Dynamic doublecortin-like kinase 1 (DCLK1) expression on alveolar epithelial type II cells (AT2) in acute respiratory distress syndrome (ARDS) mouse model
Conclusions: Our results showed that DCLK1 was dynamically expressed on AT2 cells in different stages of ARDS pathogenesis, which could be involved in the underlying mechanisms of ARDS. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Chen, X.-Y., Kao, C., Chuang, H.-C. Tags: Mechanisms of lung injury and repair Source Type: research
The sodium-coupled neutral amino acid transporter SNAT2 regulates alveolar epithelial cell homeostasis in acute lung injury/ARDS
We reported earlier that the Na+-coupled neutral amino acid (AA) transporter SNAT2, which transports one neutral AA along with one Na+, promotes alveolar fluid clearance by AEC-mediated Na+ uptake. SNAT2s contribution to AEC homeostasis in ARDS/ALI by its role as AA transporter is, however, unknown. We hypothesize that SNAT2 is lost under inflammatory conditions, enhancing AEC apoptosis and lung permeability, thus promoting ALI.In vitro, SNAT2 was downregulated in AEC stimulated with cytomix (IFN-, TNF-α, IL-1β and LPS, 50 ng/ml) or pneumolysin (0,2 μg/ml) mimicking the inflammatory or infectious milieu of AR...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Falivene, J., Weidenfel, S., Kuebler, W. M. Tags: Mechanisms of lung injury and repair Source Type: research
Adipose mesenchymal stem cells from COPD patients are capable of restoring elastase-induced emphysema in a murine experimental model
Conclusions: Our data demonstrate equal therapeutic potential of AD-MSC from COPD and non-COPD subjects in the pre-clinical model, thus supporting their autologous use in disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Martin Medina, A., Rio, C., Jahn, A. K., Calvo Bota, A. M., De Francisco Casado, M. T., Pont Antona, P. J., Gigirey Castro, O., Carvajal, A. F., Villena Portella, C., Gomez Bellvert, C., Iglesias, A., Calvo Benito, J., Gaya Puig, A., Ortiz, L. A., Sala-Ll Tags: Mechanisms of lung injury and repair Source Type: research
Benefits of bronchial epithelial repair by iPSC in COPD
Conclusions: Repairing the pathological epithelium of a patient with COPD with epithelia derived from iPSC from the same patient would make it possible to explore the avenues of a possible therapy targeting epigenetics, and why not cell therapy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Nadaud, M., Bourdais, C., Fort-Petit, A., De Vos, J., Hireche, K., Vachier, I., Ahmed, E., Bourdin, A. Tags: Mechanisms of lung injury and repair Source Type: research
Lipofibroblast derived-extracellular vesicles attenuate cigarette smoke-induced lung injury
Conclusion: Our data indicate that LiF-derived EVs induced by metabolic modulators may be a novel therapeutic modality for COPD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Fujimoto, S., Fujita, Y., Watanabe, N., Matsubayashi, S., Kawamoto, H., Takekoshi, D., Ito, S., Minagawa, S., Hara, H., Araya, J., Kuwano, K. Tags: Mechanisms of lung injury and repair Source Type: research
