Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice
Conclusion
In a therapeutic approach, FGF10 overexpression successfully restored lung alveolar and vascular structure in mice with established cigarette smoke- and elastase-induced emphysema and PH. FGF10 treatment triggered an initial increase in the number of alveolar type 2 cells that gradually returned to the basal level when the FGF10-mediated repair process progressed. Therefore, the application of recombinant FGF10 or stimulation of the downstream signalling cascade might represent a novel therapeutic strategy in the future. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 9, 2023 Category: Respiratory Medicine Authors: Hadzic, S., Wu, C.-Y., Gredic, M., Pak, O., Loku, E., Kraut, S., Kojonazarov, B., Wilhelm, J., Brosien, M., Bednorz, M., Seimetz, M., Günther, A., Kosanovic, D., Sommer, N., Warburton, D., Li, X., Grimminger, F., Ghofrani, H. A., Schermuly, R. T., Tags: COPD and smoking, Lung biology and experimental studies Original Articles: Basic mechanisms of lung disease Source Type: research
"Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury." C.C. dos Santos, H. Amatullah, C.M. Vaswani, et al. Eur Respir J 2022; 59: 2004216.
(Source: European Respiratory Journal)
Source: European Respiratory Journal - November 9, 2023 Category: Respiratory Medicine Tags: Erratum Source Type: research
Viewpoint: activin signalling inhibitors for the treatment of pulmonary arterial hypertension
Extract
Pulmonary vascular remodelling and dysfunction are hallmarks of pulmonary arterial hypertension (PAH), a rare and severe form of pre-capillary pulmonary hypertension, causing shortness of breath, fatigue, chest pain, exercise limitation, altered quality of life and markedly reduced life expectancy, despite guideline-supported management with approved medications [1–5]. In the past 30 years, several drugs with predominant vasodilator properties have been successfully developed for PAH, targeting the endothelin, nitric oxide and prostacyclin pathways (endothelin receptor antagonists, phosphodiesterase type-5 in...
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Humbert, M. Tags: Editorials Source Type: research
Can the curse of mood disorders in COPD be lifted and enable pulmonary rehabilitation?
Extract
Pulmonary rehabilitation is not only strongly recommended for people with COPD by a new American Thoracic Society clinical practice guideline [1], it is championed by the World Health Organization (WHO) in new recommendations for payers/commissioners [2]. Mood disorders such as anxiety and depression are highly prevalent in COPD (estimated between 13% and 46%, increasing with severity of COPD [3]) and, importantly, are associated with increased healthcare utilisation, worse quality of life and reduced survival [4]. Pulmonary rehabilitation is effective at improving anxiety and depression [5] and the recent WHO 2023...
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Evans, R., Doe, G. Tags: Editorials Source Type: research
Reply: Tuberculosis screening in migrants to the EU/EEA and UK
Extract
We would like to thank N. Köhler and co-workers for their correspondence regarding our recent paper [1], comparing and contrasting it with their large pan-European study. Their study collected aggregate country-specific tuberculosis (TB) incidence rates as measured by infectious disease surveillance systems in the country of arrival (CoA) [2] and compared these to World Health Organization (WHO) TB incidence estimates from their respective country of origin (CoO). The authors found considerable differences between these incidence rates and conclude that there are many factors, other than incidence in the Co...
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Zenner, D., Cobelens, F., Abubakar, I. Tags: Respiratory infections and tuberculosis Correspondence Source Type: research
Tuberculosis screening in migrants to the EU/EEA and UK
Extract
With great interest we read the article by Zenner et al. [1] on drivers determining tuberculosis screening yield in four European countries. The authors pooled individual-level data from national tuberculosis screening programmes in Italy, the Netherlands, Sweden and the UK. The dataset includes 1658 tuberculosis cases among 2 107 016 migrants between 2005 and 2018. The authors show that among all types of migrants (students and workers, asylum seekers, individuals on settlement and family visas, and those on working holidays), screening asylum seekers would have the highest yield, followed by screening all other t...
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Köhler, N., Vasiliu, A., Mandalakas, A. M., Martinez, L., Lange, C., for the TBnet Tags: Respiratory infections and tuberculosis Correspondence Source Type: research
The airway smooth muscle layer is structurally abnormal in low birth weight infants: implications for obstructive disease
Extract
This research letter concerns known associations between intrauterine growth restriction (IUGR), low birth weight (LBW) and increased risk of obstructive disease [1, 2]. Our prior animal simulations, specifically a mid-gestation maternal hypoxia mouse model of IUGR, has forwarded the hypothesis that increased risk of obstructive disease is due to abnormalities of the airway wall. In mice, IUGR causes airway smooth muscle (ASM) thickening of the fetus [3], and in postnatal life, increases airway wall stiffness [4] and modifies bronchoconstrictor response to inhaled methacholine [5]. These forerunner findings support...
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Wang, K. C. W., Elliot, J. G., Saglani, S., Donovan, G. M., James, A. L., Noble, P. B. Tags: Lung structure and function Research Letters Source Type: research
Dupilumab leads to better-controlled asthma and quality of life in children: the VOYAGE study
Conclusions
In children aged 6–11 years with moderate-to-severe type 2 asthma, dupilumab treatment was associated with rapid, sustained improvements in asthma control. HRQoL was significantly improved for children and their caregivers. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Fiocchi, A. G., Phipatanakul, W., Zeiger, R. S., Durrani, S. R., Cole, J., Msihid, J., Gall, R., Jacob-Nara, J. A., Deniz, Y., Rowe, P. J., Lederer, D. J., Hardin, M., Zhang, Y., Khan, A. H. Tags: Asthma and allergy Original Articles: Asthma in children Source Type: research
Earthquake disaster and respiratory health: lessons from Turkey and Syria in 2023
Extract
On 6 February 2023, a strong earthquake of 7.8 magnitude (Mw) hit the Southeast provinces of Turkey and Northwestern territories of Syria at 04:17 h local time (figure 1). The first shake was followed by another with a similar scale of 7.5 Mw, with more than 11 000 aftershocks recorded in the following days [1, 2]: the most powerful earthquakes in Turkey since 1939 [3]! (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Mohammad, Y., Bayram, H., Kayalar, O., Madonna, F., Annesi-Maesano, I. Tags: Epidemiology, occupational and environmental lung disease Editorials Source Type: research
Sequential multimodal therapy in chronic thromboembolic pulmonary hypertension with mixed anatomical lesions: a proof of concept
Extract
Three treatment options have been successfully developed for the management of chronic thromboembolic pulmonary hypertension (CTEPH): pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA) and pulmonary arterial hypertension (PAH)-targeted medical therapy [1–3]. Management of CTEPH has greatly evolved in the past decade, with the possibility to combine these therapeutic options [4, 5]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Jevnikar, M., Solinas, S., Brenot, P., Lechartier, B., Kularatne, M., Montani, D., Savale, L., Garcia-Alonso, C., Sitbon, O., Beurnier, A., Boucly, A., Bulifon, S., Seferian, A., Roche, A., Mercier, O., Simonneau, G., Fadel, E., Humbert, M., Jaïs, Tags: Pulmonary vascular disease Research Letters Source Type: research
Tailored psychological intervention for anxiety or depression in COPD (TANDEM): a randomised controlled trial
Conclusion
This trial has shown, beyond reasonable doubt, that this cognitive behavioural intervention delivered by trained and supervised respiratory health professionals does not improve psychological comorbidity in people with advanced COPD and depression or anxiety. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 2, 2023 Category: Respiratory Medicine Authors: Taylor, S. J. C., Sohanpal, R., Steed, L., Marshall, K., Chan, C., Yaziji, N., Barradell, A. C., Font-Gilabert, P., Healey, A., Hooper, R., Kelly, M. J., Mammoliti, K.-M., Priebe, S., Rajasekaran, A., Roberts, C. M., Rowland, V., Singh, S. J., Smuk, M., U Tags: COPD and smoking Original Articles: COPD Source Type: research
Validation of a new portable system containing both FeNO analysis and spirometry measurement
Conclusion: The accuracy of FeNO and spirometry measurements by SUNVOU TM2125was validated in this study.Figure 1. Correlation and agreement between FeNO and spirometers values measured by TM2125 and VERO/MasterScreeen. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Huang, K., Li, Y., Yang, T. Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
Baseline Characteristic of participants in the National COPD Screening Program in China
The National COPD Screening Program in China is a multi-stage sequential screening program, incorporates a previously validated questionnaire (i.e. COPD Screening Questionnaire), pre- and post-bronchodilator spirometry to target the COPD high-risk population. During the first year, 949,172 participants were screened and 18.12% (171,965) of them were high risk for COPD, of whom 49.63% (85,352) accepted onsite pre- and post-bronchodilator spirometry. Then 83.45% (71,229) were categorized as High Risk Group I, 3.89% (3316) were categorized as High Risk Group II and 12.67% (10,807) were categorized as spirometry defined COPD. ...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Huang, K., Lei, J., Li, W., Pan, J., Jia, C., Yang, T. Tags: General practice and primary care Source Type: research
Late Breaking Abstract - Clinical efficacy and satisfaction with a digital wheeze detector supporting the self-management of childhood wheeze
Conclusion: In the current study population and settings, the wheeze detector was generally well accepted by parents, but did not show significant impact on the management of pre-school wheezing disorders at home. Further research is needed to enhance device usability and understand parental perception of the novel device. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Do, Y. H., Van Aalderen, W., Dellbrügger, E., Grenzbach, C., Grigg, J., Haarman, E., Karadag, B., Rossberg, S., Weichert, T.-M., Whitehouse, A., Matricardi, P. M., Dramburg, S. Tags: Paediatric asthma and allergy Source Type: research
Late Breaking Abstract - Title: Association between Apgar-scores within normal range and development of asthma, allergy, and eczema in childhood: a Danish nationwide register study
Conclusions: Lower Apgar-scores within the normal range increases the overall risk of asthma and eczema before school-age. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Hansen, E. S. H., Kaiser, H., Hansen, K. T., Bonnelykke, K., Chawes, B., Backer, V., Suppli Ulrik, C., Torp-Pedersen, C., Brustad, N. Tags: Paediatric asthma and allergy Source Type: research
