Identifying inconsistencies in intervention descriptors and outcome reporting within systematic reviews of physical activity interventions in COPD
Conclusion: When the same studies are included within different SRs, inconsistencies in intervention descriptors and outcome reporting occur, this may lead to misinterpretation of results by readers. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lewthwaite, H., Effing, T. W., Olds, T., Williams, M. T. Tags: Physiotherapists Source Type: research

Using physical capacity to classify inactivity in COPD
Background: Absolute cut-off points are commonly used to classify the level of physical activity. However, physical activity of COPD patients may be limited by reduced physical capacity, which hampers the use of absolute cut-off points.Aim: To investigate if cut-off points relative to individual physical capacities can be used to differentiate in classification of physical activity in COPD patients.Methods: 101 COPD patients who attended assessment for pulmonary rehabilitation were included. Patients wore an accelerometer to measure physical activity. Accelerations were recalculated to estimate the Metabolic Equivalent of ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lassche, S., Peters, J., van Helvoort, H., van t Hul, A., van Hees, J. Tags: Physiotherapists Source Type: research

Influence of physical activity, sedentary behaviour, body composition and skeletal muscle force to identify phenotypes in COPD patients: a 12 months follow-up
Conclusion: Our results describe a phenotype with higher sedentary behaviour presenting higher hospitalization and while it seems that neither physical activity nor sedentary behaviour is related to exacerbation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Xavier, R., Lopes, A., Caporali, A. C., Stelmach, R., Fernandes, F., Carvalho, R., Cukier, A., Ramos, E., Carvalho, C. Tags: Physiotherapists Source Type: research

Impact of physical activity level on symptomatology and functionality during an acute exacerbation in COPD patients
Conclusion: Patients with COPD who perform physical activity prior to hospital admission have less dyspnea and cough during an exacerbation, without relationship to the severity of the pathology. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lopez Lopez, L., Merlos Navarro, S., Romero Fernandez, R., Granados Santiago, M., Rodriguez Torres, J. R., Torres Sanchez, I. Tags: Physiotherapists Source Type: research

Previous physical activity level as a predictor of cognitive and emotional status during acute exacerbation of COPD
Introduction: Sedentary behavior has been shown to be associated with adverse health outcomes in middle to older age adults and patients with COPD. However no previous studies have determined if previous PA levels are related to cognitive and emotional status when COPD patients suffer an exacerbation.Objective: The aim of this study was to examine the association between previous PA levels and cognitive and emotional status during an exacerbation of COPD.Methods: An observational study was performed. Patients admitted to the Pneumology Service of Complejo Hospitalario Universitario de Granada suffering an exacerbation of C...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Torres Sanchez, I., Granados Santiago, M., Romero-Fernandez, R., Valenza, M. C., Rodriguez-Torres, J., Lopez-Lopez, L. Tags: Physiotherapists Source Type: research

Identification of asthma phenotypes using cluster analysis
Asthma is a complex heterogeneous condition, best understood in terms of underlying phenotypes. Physical activity (PA) improves asthma symptoms and reduces obesity; however, the role of PA on asthma phenotypes remains unknown.Aim: To identify asthma phenotypes including analysis on daily life PA and in sedentary behavior (SB).Methods: 119 patients with moderate and severe asthma, who were under optimal medical treatment according to the GINA, were consecutively enrolled in a cross-sectional study and assessed by PA, clinical control, body composition, quality of life, anxiety/depression symptoms and lung function. Patients...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Freitas, P. D., Xavier, R. F., da Silva, S. T. C., Carvalho-Pinto, R. M., Stelmach, R., Cukier, A., Martins, M. A., Carvalho, C. R. F. Tags: Physiotherapists Source Type: research

Factors associated with daily life physical activity in patients with asthma
Habitual: physical activity seems to have an important role in the development of exacerbation in patients with asthma. However, the factors associated with daily life physical activity (DLPA) in patients with asthma remains poorly known.Aim: To identify factors associated with DLPA in patients with moderate and severe asthma.Methods: This cross-sectional study included 119 patients with moderate and severe asthma recruited in a tertiary outpatient clinic in a University hospital, who were under optimal medical treatment according to the GINA (44.8±10.1 years-old, 81.5% female and FEV1 69.7±18.6 %predicted). ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Freitas, P. D., da Silva, S. T. C., Xavier, R. F., Carvalho-Pinto, R. M., Stelmach, R., Cukier, A., Martins, M. A., Carvalho, C. R. F. Tags: Physiotherapists Source Type: research

Long term positive airway pressure effectiveness in obesity hypoventilation syndrome. Pickwick study results
Conclusion: NIV and CPAP have similar long-term effectiveness. Because CPAP has economical advantages and simplicity, CPAP should be the preferable treatment for OHS patients with severe OSA. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sanchez Quiroga, M. A., Mokhlesi, B., Corral Penafiel, J., Alonso Alvarez, M. L., Ordax Carbajo, E., Troncoso Acevedo, M. F., Gonzalez Martinez, M., Lopez Martin, S., Marin Trigo, J. M., Marti, S., Diaz Cambriles, T., Chiner Vives, E., Aizpuru Barandiaran Tags: Noninvasive Ventilatory Support Source Type: research

Respiratory Physiology-oriented High-intensity Non-invasive Ventilation
Introduction: High-intensity non-invasive ventilation (HI-NIV) is a strategy aimed at maximumly improving PaCO2. Most studies increased inspiratory positive airway pressure (IPAP) depending on patient's maximum tolerance. However, excessive IPAP may result in lung hyperinflation, increased oxygen consumption, and ineffective work of breathing.Objectives: To establish respiratory physiology-oriented HI-NIV and investigate its physiological effect.Methods: Diaphragm electromyogram (EMGdi) and other respiratory physiological parameters were recorded through the esophageal electrode catheter during pressure titration process. ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Guan, L., Zhou, L., Chen, R. Tags: Noninvasive Ventilatory Support Source Type: research

Patient attitudes toward a handheld non-invasive ventilator to relieve breathlessness.
Discussion: At 12 weeks most patients continued to use the device frequently, with a trend toward more rapid recovery from, and reduced anxiety about, breathlessness during activities. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lane, N., Hartley, T., Ferguson, V., Chynkiamis, N., Gray, K., Vogiatzis, I., Bourke, S. Tags: Noninvasive Ventilatory Support Source Type: research

Dexmedetomidine for sedation during nonivasive ventilation in acute respiratory syndrome patients
Noninvasive ventilation (NIV) is commonly used to prevent endotracheal intubation in patients with mild to moderate acute respiratory distress syndrome (ARDS). Dexmedetomidine (DEX) provide cooperative sedation, and could be beneficial for patients with ARDS receiving NIV. Aim of this study was to compare DEX with placebo for sedation during NIV.Adults with ARDS due to community aquired pneumonia with PaO2/FiO2 ratio 150-300 mmHg were randomly allocated to receive IV dexmedetomidine (0.2 μg/kg/h titrated every 30 min to 0.7 μg/kg/h to maintain a Richmond sedation agitation score (RASS) of 0 to -2) or placebo up to 72...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bielka, K., Kuchyn, I. Tags: Noninvasive Ventilatory Support Source Type: research

A multicenter randomized trial for the effectiveness of structured discharge and follow-up protocol on readmission rate in COPD patients receiving LTOT/NIV: one-year interim analysis.
Conclusion: The preliminary results showed that structured discharge and follow up protocol might be a helpful approach for prevention of recurrent admissions in COPD patients with chronic respiratory failure (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ergan, B., Goktalay, T., Ergun, P., Yilmaz, D., Ocakli, B., Gurgun, A., Demirci, N., Elverisli, F., Yilmazer Ucar, E., Durmaz, A., Gorek Dilektasli, A., Aksoy, E., Elmas, F., Kokturk, N., Aytekin, F., Akgun, M., Ozyilmaz, E., Demirdogen Cetinoglu, E., Aca Tags: Noninvasive Ventilatory Support Source Type: research

The implementation of a psychological support during the adaptation to Non Invasive Ventilation (NIV) in Chronic Obstructive Pulmonary Disease (COPD): a Randomized Controlled Trial
This study aims to investigate the impact of a brief psychological support on acceptance and adherence to NIV in COPD patients.Methods: Eighty-four COPD patients with an indication for NIV were recruited and involved in a two-branch randomised controlled trial, single-blind. The experimental group underwent a psychological support including counselling, relaxation and mindfulness-based exercises and neuropsychological rehabilitation exercises. Controls received standard care and watched educational videos related to the disease’s management. The interventions were delivered at the HD Respiratory Rehabilitation Unit o...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Volpato, E., Pagnini, F., Banfi, P. Tags: Noninvasive Ventilatory Support Source Type: research

Approaching the Non Invasive Ventilation (NIV) in Amyotrophic Lateral Sclerosis (ALS) at home: a Randomized Controlled Trial
Background: Respiratory failure is one of the most common causes of death in ALS patients. Treatment of ALS patients with NIV when FVC
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Volpato, E., D'Ascenzo, S., Montini, A., Paneroni, M., Grilli, S., Vitacca, M., Banfi, P. Tags: Noninvasive Ventilatory Support Source Type: research

Late Breaking Abstract - Exhaled air dispersion during application of CPAP via nasal pillows and oronasal mask versus high flow nasal cannula therapy
Conclusion: Exhaled air dispersion from the patient’s nostrils was limited to 172mm along the sagittal plane when HFNC was delivered at 60L/min. Exhaled air dispersed to 264mm during CPAP via nasal pillows but that from Quattro oronasal mask was negligible. Projected funded by HMRF#15140282, Food & Health Bureau, HK (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hui, D. S. C., Chow, B., Chan, M. Tags: Noninvasive Ventilatory Support Source Type: research

Physical activity in patients with endoscopic lung volume reduction measured with a SenseWear Armband
Conclusions: PAL and sleeping efficiency improves after ELVR with valves in patients with TLVR. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Schotten, L., Oezkan, F., Schwarz, B., Winantea, J., Taube, C., Darwiche, K. Tags: Interventional Pulmonology Source Type: research

Reasons for not receiving interventional therapy in patients with severe emphysema
Background: Endoscopic/surgical interventions may be beneficial in selected emphysema patients. Knowing predictors for successful therapy, rates of treatment failure decreased. Our aim was to evaluate the number of patients eligible for any intervention and exclusion criteria.Methods: Retrospective analysis of 232 consecutive emphysema patients who were considered for interventional therapy in 2016. Reasons for not receiving valve or coil therapy were assessed for all the patients who did not receive any therapy.Results: 50% (116/232) of the patients received any interventional therapy (82% valve therapy, 6% coil therapy, ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Polke, M., Roetting, M., Sarmand, N., Eberhardt, R., Herth, F., Gompelmann, D. Tags: Interventional Pulmonology Source Type: research

Fissure analisys with StratX software and Chartis system for bronchoscopic lung volume reduction (BLVR) with valves
Background: Collateral ventilation (CV) can be assessed directly with the Chartis System (Pulmonx Inc)[Herth F et al ERJ 2013;41:302–308] or indirectly at computed tomography through visual or computerized methods. We evaluated the agreement between Chartis and StratX (Thirona) in detecting fissure completeness.Methods: Emphysema patients referred for BLVR in 2017 underwent Chartis assessment and StratX analisys to quantify fissure integrity on the basis of a Fissure Completeness Score (FCS). CV was assumed to be absent if FCS>95%, FCS
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Luzzi, V., Innocenti, M., Leoncini, F., Bezzi, M. Tags: Interventional Pulmonology Source Type: research

Pneumothorax after Bronchoscopic Lung Volume Reduction with Endobronchial Valves(EBV-BLVR): Is there any correlation with number of valves?
Purpose: EBV-BLVR has evolved as a minimally invasive therapy for advanced emphysema. Optimal patient selection improves results, but also the likelihood of pneumothorax (pnx). There is, however, little evidence of what its rate could be influenced by. We hypothesized an association with the number of valves used.Aim: to investigate a correlation between the rate of pnx and the number of valves used.Methods: we performed a retrospective evaluation of pnx rate in correlation with number of valves andtreatedlobein all EBV-BLVR procedures from 2015 to 2017 in two referral centers.Results: Overall pnx rate in 99 patientswas 24...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Luzzi, V., Novali, M., Bezzi, M. Tags: Interventional Pulmonology Source Type: research

Is bronchoscopic follow up useful after Bronhoscopic Lung Volume Reduction (BLVR) with endobronchial valves?
Conclusion: Brochoscopy is not needed after BLVR if the patient is asymptomatic unless valve migration/leaking is suspected. It could be useful to re-evaluate patients whose microbiological examination at baseline is positive, but data to support this are poor. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Luzzi, V., Innocenti, M., Romani, S., Leoncini, F., Bezzi, M. Tags: Interventional Pulmonology Source Type: research

Changes in functional capacity after endoscopic lung volume reduction in patients with chronic obstructive lung disease and severe emphysema
Conclusion: Successful ELVR significantly predicts improvements in functional capacity in patients with COPD and severe emphysema. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Geissenberger, F., Bader, S., Faul, C., Schwaiblmair, M., Berghaus, T. Tags: Interventional Pulmonology Source Type: research

Endobronchial valves and spigots in a non-standard indication
Conclusions: EV and spigots in a non-standard indication is an effective and substantially safe method, which can improve and shorten a treatment of the patients, including in those who are ventilator-depended. Next trials should be focused on a standardization and cost-efficacy of the application (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bartakova, H., Simovic, J., Votruba, J. Tags: Interventional Pulmonology Source Type: research

Altered intercostal muscle structure following successful endobronchial lung volume reduction: a pilot study
Conclusions: Patients with hyperinflation due to severe COPD who respond to EBV insertion exhibit dynamic changes in intercostal muscle thickness on ultrasound measurement. This finding requires replication in a larger cohort of patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wallbridge, P., Hew, M., Parry, S., Hammerschlag, G., Irving, L., Steinfort, D. Tags: Interventional Pulmonology Source Type: research

Efficacy and safety of bronchoscopic lung volume reduction (BLVR) modalities functioning independent of collateral ventilation in advanced emphysema: Systematic review and meta-analysis
Conclusions: BLVR procedures, especially endobronchial coils are found to be effective in management of patients of severe emphysema irrespective of collateral ventilation. However, characterization of patients who would be most benefitted from these procedures is required and effectiveness of these procedures in long run is also to be established. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Dutt, N., Rustagi, N., Singh, S., Shekhar, S., Kuwal, A., Chaudhry, K., Kirubakaran, R. Tags: Interventional Pulmonology Source Type: research

Impact of radiological changes on treatment outcome following endoscopic lung volume reduction with coils (LVRC) in patients with advanced emphysema
Conclusion: In the interim analysis it seems that the radiological changes after LVRC have no impact on the clinical outcome. However further evaluation of a larger patient cohort is needed in order to confirm these results. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kontogianni, K., Gerovasili, V., Eberhardt, R., Herth, F. J. F., Heussel, C. P., Gompelmann, D. Tags: Interventional Pulmonology Source Type: research

The "Coil Associated Opacity" in endoscopic emphysema treatment. Friend or foe?
The RENEW study was the first to report "Coil Associated Opacity" (CAO) as a specific complication to Endobronchial Coil treatment for severe emphysema. CAO is defined as an opacity occurring in the area around the Coils on chest x-ray, low grade fever
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Perch, M., Johannesen, H. H., Fiehn, A.-M. K., Siemsen, M., Mortensen, J. Tags: Interventional Pulmonology Source Type: research

Computed Tomography Predictors of Pneumothorax and Hemoptysis after Endobronchial Valve Therapy for Emphysema
Conclusions: CT measures predicted pneumothorax/hemoptysis after lobar exclusion with EBV. Future studies should investigate the potential of CT measurements to identify patient with high risk of pneumothorax/hemoptysis before EBV treatment and enable more careful monitoring of these patients after EBV treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Oliveira, D., Kirby, M., Schirm, J., Munhoz Svartman, F., Rodrigues, M., Grynblat, P., Defranchi, H., Caballero Duran, H., Macedo Neto, A. V., Oliveira, H. Tags: Interventional Pulmonology Source Type: research

Five years outcome of Karakoca Resector Balloon dilalation and curetage method in Severe COPD (chronic obstructive pulmonary disease)
Conclusion: These results confirmed our early observations that balloon dilatation and curettage is safe and successful technique for medical treatment-resistant COPD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Karakoca, Y., Gogus, G., Akduman, S., Erturk, B. Tags: Interventional Pulmonology Source Type: research

Quantitative CT Analysis for Fissure Completeness in Bronchoscopic Lung Volume Reduction
Conclusions: The quantitative analysis of fissure shows that incomplete fissures increased the probability of CV on ChartisTM, while the defect size did not affect the overall rates. CT cannot substitute ChartisTM completely, because TLVR could be achieved even in some patients with relatively large fissure defect, if they showed negative CV on ChartisTM. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lee, S. W., Shin, S. Y., Park, T. S., Oh, S. Y., Lee, S. M. Tags: Interventional Pulmonology Source Type: research

Removal of diseased emphysematous tissue with bronchoscopic thermal vapor ablation (BTVA)
Conclusion: BTVA typically removes mass of ablated diseased segments and increases mass in healthier segments. Additionally, data from these measurements may result in ways to better identify BTVA responders and continue to improve on good patient outcomes. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Herth, F. J. F., Gompelmann, D., Valipour, A., Snell, G., Grah, C., Witt, C., Hopkins, P., Eberhardt, R., Shah, P. Tags: Interventional Pulmonology Source Type: research

Electromagnetic navigation bronchoscopy: parameters associated with a positive result
Introduction: Peripheral lung lesions are a diagnostic challenge. Electromagnetic navigation bronchoscopy (ENB) is a procedure that facilitates lesion sampling while avoiding more invasive diagnostic methods.Aims and Objective: To define which factors may be associated with a positive result via ENB.Methods: A retrospective study of ENB in 234 consecutive cases, between March 2008 and January 2018, collecting data pertaining to past medical history, chest computed tomography (CT) and positron emission tomography (PET) findings and variables belonging to the bronchoscopy procedure. A descriptive analysis and multiple linear...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Claveria, O., Gonzalez, J., Blanco, A., Seijo, L., Berto, J., Zulueta, J. J. Tags: Interventional Pulmonology Source Type: research

Influence of endoscopic lung volume reduction with valves on the pulmonary gas exchange
In this study we analyse how a complete lobar occlusion effect the overall gas exchange and whether discrepancy of the most diseased lobe in CT-scan and lung perfusion scintigraphy leads to a different outcome.Methods: Data of 34 patients with severe lung emphysema who underwent a complete lobar occlusion with valves between 2015 and 2017 was retrospectively analysed.Results: A significant target lobe volume reduction (TLVR>350ml) was achieved in 22 patients. In 17 patients the most diseased lobe in CT-scan correspond to the lobe with the most reduced perfusion. In these patients FEV1% predicted improved from 31, 7% to 36, 8% (p
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Stiehl, K., Kaid, D., Karpf-Wissel, R., Steveling, H., Taube, C., Winantea, J. Tags: Interventional Pulmonology Source Type: research

Long-term follow-up after endoscopic valve therapy in patients with severe emphysema
Conclusions: Patients treated by valves experienced clinical improvement over one year. Afterwards, benefit gradually declines more likely due to COPD progression; nevertheless, a high proportion of patients are still clinical responders. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Gompelmann, D., Heinhold, T., Bischoff, E., Eberhardt, R., Kontogianni, K., Herth, F. J., Rötting, M. Tags: Interventional Pulmonology Source Type: research

Biomarker measurement in asthma patients receiving biologic therapy: a real-world retrospective study
Conclusion: In the real-world setting, physicians under-utilise biomarkers to assess their patients with severe asthma and help guide selection of biologic therapy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hanania, N. A., Fang, J., Zhou, L., Ortiz, B., Kavati, A., Jaumont, X., Alvares, L., Cao, H. Tags: Monitoring Airway Disease Source Type: research

Persistent blood eosinophilia and COPD exacerbation risk after ICS withdrawal from triple therapy in the SUNSET study
Conclusions: The direct ICS withdrawal from triple therapy may lead to increased risk of moderate/severe exacerbations in patients with consistently high blood eosinophils at both screening and baseline. Patients without eosinophilia or with intermittent eosinophilia did not present increased exacerbation risk. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hurst, J. R., Kostikas, K., Chapman, K. R., Frent, S.-M., Larbig, M., Fogel, R., Guerin, T., Banerji, D., Patalano, F., Goyal, P., Pfister, P., Wedzicha, J. A. Tags: Monitoring Airway Disease Source Type: research

Increased IL5, IL8 and eosinophils in induced sputum of asthmatics with accelerated FEV1 decline
Introduction: A considerable number of asthmatic patients is characterized with accelerated lung function decline, which is probably a functional reflection of airway remodelling. Risk factors for long term excessive loss of lung function are currently not clearly understood.Objectives: The aim of our study was to evaluate long-term FEV1 decline in patients with controlled asthma, and to discriminate the possible clinical, functional and inflammatory risk factors or biomarkers for accelerated decline (>30ml/year).Methods: We included 33 well-defined patients with mild asthma, and recall them 12 - 15 years after the init...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Marc Malovrh, M., Camlek, L., Skrgat, S., Dezman, M., Kern, I., Korosec, P. Tags: Monitoring Airway Disease Source Type: research

Blood eosinophil count predicts severity of respiratory failure, death and future exacerbations in severe life-threatening asthma
Conclusion: BEC at index SLTA predicts more severe respiratory acidosis, higher risk of death and future exacerbations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Yii, A., Tay, T. R., Puah, S. H., Lim, H. F., Li, A., Lau, P., Tan, R.-A., Neo, L. P., Koh, M. S. Tags: Monitoring Airway Disease Source Type: research

Relationship between blood eosinophil count and bronchial epithelial gene expression in COPD versus Asthma
In this study, we used a regression transcriptome analysis of bronchial brushings (BB) vs blood EOS level from a COPD cohort (Emphysema vs airway disease (EvA) and from Asthma U-BIOPRED.Aims: To determine if airway gene expression is similar in eosinophilic patients in COPD and Asthma.Methods: A regression analysis determined the relationship between BB gene expression and EOS count in blood. In EvA (n=185) RNA seq was used to characterise RNA expression, in U-BIOPRED (n=95) arrays were used. Differentially expressed genes (DEG's) showing a significant regression coefficient (RC) after FDR correction p
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: George, L., Riley, J., Taylor, A., Bates, S., Wagers, S., Esteve-Codina, A., Artigas, M., Pavlidis, S., Singh, D., Fan-Chung, K., Sterk, P., Brightling, C. Tags: Monitoring Airway Disease Source Type: research

Peripheral eosinophils and mortality in COPD patients over nine years
Introduction: Local and systemic manifestations of COPD are well reported. However, there are few studies that have evaluated the association of peripheral eosinophils and mortality rate over nine years.Objective: Evaluate the association of peripheral eosinophils in the mortality of patients with COPD over nine years.Methods: We followed 110 COPD patients (67% men, 65±9 years) with mild to very severe COPD [forced expiratory volume in one second (FEV1) of 58±25%] during nine years. At the baseline we performed a complete blood count, spirometry, pulse oximetry (SpO2), body composition, dyspnea intensity [Med...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Prudente, R., Mesquita, C., Ferrari, R., Franco, E., Tanni, S. Tags: Monitoring Airway Disease Source Type: research

Blood eosinophilia(BE) and outcomes in patients with acute severe exacerbations of COPD(AECOPD)
Background: Recent studies have shown the usefulness of BE as a biomarker of response to systemic or inhaled corticosteroid therapy. However, little is known whether BE has predictive value of positive clinical outcomes in AECOPD requiring hospitalization.Aim: To evaluate the associations of BE with outcomes of patients with AECOPD.Methods: This was a retrospective observational cohort study, conducted in pulmonology department of Clinical hospital during 2015-2016, including patients hospitalized for severe AECOPD. Subjects were divided into 2 groups: NE, non-eosinophilic (
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Soe, A. K., Kevorkova, M. S., Nuralieva, G. S., Belevskiy, A. S., Avdeev, S. N., Chuchalin, A. G. Tags: Monitoring Airway Disease Source Type: research

Late Breaking Abstract - Protection by budesonide against clinically important deteriorations (CID) in patients with COPD is dependent on blood eosinophil counts (EOS)
Conclusion: The benefit of BUD treatment in reducing risk of CID is dependent on EOS. EOS may be used to identify COPD patients suitable for ICS treatment and studies evaluating ICS treatment effect. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bafadhel, M., Sing, D., Jenkins, C., Peterson, S., Bengtsson, T., Fageras, M. Tags: Monitoring Airway Disease Source Type: research

Inhibitory effects of mitochondrial TRAP1 on gefitinib-resistancein non-small lung cancer cells
This study was designed to investigate overcoming gefitinib resistance in NSCLC through a mechanism-based approach using gamitrinib variant containing triphenylphosphonium (G-TPP), TRAP1 inhibitor.We developed an in vitro model of acquired resistance to gefitinib. The effects of G-TPP on apoptosis and ROS-dependent mitochondrial dysfunction in HCC827GR cells were examined by annexin V binding assay, MitoSoX, and immunoblot analysis. and we tested the effects of pretreated with NAC or DPI, free radical scavenger. In addition, TRAP1 and antioxidant MnSOD were respectively knocked down or overexpressed to determine its role i...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hwang, K. E., Oh, S. J., Jeong, E. T., Kim, H. R. Tags: Lung Cancer Source Type: research

NTHi-induced inflammation activates the PD-1 immune checkpoint in the tumor microenvironment
Conclusion: Chronic neutrophilic inflammation induced by NTHi activates the PD-1 immune checkpoint in the tumor microenvironment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ritzmann, F., Vella, G., Herr, C., Bals, R., Beisswenger, C. Tags: Lung Cancer Source Type: research

ADAM28 deletion in mice impacts lung metastasis formation
ADAM28 expression is upregulated in non-small cell lung carcinoma and correlated with cell proliferation and metastatic dissemination. In addition, ADAM28 is thought to be an important regulator of inflammatory signaling pathways as this protease shed the pro-inflammatory cytokine, pro-TNF-alpha. ADAM28 also interacts with integrins and a P-selectin ligand (PSGL-1) involved in inflammatory cell migration. All these findings suggest that ADAM28 contributes to cancer development and progression.This project aims to characterize the effects of host-derived ADAM28 on lung metastasis formation using an ADAM28-/- mouse model.Lew...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hubeau, C., Gerard, C., Carnet, O., Moser, M., Noël, A., Cataldo, D., Rocks, N. Tags: Lung Cancer Source Type: research

TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal
In conclusions, these results suggested that TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal in tumor microenvironment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hwang, K. E., Oh, S. J., Jeong, E. T., Kim, H. R. Tags: Lung Cancer Source Type: research

Long-term objective compliance with a mandibular advancement device and continuous positive airway pressure in moderate obstructive sleep apnea
Conclusion: Objective compliance with MAD and CPAP was comparable and consistent over time. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: De Vries, G. E., Hoekema, A., Claessen, J., Stellingsma, C., Stegenga, B., Kerstjens, H., Wijkstra, P. Tags: Sleep and control of breathing Source Type: research

Mandibular advancement therapy does not reduce inflammatory and metabolic biomarkers in patients with severe OSA: a randomized controlled trial
Rational: Obstructive sleep apnea (OSA) is associated with enhanced vascular inflammation and metabolic dysfunction. Mandibular advancement device (MAD) is an effective treatment for OSA patients with daytime sleepiness but its impact on inflammation and metabolic dysfunction is unknown. This trial investigated the effects of MAD on inflammatory and metabolic markers in patients with OSA.Methods: Patients with severe OSA and no overt cardiovascular disease were randomized to receive 2 months of treatment with either MAD or a sham device. Levels of blood glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), leptin...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Trzepizur, W., Recoquillon, S., Pepin, J.-L., Vielle, B., Bironneau, V., Chouet-Girard, F., Launois, S., Meslier, N., Meurice, J.-C., Nguyen, X.-L., Paris, A., Priou, P., Tamisier, R., Goupil, F., Fleury, B., Gagnadoux, F. Tags: Sleep and control of breathing Source Type: research

Spectral analysis of peri-pharyngeal muscles EMG in patients with OSA and healthy subjects during wakefulness and sleep.
Background: We have recently shown that during sleep, EMG activity of several dilator muscles remained low during flow-limitation–induced respiratory efforts. In contrast, genioglossus (GG) activity rose above the wakefulness level, but failed to ameliorate flow.Goal: We compared centroid EMG frequency (Fc) of dilator muscles during wakefulness and sleep. We hypothesized that left-shift of Fc due to muscle fatigue should worsen overnight, affect GG>other muscles and OSA>healthy subjects. In contrast, a similar shift in all muscles and subjects suggests a sleep-related change in muscle unit synchronization.Metho...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Oliven, A., Cohen, G., Oliven, R., Schwartz, A. Tags: Sleep and control of breathing Source Type: research

Evaluation of upper airway anthropometry by ultrasonography in obstructive sleep apnea patients
Introduction: Anatomical and non-anatomical factors are implicated in repetitive collapse of upper airway (UA) in OSA patients.Aims: To study the anthropometry (static & dynamic) of UA in patients of OSA by US & assess the relation between UA anatomy and severity of OSA.Methods: 30 each of OSA patients, overweight non-OSA persons & healthy individuals with normal BMI, after their polysomnography underwent US measurements of tongue thickness(TT), upper airway length (UAL), lateral pharyngeal wall thickness (LPW) and oropharynx [retropalatal (RP) & retroglossal (RG) levels]. Oropharynx was measured on tidal e...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Govindagoudar, M., Chaudhry, D., Sen, J., Jain, N., Jash, D., Prajapat, B. Tags: Sleep and control of breathing Source Type: research

How lateral airway tissues affect upper airway dimensions with mandibular advancement in obstructive sleep apnoea.
Mandibular advancement increases the lateral dimensions of the nasopharynx via a direct connection between the lateral upper airway and the ramus of the mandible (Brown et al. Sleep 2013;36:397-404). However the mechanical properties of this connection are poorly understood. The aim of this study was to investigate whether a tendinous component influences the mechanical properties of the lateral walls and the effect of mandibular advancement on airway dimensions.Methods: Detailed anatomical MRI of the tissues surrounding the nasopharynx of 101 subjects with obstructive sleep apnoea (OSA) with and without mandibular advance...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Brown, L., Juge, L., Burke, P., Sutherland, K., Cistulli, P., Bilston, L. Tags: Sleep and control of breathing Source Type: research