The prevalence of and risk factors for non-smoking chronic obstructive pulmonary disease in China: A systematic review and meta-analysis
Conclusions: This review confirmed the highly different proportions of never-smokers in male and female COPD patients. Biomass fuel might have important roles in the risk for COPD among never-smokers. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Zhang, Y., Gai, X., Chu, H., Qu, J., Li, L., Sun, Y. Tags: Monitoring airway disease Source Type: research
Sputum rheology is associated with asthma control
Conclusions: Patients with better asthma control exhibited lower force needed for the sputum to flow from airways, independent of eosinophilic airway inflammation.Future studies are warranted to investigate mucus behaviour, an unmet need in severe asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Tavernier, G., Qureshi, T., Zurel, F., Holmes, L., Elsey, L., Thornton, D., Fowler, S., Pantin, T. Tags: Monitoring airway disease Source Type: research
The role of vitamin D in COPD.
Conclusion: Insufficient content and deficiency of vitamin Bit D is a biomarker that determines the nature of the course of COPD, which justifies the need for measures to correct these changes. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Tashmetova, G., Liverko, I. Tags: Monitoring airway disease Source Type: research
Abnormalities of sputum rheological characteristics in patients with chronic cough and bronchial asthma
Conclusion: Quantitative measurement of sputum rheological parameters by Rheomco revealed their abnormalities in CC and BA. More work is needed to understand the abnormalities in different diseases, and usefulness of the parameters in clinical practice. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Ogawa, H., Uchida, Y., Ito, K. Tags: Monitoring airway disease Source Type: research
Air pollution and influence of deleterious levels of atmospheric nitrogen dioxide in the development of asthma
Conclusion: Improving public awareness regarding air pollution regarding air quality standards to reduce NO2. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Bhaskaran, I. P., Bhaskaran, A. P., Bhaskarn, A. P., Bhaskaran, P. Tags: Monitoring airway disease Source Type: research
Sputum rheology measurements in chronic respiratory diseases are similar across specialist centres
Conclusions: Critical stress, believed to measure the force needed to make sputum flow in the airways is a reproducible rheological parameter across specialist centres in obstructive diseases with potential clinical management applications. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Tavernier, G., Qureshi, T., Volpato, M., Vachier, I., Wood, M., Zurel, F., Thornton, D., Robert De Saint Vincent, M., Patarin, J., Lord, R., Fowler, S., Charriot, J. Tags: Monitoring airway disease Source Type: research
The pH of the human airway: A novel technique to measure distal airway pH.
We describe a novel method utilizing a gastric pH probe to directly measure airway surface pH.Bronchoscopy was performed in three subjects. ASL pH in subcarinal airway was measured by two methods 1. As described above. 2. A gastric pH probe was advanced through the working channel and used to measure pH in the same bronchus. Three samples using each method were obtained from both the right and left lower lobes.The pH was similar when measured by skin pH meter or gastric pH probe (means 6.6 and 6.8 respectively). There was no significant difference in pH measured by the different methods (p=0.2 by two sample t-Test assuming...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Giddings, O., Twigg, H., Marozkina, N., Ross, K., Smith, L., Gaston, B., Davis, M. Tags: Monitoring airway disease Source Type: research
Correlation between systemic inflammation and cardiovascular risk in COPD patients. development of an inflammatory score
Conclusions: 1-The exacerbator phenotype shows a higher inflammatory SCORE than non-exacerbator patients.2- The inflammatory-SCORE could be a useful tool to assess CVR in COPD patients or even predicts future cardiovascular events. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Munoz Montiel, A., Ruiz Esteban, P., Garcia Florido, N., Dona Diaz, E., Domenech Del Rio, A., Olveira Fuster, C. Tags: Monitoring airway disease Source Type: research
Sputum viscosity is correlated with Computed Tomography (CT) mucus score in muco-obstructive lung diseases
Conclusion: CT mucus score is correlated with sputum viscosity, independently of the underlying muco-obstructive lung disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Charriot, J., Petit, A., Suehs, C., Patarin, J., Matzner-Lober, E., Vachier, I., Molinari, N., Bourdin, A. Tags: Monitoring airway disease Source Type: research
Small airway obstruction according to emphysema severity in human lungs
Small airway obstruction is a major feature of COPD besides alveolar emphysema. Our aim was to investigate the lower airway zones up to the functional terminal bronchioles (TB) in a spectrum from healthy and early emphysematous to end-stage COPD lungs.Explanted lungs from 9 healthy donors, rejected for extrapulmonary reasons, 10 donors radiologically and histologically characterized with emphysema (EMPH) and 9 COPD patients (GOLD 4) were frozen at TLC and processed in small cylinders (1.4 cm diameter). Of each lung, 4 samples were scanned by microCT (resolution 10 µm). TB were counted, discriminating ventilated and n...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Geudens, V., De Fays, C., Vermaut, A., Willems, L., Kaes, J., Goos, T., Vermant, M., Gyselinck, I., Aversa, L., Beeckmans, H., Jin, X., Hooft, C., Verhaegen, J., Aerts, G., Kerckhof, P., E. Mcdonough, J., Quarck, R., Everaerts, S., Weynand, B., Pilette, C Tags: Monitoring airway disease Source Type: research
Assessment of eosinophilic airway inflammation using formalin-fixed, paraffin-embedded sputum plugs
Conclusion: FFPE sputum plugs as a "biopsy tissue block" are feasible for detecting airway eosinophilia, and non-inferior to clinical protocol. Further validation in a healthy cohort is underway. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Patel, Z., Suray Tan, N., Huynh, A., Calma, N., Radford, K., Somalwar, S., Huang, C., Kjarsgaard, M., Ayoub, A., Nair, P., Mukherjee, M. Tags: Monitoring airway disease Source Type: research
Validation of exhaled-breath data for the differentiation between COPD and Asthma
Conclusion: Analysis of exhaled breath with Aeonose allowed accurate differentiation between patients with COPD and asthma. The differentiation between stable and exacerbated disease in the COPD subgroup was moderate. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Röcken, J., Darie, A., Stalder Siebeneichler, A., Pascarella, M., Grize, L., Tamm, M., Stolz, D. Tags: Monitoring airway disease Source Type: research
Albuterol-budesonide asthma rescue inhaler: patterns of as-needed use
Conclusions: Use patterns were similar between treatment groups indicating pts use ABD rescue in the same manner as their SABA. High daily use was uncommon. ABD was well tolerated. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Papi, A., Chipps, B., Albers, F., Dunsire, L., Gilbert, I., Harrison, T., Trudo, F., Weinberg, M., Cappelletti, C. Tags: Airway pharmacology and treatment Source Type: research
Clinical characteristics of responders and non-responders: experience following four years of Benralizumab therapy
Conclusion: Benralizumab responders have improved asthma control, reduction in exacerbations and OCS use that persists after four years of treatment. Non-responders had significantly higher rates of co-existing BPD, highlighting the importance of MDT team assessment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Nuttall, A., Fyles, F., Joplin, H., Burhan, H., Watkins, L. Tags: Airway pharmacology and treatment Source Type: research
Baseline characteristics of patients with asthma and prior systemic corticosteroid use in the RAPID (dupilumab) registry
Conclusions: In this initial presentation of baseline characteristics of patients from RAPID initiating dupilumab for moderate-to-severe asthma, we show that ≥ 25% of patients were currently or had recently received SCS, indicating a high unmet need in this population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Lugogo, N. L., Heffler, E. M., Plaza, V., Hilberg, O., Xia, C., Nash, S., Pandit-Abid, N., Jacob-Nara, J. A., Sacks, H., Rowe, P. J., Deniz, Y., Hardin, M., Soler, X. Tags: Airway pharmacology and treatment Source Type: research
