LSC - 2017 - Reprogramming Of Tumor Associated Macrophages By Modulating Wnt/ss-catenin Signalling In Lung Cancer
Data from clinical and experimental studies suggest that Tumor Associated Macrophages (TAMs) contribute to cancer progression and metastasis. We aim to identify and manipulate TAMs specific signalling pathways, which are responsible for shift of macrophage from pro-tumorigenic(M2 like-TAMs) to anti-tumorigenic(M1 like-TAMs). We established and characterized a novel in vitromodel, training macrophages with tumor cell for 3 days (M1 like TAMs) and 5 days (M1 like-TAMs). These M2 like TAMs showed reduced apoptosis in tumor cells, increased tumor cell migration and proliferation compared to M1 like-TAMs. RNA sequencing of M1 a...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sarode, P., Zheng, X., Weigert, A., Tretyn, A., Pullamsetti, S. S., Seeger, W., Savai, R. Tags: Lung Cancer Source Type: research

Thoracic surgery may improve outcome for bilateral cavitary multidrug- and extensively drug-resistant TB
Background: Treatment for multidrug (MDR) and extensively drug-resistant (XDR) TB remains a challenge to public health.Methods: A retrospective case study was carried out to estimate value of adjunctive surgery for bilateral cavitary MDR and XDR TB.Results: We identified 57 consecutive patients, 44(77.2%) were males, aged 18 to 61. Twenty-two (38.6%) cases were MDR TB, and 35(72.4%) were XDR TB, all confirmed with cultures. Fifty one patients were smear-positive. Best available TB treatment was performed before and after surgery. Patients were divided to groups by the extent of disease and performed surgery.In group A (n=8...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Marfina, G., Vladimirov, K., Kudriashov, G., Starshinova, A., Sokolovich, E., Yablonskii, P., Avetisian, A. Tags: Tuberculosis Source Type: research

The effect of resection surgery on long-term treatment outcomes of patients with MDR/XDR-TB
Background: In previous study we found out that use of resection surgery (RS) in treatment of patients with MDR/XDR-TB improved immediate treatment outcomes (TO) – 91,7% cured with RS vs 66,8% without one, p
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Batyrshina, Y. Tags: Tuberculosis Source Type: research

The efficacy, safety and tolerability of the short 12-month MDR-TB regimen in Ukraine at the expense of using intravenous administration of anti-tuberculosis drugs during intensive phase
Conclusions: Administration of intravenous ATDs at the 1st month of treatment, using linezolid for short 12-month regimen of chemotherapy allows improve the outcomes in patients with MDR-TB and save total cost of treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lytvynenko, N., Gumenuk, M., Varytska, H., Chobotar, O., Grankina, N. Tags: Tuberculosis Source Type: research

High rates of resistance to second line drugs are routinely encountered in Mumbai,India for XDR-TB;highlighting the need for new agents
Conclusion: Given the high rates of concomitant resistance to other second line drugs in XDR isolates of our cohort, urgent access to newer drugs such as Bedaquiline and Delaminid as well as newer regimens are the need of the hour. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Banka, R., Mullerpattan, J., Ganatra, S., Udwadia, Z., Rodrigues, C., Parmar, A., Khillari, A. Tags: Tuberculosis Source Type: research

Eligibility for WHO shorter MDR treatment regimen among foreign-born MDR PTB patients in Singapore
We report the phenotypic drug susceptibility pattern of these cases to detemine their eligibility for the WHO shorter MDR-TB regimen.From 2002 to 2016, there were 214 foreign-born MDR PTB cases diagnosed in Singapore. These originated from Indonesia (n=76), Myanmar (n=54), China (n=37), Philiippines (n=18), Vietnam (n=15), India (n-7), Bangladesh (n=4) and others (n=3). Nine (4.2%) were XDR and 28 (13.1%) pre-XDR cases. Phenotypic DST showed 16.7% (35/209) resistance to ofloxacin, 5.2% (11/213) resistance to kanamycin, 23% (49/213) resistance to ethionamide, 47.2% (101/214) resistance to ethambutol, 56.7% (68/120) resistan...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Chee, C., KhinMar, K. W., Sng, L. H., Jureen, R., Cutter, J., Lee, V., Wang, Y. T. Tags: Tuberculosis Source Type: research

New and repurposed TB drugs use in children and adolescents with M/XDR-TB
Conclusion: The study preliminary results show that children and adolescents with M/XDR-TB respond favorably to new and repurposed TB drugs containing regimens confirming their safety and effectiveness. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Skrahina, A., Klimuk, D., Babchenok, I., Solodovnikova, V., Skrahin, A., Hurevich, H. Tags: Tuberculosis Source Type: research

Bedaquiline (BQ)-containing regimen at the programmatic level for MDR-TB: preliminary results
Conclusions: The results of this study, the largest ever done, indicate that BQ-containing regimens used at the programmatic level achieve satisfactory outcomes and bacteriological conversion rates even with a significant proportion of XDR-TB cases. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Borisov, S. E., Dheda, K., Enwerem, M., Romero Leyet, R., DAmbrosio, L., Centis, R., Sotgiu, G., Tiberi, S., Alffenaar, J.-W., Maryandyshev, A., Belilowski, E., Ganatra, S., Skrahina, A., Akkerman, O., Aleksa, A., Amale, R., Artsukevich, J., Bruchfeld, J. Tags: Tuberculosis Source Type: research

Regulation of tracheal parasympathetic nerve ganglia development by eosinophils
Background: Eosinophils interact directly with airway nerves in patients and mouse models of asthma.Aim: We investigated the effects of eosinophils on airway ganglia number and neurotransmitter expression.Methods: Adult wild-type (WT, C57Bl/6), eosinophil-deficient (PHIL, diphtheria toxin expression driven by the eosinophil peroxidase promoter), and airway eosinophilia mice (NJ1726, IL5 expression driven by the CC10 airway epithelium specific promoter) were studied. Whole mount tracheas were labeled with antibodies against the pan-neuronal marker PGP9.5 and with either: substance P, neuronal nitric oxide synthase (nNOS), o...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Pincus, A., Drake, M., Fryer, A., Lee, N., Lee, J., Jacoby, D., Lebold, K. Tags: Allergy and immunology Source Type: research

NTPDase activity in circulatory eosinophils from patients with allergic asthma
In this study we determined total NTPDase activity in leukocytes and eosinophil cells from acute asthma patients and healthy subjects using magnetic-activated cell sorting to separate eosinophils, and to determinate the activity we performed a enzyme kinetics with malachita green and ammonium molibdate counting inorganic phosphates release by the cells. Total leukocytes activity stimulated with 500 uM ATP from asthmatics patients presents a highly activity since the first minute than leukocytes from healthy subjects (p
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Martinez Zuniga, J. d. J., Falfan-Valencia, R., Ambrocio-Ortiz, E., Hernandez-Zenteno, R., Flores, F., Chavez, J. Tags: Allergy and immunology Source Type: research

Distinct Tryptase and CPA3-positive Basophil Phenotypes in Healthy Individuals, Asthma, and COPD
Conclusion: Our study reveals that tryptase and CPA3 are commonly expressed among peripheral blood basophils in health, asthma and COPD. These distinct basophil phenotypes warrants further clinical studies to the exploration of tryptase and CPA3 expressing phenotypes in healthy and diseases. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Siddhuraj, P., Mori, M., Bjermer, L., Erjefält, J. Tags: Allergy and immunology Source Type: research

Asthma phenotyping through CD26, CD126 and LRRC32 biomarkers: a prospective study
In conclusion, our results open a way to differentiate different phenotypes of asthma according to different levels of T cell surface markers. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Nieto Fontarigo, J. J., Gonzalez Barcala, F. J., Cruz, M. J., Valdes Cuadrado, L., San Jose Capilla, M. E., Faraldo Garcia, A., Garcia Gonzalez, M. A., Takkouche Souilamas, E. B., Arias Crespo, P., Nogueira Alvarez, M., Salgado Castro, F. J., Carreira Vil Tags: Allergy and immunology Source Type: research

Late Breaking Abstract - IL-36 receptor agonists contribute to a pro-inflammatory milieu in smokers with and without COPD
Conclusion: IL-36α and - are produced by lung cells in vitro and are increased in smokers with and without COPD in vivo, correlating with a decline in lung function and induction of pro-inflammatory chemokines. This suggests that IL-36 agonists may play a pro-inflammatory role in the lungs of long-term smokers. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kovach, M., Levanen, B., Andersson, A., Asgeirsdottir, H., Prada, M., Linden, S., Qvarfordt, I., Standiford, T., Linden, A. Tags: Allergy and immunology Source Type: research

Platelets roll and adhere to the vascular bed in response to allergen challenge in allergic mice
In an allergic inflammatory disease such as asthma, platelets can migrate through lungs in response to allergen (Pitchford, S. et al. Am J Resp Crit Care Med 2008; 177:604-612). Platelet activity and their interaction with the endothelium in response to allergen requires further investigation. The aim of this study was to investigate the vascular interactions of platelets in allergic mice following allergen challenge using intravital microscopy of the mouse cremaster muscle (CM) to visualize platelets in real time.Mice were sensitised intra-nasally with 25 μg house dust mite extract (HDM), 10 times over 2 weeks. 100 &mu...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Shah, S., Riffo Vasquez, Y., Page, C., Pitchford, S. Tags: Allergy and immunology Source Type: research

Evaluation of sleep architecture in patients recovering from critical care illness (CCI)
Introduction: Sleep disruption is a well known problem among critically ill patients in an intensive care unit (ICU) which persist during recovery and after transfer to step down unit (SDU).Aim: To evaluate patterns of sleep in patients recovering from CCI and factors (noise, light) affecting sleep.Materials and Methods: 24 hr polysomnography (PSG) study was done in patients recovering from CCI in ICU with simultaneous recording of noise, light and nursing care activities and repeated after shifting to step down unit (SDU).Results: 26 patients underwent PSG study in ICU and then in SDU. Mean APACHE II and SOFA Score were 1...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Prajapat, B., Chaudhry, D., Sandhya, A. S. Tags: Sleep and Control of Breathing Source Type: research

Association between COPD and OSA: impact on cardiorespiratory dynamics during sleep
Introduction: Nocturnal hypoxemia observed in the overlap between OSA and COPD may have an association with the development of cardiovascular consequences. The aim of this study was to investigate the impact of overlap COPD+OSA on heart rate variability (HRV) and cardiorespiratory coupling (CRC) during sleep.Methods: After overnight polysomnography, 113 subjects were divided in groups: 24 COPD (GOLD 2-4); 29 COPD+OSA (GOLD 2-4) and (AHI= 55±23); 30 OSA (AHI= 37±20) and 30 controls. Conducted linear and Poincare analysis of R-R intervals (RRi) and bivariate analysis on the tachogram and the respirogram portion...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Trimer, R., Cabiddu, R., Mendes, R. G., Costa, F. S. M., Oliveira Junior, A. D., Bianchi, A. M., Borghi-Silva, A. Tags: Sleep and Control of Breathing Source Type: research

Pulmonary functions and sleep related breathing disorders in lipid storage disease
Introduction: Impairment in pulmonary functions and sleep related breathing disorders in patients with lipid storage disease (LSD) are unknown. We aimed to evaluate impairment in pulmonary functions and sleep related breathing disorders in patients with LSD.Methods: Pulmonary functions (FEV1, FVC, upright-supine %FVC change, MIP, MEP, PCF), arterial blood gas analysis (ABG) and polysomnography of patients with LSD were evaluated.Results: Twenty-five patients with LSD are evaluated [17 male, 8 female; age:34.9±15.02years, BMI:26.5±3.4kg/m2(19-31kg/m2)]. MIP:72.2±32.7cmH2O (
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kaya Bingöl, Z., Sagcan, G., Durmus Tekce, H., Serdaroglu, P., Kiyan, E. Tags: Sleep and Control of Breathing Source Type: research

Sleep-disordered breathing and pregnancy-induced hypertension in women with and those without obesity
Introduction: Sleep-disordered breathing (SDB) is a potential risk factor for pregnancy-induced complications.Aim: The present study investigated the relationship between SDB and pregnancy-induced hypertension (PIH), by examining nocturnal sleep and respiratory conditions in pregnant women with and those without obesity.Methods: The study involved 14 pregnant women with body mass index (BMI: kg/m2) ≥ 30 (mean age, 31.6 years; group 1), 15 pregnant women with BMI
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ura, M., Fujimoto, K. Tags: Sleep and Control of Breathing Source Type: research

Arterial stiffness and obstructive sleep apnea in the elderly - the PROOF cohort study
Conclusions: In this sample of older healthy subjects, PWV is not affected by AHI and ODI and was not associated to the presence of hypertension. These results may suggest potential protective and adaptive mechanisms in older subjects. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Roche, F., Hupin, D., Millasseau, S., Barthelemy, J. C., Sforza, E. Tags: Sleep and Control of Breathing Source Type: research

Diagnostic accuracy of questionnaires to sleep apnea in the elderly
Conclusions: This is the first report of the suitability of an ESS cut-point of 8 as an indicator of moderate-severe OSA in elderly community-dwelling people. Because sleepiness is less frequent in elderly persons, the ESS, a recognized poor predictor of OSA among adults, may become a useful screening instrument among elderly. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Caruccio Montanari, C., Facco Piccin, C., Schenkel Kaminski, R., Martins, E., Pacheco da Silva, R., Kraide Fischer, M., Ricardo Zibetti, M., Madalena Pedroso, M., Fagundes, M., Uribe Ramos, J., Neves Giordani, J., Silveira da Silva Bueno, K., de Brito Lop Tags: Sleep and Control of Breathing Source Type: research

Sleep apnea as a cause of sleep misperception in elderly insomnia patients
Conclusions: The finding that elderly insomnia patients with sleep misperception have more severe OSA, independently of sleepiness, warrants future research on the participation of OSA severity in the mechanisms of sleep misperception. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Silveira da Silva Bueno, K., Ferreira Martins, E., Facco Piccin, C., Schenkel Kaminski, R., Pacheco da Silva, R., Kraide Fischer, M., Ricardo Zibetti, M., Uribe Ramos, J., Garcia Oliveira, P., Neves Giordani, J., de Brito Lopes, B., da silva Rodrigues, L. Tags: Sleep and Control of Breathing Source Type: research

Assessing the synergistic effect of the enhancer compound HT61 on Tobramycin activity in a murine model of pulmonary infection
Background: Pulmonary colonisation by bacterial species such as Pseudomonas aeruginosa (P.a) presents a therapeutic challenge due to antimicrobial resistance (AMR). A new approach in targeting AMR is enhancer compounds, which improve the efficacy of current antimicrobials. Compound HT61 has shown efficacy against gram-positive bacteria in vitro and in the present study we evaluated its effects on Tobramycin activity in a murine model of P.a. pulmonary infection.Methods: Male C57/Bl6 mice were inoculated with PBS or 1x106 colony forming units (cfu) P.a. strain RP73, embedded in agar beads. 24 hours post infection (p.i.) ani...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: O'Shaughnessy, B., Amison, R., Coates, A., Page, C. Tags: Airway Pharmacology and Treatment Source Type: research

Evaluation of a selective 5-hydroxytryptamine 2B receptor antagonist designed to alter the fibrotic process
Introduction: Serotonin (5-hydroxytryptamine, 5-HT) acts as a regulator of myofibroblast differentiation, matrix deposition and inflammation in the fibrotic lung by activating peripheral 5-HT2B receptors. Pharmacologic inhibition of 5-HT2B receptors could represent a new treatment opportunity for fibrosis.Aim: To investigate possible effects of a selective 5-HT2B receptor antagonist on fibrosis development and on inflammatory cytokines.Methods: Normal human lung fibroblasts were cultured with TGF-β and 5-HT. Effects on collagen synthesis of the small molecule, 5-HT2B receptor antagonist AM1125 were evaluated by measur...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Wenglen, C., Pettersson, L., Arozenius, H., Ekstrom, G. Tags: Airway Pharmacology and Treatment Source Type: research

Imatinib-loaded gold nanoparticles ameliorate experimental lung fibrosis induced by bleomycin
Systemic Sclerosis (SSc) is an autoimmune disorder associated to interstitial lung involvement (ILD). In previous in vitro studies we proved that CD-44 functionalized gold nanoparticles loaded with imatinib (GNP-HCim) significantly inhibited fibroblast-like cells from ILD-SSc patients. The aim of this work is to demonstrate the in vivo efficacy of GNP-HCim in ameliorating bleomycin-induced lung fibrosis.C57BL6 male mice were treated with: (1) intratracheal aerosolization (i.a.) of saline solution and unloaded, functionalized GNP (GNP-HC); (2) bleomycin plus GNP-HC i.a. on day 0 (CTR); (3) bleomycin plus GNP-HCim i.a. on da...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Cova, E., Piloni, D., Codullo, V., Inghilleri, S., Breda, S., Prosperi, D., Colombo, M., Montecucco, C., Distler, J. H. W., Meloni, F. Tags: Airway Pharmacology and Treatment Source Type: research

Modulation of pro-inflammatory and anti-viral responses in BEAS2B cells by glucocorticoid agonists
In conclusion, we showed the expected inhibitory effect of FP on pro-inflammatory cytokines and in addition a suppression of the cellular anti-viral response and an enhanced viral replication. These studies may have implications for the use of ICS during virally induced exacerbations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Marcellini, A., Swieboda, D., Guedan, A., Papi, A., Johnston, S. L., Solari, R. Tags: Airway Pharmacology and Treatment Source Type: research

Roflumilast N- oxide combined with sildenafil reverses cellular remodeling on IPF models
Conclusions: RNO/sildenafil combination show synergic activity, reduces mesenchymal markers expression and reverses EMT, improving anti-fibrotic effects in human AECII and fibrocytes. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Contreras, S., Ribera, P., Morell, A., Serrano, A., Milara, J., Milara, J. Tags: Airway Pharmacology and Treatment Source Type: research

Effects of phosphodiesterase inhibitors on the lung functions in a saline lavage-induced model of acute lung injury
Introduction: Acute lung injury (ALI) is characterized by inflammation, excessive transepithelial migration of inflammatory cells. Cyclic AMP is a key intracellular second messenger which at higher levels has anti-inflammatory effect. Its concentration is determined by activity of the phosphodiesterase (PDE) enzymes.Aim of the study: The study evaluated if intravenous administration of selective (PDE3, PDE5) and non-selective PDE inhibitors enhances lung functions in a model of ALI.Methods: ALI was induced in rabbits by repetitive saline lung lavage (30 ml/kg, 6-12 times) until PaO2 reached values
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kosutova, P., Mikolka, P., Kolomaznik, M., Calkovska, A., Mokra, D. Tags: Airway Pharmacology and Treatment Source Type: research

Effects of CHF6297, a potent and selective p38{alpha} MAPK inhibitor, in murine models of steroid resistant lung inflammation
We report here the effect of CHF6297, a potent and selective inhaled p38MAPK inhibitor, in three murine models of steroid-resistant lung inflammation. In mice exposed to tobacco smoke (TS), CHF6297, administered intranasally (i.n.) b.i.d. for 4 days at 0.03 or 0.3mg/kg, dose-dependently inhibited the corticosteroid-resistant TS-induced neutrophil influx in bronchoalveolar lavage (BAL) reaching a % of inhibition of 29.7±15.3 (n.s.) and 62±8.4 (p
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Martucci, C., Miglietta, D., Puviani, V., Allen, A. D., Carnini, C., Patacchini, R., Facchinetti, F., Civelli, M., Villetti, G., Pappani, A. Tags: Airway Pharmacology and Treatment Source Type: research

Late Breaking Abstract - Blood eosinophils in inhaled steroid dose titration
Whilst it is known that titrating inhaled corticosteroid (ICS) dose against sputum eosinophils improves asthma control, the effect of increasing ICS dose on blood eosinophils are uncertain. We explored if ICS dose titration suppresses blood eosinophil counts and exhaled nitric oxide (FeNO) in patients with asthma, and whether leukotriene receptor antagonists (LTRA) had additive effect.14 studies were pooled for analysis: n=217, non-smoking, mild-moderate persistent asthmatics, mean age of 38 years, and a mean FEV1 of 85% predicted. Patients received ICS dose titration from a baseline of none or low dose ICS [median 200 &mi...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Jabbal, S., Lipworth, B. Tags: Airway Pharmacology and Treatment Source Type: research

Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation
Introduction: Resistive breathing (RB) is the hallmark of diseases of airway obstruction, such as chronic obstructive pulmonary disease (COPD), especially during exacerbations. RB results in increased mechanical stress and inflammation in the lung of previously healthy mice. Cigarette smoke (CS) exposure, the main cause of COPD, also induces pulmonary inflammation.Aim: To investigate the potential synergistic effect of the combination of RB with CS exposure model.Methods: Mice were exposed to CS of 5 reference cigarettes, 4 times daily, 5 days per week for one month. Control mice were exposed to room air. By the end of the...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Mizi, E., Toumpanakis, D., Chatzianastasiou, A., Vassilakopoulou, V., Glynos, C., Vassilakopoulos, T. Tags: Tobacco, Smoking Control and Health Education Source Type: research

Inflammation of airways and results of 6-MWT at smokers with bronchial asthma
Examined 16 healthy smokers (control group - CG) and 16 patients with persistent asthma (main group – MG) with different levels of disease control.Patients with bronchial asthma revealed the dependence (p
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Smirnova, A. Y., Gnoevikh, V. V., Shorohova, J. A. Tags: Tobacco, Smoking Control and Health Education Source Type: research

Comparison of the immune response in a mouse model of whole body and nose-only cigarette smoke-exposure
In conclusion, both CS-exposure systems resulted in a pattern consistent with emphysema in a mouse model, however the whole body CS-exposure system additionally increases the lymphocytic response in BAL, and lymph nodes and might therefore be resembling the human situation more accurately. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Serre, J., Tanjeko Ajime, T., Mathyssen, C., Heigl, T., Maes, K., Vanaudenaerde, B., Janssens, W., Gayan-Ramirez, G. Tags: Tobacco, Smoking Control and Health Education Source Type: research

The change of heat shock protein in tobacco users and clinical and laboratory characteristics as markers to evaluate the pathophysiological process promoted by cigarette
Experimental and clinical studies have provided increasing scientific evidence to demonstrate that heat shock protein 70 (HSP70) is an important marker for many diseases. However, no consensus was reached as to function of that protein inside the prognosis of asymptomatic smokers. Therefore, the aim of this study was to evaluate levels of peripheral blood HSP 70 in 40 smokers (mean age 36± 8,49 years) and to compare with 40 healthy individuals non-smokers (mean age 35±7,29 years) and the haematological and physiological parameters, who comsumed a pack per day for used at least 10 years. Peripheral blood were ...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Moreira Santos, T. M., Godoy, I., Castro Marcondes, J. P., Tanni Minamoto, S. E., Garcia, T., Godoy, I. Tags: Tobacco, Smoking Control and Health Education Source Type: research

Urinal expression profile of miRNAs after smoking cessation in healthy subjects: a pilot study
Background: Cigarette smoking and respiratory diseases due to chronic smoking have been associated with several alterations in lung expression of miRNAs; small single-stranded non-coding ribonucleic acids. Although cigarette smoking affects primarily lung tissue, several chemical components of cigarette smoke are present in circulation and even in urinal samples indicating its possible systemic effect. However, there are no data on urinal miRNAs expression and smoking. Hereby we tested urine for presence of miRNAs and searched for possible effect of smoking cessation.Method: Affymetrix miRNA 4.0 arrays with 2.578 mature mi...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Navratilova, Z., Chabronova, A., Losse, S., Kolek, V., Petrek, M. Tags: Tobacco, Smoking Control and Health Education Source Type: research

Pulmonary functions, respiratory complaints and radiographic findings in aluminium foundry workers
Introduction: It has been well known that occupational exposure to aluminium leads to smelter asthma and pneumoconiosis. Epidemiological studies are needed to search the exposure conditions and duration.Scope: It is aimed to investigate the type of respiratory involvement.Materials and Methods: Male aluminium foundry workers living in Adapazar─▒ district (42 male, mean age: 32.2 ± 6.9 years) compared with 33 male controls without exposure (mean age: 30.0 ± 7.9 years). Mean urine aluminium levels of workers (10.7 ± 8.8 mcg/lt) were significantly higher than those of controls (2.2 ± 0.8, p
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Bilgin, C., Arbak, P., Ünlü, E. N., Gülec Balbay, E., Balbay, O., Annakkaya, A. N., Akdogan, M. Tags: Occupational and Environmental Health Source Type: research

Phthalates trigger respiratory reflexes
Epidemiological studies suggest that environmental exposure to Dibutyl phthalate (DBP), a commonly used plasticiser, found in flooring, cosmetics and food packaging, is linked with worsening or development of asthma (Bølling EXCLIJ:2013,12,733-59). DBP can accumulate in lung tissues and has been previously shown to activate some of the Transient Receptor Potential (TRP) family of ion channels expressed on airway sensory nerves (Shiba J Neuroimm:2009,66-74). Activation of these nerves can lead to respiratory reflexes which are exacerbated in asthma, such as cough and bronchospasm. The aim of this study was to investi...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Bolaji, J. A., Bonvini, S. J., Wortley, M. A., Adcock, J. J., Dubuis, E., Carlsten, C., Tetley, T. D., Birrell, M. A., Belvisi, M. G. Tags: Occupational and Environmental Health Source Type: research

Respiratory symptoms in adults living in pesticides applied fields
Introduction: The effects of pesticide application on the health of the individuals living in the same environment should be considered as a public health problem.Objective: We aimed to compare respiratory complaints and respiratory functions of people living in agricultural areas, before and after pesticide application which cause air pollution.Materials and Methods: Two hundred and fifty two individuals (144 women, 108 men) living in Sanliurfa Province in Turkey (widespread cotton farming area) were asked about respiratory and systemic complaints, lung function tests were applied. After administration of pesticide, 66 in...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sak, Z. H. A., Kurtulus, S., Ocaklı, B., Töreyin, Z. N., Bayhan, I., Yesilnacar, M. I., Akgün, M., Arbak, P. Tags: Occupational and Environmental Health Source Type: research

Respiratory health of children in pesticide applied areas
Introduction: The increasing incidence of asthma and chronic respiratory diseases among children living in pesticides applied areas has been shown.Objective: It is aimed to evaluate the effects of PM2.5 and PM10 air pollution caused by pesticide application on children's respiratory system.Materials and Methods: In Sanliurfa cotton producer province of Turkey, 266 children (126 girls, 140 boys) were included in the study in June and August 2016. Peak expiratory flow (PEF) were measured in children before and after the administration of pesticide, respiratory complaints were recorded. PM2.5, PM10, temperature and humidity w...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sak, Z. H. A., Kurtulus, S., Ocaklı, B., Töreyin, Z. N., Bayhan, I., Yesilnacar, M. I., Akgün, M., Arbak, P. Tags: Occupational and Environmental Health Source Type: research

Pesticides exposure in vineyard rural area and asthma in children
Conclusions: Children in schools near vineyard are at higher risk of dithiocarbamates exposure during summer period. Despite the limited size of our sample, our results suggest possible link between pesticide exposure and respiratory health. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Raherison-Semjen, C., Canal-Raffin, M., Pouquet, M., Berteaud, E., Bouvier, G., Baldi, I. Tags: Occupational and Environmental Health Source Type: research

Farm environment during infancy and incidence of allergic diseases between the age of 31 and 46 years - results from a prospective birth cohort study from Finland
Conclusions: This prospective birth cohort study shows, that farm environment during early life may protect from allergic rhinitis, but not from asthma, throughout the life. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lampi, J., Auvinen, J., Hartikainen, A.-L., Järvelin, M.-R., Pekkanen, J., Toppila-Salmi, S. Tags: Occupational and Environmental Health Source Type: research

Laboratory animal workers exposure to mouse allergen in animal research facilities
Conclusions: Mus m 1 exposure is generally much lower in IVC units than open cage/mixed units and is influenced by specific tasks. These results may be used to modify practice and reduce the risk of laboratory animal allergy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Feary, J., Canizales, J., Jones, M., Semple, S., Schofield, S., Cullinan, P. Tags: Occupational and Environmental Health Source Type: research

Sensitisation to mouse allergens in contemporary laboratory animal practice
Background: Around 12,000 people in the UK work with laboratory animals. Historical data suggest 15% develop IgE sensitisation to laboratory animal proteins and 10% clinical symptoms of laboratory animal allergy (LAA). Individually ventilated cages (IVC) are replacing conventional (open) cages; lower ambient aeroallergen levels are reported but no reduction in LAA incidence is yet apparent.Aim: To identify factors associated with contemporary development of LAA.Methods: A cross-sectional survey at 7 UK research institutions is almost complete. Primary analysis is comparison of prevalence of sensitisation to mouse proteins ...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Feary, J., Canizales, J., Schofield, S., Fitzgerald, B., Jones, M., Cullinan, P. Tags: Occupational and Environmental Health Source Type: research

Trends in work sectors and exposures among patients with work-related asthma in the Tunisian central region
Conclusion: Our results suggest that the frequency of WRA is evolving because of industry and exposures developement. This information may assist in plans to develop WRA preventive programs and in facilitating early recognition and diagnosis by health care practitioners. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: kacem, I., Aissa, S., Maoua, M., Boughattas, W., Chatti, S., Mrizek, N. Tags: Occupational and Environmental Health Source Type: research

Job-titles classified into socioeconomic and occupational groups identify subjects with increased risk for respiratory symptoms, independent of occupational exposure
Conclusions: Classification of SES and occupational groups based on job titles identified subjects with increased risk for respiratory symptoms independent of exposure to VGDF, indicating that also other job-related factors are of importance. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Schyllert, C., Andersson, M., Hedman, L., Ekström, M., Backman, H., Ronmark, E., Lindberg, A. Tags: Occupational and Environmental Health Source Type: research

The nose-lung interaction in occupational allergic rhinitis and asthma in Tunisian textile industry workers
Conclusion: The typical profile of our population at risk for the combination of rhinitis and occupational allergic asthma is a low-skilled worker with a long durations of activity and exposure to air pollutants. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Maoua, M., Rouis, h., Aissa, S., Guedri, S., Kacem, I., Boughattas, W., Brahem, A., Kalboussi, H., El Maalel, O., Chatti, S., Mrizak, N. Tags: Occupational and Environmental Health Source Type: research

Association between job title, occupational exposures, and incidence of asthma
Conclusion: The combination of nationwide high quality public databases about occupational activity and of asthma provides a unique opportunity to investigate the influence of work on the occurrence and worsening of the disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Baelum, J., Meyer, H. W., Flachs, E. M., Bräuner, E. V., Bonde, J. P., Schlünssen, V., Backer, V. Tags: Occupational and Environmental Health Source Type: research

Serial FEV1 measurements: an improved diagnostic tool for occupational asthma?
Conclusions: The ABC FEV1 score is less sensitive and specific in the diagnosis of OA compared to the ABC PEF score, probably due to the greater reproducibility of self-recorded PEF measurement. The continued use of serial PEF measurements in the diagnosis of OA is recommended. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Parkes, E., Moore, V., Walters, G., Robertson, A., Burge, S. Tags: Occupational and Environmental Health Source Type: research

Occupational asthma: are we recognising at risk patients?
Occupational aetiology accounts for 1 in 6 cases of new onset adult asthma. Better health and employment outcomes from occupational asthma are achieved with rapid diagnosis and removal from exposure to or avoidance of the causative agent1. Despite this, occupational asthma remains poorly recognized by healthcare professionals, demonstrated previously in UK primary care2. We aimed to determine whether an occupational cause is considered in adult asthmatic patients when attending hospital.We assessed medical records of 200 working-age adults with asthma symptoms. One hundred patients presented to the emergency department (ED...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ellis, P., Walters, G. Tags: Occupational and Environmental Health Source Type: research

Asthma in military personnel: appropriate diagnosis and treatment allows for continuous deployment
Conclusions: At referral, the majority of recruits were on no medication or inhaled SABA only. Appropriate treatment allowed a return to unrestricted duties in most cases. Prompt referral for investigation and titration of treatment is likely to reduce time out of service.1) Dickinson JW et al. Impact of changes in the IOC-MC asthma criteria: a British perspective. Thorax. 2005;60(8):629-32. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Charlton, T., Davidson, J., Buckley, A., Bradley, B., Orhan, O., Davies, G., Nanzer, A. Tags: Occupational and Environmental Health Source Type: research

Seasonal dynamics of the quality of life of asthmatics with osmotic airway hyperresponsiveness
Background: The changes in the quality of life (QoL) in the seasons with different humidity can be expected in the people with osmotic airway hyperresponsiveness (OAH). Aim was to assess QoL in asthmatics with OAH in contrast seasons of the year.Methods: 65 asthma patients with OAH were examined in the wet (July-August) and relatively dry seasons (April, May, October). QoL was assessed using SF-36, AQLQ, the level of anxiety by HADS. OAH was diagnosed if the fall of FEV1 was by more than 10% from baseline after 3-minute inhalation with ultrasound-nebulized distilled water.Results: QoL was significantly worse in the wet sea...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Perelman, J. M., Perelman, N. L. Tags: Occupational and Environmental Health Source Type: research