Combined loss of CDH1 and downstream regulatory sequences drive early-onset diffuse gastric cancer and increase penetrance of hereditary diffuse gastric cancer

ConclusionIn this work, we demonstrated that regulatory elements lying down-stream ofCDH1 are part of a chromatin network that controlCDH1 expression and influence cell transcriptome and associated signalling pathways, likely explaining high disease penetrance and very young cancer-onset. This study highlights the importance of incorporating scientific –technological updates and clinical guidelines in routine diagnosis, given their impact in timely genetic diagnosis and disease prevention.Graphical abstract
Source: Gastric Cancer - Category: Gastroenterology Source Type: research