits from T-DM1 and taxane therapy.Clinical trials registrationNCT01641939 (https://clinicaltrials.gov/ct2/show/NCT01641939). (Source: Gastric Cancer)
Source: Gastric Cancer - January 31, 2019 Category: Gastroenterology Source Type: research

MiR-6872 host gene SEMA3B and its antisense lncRNA SEMA3B-AS1 function synergistically to suppress gastric cardia adenocarcinoma progression
ConclusionsSEMA3B, SEMA3B-AS1, and miR-6872 may act as tumor suppressors and may serve as potential targets for antitumor therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - January 17, 2019 Category: Gastroenterology Source Type: research

Correction to: Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma
The authors would like to correct the error in the publication of the original article. The surname and given names of the authors were swapped in the “Acknowledgements”. The corrected detail is given below. (Source: Gastric Cancer)
Source: Gastric Cancer - January 10, 2019 Category: Gastroenterology Source Type: research

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer
AbstractBackgroundHyperprogressive disease (HPD) during treatment with anti-programmed death-1/programmed death-ligand 1 monoclonal antibodies has anecdotally been reported in some types of cancers, but is not well-characterized in patients with advanced gastric cancer (AGC).MethodsTotal 62 AGC patients treated with nivolumab in a single institution from September 2017 to April 2018 were enrolled in this study. Tumor responses were assessed according to Response Evaluation Criteria in Solid Tumors version 1.1, and HPD was defined as ≥ two fold increase in tumor growth rate. Clinicopathological and molecular ...
Source: Gastric Cancer - January 9, 2019 Category: Gastroenterology Source Type: research

Predictive value of MLH1 and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer
We examined MLH1 and PD-L1 expression in surgical specimens from 285 gastric cancer patients treated with or without preoperative chemotherapy, and assessed the relation between expression results and both histological response and recurrence-free survival (RFS).ResultsOf 285 patients, 28 (9.8%) and 70 (24.6%) exhibited negative MLH1 and high PD-L1 expression, respectively. Most MLH1-negative tumors (85.7%) showed high MSI, and these tumors exhibited high PD-L1 expression more frequently than MLH1-positive tumors (57.1% vs. 21.0%,P 
Source: Gastric Cancer - January 8, 2019 Category: Gastroenterology Source Type: research

A novel TNM staging system for gastric cancer based on the metro-ticket paradigm: a comparative study with the AJCC-TNM staging system
The objective of the current study was to apply the principles of the metro-ticket paradigm to develop a novel TNM staging system (nTNM) for gastric cancer (GC).MethodsThe nTNM considered the distance from the origin on a Cartesian plane incorporating the pN (x-axis) and pT (y-axis) stages. GC patients undergoing radical resection at Fujian Medical University Union Hospital (FMUUH) (n = 4267) were included. The nTNM was validated using 2 external cohorts from the Sun Yat-sen University Cancer Center (SYSUCC) (n = 1800) and Surveillance, Epidemiology, and End Results (SEER) (n = 322...
Source: Gastric Cancer - January 5, 2019 Category: Gastroenterology Source Type: research

Prospective feasibility study for single-tracer sentinel node mapping by ICG (indocyanine green) fluorescence and OSNA (one-step nucleic acid amplification) assay in laparoscopic gastric cancer surgery
ConclusionsSingle-tracer SN mapping by ICG fluorescence imaging with intraoperative diagnosis by OSNA assay is feasible and safe. SNs can be identified in most patients, without producing false-negative results. Further clinical trial to demonstrate the sensitivity is ongoing. (Source: Gastric Cancer)
Source: Gastric Cancer - January 3, 2019 Category: Gastroenterology Source Type: research

Association between UGT1A1 gene polymorphism and safety and efficacy of irinotecan monotherapy as the third-line treatment for advanced gastric cancer
ConclusionsTheUGT1A1 polymorphism may be related to the clinical outcomes of irinotecan monotherapy as the third-line treatment for advanced gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 2, 2019 Category: Gastroenterology Source Type: research

Unequal burden of mortality from gastric cancer in Brazil and its regions, 2000 –2015
AbstractBackgroundGastric cancer (GC) is an important cause of morbidity and mortality worldwide. However, population-based data on GC mortality dynamics in low and middle income countries are scarce.MethodsWe analyzed GC mortality in Brazil based on all GC-related deaths registered 2000 –2015.ResultsA total of 17,374,134 deaths were recorded, with GC identified in 214,808 (1.24%) cases —203,941 (94.9%) as underlying cause, and 10,867 (5.1%) as associated cause of death. Adjusted rates for age and sex was 6.85 deaths/100,000 inhabitants [95% confidence interval (CI) 6.73–6.97]. The highest mortality rates...
Source: Gastric Cancer - January 2, 2019 Category: Gastroenterology Source Type: research

Gastric lymphatic flows may change before and after endoscopic submucosal dissection: in vivo porcine survival models
ConclusionsOur study revealed that, despite ESD, lymphatic flows remained unchanged in most parts of the stomach. The SN concept may be applied after ESD, except for lesions on the lesser curvature. However, in the case of the lesser curvature, special care must be given to the SN concept. (Source: Gastric Cancer)
Source: Gastric Cancer - January 2, 2019 Category: Gastroenterology Source Type: research

Genome-wide long non-coding RNAs identified a panel of novel plasma biomarkers for gastric cancer diagnosis
AbstractBackgroundAlthough long non-coding RNAs (lncRNAs) are regarded as useful plasma-based biomarkers for cancer detection, the potential diagnostic value of lncRNAs in gastric cancer (GC) remains unclear.MethodsTo screen promising lncRNAs biomarkers for GC, we performed genome-wide lncRNA microarray assay between five GC cases plasma and matched healthy controls plasma. The expression of candidate plasma-related lncRNAs were validated in two-phase validation of 446 subjects. The receiver operating characteristic curve was constructed for evaluating diagnostic accuracy. We also determined the origin and stability of pla...
Source: Gastric Cancer - January 2, 2019 Category: Gastroenterology Source Type: research

Outcomes of endoscopic submucosal dissection for gastric epithelial neoplasm in chronic kidney disease patients: propensity score-matched case –control analysis, methodological and statistical issues
(Source: Gastric Cancer)
Source: Gastric Cancer - December 18, 2018 Category: Gastroenterology Source Type: research

Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer
AbstractBackgroundCompelling studies have demonstrated the correlation between aberrant expressed lncRNAs and human cancers, and revealed promise of these lncRNAs as biomarkers in predicting patients ’ survival and outcome.MethodsWe downloaded the RNA-seq data from the Cancer Genome Atlas, and screened out DEGs and DELs between gastric cancer tissues and normal gastric tissues. By bioinformatics analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA. The expression levels of CTD-2510F5.4 in tissues were detected by ISH, and the relationships between CTD-2510F5.4 expression and clinicopatholo...
Source: Gastric Cancer - December 17, 2018 Category: Gastroenterology Source Type: research

Long-term outcomes and prognostic factors with non-curative endoscopic submucosal dissection for gastric cancer in elderly patients aged  ≥ 75 years
AbstractBackgroundLittle is known about the long-term outcomes and prognostic factors with non-curative endoscopic submucosal dissection (ESD) in elderly patients with early gastric cancer.MethodsClinicopathological findings and long-term outcomes were evaluated in 87 patients with early gastric cancer (EGC) aged  ≥ 75 years who were treated with non-curative ESD. Prognostic factors for overall survival (OS) were analyzed with the Kaplan–Meier method and a Cox proportional hazards model.ResultsDuring the follow-up period, among 27 patients who died of any cause, only one patient died of gastric ...
Source: Gastric Cancer - December 17, 2018 Category: Gastroenterology Source Type: research

Genetic analysis of a case of Helicobacter pylori -uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer
AbstractGermline mutations inCDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cancer. His younger sister aged 27 (Case 2) was diagnosed with intramucosal signet ring cell carcinoma (SRCC). Both had identical germlineCDH1 mutations, but Case 1 was positive forHelicobacter pylori infection, whereas Case 2 was negative. Case 2 underwent total gastrectomy. Whole-exome sequencing of an intramucosal SRCC in Case 2 revealed seven somatic mutat...
Source: Gastric Cancer - December 12, 2018 Category: Gastroenterology Source Type: research

Surgical risk and benefits of laparoscopic surgery for elderly patients with gastric cancer: a multicenter prospective cohort study
AbstractBackgroundLaparoscopic gastrectomy (LG) might have greater clinical benefits for elderly patients as less invasive surgery; however, there is still little evidence to support its benefit. We evaluated the surgical outcomes of elderly patients in a nationwide prospective cohort study.MethodsOne hundred and sixty-nine participating institutions were identified by stratified random sampling, and were adjusted for hospital volume, type and location. During 1 year from 2014 to 2015, consecutive patients who underwent gastrectomy for gastric cancer were prospectively enrolled. ‘Elderly’ was defined as ≥&th...
Source: Gastric Cancer - December 11, 2018 Category: Gastroenterology Source Type: research

Impact of preoperative wait time on survival in patients with clinical stage II/III gastric cancer
ConclusionPreoperative wait time up to 90  days does not affect survival in patients with cStage II/III gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - December 10, 2018 Category: Gastroenterology Source Type: research

Gastric sub-epithelial tumors: identification of gastrointestinal stromal tumors using CT with a practical scoring method
AbstractObjectivesTo determine CT features that can identify gastrointestinal stromal tumors (GISTs) among gastric sub-epithelial tumors (SETs) and to explore a practical scoring method.MethodsSixty-four patients with gastric SETs (51 GISTs and 13 non-GISTs) from hospital I were included for primary analyses, and 92 (67 GISTs and 25 non-GISTs) from hospital II constituted a validation cohort. Pre-operative CT images were reviewed for imaging features: lesion location, growth pattern, lesion margin, enhancement pattern, dynamic pattern, attenuation at each phasic images and presence of necrosis, superficial ulcer, calcifica...
Source: Gastric Cancer - December 9, 2018 Category: Gastroenterology Source Type: research

Effect of double-layer structure in intramucosal gastric signet-ring cell carcinoma on lymph node metastasis: a retrospective, single-center study
Conclusions“DLS absent” is a risk factor of LNM detected by the multivariate analysis. In pT1a (M), LVI absent, UL absent, tumor size >  20 mm, sig-GC, no LNM occurred in “DLS present” cases. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2018 Category: Gastroenterology Source Type: research

Phase 1 trial of avelumab (anti-PD-L1) in Japanese patients with advanced solid tumors, including dose expansion in patients with gastric or gastroesophageal junction cancer: the JAVELIN Solid Tumor JPN trial
ConclusionsAvelumab showed acceptable safety in Japanese patients with advanced solid tumors and clinical activity in patients with advanced gastric cancer/gastroesophageal junction cancer and disease progression after chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - December 4, 2018 Category: Gastroenterology Source Type: research

Clinical implications of CTNNA1 germline mutations in asymptomatic carriers
AbstractIn 2017, we implementedCTNNA1 germline analysis in probands suspected of having hereditary diffuse gastric cancer. Here, we report the results from a retrospective series of 41 cases, including the identification of a new family with aCTNNA1 mutation and the first prophylactic total gastrectomy in an asymptomatic carrier after a normal upper endoscopy. Diffuse gastric cancer foci with loss of catenin alpha-1 expression were seen in the resected tissue, suggesting thatCTNNA1 andCDH1 germline mutations behave in a similar manner. Life-changing prophylactic total gastrectomy should therefore also be considered inCTNNA...
Source: Gastric Cancer - December 4, 2018 Category: Gastroenterology Source Type: research

Clinical advantages of robotic gastrectomy for clinical stage I/II gastric cancer: a multi-institutional prospective single-arm study
ConclusionsRG for cStage I/II GC is safe and feasible. It may be effective in reducing morbidity with LG. (Source: Gastric Cancer)
Source: Gastric Cancer - December 3, 2018 Category: Gastroenterology Source Type: research

A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2)
ConclusionsIn the Japanese subpopulation, patients receiving nivolumab had longer OS, similar to the overall population, with a manageable safety profile. The interaction between nivolumab and ramucirumab will be clarified in ongoing clinical trials. (Source: Gastric Cancer)
Source: Gastric Cancer - December 1, 2018 Category: Gastroenterology Source Type: research

Neoadjuvant chemoradiotherapy or chemotherapy for gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis
AbstractObjectiveThe preferred neoadjuvant treatment for gastroesophageal junction (GEJ) adenocarcinoma is still matter of debate. We conducted a meta-analysis to assess the different impact of neoadjuvant combined chemotherapy and radiotherapy (CTRT) versus chemotherapy (CT) alone.MethodsA comprehensive search was performed in EMBASE, PubMed, and Cochrane Library databases from inception to 30th June 2018. Studies comparing survival of patients who underwent CTRT or CT alone before surgery for GEJ adenocarcinoma were included. Hazard ratio (HR) for overall survival (OS) was extracted, and a random-effects model was used f...
Source: Gastric Cancer - November 27, 2018 Category: Gastroenterology Source Type: research

Number of retrieved lymph nodes is an independent prognostic factor after total gastrectomy for patients with stage III gastric cancer: propensity score matching analysis of a multi-institution dataset
AbstractBackgroundThe prognostic significance of the number of retrieved lymph nodes (RLNs) in gastric cancer remains controversial. Therefore, we designed a multicenter collaborative database to investigate the correlation between the number of RLNs and prognosis of patients with advanced gastric cancer after curative resection.MethodsWe retrospectively analyzed 1103 patients who underwent gastrectomy for stage II/III gastric cancer between 2010 and 2014. Lymph nodes, which were retrieved by surgeons from surgically resected specimens, were validated by pathologists. A target population and the optimal cutoff were determi...
Source: Gastric Cancer - November 27, 2018 Category: Gastroenterology Source Type: research

Perioperative risk calculator for distal gastrectomy predicts overall survival in patients with gastric cancer
ConclusionsWe elucidated the associations among risk calculator values and OS rates of patients with gastric cancer. Time-dependent ROC curve analysis suggested that the AUC value of the risk model for operative mortality was high, indicating that this risk calculator would be useful for not only short-term outcomes, but also long-term outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - November 26, 2018 Category: Gastroenterology Source Type: research

Correction to: Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer
In the original publication of this article, Table  4 was published incorrectly. The correct Table 4 is given below. (Source: Gastric Cancer)
Source: Gastric Cancer - November 22, 2018 Category: Gastroenterology Source Type: research

The role of oxaliplatin in the adjuvant setting of different Lauren ’s type of gastric adenocarcinoma after D2 gastrectomy: a real-world study
AbstractBackgroundTo compare the efficacy of oxaliplatin-based and oxaliplatin-free adjuvant chemotherapies in patients with different Lauren type gastric cancers after D2 gastrectomy.MethodsFrom our established gastric cancer database, patients with pathological stage II and III gastric cancer who received adjuvant chemotherapy after D2 gastrectomy at Zhongshan Hospital of Fudan University were analyzed. Patients who received different adjuvant chemotherapy regimens were divided into two subgroups: oxaliplatin-based and oxaliplatin-free subgroup. Clinical outcomes were analyzed according to pathological stage and differen...
Source: Gastric Cancer - November 13, 2018 Category: Gastroenterology Source Type: research

Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma
ConclusionsAutoantibodies against an optimized TAA panel as serum biomarkers appear to help identify the present of early stage EJA. (Source: Gastric Cancer)
Source: Gastric Cancer - November 13, 2018 Category: Gastroenterology Source Type: research

Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer
ConclusionsHigh level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - November 11, 2018 Category: Gastroenterology Source Type: research

Comparison between gastric and esophageal classification system among adenocarcinomas of esophagogastric junction according to AJCC 8th edition: a retrospective observational study from two high-volume institutions in China
This study aimed to illuminate the 8th TNM-EC or TNM-GC system which was more rational for type II, especially for patients underwent transhiatal approaches.MethodsWe collected the database of patients with AEG who underwent radical surgical resection from two high-volume institutions in China: West China Hospital (N = 773) and Xi Jing Hospital of Fourth Military University (N = 637). The cases were randomly matched into 705 training cohort and 705 validation cohort. All the cases were reclassified by the 8th edition of TNM-EC and TNM-GC. The distribution of patients in each stage, the hazard ra...
Source: Gastric Cancer - November 2, 2018 Category: Gastroenterology Source Type: research

Gastrokine 1 protein is a potential theragnostic target for gastric cancer
ConclusionsThe GKN1 is secreted and internalized in the gastric epithelium by exosome-driven transfer, which inhibits gastric tumorigenesis and supports the clinical application of GKN1 protein in gastric cancer diagnosis and treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Favorable long-term outcomes of one-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer treated at a high-volume center
ConclusionsSurvival outcome shown in this study of patients treated with 1-year adjuvant S-1 after D2 gastrectomy at a high-volume cancer hospital will provide a reference for future adjuvant trials targeting JC-14/TNM-7 stage II/III disease. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Cancer –adipose tissue interaction and fluid flow synergistically modulate cell kinetics, HER2 expression, and trastuzumab efficacy in gastric cancer
ConclusionWe have demonstrated that cancer –adipocyte interaction and physical microenvironment mutually modulate gastric cancer cell kinetics. Further elucidation of the microenvironmental regulation in gastric cancer will be very important for the development of strategies involving molecular targeted therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Gastric washing by distilled water can reduce free gastric cancer cells exfoliated into the stomach lumen
ConclusionsCancer cells can be highly exfoliated from the tumor surface into the gastric lumen by endoscopic irrigation in large gastric cancer with lymphatic involvement. Gastric washing by DW can lead to cytoclasis of free cancer cells; therefore, it may minimize the possibility of cancer-cell seeding in procedures carrying potential risks of tumor-cell seeding upon transluminal communication, such as endoscopic full-thickness resection and laparoscopy –endoscopy cooperative surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Prognostic factors in patients treated with second-line chemotherapy for advanced gastric cancer: results from the randomized prospective phase III FFCD-0307 trial
AbstractAimThe aim of this study was to determine prognostic factors in patients treated with second-line therapy (L2) for locally advanced or metastatic gastric and gastro-esophageal junction (GEJ) adenocarcinoma in a randomized phase III study with predefined L2.MethodsIn the FFCD-0307 study, patients were randomly assigned to receive in L1 either epirubicin, cisplatin, and capecitabine (ECX arm) or fluorouracil, leucovorin, and irinotecan (FOLFIRI arm). L2 treatment was predefined (FOLFIRI for the ECX arm and ECX for the FOLFIRI arm). Chi square tests were used to compare the characteristics of patients treated in L2 wi...
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Effect of hospital and surgeon volume on postoperative outcomes after distal gastrectomy for gastric cancer based on data from 145,523 Japanese patients collected from a nationwide web-based data entry system
AbstractBackgroundDespite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system.MethodsWe extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015. The primary outcome was operative mortality. Hospital volume was divided into 3 tertiles: low (1 –22 cases per year), medium...
Source: Gastric Cancer - October 9, 2018 Category: Gastroenterology Source Type: research

A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1, followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer: results of the KDOG1001 trial
ConclusionsNeoadjuvant chemotherapy with DCS was feasible and showed a sufficient R0 resection rate. A future study with a sufficient follow-up period should confirm survival outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - October 3, 2018 Category: Gastroenterology Source Type: research

Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis
AbstractIntroductionThere has recently been increased interest in the assessment of body composition in patients with gastric cancer for the purpose of prognostication. This systematic review and meta-analysis aim to evaluate the current literature on body composition assessment in patients with gastric cancer and its impact on peri-operative outcomes.MethodsA systematic literature search was conducted for studies reporting assessment of body composition in patients with gastric cancers. Meta-analysis of postoperative outcomes (overall and major complications, anastomotic leaks, pulmonary complications) and survival was pe...
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

The inhibition of thymidine phosphorylase can reverse acquire 5FU resistance in gastric cancer cells
ConclusionsIn MKN45/F2R cells, the reduction of FdUMP through the TP –TK pathway caused 5FU resistance, and the inhibition of TP reversed the resistance to 5FU, suggesting that the combination of 5FU and TPI is a promising cancer therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis
AbstractIntroductionThere has recently been increased interest in the assessment of body composition in patients with gastric cancer for the purpose of prognostication. This systematic review and meta-analysis aim to evaluate the current literature on body composition assessment in patients with gastric cancer and its impact on peri-operative outcomes.MethodsA systematic literature search was conducted for studies reporting assessment of body composition in patients with gastric cancers. Meta-analysis of postoperative outcomes (overall and major complications, anastomotic leaks, pulmonary complications) and survival was pe...
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research