Priority of lymph node dissection for proximal gastric cancer invading the greater curvature
ConclusionsThe metastatic rate of #10 was relatively high at 13%, and the therapeutic value index was as high as those of other suprapancreatic nodes. D2 dissection for proximal cancer located in the greater curvature should include removal of node #10. (Source: Gastric Cancer)
Source: Gastric Cancer - November 8, 2017 Category: Gastroenterology Source Type: research

Factors influencing health-related quality of life after gastrectomy for cancer
This study aimed to evaluate and identify factors associated with HRQoL after gastrectomy.MethodsThis cross-sectional study used prospective databases from seven Dutch centers (2001 –2015) including patients who underwent gastrectomy for cancer. Between July 2015 and November 2016, European Organization for Research and Treatment of Cancer HRQoL questionnaires QLQ-C30 and QLQ-STO22 were sent to all surviving patients without recurrence. The QLQ-C30 scores were compared to a D utch reference population using a one-samplet test. Spearman ’s rank test was used to correlate time after surgery to HRQoL, and multivar...
Source: Gastric Cancer - October 24, 2017 Category: Gastroenterology Source Type: research

Regional differences in advanced gastric cancer: exploratory analyses of the AVAGAST placebo arm
ConclusionsRegional differences in the healthcare environment may have contributed to the differences in overall survival observed in the AVAGAST study. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2017 Category: Gastroenterology Source Type: research

Validation of the American Joint Committee on Cancer (AJCC) 8th edition stage system for gastric cancer patients: a population-based analysis
ConclusionThe AJCC 8th stage system for gastric cancer performs as well as the AJCC 7th edition in the United States (USA). Importantly, when more than 15 lymph nodes are examined, the discriminatory performance of the new edition is improved. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2017 Category: Gastroenterology Source Type: research

Long-term outcomes of endoscopic submucosal dissection versus surgery in early gastric cancer meeting expanded indication including undifferentiated-type tumors: a criteria-based analysis
This study included 1823 consecutive EGC patients meeting expanded indication conditions and treated at a tertiary referral center: 916 and 907 patients underwent surgery or ESD, respectively. The expanded indication included four discrete criteria: (I) intramucosal differentiated tumor, without ulcers, size  >2  cm; (II) intramucosal differentiated tumor, with ulcers, size ≤3 cm; (III) intramucosal undifferentiated tumor, without ulcers, size ≤2 cm; and (IV) submucosal invasion 
Source: Gastric Cancer - October 19, 2017 Category: Gastroenterology Source Type: research

Development and validation of a risk assessment tool for gastric cancer in a general Japanese population
AbstractBackgroundThere have been very few reports of risk score models for the development of gastric cancer. The aim of this study was to develop and validate a risk assessment tool for discerning future gastric cancer risk in Japanese.MethodsA total of 2444 subjects aged 40  years or over were followed up for 14 years from 1988 (derivation cohort), and 3204 subjects of the same age group were followed up for 5 years from 2002 (validation cohort). The weighting (risk score) of each risk factor for predicting future gastric cancer in the risk assessment tool was deter mined based on the coefficients of a Co...
Source: Gastric Cancer - October 17, 2017 Category: Gastroenterology Source Type: research

Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study
ConclusionsThe eCura system is a useful aid for selecting the appropriate treatment strategy after noncurative ESD for EGC. However, caution is needed when applying this system to patients with undifferentiated-type EGC. (Source: Gastric Cancer)
Source: Gastric Cancer - October 5, 2017 Category: Gastroenterology Source Type: research

Time to initiation or duration of S-1 adjuvant chemotherapy; which really impacts on survival in stage II and III gastric cancer?
AbstractBackgroundSurgical resection with S-1 adjuvant chemotherapy (AC) is the standard of care for stage II –III gastric cancer (GC). However, it is unclear if time to initiation and duration of S-1 AC impact on survival.MethodsA multi-institutional GC database identified 498 patients who were treated with S-1 AC after D2 or more extended radical surgery for stage II –III gastric cancer. Patients were divided into four groups according to the interval between surgery and initiation of AC and the duration of AC as follows: group A (n = 226), who received AC earlier (≤6 weeks) and for longer (...
Source: Gastric Cancer - September 30, 2017 Category: Gastroenterology Source Type: research

The newly proposed clinical and post-neoadjuvant treatment staging classifications for gastric adenocarcinoma for the American Joint Committee on Cancer (AJCC) staging
This article summarizes the analysis for these stages.MethodsGastric adenocarcinoma patients diagnosed in 2004 –2009 were identified from the National Cancer Database (NCDB). The cStage cohort included both surgical and nonsurgical cases, and the ypStage cohort included only patients who had chemotherapy or radiation therapy before surgery. Survival differences between the stage groups were determined by t he log-rank test and prognostic accuracy was assessed by concordance index. Analysis was performed using SAS 9.4 (SAS, Cary, NC, USA).ResultsFive strata for cStage and four strata for ypStage were developed. The 5-...
Source: Gastric Cancer - September 25, 2017 Category: Gastroenterology Source Type: research

Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06)
ConclusionsTrastuzumab in combination with S-1 alone demonstrated promising antitumor activity and manageable toxic effects as well as promising survival results in elderly patients with HER2-positive AGC.Clinical trials registrationUMIN000007368. (Source: Gastric Cancer)
Source: Gastric Cancer - September 21, 2017 Category: Gastroenterology Source Type: research

Higher incidence of pancreatic fistula in laparoscopic gastrectomy. Real-world evidence from a nationwide prospective cohort study
ConclusionThe safety and minimal invasiveness of LDG were confirmed in the present Japanese nationwide survey. However, care must be taken to prevent the formation of pancreatic fistulas with LDG, and further improvements in surgical quality are warranted in this regard. (Source: Gastric Cancer)
Source: Gastric Cancer - September 8, 2017 Category: Gastroenterology Source Type: research

How to adjust endoscopic findings to histopathological findings of the stomach: a “histopathology-oriented” correspondence method helps to understand endoscopic findings
ConclusionsThe histological structure of gastric cancers of the same histological subtype may not be similar. One-to-one correspondence between endoscopic images and gastric mucosal histology (histopathology-oriented correspondence) will improve endoscopic diagnosis and provide more useful information for pathological diagnosis. (Source: Gastric Cancer)
Source: Gastric Cancer - September 5, 2017 Category: Gastroenterology Source Type: research

An application study of low-dose computed tomography perfusion imaging for evaluation of the efficacy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma
This study used low-dose computed tomography (CT) perfusion imaging technology to evaluate the efficacy of neoadjuvant chemotherapy in patients with advanced gastric adenocarcinoma and to determine whether any of the perfusion parameters could predict tumor response to chemotherapy.MethodsForty patients with gastric adenocarcinoma (T3-4NxM0) received three cycles of neoadjuvant chemotherapy and low-dose spiral CT perfusion imaging prior to and after the first and third series of chemotherapy. We calculated tissue blood flow (BF) and blood volume (BV) using commercial software. One-way analysis of variance (ANOVA) was used ...
Source: Gastric Cancer - September 4, 2017 Category: Gastroenterology Source Type: research

In situ analysis of FGFR2 mRNA and comparison with FGFR2 gene copy number by dual-color in situ hybridization in a large cohort of gastric cancer patients
ConclusionRNAscope and DISH are suitable methods to evaluate FGFR2 status in gastric cancer. Formalin-fixed paraffin-embedded (FFPE) tissue slides allowed evaluation of the intratumor heterogeneity of these FGFR2 biomarkers. (Source: Gastric Cancer)
Source: Gastric Cancer - August 29, 2017 Category: Gastroenterology Source Type: research

Health-related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma
ConclusionsExtended total gastrectomy, subtotal esophagectomy, and combined esophagogastrectomy seemed to yield similar 6-month postoperative HRQOL outcomes for patients with GEJ adenocarcinoma. (Source: Gastric Cancer)
Source: Gastric Cancer - August 29, 2017 Category: Gastroenterology Source Type: research

DNA diagnosis of peritoneal fluid cytology test by CDO1 promoter DNA hypermethylation in gastric cancer
ConclusionsDNA CY1 detected by Q-MSP forCDO1 gene promoter DNA methylation has a great potential to detect minimal residual disease of the peritoneum in GC clinics as a novel DNA marker. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2017 Category: Gastroenterology Source Type: research

Clinical significance of altering epithelial –mesenchymal transition in metastatic lymph nodes of gastric cancer
ConclusionsThe expression of N-cadherin in metastatic lymph nodes is useful for predicting the prognosis of patients with gastric cancer. The Snail switch —namely, the positive-to-negative conversion of the Snail status—between primary tumors and lymph node metastasis may be important for confirming EMT and mesenchymal–epithelial transition. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2017 Category: Gastroenterology Source Type: research

Nomograms predicting survival of patients with unresectable or metastatic gastric cancer who receive combination cytotoxic chemotherapy as first-line treatment
AbstractBackgroundSome clinicopathological variables are known to influence the survival of patients with advanced gastric cancer. A comprehensive model based on these factors is needed for prediction of an individual ’s survival and appropriate patient counseling.MethodsA nomogram for predicting 1-year survival in patients with advanced gastric cancer in the palliative chemotherapy setting was developed using clinicopathological data from 949 patients with unresectable or metastatic gastric cancer who had received first-line doublet cytotoxic chemotherapy from 2001 to 2006 at the National Cancer Center, Korea (Basel...
Source: Gastric Cancer - August 21, 2017 Category: Gastroenterology Source Type: research

Short-term outcomes and nutritional status after laparoscopic subtotal gastrectomy with a very small remnant stomach for cStage I proximal gastric carcinoma
ConclusionsLsTG with a very small remnant stomach had favorable short-term outcomes and nutritional status compared with LTG and LPG, so it may be a better treatment option for cStage I proximal gastric carcinoma. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2017 Category: Gastroenterology Source Type: research

Health-related quality of life associated with regorafenib treatment in refractory advanced gastric adenocarcinoma
ConclusionsRegorafenib improved DFS without an excessively negative effect on QoL. Progressing development to the phase III setting is warranted. (Source: Gastric Cancer)
Source: Gastric Cancer - August 16, 2017 Category: Gastroenterology Source Type: research

Pancreatic enzyme supplementation after gastrectomy for gastric cancer: a randomized controlled trial
ConclusionsPES-d improves nutritional status and quality of life after gastrectomy for gastric cancer, particularly within 3 months from the operation. A larger, multicenter trial is necessary to address the potential influence of several confounding variables such as disease stage and adjuvant treatments. (Source: Gastric Cancer)
Source: Gastric Cancer - August 14, 2017 Category: Gastroenterology Source Type: research

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma
AbstractBackgroundProgrammed death ligand 1 (PD-L1) is a key protein upregulated by tumor cells to suppress immune responses. Tumor-associated macrophages (TAMs) play a major role in this immunosuppression, but the relationship between PD-L1 expression and TAMs remains unclear in gastric adenocarcinoma (GAC). We simultaneously examined expression of PD-L1 and TAMs in GAC.MethodsWe performed immunohistochemical staining for PD-L1, CD68 (pan-macrophage), and CD163 (M2-like macrophage) in 217 GAC samples using a tissue microarray. Expression of PD-L1 and CD68- and CD163-positive cells was evaluated using the Cytoplasmic V2.0 ...
Source: Gastric Cancer - August 11, 2017 Category: Gastroenterology Source Type: research

Irinotecan monotherapy as third-line or later treatment in advanced gastric cancer
ConclusionsIrinotecan monotherapy was relatively safely performed as salvage-line treatment for AGC in Japanese clinical practice. Careful patient selection and intensive modification of the dose of irinotecan might possibly be associated with favorable survival. (Source: Gastric Cancer)
Source: Gastric Cancer - August 10, 2017 Category: Gastroenterology Source Type: research

Prognostic significance of peritoneal lavage cytology in staging gastric cancer: systematic review and meta-analysis
AbstractBackgroundPeritoneal cytology has been used as a part of the cancer staging of gastric cancer patients. The primary aim of this systematic review was to evaluate the value of peritoneal cytology as part of the staging of gastric cancer and survival prediction. The second aim was to establish if positive cytology may be modified by neoadjuvant therapy, to improve prognosis.MethodsAn electronic literature search was performed using Embase, Medline, Web of Science, and Cochrane library databases up to January 2016. The logarithm of the hazard ratio (HR) with 95% confidence intervals (CI) was used as the primary summar...
Source: Gastric Cancer - August 4, 2017 Category: Gastroenterology Source Type: research

A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer
ConclusionsCombination chemotherapy with S-1 and cisplatin is an effective and well-tolerated regimen for elderly patients with advanced gastric cancer when the dose is adjusted according to renal function. (Source: Gastric Cancer)
Source: Gastric Cancer - August 1, 2017 Category: Gastroenterology Source Type: research

Optimal minimally invasive surgical procedure for gastric submucosal tumors
ConclusionsThe surgical procedure for gastric SMTs must be carefully chosen according to tumor size, location, and presence or absence of ulceration. For selected patients, NEWS is suggested to be an appropriate option for the treatment of gastric SMTs. (Source: Gastric Cancer)
Source: Gastric Cancer - July 25, 2017 Category: Gastroenterology Source Type: research

Postoperative follow-up programs improve survival in curatively resected gastric and junctional cancer patients: a propensity score matched analysis
This study aimed to evaluate the impact of standardized surveillance by a specialized center after resection on survival.MethodsData of 587 patients were analyzed who underwent curative surgery for esophagogastric adenocarcinoma in our institution. Based on their postoperative surveillance, patients were assigned to either standardized follow-up (SFU) by the National Center for Tumor Diseases (SFU group) or individual follow-up by other physicians (non-SFU group). Propensity score matching (PSM) was performed to compensate for heterogeneity between groups. Groups were compared regarding clinicopathological findings, recurr...
Source: Gastric Cancer - July 24, 2017 Category: Gastroenterology Source Type: research

The increasing trend in the incidence of gastric cancer in the young population, not only in young Hispanic men
(Source: Gastric Cancer)
Source: Gastric Cancer - July 24, 2017 Category: Gastroenterology Source Type: research

Short-term outcomes in minimally invasive versus open gastrectomy: the differences between East and West. A systematic review of the literature
ConclusionImproved outcomes are observed following minimally invasive gastrectomy in comparison to open procedures in both Western and Asian studies. There are differences in patient characteristics between the Western and Asian populations. Overall outcomes seem to be in favor of the Asian population. These differences may fade with centralization of care for gastric cancer patients in the West and increasing surgical experience. (Source: Gastric Cancer)
Source: Gastric Cancer - July 20, 2017 Category: Gastroenterology Source Type: research

Toward early detection of Helicobacter pylori -associated gastric cancer
ConclusionsWe present an approach designed to integrate pathology, mathematics, and statistics for detection of the earliest precancerous, treatable lesion. Given the simplicity and robustness of the framework, such technique has the potential to guide personalized screening schedules to minimize the risk of undetected malignant transformation. (Source: Gastric Cancer)
Source: Gastric Cancer - July 19, 2017 Category: Gastroenterology Source Type: research

Surgical strategies in true adenocarcinoma of the esophagogastric junction (AEG II): thoracoabdominal or abdominal approach?
This study aims to evaluate the differences between right thoracoabdominal esophagectomy (TAE) (Ivor –Lewis operation) and transhiatal extended gastrectomy (THG) for AEG II.MethodsFrom a prospective database, 242 patients with AEG II (TAE,n = 56; THG,n = 186) were included and analyzed according to characteristics and perioperative morbidity and mortality and overall survival (chi-square, Mann–WhitneyU, log-rank, Cox regression).ResultsGroups were comparable at baseline with exception of age. Patients older than 70  years were more frequently resected by THG (p = 0.003). No di...
Source: Gastric Cancer - July 6, 2017 Category: Gastroenterology Source Type: research

The prognostic value of volume-based parameters using 18 F-FDG PET/CT in gastric cancer according to HER2 status
AbstractBackgroundWe aimed to find the clinical value of metastatic tumor burden evaluated with F18-FDG PET/CT in gastric cancer patients, considering the human epidermal growth factor receptor 2 (HER2) status.MethodsWe retrospectively reviewed 124 patients with locally advanced or metastatic gastric cancer at Yonsei Cancer Center between January 2006 and December 2014 who had undergone baseline FDG PET/CT before first-line chemotherapy. We measured the maximum standardized uptake value from the primary tumor (SUVmax) and whole-body (WB) PET/CT parameters, including WB SUVmax, WB SUVmean, WB metabolic tumor volume (WB MTV)...
Source: Gastric Cancer - June 22, 2017 Category: Gastroenterology Source Type: research

Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy
The objective of this retrospective study was to apply the new ypStage to patients who have undergone preoperative therapy and potentially curative gastrectomy.MethodsWe collected data from a prospectively maintained institutional database of gastric cancer patients who underwent potentially curative gastrectomy after preoperative therapy (1995 –2015). Kaplan–Meier survival estimations and log-rank tests were performed to compare survival. Univariable and multivariable analyses were performed to determine risk factors for overall survival.ResultsA total of 354 patients met our criteria. Most patients completed ...
Source: Gastric Cancer - June 22, 2017 Category: Gastroenterology Source Type: research

Long-term oncologic outcomes of robotic gastrectomy for gastric cancer compared with laparoscopic gastrectomy
ConclusionThe potential technical superiority of robotic system over laparoscopy did not improve oncological outcomes after gastrectomy. Long-term oncological outcomes were not different between RG and LG. Nevertheless, robotic applications in minimally invasive gastric cancer surgery may be an oncologically safe alternative. (Source: Gastric Cancer)
Source: Gastric Cancer - June 21, 2017 Category: Gastroenterology Source Type: research

Histological verification of the usefulness of magnifying endoscopy with narrow-band imaging for horizontal margin diagnosis of differentiated-type early gastric cancers
ConclusionsDifferences of IP width, SD, and IP number may be factors for identifying HMs with conventional endoscopy. Because NBI can better visualize vessel structures, the increased SEC number and shallow SECs may clarify the HM. (Source: Gastric Cancer)
Source: Gastric Cancer - June 21, 2017 Category: Gastroenterology Source Type: research

Exposure –response relationship of ramucirumab in East Asian patients from RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer
ConclusionsThis exploratory analysis suggests a positive relationship between efficacy and ramucirumab exposure with manageable toxicities in East Asian patients from RAINBOW, consistent with the overall exposure –response analysis from this trial. A regimen with a higher dosage of ramucirumab warrants further consideration for East Asian patients with gastric/GEJ cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - June 20, 2017 Category: Gastroenterology Source Type: research

Does a laparoscopic approach attenuate the body weight loss and lean body mass loss observed in open distal gastrectomy for gastric cancer? a single-institution exploratory analysis of the JCOG 0912 phase III trial
ConclusionsThe laparoscopic approach did not attenuate the loss of body weight and lean body mass in comparison to patients who underwent open distal gastrectomy for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - June 16, 2017 Category: Gastroenterology Source Type: research

The long-term survival of stage IV gastric cancer patients with conversion therapy
ConclusionThere were long-term survivors who underwent conversion therapy for stage IV GC. Adequate selection of stage IV GC patients for conversion therapy may be an important role for the surgical oncologist in the new era. (Source: Gastric Cancer)
Source: Gastric Cancer - June 14, 2017 Category: Gastroenterology Source Type: research

Prospective phase II study evaluating the efficacy of swallow ability screening tests and pneumonia prevention using a team approach for elderly patients with gastric cancer
ConclusionIn conclusion, although the screening tests we adopted here were not sufficient to identify patients at high risk of aspiration pneumonia, perioperative interventions using a team approach might be effective in reducing the incidence of PP in elderly patients with gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - June 13, 2017 Category: Gastroenterology Source Type: research

The comprehensive complication index (CCI) is a more sensitive complication index than the conventional Clavien –Dindo classification in radical gastric cancer surgery
AbstractBackgroundThe comprehensive complication index (CCI) integrates all complications of the Clavien –Dindo classification (CDC) and offers a metric approach to measure morbidity. The aim of this study was to evaluate the CCI at a high-volume center for gastric cancer surgery and to compare the CCI to the conventional CDC.MethodsClinical factors were collected from the prospective complication data of gastric cancer patients who underwent radical gastrectomy at Seoul National University Hospital from 2013 to 2014. CDC and CCI were calculated, and risk factors were investigated. Correlations and generalized linear...
Source: Gastric Cancer - June 8, 2017 Category: Gastroenterology Source Type: research

Associations between early tumor shrinkage and depth of response and clinical outcomes in patients treated with 1st-line chemotherapy for advanced gastric cancer
AbstractBackgroundAlthough early tumor shrinkage (ETS) predictions of the efficacy and depth of response (DpR) reflects clinical outcomes in chemotherapy with epidermal growth factor receptor inhibitor regimens to treat metastatic colorectal cancer, their value in assessing treatments for advanced gastric cancer (AGC) is unclear. Here we evaluated relationships between ETS and DpR and clinical outcomes in AGC patients treated with first-line chemotherapy.MethodsWe retrospectively enrolled 612 consecutive patients treated with first-line chemotherapy for AGC between January 2010 and June 2016. ETS and DpR were defined as ch...
Source: Gastric Cancer - June 5, 2017 Category: Gastroenterology Source Type: research

Survival benefit of “D2-plus” gastrectomy in gastric cancer patients with duodenal invasion
ConclusionIn a potentially curative gastrectomy for gastric cancer with duodenal invasion, there may be some survival benefit in dissection of nos. 12b, 13, 14v, 16a2 and 16b1 LNs, while no benefit was seen in dissection of nos. 8p or 12p LNs. (Source: Gastric Cancer)
Source: Gastric Cancer - June 5, 2017 Category: Gastroenterology Source Type: research

Automated histological classification of whole-slide images of gastric biopsy specimens
ConclusionsAlthough there are limitations and requirements for applying automated histopathological classification of gastric biopsy specimens in the clinical setting, the results of the present study are promising. (Source: Gastric Cancer)
Source: Gastric Cancer - June 2, 2017 Category: Gastroenterology Source Type: research

Role of hepatectomy in gastric cancer with multiple liver-limited metastases
ConclusionsAlthough hepatectomy for patients with GC with multiple LLM is not recommended as the initial therapy, it prolonged the survival of patients with tumors controlled using systemic chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - June 2, 2017 Category: Gastroenterology Source Type: research

Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients
AbstractBackgroundNeuregulin 1 (NRG1), a ligand for human epidermal growth factor (HER) 3 and HER4, can activates cell signaling pathways to promote carcinogenesis and metastasis.MethodsTo investigate the clinicopathologic significance of NRG1 and its receptors, immunohistochemistry was performed for NRG1, HER3, and HER4 in 502 consecutive gastric cancers (GCs). Furthermore, HER2, microsatellite instability (MSI), and Epstein-Barr virus (EBV) status were investigated.NRG1 gene copy number (GCN) was determined by dual-color fluorescence in situ hybridization (FISH) in 388 available GCs.ResultsNRG1 overexpression was observe...
Source: Gastric Cancer - June 1, 2017 Category: Gastroenterology Source Type: research

Minimally invasive surgery for advanced gastric cancer: are we sure?
(Source: Gastric Cancer)
Source: Gastric Cancer - May 31, 2017 Category: Gastroenterology Source Type: research

Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast
ConclusionsTranilast acts on the TGF- β/Smad pathway to inhibit interactions between cancer cells and cancer-associated fibroblasts, thereby inhibiting tumor growth and fibrosis. This study supports the hypothesis that tranilast represents a novel strategy to prevent fibrous tumor establishment represented by peritoneal dissemination. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2017 Category: Gastroenterology Source Type: research

Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G)
ConclusionsFive-weekly SP therapy combined with trastuzumab therapy showed a good antitumor response and acceptable toxicity in HER2-positive advanced GC/EGJC. Serum neuregulin  1 might be associated with the efficacy of this treatment regimen. (Source: Gastric Cancer)
Source: Gastric Cancer - May 11, 2017 Category: Gastroenterology Source Type: research

MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer
ConclusionsMiR-1 acts as a tumor suppressor by inhibiting angiogenesis-related growth factors in human gastric cancer. Downregulated miR-1 not only promotes cellular proliferation and migration of GC cells, but may activates proangiogenesis signaling and stimulates the proliferation and migration of endothelial cells, indicating the possibility of new strategies for GC therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - May 10, 2017 Category: Gastroenterology Source Type: research

The value of diagnostic endoscopic submucosal dissection for patients with clinical submucosal invasive early gastric cancer
ConclusionsThe stomach was preserved in 28.8% of patients, and preceding ESD did not show obvious disadvantages. Therefore, diagnostic ESD should be considered as an initial treatment for limited cT1b gastric cancer cases. (Source: Gastric Cancer)
Source: Gastric Cancer - May 8, 2017 Category: Gastroenterology Source Type: research