Cluster analysis to identify long COVID phenotypes using 129Xe magnetic resonance imaging: a multicentre evaluation
Conclusions
We identified four 129Xe MRI long COVID phenotypes with distinct characteristics. 129Xe MRI can dissect pathophysiological heterogeneity of long COVID to enable personalised patient care. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Authors: Eddy, R. L., Mummy, D., Zhang, S., Dai, H., Bechtel, A., Schmidt, A., Frizzell, B., Gerayeli, F. V., Leipsic, J. A., Leung, J. M., Driehuys, B., Que, L. G., Castro, M., Sin, D. D., Niedbalski, P. J. Tags: Respiratory infections and tuberculosis Original Articles: Long COVID series Source Type: research
Reversal of cylindrical bronchial dilatations in a subset of adults with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor
Conclusions
Although bronchial dilatations are generally considered irreversible, ETI was associated with reversal, which was limited to the cylindrical bronchial dilatation subtype, and occurred in a small subset of awCF. Initiating ETI earlier in life may reverse early bronchial dilatations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Authors: Cazier, P., Chassagnon, G., Dhote, T., Da Silva, J., Kanaan, R., Honore, I., Carlier, N., Revel, M.-P., Canniff, E., Martin, C., Burgel, P.-R. Tags: CF and non-CF bronchiectasis Original Articles: Cystic fibrosis Source Type: research
ERS/EBMT clinical practice guidelines on treatment of pulmonary chronic graft-versus-host disease in adults
Chronic graft-versus-host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available. The purpose of this joint European Respiratory Society (ERS) and European Society for Blood and Marrow Transplantation task force was to develop evidence-based recommendations regarding the treat...
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Authors: Bos, S., Murray, J., Marchetti, M., Cheng, G.-S., Bergeron, A., Wolff, D., Sander, C., Sharma, A., Badawy, S. M., Peric, Z., Piekarska, A., Pidala, J., Raj, K., Penack, O., Kulkarni, S., Beestrum, M., Linke, A., Rutter, M., Coleman, C., Tonia, T., Schoema Tags: Respiratory clinical practice Original Articles: ERS/EBMT guidelines Source Type: research
Pulmonary phase contrast CT imaging: a novel setup at the Italian synchrotron for the study of fresh lungs at human scale
Extract
High-resolution computed tomography (HRCT) remains the current gold standard for detailed morphological assessment of the human lung, but is intrinsically limited in spatial resolution to about 0.5 mm, because an increase in spatial resolution is accompanied by a significant increase in the required radiation dose. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Authors: Dullin, C., Wagner, W. L., Confalonieri, M., Tromba, G. Tags: Lung imaging Research Letters Source Type: research
"Aberrant anti-viral response of natural killer cells in severe asthma." J. Devulder, C. Chenivesse, V. Ledroit, et al. Eur Respir J 2020; 55: 1802422.
(Source: European Respiratory Journal)
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Tags: Erratum Source Type: research
Systematic pulmonary embolism follow-up: why we should all do it!
Extract
For many years now, the pulmonary hypertension community has been trying to narrow down on the true incidence of chronic thromboembolic pulmonary hypertension (CTEPH) following pulmonary embolism. The study by Durrington et al. [1] in this issue of the European Respiratory Journal undoubtedly gets us closer, suggesting a cumulative incidence of 2.1%; however, with 41% of the entire post-pulmonary embolism cohort missing, we are still a way off truly knowing this figure. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Howard, L. S., Price, L. C. Tags: Editorials Source Type: research
Reply to: Insights on the ERS/ESTS statement on the management of pleural infection in adults
Extract
We thank Y. Li and co-workers for their interest in the European Respiratory Society/European Society of Thoracic Surgeons statement on the management of pleural infection, recently published in the European Respiratory Journal [1]. Our interpretation of their correspondence is that they have misunderstood "IPC" to denote a standard chest drain or tube used, with a well-established evidence base, in the acute management of pleural infection [2]. This is also sometimes referred to as an intercostal catheter or an intercostal drain. In the statement, IPC refers specifically to "indwelling pleural catheter", and the a...
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Bedawi, E. O., Rahman, N. M. Tags: Correspondence Source Type: research
Insights on the ERS/ESTS statement on the management of pleural infection in adults
Extract
We read with great interest the article by Bedawi et al. [1], recently published in the prestigious European Respiratory Journal, on the management of pleural infection in adults. We highly commend this work and here we wish to focus on the management of pleural infection with indwelling pleural catheters (IPC). The statement suggested that recurrent or chronic pleural infection created difficult management issues, especially in those with trapped lung and where there was no surgical option [1]. However, we reviewed previous publications and wish to bring forth some different insights on the management of pleural i...
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Li, Y., Zeng, H., Tian, P., Li, W. Tags: Correspondence Source Type: research
Haemodynamic phenotypes of pulmonary hypertension associated with left heart disease: a moving target
(Source: European Respiratory Journal)
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Gerges, C., Montani, D., Humbert, M., Lang, I. M. Tags: RESEARCH LETTER Source Type: research
Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children"
The coronavirus disease 2019 (COVID-19) pandemic substantially impacted different age groups, with children and young people not exempted. Many have experienced enduring health consequences. Presently, there is no consensus on the health outcomes to assess in children and young people with post-COVID-19 condition. Furthermore, it is unclear which measurement instruments are appropriate for use in research and clinical management of children and young people with post-COVID-19. To address these unmet needs, we conducted a consensus study, aiming to develop a core outcome set (COS) and an associated core outcome measurement ...
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Seylanova, N., Chernyavskaya, A., Degtyareva, N., Mursalova, A., Ajam, A., Xiao, L., Aktulaeva, K., Roshchin, P., Bobkova, P., Aiyegbusi, O. L., Anbu, A. T., Apfelbacher, C., Asadi-Pooya, A. A., Ashkenazi-Hoffnung, L., Brackel, C., Buonsenso, D., de Groot Tags: Respiratory infections and tuberculosis Original Articles: Long COVID series Source Type: research
Systematic pulmonary embolism follow-up increases diagnostic rates of chronic thromboembolic pulmonary hypertension and identifies less severe disease: results from the ASPIRE Registry
Extract
Pulmonary embolism (PE) is a condition in which thrombus, usually embolised from the veins of the pelvis or lower limbs, obstructs the pulmonary arterial vascular bed. The incidence of PE is estimated at 60–70 per 100 000 per year [1] with a 1-year mortality of 15% [2, 3]. In survivors, patency of the pulmonary vasculature is restored, in most patients, within the first few months [4]. However, pulmonary emboli may not resolve and patients may also develop a chronic obstructing microvasculopathy [5, 6]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 14, 2024 Category: Respiratory Medicine Authors: Durrington, C., Hurdman, J. A., Elliot, C. A., Maclean, R., Van Veen, J., Saccullo, G., De-Foneska, D., Swift, A. J., Smitha, R., Hill, C., Thomas, S., Dwivedi, K., Alabed, S., Wild, J. M., Charalampopoulos, A., Hameed, A., Rothman, A. M. K., Watson, L., Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular disease Source Type: research
Socioeconomic disparities in European cystic fibrosis outcomes: time to close the gap
Extract
Cystic fibrosis (CF) is one of the most common autosomal recessive genetic conditions that causes progressive lung disease and premature death [1]. Median survival worldwide is estimated to be around 50 years, but there is variation between countries [2–4]. Reasons for this variation are complex, and include genetic factors such as cystic fibrosis transmembrane conductance regulator (CFTR) genetic mutations in the population [5], as well as non-genetic factors such as access to lung transplantation and socioeconomic status (SES) [4]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: McKone, E. F. Tags: Editorials Source Type: research
Some future directions for genome-wide association studies of preserved ratio impaired spirometry
Extract
We read with interest the paper by Higbee et al. [1] that was recently published in the European Respiratory Journal. They discovered 22 single nucleotide polymorphisms (SNPs) associated with preserved ratio impaired spirometry (PRISm) through a two-stage sample population, four of which were associated with lung function, highlighting the usefulness of performing genome-wide association study (GWAS) of different lung function traits and phenotypes to maximise discovery of heritable genetic variants of lung function and disease, and that genetic risk factors for PRISm overlap with those for other lung diseases and ...
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Jin, Z., Wang, G. Tags: Correspondence Source Type: research
Omics-based profiles and biomarkers of respiratory infections: are we there yet?
Extract
From the influenza pandemic of 1918–1919 to the most recent COVID-19 pandemic, respiratory infections remain a leading cause of mortality worldwide [1, 2]. Concurrently, the development of high-throughput omics technologies has revolutionised research about host responses to known and emerging respiratory pathogens [3], accelerating our understanding of highly prevalent pulmonary diseases [4]. Notably, omics technology-based characterisation of pathogens and host pathophysiology have critically supported diagnostic and therapeutic global health efforts during both the influenza A H1N1 and SARS-CoV-2 pandemics...
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Pantaleon Garcia, J., Evans, S. E. Tags: Editorials Source Type: research
High altitude travelling with pulmonary arterial hypertension
Extract
Altitude exposure is generally considered to be contraindicated in pulmonary arterial hypertension (PAH), out of concern that (hypobaric) hypoxic pulmonary vasoconstriction (HPV) might further increase pulmonary vascular resistance (PVR) and worsen right heart failure [1]. This notion is mentioned in the guidelines of the European Society of Cardiology (ESC) and European Respiratory Society (ERS), who provide a recommendation against the travel to altitude of >1500 m without supplemental oxygen [2, 3]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - March 7, 2024 Category: Respiratory Medicine Authors: Naeije, R. Tags: Editorials Source Type: research
