Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation
Abstract Background Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated. Methods We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants. Result...
Source: Gastric Cancer - October 20, 2015 Category: Gastroenterology Source Type: research

BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer
Conclusions BH3 profiling clearly showed that BIM expression, which depends on BAK expression, correlated with docetaxel sensitivity. BAK expression in gastric cancer is thus predictive of chemotherapeutic responses to docetaxel and clinical prognosis in patients treated with preoperative chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2015 Category: Gastroenterology Source Type: research

Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia
Abstract Background Polymorphism in the gene of pepsinogen-II (PG-II) and its serum level are effective biomarkers for terminal differentiation of gastric mucosa into gastritis, intestinal metaplasia (IM), and gastric cancer (GC) in relationship to Helicobacter pylori infection. Methods Genotyping of the PG-II 100 bp insertion/deletion (ins/del) polymorphism was performed in patients with GC (n = 192) and age- and gender-matched H. pylori-associated dyspepsia (n = 180) and healthy subjects (HS, n = 240) by PCR. IgG anti...
Source: Gastric Cancer - October 20, 2015 Category: Gastroenterology Source Type: research

Antitumor effect of antiplatelet agents in gastric cancer cells: an in vivo and in vitro study
Conclusions Our study showed that platelets increased the proliferation of gastric cancer cells and that this increase was inhibited by antiplatelet antibody or aspirin. Mir-4670-5p may play an important role in these responses. (Source: Gastric Cancer)
Source: Gastric Cancer - October 20, 2015 Category: Gastroenterology Source Type: research

A Hercule Poirot of clinical research
(Source: Gastric Cancer)
Source: Gastric Cancer - October 19, 2015 Category: Gastroenterology Source Type: research

Efficacy and safety of S-1 and oxaliplatin combination therapy in elderly patients with advanced gastric cancer
Conclusions SOX is an effective and feasible therapy in both nonelderly and elderly patients with advanced gastric cancer. In elderly patients, SOX demonstrated favorable efficacy and safety compared with CS. (Source: Gastric Cancer)
Source: Gastric Cancer - October 16, 2015 Category: Gastroenterology Source Type: research

Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients
Conclusion Our data suggest that the evaluation of PRMT1 expression in GC is a useful predictor of poor prognosis and recurrence after adjuvant chemotherapy. Moreover, these data suggest that PRMT1 is a promising therapeutic tool for overcoming refractory GC. (Source: Gastric Cancer)
Source: Gastric Cancer - October 15, 2015 Category: Gastroenterology Source Type: research

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery
Conclusions A low hand grip strength was a significant risk factor for morbidity after gastric cancer surgery. The importance of the hand grip strength as a risk factor should be examined in future prospective studies. (Source: Gastric Cancer)
Source: Gastric Cancer - October 14, 2015 Category: Gastroenterology Source Type: research

Clinicopathologic features of gastric cancer with synchronous and metachronous colorectal cancer in Korea: are microsatellite instability and p53 overexpression useful markers for predicting colorectal cancer in gastric cancer patients?
Abstract Background A large-scale study was performed to identify the risk factors for developing synchronous and metachronous colorectal cancer (CRC) in gastric cancer (GC) patients, including microsatellite instability (MSI) and p53 overexpression. Methods A total of 1041 GC patients who underwent endoscopic resection or surgery and underwent colonoscopy simultaneously or during surveillance for GC were consecutively enrolled. Clinicopathologic characteristics, MSI, and p53 overexpression were compared between the GC patients with and those without syn...
Source: Gastric Cancer - October 7, 2015 Category: Gastroenterology Source Type: research

Unplanned admission after gastrectomy as a consequence of fast-track surgery: a comparative risk analysis
Conclusions Patients with a long hospital stay after gastrectomy are at an increased risk of early readmission, which was likely related to the incidence of severe sequelae specific to gastrectomy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 7, 2015 Category: Gastroenterology Source Type: research

Erratum to: Trends in gastric cancer incidence: a period and birth cohort analysis in a well-defined French population
(Source: Gastric Cancer)
Source: Gastric Cancer - October 7, 2015 Category: Gastroenterology Source Type: research

Preferential HER2 expression in liver metastases and EGFR expression in peritoneal metastases in patients with advanced gastric cancer
Conclusion These results indicate that HER2 and EGFR are preferentially expressed in the liver and peritoneal metastases, respectively, which would be potential targets for anti-HER2 and anti-EGFR molecular therapy in metastatic gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

MiR-125b promotes cell migration and invasion by targeting PPP1CA-Rb signal pathways in gastric cancer, resulting in a poor prognosis
Abstract Background MiR-125b functions as an oncogene in many cancers; however, its clinical significance and molecular mechanism in gastric cancers have never been sufficiently investigated. Here, we elucidated the functions and molecular regulated pathways of MiR-125b in gastric cancer. Methods We investigated MiR-125b expression in fresh tissues from 50 gastric cancer patients and 6 gastric cancer cell lines using RT-PCR, and explored its prognostic value by hybridizing MiR-125b in situ for 300 clinical gastric tumor tissues with pathological d...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

KIT and BRAF heterogeneous mutations in gastrointestinal stromal tumors after secondary imatinib resistance
Conclusions This finding, in combination with the loss of KIT expression, suggests the possibility of activation of RAS-RAF-MEK-ERK pathways driven by a KIT-independent oncogenic mechanism. Understanding the genetic aberrations beyond KIT and PDGFRA may lead to the identification of additional therapeutic targets for GISTs. (Source: Gastric Cancer)
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Multicenter large-scale study of prognostic impact of HER2 expression in patients with resectable gastric cancer
This study included 1,148 gastric cancer patients who underwent gastrectomy in 11 institutions. HER2 expression was centrally evaluated with immunohistochemistry and fluorescence in situ hybridization, and intratumoral HER2 heterogeneity was evaluated for HER2-positive tumors. Overall survival was compared between HER2-positive and HER2-negative patients and between the homogeneous and heterogeneous groups. Results The HER2-positive rate was 15.7 %, and HER2 expression was significantly associated with histological type. HER2 expression scores obtained by immunohistochemistr...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Epithelial dysplasia of the stomach with gastric immunophenotype shows features of biological aggressiveness
Abstract Background Gastric dysplasia is classified as adenomatous/type I (intestinal phenotype) and foveolar or pyloric/type II (gastric phenotype) according to morphological (architectural and cytological) features. The immunophenotypic classification of dysplasia, based on the expression of the mucins, CD10 and CDX2, recognizes the following immunophenotypes: intestinal (MUC2, CD10, and CDX2); gastric (MUC5AC and/or MUC6, absence of CD10, and absent or low expression of CDX2); hybrid (gastric and intestinal markers); and null. Methods Sixty-six...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Randomized phase II trial of nimotuzumab plus irinotecan versus irinotecan alone as second-line therapy for patients with advanced gastric cancer
Conclusions There was no superiority of N-IRI over IRI alone in terms of PFS in 5-fluorouracil-refractory AGC patients. However, N-IRI showed potential improvement in the EGFR 2+/3+ subgroup based on improved RR, PFS, and OS. (Source: Gastric Cancer)
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Short- and long-term outcomes of LigaSure versus conventional surgery for curative gastric cancer resection: a matched pair analysis
Abstract Background The LigaSure vessel sealing system allows dissection and hemostasis in a safe and quick way, and it has been reported to be an effective tool to shorten operative time and reduce intraoperative blood loss for various surgeries. However, short- and long-term outcomes in comparison with conventional surgery for gastric cancer resection are limited. Methods Between January 2005 and December 2009, 121 patients underwent curative resection for gastric cancer with LigaSure. Perioperative and long-term results were compared with those...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection
Abstract Background Tumor-associated macrophages (TAMs), the most predominant tumor-infiltrating immune cells, are emerging prognostic factors and therapeutic targets for personalized therapy against malignant neoplasms. We aimed to evaluate the prognostic significance of diametrically polarized TAMs in gastric cancer and generate a predictive nomogram to refine a risk stratification system. Methods We evaluated polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68, CD11c, and CD206 in 180 consecutive gastric canc...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Preoperative smoking cessation can reduce postoperative complications in gastric cancer surgery
Abstract Background Despite the close link between cigarette smoking and the development of gastric cancer, little is known about the effects of cigarette smoking on surgical outcomes after gastric cancer surgery. The aim of this study was to investigate whether preoperative smoking status and the duration of smoking cessation were associated with short-term surgical consequences in gastric cancer surgery. Methods Among 1,489 consecutive patients, 1,335 patients who underwent curative radical gastrectomy at the Samsung Medical Center between Janua...
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

Anatomical considerations of the infrapyloric artery and its associated lymph nodes during laparoscopic gastric cancer surgery
Conclusion The IPA most commonly originates from the ASPDA and is associated with a certain number of lymph nodes. Vascular distribution from the IPA depends on the anatomic variation. (Source: Gastric Cancer)
Source: Gastric Cancer - September 18, 2015 Category: Gastroenterology Source Type: research

The adjacent to tumor sample trap
(Source: Gastric Cancer)
Source: Gastric Cancer - September 10, 2015 Category: Gastroenterology Source Type: research

Angiogenesis inhibitors in gastric and gastroesophageal junction cancer
Abstract Despite significant improvements in systemic chemotherapy during the past two decades, the prognosis of patients with advanced gastric and gastroesophageal junction adenocarcinoma remains poor. Because of molecular heterogeneity, it is essential to classify tumors based on the underlying oncogenic pathways and to develop targeted therapies acting on individual tumors. Unfortunately, although a number of molecular targets have been studied, very few of these agents can be used in a clinical setting. In this review, we summarize the available data on anti-angiogenic agents in advanced/metastatic gastric can...
Source: Gastric Cancer - September 2, 2015 Category: Gastroenterology Source Type: research

Is the recent WHO histological classification for gastric cancer helpful for application to endoscopic resection?
Conclusions The clinical behavior differs in diffuse-type PD adenocarcinoma and SRC carcinoma. On the basis of LNM and outcomes of endoscopic resection, the recent WHO classification may not be helpful when endoscopic resection is performed for treatment of UD-EGC. (Source: Gastric Cancer)
Source: Gastric Cancer - September 1, 2015 Category: Gastroenterology Source Type: research

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study
Conclusions We have developed a novel formula for determining the S-1 dosage on the basis of renal function. Further validation is needed to confirm the formula for practical application. (Source: Gastric Cancer)
Source: Gastric Cancer - August 25, 2015 Category: Gastroenterology Source Type: research

Lymph node metastasis risk according to the depth of invasion in early gastric cancers confined to the mucosal layer
Conclusions EGCs invading the MM had a higher rate of lymph node metastasis than those confined to the LP. Further study is needed to evaluate whether different curative treatment criteria are needed for LP-confined and MM-invading EGCs. (Source: Gastric Cancer)
Source: Gastric Cancer - August 25, 2015 Category: Gastroenterology Source Type: research

Statistical monitoring of data quality and consistency in the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial
Discussion CSM can be used to provide a check of the quality of the data from completed multicenter clinical trials before analysis, publication, and submission of the results to regulatory agencies. It can also form the basis of a risk-based monitoring strategy in ongoing multicenter trials. CSM aims at improving data quality in clinical trials while also reducing monitoring costs. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2015 Category: Gastroenterology Source Type: research

Impact of being underweight on the long-term outcomes of patients with gastric cancer
This study reviewed the medical records of 638 patients with gastric cancer who underwent gastrectomy between January 2003 and December 2011. The patients were divided into three groups according to the WHO classification: underweight (BMI
Source: Gastric Cancer - August 23, 2015 Category: Gastroenterology Source Type: research

RHOA mutation may be associated with diffuse-type gastric cancer progression, but is it gain or loss?
(Source: Gastric Cancer)
Source: Gastric Cancer - August 21, 2015 Category: Gastroenterology Source Type: research

Reply to the Letter to the Editor
(Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2015 Category: Gastroenterology Source Type: research

The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines
Abstract Although gastrointestinal stromal tumors (GISTs) are a rare type of cancer, they are the commonest sarcoma in the gastrointestinal tract. Molecularly targeted therapy, such as imatinib therapy, has revolutionized the treatment of advanced GIST and facilitates scientific research on GIST. Nevertheless, surgery remains a mainstay of treatment to obtain a permanent cure for GIST even in the era of targeted therapy. Many GIST guidelines have been published to guide the diagnosis and treatment of the disease. We review current versions of GIST guidelines published by the National Comprehensive Cancer Network, ...
Source: Gastric Cancer - August 14, 2015 Category: Gastroenterology Source Type: research

Quality of life and nutritional consequences after aboral pouch reconstruction following total gastrectomy for gastric cancer: randomized controlled trial CCG1101
Conclusions Although AP was safely implemented, no increased benefits in nutritional or QOL-related parameters were observed for this method over RY within 12 months postoperatively. (Source: Gastric Cancer)
Source: Gastric Cancer - August 14, 2015 Category: Gastroenterology Source Type: research

Epstein-Barr virus infection serves as an independent predictor of survival in patients with lymphoepithelioma-like gastric carcinoma
Conclusions EBV infection serves as an independent predictor of survival in patients with LELC. EBV-negative LELC exhibited clinicopathologic features and prognosis distinct from those of EBV-positive LELC. (Source: Gastric Cancer)
Source: Gastric Cancer - August 12, 2015 Category: Gastroenterology Source Type: research

Clinicopathological factors associated with HER2 status in gastric cancer: results from a prospective multicenter observational cohort study in a Japanese population (JFMC44-1101)
Conclusions HER2 expression in Japanese patients was comparable to that in other populations examined. Intestinal type was an independent factor related to HER2 positivity and low HER2 expression. (Source: Gastric Cancer)
Source: Gastric Cancer - August 12, 2015 Category: Gastroenterology Source Type: research

Chemotherapy is effective for stage I gastric cancer in patients with synchronous esophageal cancer
Conclusions FP was effective for EGC. EGC was stable without progression for more than 6 months while patients underwent FP treatment for EC. We consider observing EGC with no treatment during chemotherapy for EC to be appropriate disease management. (Source: Gastric Cancer)
Source: Gastric Cancer - August 11, 2015 Category: Gastroenterology Source Type: research

Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)
Conclusions To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited metastasis of gastric cancer. The study indicated that patients with a single liver metastasis with a grade lower than N2 lymph node metastasis of the primary lesion are the best candidates for liver resection. (Source: Gastric Cancer)
Source: Gastric Cancer - August 11, 2015 Category: Gastroenterology Source Type: research

A phase II study of an enhanced recovery after surgery protocol in gastric cancer surgery
Conclusions The ERAS protocol can be safely used in patients undergoing gastric cancer surgery. The superiority of the ERAS protocol over non-ERAS perioperative management should be clarified. (Source: Gastric Cancer)
Source: Gastric Cancer - August 11, 2015 Category: Gastroenterology Source Type: research

Outcome of gastric cancer in the elderly: a population-based evaluation of the Munich Cancer Registry
Abstract Background Gastric cancer accounts for 5 % of cancer deaths. Proportions of older stomach cancer patients are increasing. Despite the still poor prognosis, standardised treatment has achieved improvements; nonetheless it is questionable whether all age groups have benefitted. Age and outcome need to be examined in a population-based setting. Methods Analyses included Munich Cancer Registry (MCR) data from 8601 invasive gastric cancer patients, diagnosed between 1998 and 2012. Tumour and therapy characteristics and outcome were analysed by two age groups (
Source: Gastric Cancer - August 11, 2015 Category: Gastroenterology Source Type: research

CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent
Abstract Background CD97 knockdown impairs the metastatic capacity of SGC-7901 gastric cancer cells. However, the role of CD97 in the distant lymphatic premetastatic niche formation of gastric cancer remains unknown. Methods Exosomes and the soluble fraction were isolated from SGC-L (an SGC-7901-cell-derived highly lymphatic metastatic cell line) and CD97-knockdown (SGC-L/CD97-kd) cells, and were co-cultured with gastric cancer cells. The metastatic capacity of the two cell lines was evaluated in vitro and in a footpad lymph node metastasis mouse model. ...
Source: Gastric Cancer - August 2, 2015 Category: Gastroenterology Source Type: research

Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer
Conclusions Serum miR-203 has the potential to serve as a noninvasive biomarker for prognosis and to predict metastasis in patients with GC. (Source: Gastric Cancer)
Source: Gastric Cancer - August 1, 2015 Category: Gastroenterology Source Type: research

Is preoperative staging enough to guide lymph node dissection in clinically early gastric cancer?
Abstract Background Limited by the accuracy of preoperative staging, some cases of gastric cancer invading the muscularis propria (pT2) are underestimated as early gastric cancer (EGC) in the preoperative assessment. The aim of this present study was to determine prognostic factors and to propose indications for limited lymph node dissection in patients with clinically EGC (cEGC). Methods Patients of cEGC (n = 2072) who were postoperatively diagnosed as pT1 (cT1pT1, n = 1858) and pT2 (cT1pT2, n = 214) from 2005 to 2009 at Se...
Source: Gastric Cancer - August 1, 2015 Category: Gastroenterology Source Type: research

Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation
Conclusions In select patients with liver metastasis from gastric cancer, liver resection and RFA showed satisfactory and comparable short- and long-term results. Thus, systemic chemotherapy may not be the only therapeutic option for patients with liver metastasis, and possible liver-directed treatment options for such patients should be considered on an individual basis. (Source: Gastric Cancer)
Source: Gastric Cancer - July 31, 2015 Category: Gastroenterology Source Type: research

Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer
Conclusions These results indicate that the expression of fukutin may be a key regulator for progression of GC with the intestinal mucin phenotype. (Source: Gastric Cancer)
Source: Gastric Cancer - July 30, 2015 Category: Gastroenterology Source Type: research

Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti- Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis
Abstract Background Upper gastrointestinal endoscopy (UGI-ES) and double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) are two major image-based methods to diagnose atrophic gastritis, which is mostly induced by Helicobacter pylori infection. However, there have been few studies directly comparing them. Methods Atrophic gastritis was evaluated using the data of 962 healthy subjects who underwent UGI-ES and UGI-XR within 1 year. Results and conclusion Based on UGI-ES and UGI-XR, 602 subjects...
Source: Gastric Cancer - July 30, 2015 Category: Gastroenterology Source Type: research

Comparison of laparoscopic versus open gastrectomy for advanced gastric cancer: an updated meta-analysis
Abstract Background Laparoscopic gastrectomy (LG) has been used as an alternative to open gastrectomy (OG) to treat early gastric cancer. However, the use of LG for advanced gastric cancer (AGC) has been in debate. Methods Literature retrieval was performed by searching PubMed, EMBASE, and the Cochrane library up to July 2014. Potential studies comparing the surgical effects between LG with OG were evaluated and data were extracted accordingly. Meta-analysis was carried out using RevMan. The pooled risk ratio and weighted mean difference (WMD) with 95&nb...
Source: Gastric Cancer - July 27, 2015 Category: Gastroenterology Source Type: research

Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection
Abstract Background Programmed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1 and PD-L1 expression and to analyze the relationships among PD-1, PD-L1, and Foxp3 expression in gastric cancer. Methods A total of 105 patients who underwent curative gastrectomy for stage II/III gastric cancer were included in this study. PD-1, PD-L1, and Foxp3 expression were examined by immunohistochemistry and related to prognostic factors by ...
Source: Gastric Cancer - July 26, 2015 Category: Gastroenterology Source Type: research

Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma
Conclusions The enrichment of STOP genes in regions of copy-number loss indicates that their deletion may contribute to gastric carcinogenesis. Furthermore, the presence of several deleted and downregulated CYCLOPS genes in some tumors suggests potential therapeutic targets in these tumors. (Source: Gastric Cancer)
Source: Gastric Cancer - July 24, 2015 Category: Gastroenterology Source Type: research

In vivo evaluation of a modified linear stapling device designed to facilitate accurate pathologic examination of the surgical margin
Conclusions Stapler E1 is safe and could be useful for the pathologic evaluation of the true surgical margin. (Source: Gastric Cancer)
Source: Gastric Cancer - July 22, 2015 Category: Gastroenterology Source Type: research

Follow-up after gastrectomy for cancer: the Charter Scaligero Consensus Conference
Conclusion After gastrectomy for cancer, oncological follow-up should be offered to patients; it should be tailored to the stage of the disease, mainly based on cross-sectional imaging, and should be discontinued after 5 years. (Source: Gastric Cancer)
Source: Gastric Cancer - July 4, 2015 Category: Gastroenterology Source Type: research

Predictors of postoperative complications in elderly and oldest old patients with gastric cancer
Conclusions Adjustments to the extent of surgery among oldest old patients most likely reduces the incidence of postoperative complications in this group. Preoperative serum albumin level and PNI are significant predictors of postoperative complications in oldest old patients with gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - July 1, 2015 Category: Gastroenterology Source Type: research