Physical activity level during the first three days after lung cancer surgery improves with physiotherapy: a randomized controlled trial
Conclusions: Physical activity during the first three days is increased by physiotherapy treament. The long term effect of in-hospital physiotherapy needs to be further evaluated. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Jonsson, M., Hurtig-Wennlof, A., Ahlsson, A., Vidlund, M., Cao, Y., Westerdahl, E. Tags: Physiotherapists Source Type: research

Home-based rehabilitation in inoperable lung cancer: a randomised controlled trial
Conclusions: Home-based rehabilitation resulted in significant improvements in HRQoL, symptoms and exercise motivation at 6-month follow-up but did not change physical function outcomes. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Edbrooke, L., Aranda, S., Granger, C., Mc Donald, C., Krishnasamy, M., Mileshkin, L., Clark, R., Gordon, I., Irving, L., Denehy, L. Tags: Physiotherapists Source Type: research

Impact of frailty during hospitalized exacerbations of COPD on 90-day readmissions - preliminary data.
Conclusion: Frailty appears highly prevalent in patients with AECOPD and may associate with readmissions, however confirmatory data is indicated. This subgroup may require additional supportive care after hospital discharge. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Osadnik, C., Kavanagh, A., Macdonald, M., Tran, A., Bardin, P., Haines, T. Tags: Physiotherapists Source Type: research

Chronic exposure to black carbon particles and traffic-related particulate matter (PM) specifically from traffic are associated with reduced lung-function in a general population
Introduction: Although PM is associated with adverse lung function effects, there is little agreement about which size fractions or sources are most detrimental. The aim of this study was to use source-specific exposure assessment to investigate this in a cohort from a single urban region in Sweden.Methods: A general population cohort (ADONIX) underwent spirometry 2001-2008, exposure was assigned from a PM dispersion model for different size fractions and particle sources. Linear and logistic regression were used to investigate the association between lung function (FEV1 and FVC) and PM variables including PM10, PM2.5, PMB...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Carlsen, H. K., Nyberg, F., Segersson, D., Olin, A.-C. Tags: Epidemiology Source Type: research

Lung health in adulthood after childhood exposure to air pollution and greenness
Background: Little is known on childhood exposure to air pollution and adult chronic respiratory outcomes.Aim: To investigate associations between air pollution and greenness in childhood and adult lung health.Methods: In selected centres of the RHINESSA study (age 18-52) we analysed the outcomes respiratory symptoms (≥3 symptoms), severe wheeze (wheeze last year with breathlessness, no cold) and late onset asthma (>10 years). We calculated mean annual exposures of PM2.5, PM10, NO2 (µg/m3) and greenness (Normalized Difference Vegetation Index, 100m buffer) from offspring's birth till age 18, categorised into mean exposure
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kuiper, I. N., Svanes, C., Abramson, M. J., Benediktsdottir, B., Bertelsen, R. J., Dennekamp, M., Forsberg, B., Gislason, T., Halvorsen, T., Heinrich, J., Holm, M., Janson, C., Jögi, R., Malinovschi, A., Marcon, A., Markevych, I., Moratalla, J. M. Tags: Epidemiology Source Type: research

Early life exposome and lung function in children from the HELIX cohort
Conclusion: This first exposome study on lung function in children confirmed some previously reported associations (e.g. phthalates, PFASs).Funding: Helix (EU H2020 Grant 308333) (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Siroux, V., Agier, L., Basagana, X., Urquiza, J., Sunyer, J., Casas, M., Robinson, O., Granum, B., Oftedal, B., Thomsen, C., De Castro, M., Nieuwenhuijsen, M., Wright, J., Mceachan, R., Bird, P., Uphoff, N., Grazuleviciene, R., Andrusaityte, S., Petravici Tags: Epidemiology Source Type: research

Oral microbiome and lung health
Background: Lung health might be influenced by oral bacteria through micro-aspiration and transfer of inflammatory mediators from the oral mucosa.Aim: To describe the association between oral bacteria and lung function in a healthy population from Bergen, Norway.Methods: Samples of gingival fluid were collected concurrently with spirometry in 288 adults (52% males, median age 28 years) from the RHINESSA study, Bergen centre. Bacterial DNA from the 16S rRNA gene were isolated from gingival fluid, sequenced by Illumina® and assigned bacterial taxonomy by the Human Oral Microbiome Database. Differential abundance in the g...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Svanes, O., Johannessen, A., Peddada, S., Gomez Real, F., Svanes, C., Bertelsen, R. J. Tags: Epidemiology Source Type: research

Long-term air pollution exposure is associated with sick leave 20 years later
Conclusions: Air pollution exposure in a general population is associated with sick leave in a 20-year perspective. Our findings suggest that even low air pollution levels such as in Northern Europe have societal costs over time. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Johannessen, A., Kuiper, I. N., Accordini, S., Bertelsen, R. J., Forsberg, B., Gislason, T., Heinrich, J., Holm, M., Jögi, R., Kirkeleit, J., Malinovschi, A., Marcon, A., Markevych, I., Oudin, A., Schlünssen, V., Sigsgaard, T., Svanes, C., Tags: Epidemiology Source Type: research

Body mass index trajectories during adult life and lung function decline
Body mass index (BMI) has been associated with lung function. Whether distinct BMI trajectories during adult life affect lung function differently is unknown. We assessed associations of BMI trajectories from 34 to 54 years with lung function decline over the same period of time in the ECRHS cohort.BMI trajectories were developed using Group-Based Trajectory Modeling on data collected at least twice between ECRHS I and ECRHS III (n=9327). Associations of these trajectories with lung function decline were assessed using mixed linear regression models (adjusted for sex, age, age2, height, smoking status and baseline lung fun...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peralta, G. P., Fuertes, E., Carsin, A.-E., Probst-Hensch, N., Marcon, A., Nowak, D., Amaral, A. F. S., Johannessen, A., Janson, C., Dharmage, S., Gislason, T., Garcia-Larsen, V., Abramson, M. J., Sigsgaard, T., Anto, J. M., Weyler, J., Bono, R., Holm, M. Tags: Epidemiology Source Type: research

Poor prognosis in young and middle-aged adults with airflow limitation according to lower limit of normal but not fixed ratio: a population-based prospective cohort study
Background: Previous studies have focused on the prognosis of older individuals with potentially overdiagnosed airflow limitation (AFL) (forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC]
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Colak, Y., Afzal, S., Nordestgaard, B. G., Vestbo, J., Lange, P. Tags: Epidemiology Source Type: research

Late Breaking Abstract - Accelerated lung function decline in former and light smokers: NHLBI Pooled Cohorts Study
Background: Limited data suggest normalization of lung function decline with smoking cessation and slower decline with smoking reduction; yet, mechanistic studies suggest ongoing risk.Aims: To test whether former and "light" smoking are associated with accelerated lung function decline compared to never smoking.Methods: The NHLBI Pooled Cohorts Study harmonized spirometry and other measures from US population-based cohorts. Smoking status was self-reported as never, former, or current at each exam. Light current smoking was defined as
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Oelsner, E., Balte, P., Bhatt, S., Cassano, P., Couper, D., Folsom, A., Jacobs, D., Kalhan, R., Matthew, A., Kronmal, R., Loehr, L., London, S., Newman, A., O'Connor, G., Schwartz, J., Smith, L., White, W., Yende, S. Tags: Epidemiology Source Type: research

A comparison of paraseptal to centrilobular emphysema using computed and micro-computed tomography
This study aims to compare the location and severity of PSE and CLE on MDCT and micro-computed tomography (microCT) in individual lungs with COPD.Methods: Six explanted lungs with end-stage COPD were inflated with air, frozen solid and scanned with an MDCT (0.6mm/voxel). These lungs were cut into 2cm thick transverse slices, and 8 paired cores of tissue (16mm in diameter) were taken from peripheral and central regions of the slices and scanned with a microCT (11μm/voxel). The location of cores was registered on photographs of the slice before and after sampling and the MDCT specimen scan. The volume fraction of PSE and ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tanabe, N., Vasilescu, D., Hague, C., Kirby, M., Coxson, H., Verleden, S., Vanaudenaerde, B., Hogg, J. Tags: Imaging Source Type: research

Comparison of inhaled 19F C3F8 and hyperpolarized 129Xe lung ventilation MRI
Conclusion: In a pilot study comparing 19F and 129Xe gas ventilation MRI in the lungs of healthy subjects we see qualitative agreement in ventilation patterns with slight differences in the global lung ventilation metric, %VV. Comparisons of the two gas ventilation imaging methods in patients with obstructive airways disease is the next step. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Maunder, A., Hughes, P. J. C., Norquay, G., Robb, F., Rao, M., Wild, J. Tags: Imaging Source Type: research

Bronchial and nonbronchial systemic artery embolization: Experience with 836 patients
Conclusions: The commonest etiologies for moderate recurrent or life-threatening hemoptysis in our locality are TB and bronchiectasis. The chief vascular abnormalities were hypervascular lesions from the bronchial and nonbronchial systemic arteries followed by systemic -pulmonary artery shunts. BAE and NBSAE were effective to control both acute and chronic hemoptyses, with no severe complications. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Agmy, G., Gad, Y., Mohamed, S., Imam, H., Elshakawy, M. Tags: Imaging Source Type: research

Menstrual cycle-associated PFT changes correlate with QCT of the lung
Conclusion: To date, evidence demonstrates changes in menstrual cycle-associated QCT lung density metrics which have here-to-fore been overlooked. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sieren, J. C., Guo, J., Laroia, A., Hoffman, E. A. Tags: Imaging Source Type: research

A novel imaging technique for bronchopulmonary dysplasia: functional respiratory imaging.
Background: Bronchopulmonary dysplasia (BPD) remains a common complication of preterm birth. Functional Respiratory Imaging (FRI) is a recent imaging technique based on HRCT and Computational Fluid Dynamics (CFD). FRI combines structural and functional assessment of the airways.Aim: The aim of this study is to assess BPD with FRI and to correlate these analyses with the clinical presentation.Methods: We included 37 adolescents with a history of preterm birth and need for respiratory support, 22 of whom had BPD and 15 did not. The latter were included as a preterm control group. We acquired a detailed history, lung function...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Vanhaverbeke, K., Slaats, M., Al-Nejar, M., Everaars, N., Van Eyck, A., De Winter, B., Van Hoorenbeeck, K., De Dooy, J., Mahieu, L., De Backer, J., Vos, W., Mignot, B., Lanclus, M., Mulder, A., Verhulst, S. Tags: Imaging Source Type: research

Comparison of abilities of virtual bronchoscopic navigation (VBN) software products to reproduce peripheral branches in diagnosing peripheral lung lesions
Conclusions: LungPoint was superior to VINCENT in reproducibility of the peripheral branches. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kitamura, A., Okafuji, K., Imai, R., Kanemura, H., Ishii, K., Tsugitomi, R., Tomishima, Y., Jinta, T., Nishimura, N., Tamura, T. Tags: Imaging Source Type: research

Late Breaking Abstract - Use of AI in accurate diagnosis of TB using Medical Imaging: a promising result from UAE
Conclusion: Based on the analysis of results so far, and how the AI Algorithm is performing, cases that are flagged for a disease like Tuberculosis would get followed up on the same day (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hm Shurie, H., Addow, F. Y., Ibrahim, E. I., Mahboub, B. M., Al Redha, M. A. R., Hachim, M., Hamoudi, R., Ahmed, A. A. Tags: Imaging Source Type: research

Score for the identification of osteoporosis in smokers (SIOS): its development using clinical, radiological and biochemical information
Conclusions: The present study demonstrated that radiological emphysema, a FRAX score for hip fracture>3%, and a β–CTX level>0.20 ng/mL were the best predictors of the presence of osteoporosis. A SIOS>2 could be use as a screening tool to help clinicians identify smokers at high risk of osteoporosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Rivera Ortega, P., Gonzalez Gutierrez, J., Restituto Aranguibel, P., Varo Cenarruzabeitia, N., Colina Lorda, M. I., Calleja Canelas, M. D. L. D., Rodriguez Fraile, M. M., Bastarrika Aleman, G., Alcaide Ocana, A. B., Campo Ezquibela, A., Zulueta Frances, J Tags: Clinical Problems Source Type: research

Low FFMI according to ESPEN cut-offs is a strong independent predictor of mortality in patients with COPD
Introduction: Low fat free mass index (FFMI) is a component of the ESPEN diagnosis criteria of malnutrition, and when accompanied with weight loss is considered to be a determinant of malnutrition. FFMI alone was found to predict mortality in chronic obstructive pulmonary disease (COPD) in previous studies. Our aim was to assess independent effect of low FFMI according to the ESPEN criteria cut-offs on mortality of COPD patients.Methods: Subjects of the study were COPD patients assessed for nutritional status from 2015 to 2017 in our institution. Body composition was measured by bioelectrical impedance analysis. Low fat-fr...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Sarc, I., Kosten, T., Hafner, T., Zupanc, B., Ziherl, K. Tags: Clinical Problems Source Type: research

Association between ICS therapy for COPD and diabetes onset and progression
Conclusions: Long-term, high-dose ICS therapy for COPD is associated with an increased risk of diabetes onset and progression. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Voorham, J., Roche, N., Stephens, J., Park, H. Y., Fogel, R., Clemens, A., Brusselle, G., Price, D. Tags: Clinical Problems Source Type: research

Influence of body mass on predicted values of static hyperinflation in COPD
For interpretation of bodyplethysmographic static hyperinflation, reference values are of crucial importance. Earliest reference values have been published by the European Coal and Steel Community (ECSC) and are based on gender, body height and age as predictors. As obesity can lead to a reduction of functional residual capacity (FRC) in lung-healthy subjects, more recent approaches included body weight or body surface area. This raises the question whether these models are appropriate in patients with COPD-induced hyperinflation.Several FRC prediction models and their relation to body weight were analyzed in 1513 patients...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Alter, P., Rabe, K. F., Schulz, H., Vogelmeier, C. F., Jörres, R. A. Tags: Clinical Problems Source Type: research

In people at high risk of cardiovascular disease, co-existing COPD is not independently associated with macrovascular or microvascular disease
Background: Coexistence of COPD and cardiovascular disease has been attributed to shared risk, such as sedentary behaviour and smoking, and COPD-related pathology such as inflammation.Aim: To determine the association between COPD and vascular disease, independent of other cardiovascular risk factors, including coronary artery disease (CAD).Methods: People attending for elective coronary angiography underwent measurement of Framingham score (10-year risk of cardiovascular event), spirometry and Gensini score to assess extent of CAD. Participants with CAD and COPD (FEV1/FVC
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ruickbie, S., Burrage, D. R., Bajaj, M. P. K., Spilling, C. A., Dodd, J. W., Prasad, A., Barrick, T. R., Jones, P. W., Baker, E. H. Tags: Clinical Problems Source Type: research

Association between centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort
Conclusions: CAC is independently associated with increasing airflow obstruction and the presence of substantial centrilobular emphysema, and the link between COPD and CAC is mediated by inflammatory markers of shared pathways in the pathogenesis of emphysema and atherosclerosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bhatt, S., Nath, H., Kim, Y.-I., Ramachandran, R., Watts, J., Terry, N., Sonavane, S., Deshmane, S., Woodruff, P., Oelsner, E., Bodduluri, S., Han, M., Labaki, W., Wells, J., Martinez, F., Barr, G., Dransfield, M. Tags: Clinical Problems Source Type: research

Comorbidities in chronic obstructive pulmonary disease: a nation-wide twin study
Conclusions: In this large nation-wide, COPD was only associated with increased risk of heart failure and pulmonary embolism, but none of the other major comorbidities. Sub-analyses showed that respiratory symptoms, but not airway obstruction are associated with an increased risk of comorbidities and these associations seemed not to be influenced by genetic factors. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Meteran, H., Thomsen, S. F., Miller, M. R., Sigsgaard, T., Backer, V. Tags: Clinical Problems Source Type: research

Late Breaking Abstract - Right heart structural changes, exercise capacity and stress induced right ventricle dysfunction in non- severe COPD patients without pulmonary hypertension at rest.
Conclusion: In patients with non-severe COPD right sided cardiac structural changes are associated with lower six minute walk distance and stress induced right ventricular diastolic dysfunction. These findings may indicate that echocardiographic evidence of pulmonary vasculopathy are present in patients with non-severe COPD and contributes to decreased physical activity. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Cherneva, R., Cherneva, Z., Valev, D., Petkov, R., Kostadinov, D. Tags: Clinical Problems Source Type: research

Influence of natural lung surfactant inhalations on clinical symptoms and pulmonary function parameters in patients with bronchial asthma
Background: Damage to lung surfactant (LS) enabling the lung local immunity may contribute to the development of bronchial inflammation in patients with bronchial asthma (BA). Hohlfeld discussed the possible use of LS formulations for BA.Methods and Results: 29 patients enrolled in the study received a 70-day course of 21 LS (Surfactant-BL) inhalations at the dose of 25 mg alongside inhaled corticosteroids (ICS). After 21 inhalations there was a statistically significant decrease in the number of patients showing nocturnal attacks, profuse expectoration, cough, wheezing and shortness of breath under exertion. At Day 340 th...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Rosenberg, O., Shapovalov, K., Lukyanov, S., Stepanova, O., Akulova, E., Kochneva, A., Seiliev, A., Shulga, A., Loshakova, L., Volchkov, V., Lovacheva, O. Tags: Clinical Problems Source Type: research

Phenotypic characteristics of asthmatic patients with small airways obstruction
Background: In healthy lung, distal airways represent under 25% of total airflow resistances and are the main site of airflow obstruction in asthmatics (up to 50%). Asthma is recognized as a heterogeneous disease and several asthma phenotypes have been described, however the contribution of small airways is poorly investigated.Aim: analyze the characteristics associated to the small airway phenotype among asthmatics.Methods: Retrospective study between 2005 and 2017. In asthmatics, small airway obstruction (SAO) was defined by FEV1/FVC>70%, FEV1>80% and DEM 25-75
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ben Mansour, A., Daboussi, S., Mhamdi, S., Moetemri, Z., Aichaouia, C., Mejri, I., Khadraoui, M., Cheikh, R. Tags: Clinical Problems Source Type: research

Sex differences in difficult asthma; findings in the WATCH cohort
Background: Difficult asthma is comprised of many phenotypes, but how sex influences such patterns of disease remains unclear.Aims: To assess how the nature of difficult asthma seen in clinical practice differs between males and females.Methods: We studied patients enrolled (n=380) from a tertiary difficult asthma clinic (Southampton, UK) into a longitudinal Wessex AsThma CoHort (WATCH) assessing comparisons of core features stratified by sex.Results: Two thirds of subjects were female. Male participants were significantly older (median age 59.5 years v 48; p
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Freeman, A., Mistry, H. M., Azim, A., Harvey, M. A. E., Varkonyi-Sepp, J., Barber, C., Haitchi, H. M., Newell, C., Wilkinson, T. M., Kurukulaaratchy, R. J. Tags: Clinical Problems Source Type: research

Effects of a standardized Emergency Department asthma care pathway on health services utilization
Conclusions: While ED practice patterns varied across the province, the study findings support an overall positive effect of implementing an evidence-based standardized adult asthma pathway on reducing return ED visits for asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kwok, C., Lajkosz, K., Madeley, C., Jabbour, M., To, T., Lougheed, M. D. Tags: Clinical Problems Source Type: research

Pulmonary function and levels of serum leptin and interleukin-6 in women with bronchial asthma
Asthma in obese patients is a specific condition proven to be hard to manage and control. It prevails in elderly women and is characterized by low or none eosinophilic airway inflammation. The exact mechanism of the condition remains to be unclear.The goal of the study was to investigate the relationship between body mass index (BMI), pulmonary function and serum levels of leptin and interleukin-6. The study group included 133 postmenopausal patients of average age 64. 73 of them had BMI
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Makarova, E., Ignatova, G. Tags: Clinical Problems Source Type: research

Discriminating phenotypes of severe eosinophilic asthma using gene profiling in sputum
Background: Severe asthma is characterised by frequent exacerbations despite maximal medical treatment. Monoclonal antibody treatments against IL-5, and IL-4 and IL-13 are emerging and gene profiling using PCR analyses of sputum mRNA expression has been shown to detect genes related to IL4, IL5, and IL13.The aim of this study is to describe whether IL-5 and IL4/13 associated pathways are differentially expressed in subgroups of patients with severe asthma.Methods: In a cross-sectional design 117 patients with severe asthma according to the ERS/ATS guidelines were recruited. Genes known to distinguish eosinophilia from non-...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Frossing, L., Von Bülow, A., Ross Christensen, M., Backer, V., Gibson, P., Baines, K., Porsbjerg, C. Tags: Clinical Problems Source Type: research

Late Breaking Abstract - Oral corticosteroids exposure in a Swedish nationwide asthma population during 2006-2016
Aim: To describe the cumulative risk of exposure to oral corticosteroids (OCS) in Swedish asthma patients by analysing nationwide register data.Method: All patients (≥6 years) with an asthma diagnosis (ICD10: J45-46) in out- or in-patient secondary care and a drug claim (R03) during 2006–2016 were identified (index date) and subsequently followed in national patient and drug registries to observe OCS use (excl. patients with OCS-related conditions). OCS use was defined as date of first drug claim for prednisolone or betamethasone. Yearly OCS use was classified: regular (≥5 mg/day of prednisolone); periodic (
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Nwaru, B., Ekström, M., Wiklund, F., Telg, G., Nordahl, H., Janson, C. Tags: Clinical Problems Source Type: research

Lung functional failures of aircraft crew members after "fume event": diagnostics and biomonitoring
Conclusions: Our results underline the evidence of lung function impairment after FE. The plausibility of its correlation to FE was supported by the improvement over time after the FE. Furthermore, our results are evidence for an FE-correlated internal exposure with VOCs and/or OP, which are not constituents of the general environment, but of kerosene, oil or hydraulic fluids. Further independent investigations are needed to evaluate the clinical and toxicological findings and their link to FEs. Based on a realistic toxicological risk model an evidence-based workplace safety and effective preventive strategies has to be ev...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Heutelbeck, A., Baur, X., Goen, T., Mohr, N., Powitz, F., Budnik, L. T. Tags: Occupational and Environmental Health Source Type: research

Parental concern about indoor air quality and symptom reporting in primary schools
Discussion: Parental concern about IAQ is a common part of IAQ-problems in schools and may create significant uncertainties to interpretation of IAQ-questionnaires. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lampi, J., Nissilä, J.-J., Ung-Lanki, S., Savelieva, K., Pekkanen, J. Tags: Occupational and Environmental Health Source Type: research

Work-related effects on lung function, small airways and inflammation in hairdressers with airway symptoms - a pilot study
Conclusions: hairdressers are at risk of developing airway disorders and measures need to be taken to minimize exposure. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lärstad, M., Olin, A.-C. Tags: Occupational and Environmental Health Source Type: research

Active smoking and a past myocardial infarction status induce more vulnerability to urban heat stress in COPD
Conclusions: Our results indicate that active smoking and a past myocardial infarction status induce more vulnerability to urban heat stress in COPD. If minimum outdoor temperatures in Berlin increase above 18.3°C, COPD patients should consider heat protection to prevent heat stress. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Witt, C., Hoffmann, C., Hanisch, M., Heinsohn, J. B., Dostal, V., Jehn, M., Liebers, U., Pankow, W., Donaldson, G. C. Tags: Occupational and Environmental Health Source Type: research

Indoor airborne microbiota composition associated with asthma and atopy in rural children
In this study we investigate how farming conditions shape the indoor microbiota and we identify exposures with reduced probability of asthma and atopy in children. Latent Class Analysis was performed on all questionnaire-reported practices (n=2573 children from GABRIELA study) to identify ‘rural environment’ subgroups. In a stratified random subset of children (n=371) bedroom electrostatic dustfall collectors (EDCs) were analyzed by 16S rRNA gene sequencing and their microbiota composition across latent classes (LCs) was studied by PCoA and SIMPER analyses. Relationship between LCs, bacterial taxa and health ou...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Dorado Garcia, A., Lidwien, A. M. S., Bossers, A., Inge, M. W., Schmitt, H., Markus, J. E., Depner, M., Müller-Rompa, S., Schmausser-Hechfellner, E., Michael, J. C., Cookson, W., Moffatt, M., von Mutius, E., Dick, J. H. Tags: Occupational and Environmental Health Source Type: research

Epidemiology of silicosis reported to the SWORD scheme in the UK
Background: Although silicosis is usually a long latency disease, there have been a number of high profile international reports of accelerated silicosis in younger workers due to new sources of exposure (e.g. denim sandblasting or artificial stone worktops.)Aims and Objectives: The aim of this study was to document the demographic risk factors of workers reported to have silicosis in the UK.Methods: Data was obtained for all cases of silicosis reported to the UK Surveillance of Work-related and Occupational Respiratory Disease (SWORD) scheme since 1996. From 2006, data was available relating to the date of onset of sympto...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Barber, C., Fishwick, D., Seed, M., Carder, M., van Tongeren, M. Tags: Occupational and Environmental Health Source Type: research

Influence of air pollution on the number of hospital admissions in a Pneumology service
Conclusion: PM10, PM2.5, NO2 and O3 levels in the previous week were not linked with an increased number of respiratory-related hospital admissions in Valladolid. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Cerezo Hernandez, A., Ruiz Albi, T., Crespo Sedano, A., Alvarez Gonzalez, D., Lopez Izquierdo, R., Gomez Garcia, A., Alonso Fernandez, N., Lopez Represa, C., del Campo Matias, F. Tags: Occupational and Environmental Health Source Type: research

Asthma and selective migration away from farming environments in a three-generation cohort study
Conclusions: This study does not suggest that the protective effect from farm upbringing on subsequent asthma development could be explained by selective migration. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Timm, S., Frydenberg, M., Abrahamson, M., Bertelsen, R., Brabäck, L., Benediktsdottir, B., Dharmage, S., Forsberg, B., Gislason, T., Holm, M., Janson, C., Jogi, R., Malinovschi, A., Ramos, J., Sigsgaard, T., Svanes, C., Schlünssen, V. Tags: Occupational and Environmental Health Source Type: research

Influence of air pollution residues on the respiratory health of urban public transport drivers in a city of Sao Paulo State - Brazil
Introduction: Air pollution has been one of the biggest problems for society. In the state of São Paulo - Brazil, there are several factors that contribute to this pollution, among them the increase of the fleet of vehicles, the lack of suitable places for solid waste disposal and the burning of sugarcane. Air quality interferes directly with respiratory health. The mucociliary system is the first mechanical barrier to come into contact with these air pollutants and its integrity is fundamental for the protection of the respiratory system.Objective: to evaluate the influence of air pollution residues on the respirat...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Rossi, R. C., Vicente, D. N., Vilela, C. S., Souza, I. S., Dircksen, N. F. P., Rodrigues, M. V. P. Tags: Occupational and Environmental Health Source Type: research

Benefits of improved air quality on the aging lungs
Background: The beneficial effect of a reduction of outdoor air pollution on lung function in the elderly remains unclear, and scarce data exist regarding modifying factors such as BMI and genetics.Objectives: To examine associations between decline in air pollutants (nitrogen dioxide [NO2], particulate matter [PM2.5, PM10] exposure) and lung function measures in elderly German women.Methods: Data from the SALIA study (Study on the influence of Air pollution on Lung function, Inflammation and Aging) of elderly women were analysed (n=592). Spirometry (FEV1, FVC) was done at baseline (1985-1994; all women 55 years of age), f...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hüls, A., Sugiri, D., Abramson, M. J., Hoffmann, B., Krämer, U., Schikowski, T. Tags: Occupational and Environmental Health Source Type: research

Airborne pollen concentrations and daily respiratory disease mortality
Conclusions: Our results provide new evidence of relation between daily levels of alder pollen and respiratory mortality. These findings identify an important global public health impact and the results support development of population-based prevention through alarm systems and personalised medical advice at the clinics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Jaakkola, J. J. K., Kiihamäki, S.-P., Näyhä, S., Ryti, N. R. I., Jaakkola, M. S. Tags: Occupational and Environmental Health Source Type: research

Atmospheric simulation chamber: a versatile tool to get a comprehensive understanding of Air Quality impacts on health in preclinical models
Conclusion: These preliminary results demonstrate the feasibility of our innovative experimental approach, which represents a versatile tool to get a better understanding of AP impacts on health. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zysman, M., Franco-Montoya, M.-L., der Vartanian, A., Cazenau, M., Pini, M., Doussin, J.-F., Ridoux, A., Hue, S., Relaix, F., Derumeaux, G., Boczkowski, J., Lanone, S. Tags: Occupational and Environmental Health Source Type: research

Controlled human exposure study of diesel exhaust on older volunteers with and without COPD
Conclusion: Airflow in individuals with COPD appears to be impacted acutely by air pollution more than those without COPD. In next steps, we will investigate changes in mucins and inflammatory cytokines that may be responsible for changes in airflow dynamics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ryu, M. H., Wooding, D., Syed, N., Guenette, J., Carlsten, C. Tags: Occupational and Environmental Health Source Type: research

Diastolic blood pressure effect of traffic-related air pollution: a trial of vehicle filtration
Traffic-related air pollutants (TRAPs) are implicated in cardiovascular disease and increases in blood pressure. We tested whether real-world commute exposures to TRAPs affect blood pressure in healthy subjects. We conducted a double-blind crossover trial, randomized to order, in which 16 young healthy participants took three 2-hr drives in heavy Seattle traffic, separated by several weeks. On two days, on-road air was entrained into the cabin through the vehicle’s factory air vents and sham filters. On a third day, the vehicle was equipped with effective filtration. Blood pressure was measured before, during, and af...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Young, M., Jansen, K., Gould, T., Sack, C., Hooper, L., Stewart, J., Larson, T., Vedal, S., Kaufman, J. Tags: Occupational and Environmental Health Source Type: research

Occupational and environmental risk factors for Idiopathic Pulmonary Fibrosis in Australia
Conclusion: The burden of IPF could be reduced by continued tobacco control and occupational dust control measures. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Abramson, M. J., Murambadoro, T., Alif, S. M., Benke, G., Dharmage, S., Glaspole, I., Hopkins, P., Hoy, R., Klebe, S., Moodley, Y., Rawson, S., Reynolds, P., Wolfe, R., Walters, E. H., Corte, T. J., The Australian I.P.F. Registry F O R Tags: Occupational and Environmental Health Source Type: research

Relationships between nitrogen dioxide exposure, post-bronchodilator airflow obstruction and gas transfer in middle-age
Rationale: The contribution of outdoor air pollution to chronic obstructive pulmonary disease (COPD) is not well defined, and studies examining transfer factor are lackingAim: To examine relationships between nitrogen dioxide (NO2) exposure and post-bronchodilator (BD) lung function in middle-aged AustraliansMethods: Data were from the 5th decade follow-up of the Tasmanian Longitudinal Health Study. Annual mean NO2 concentration was estimated at residential addresses using a satellite-based land-use regression model (n=1, 355). Post-BD FEV1/FVC and transfer factor (TLco) were categorised by the lower limit of normal (LLN) ...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Perret, J., Bowatte, G., Knibbs, L., Johns, D., Lodge, C., Lowe, A., Bui, D., Matheson, M., Thompson, B., Morrison, S., Giles, G., Walters, E. H., Abramson, M., Dharmage, S. Tags: Occupational and Environmental Health Source Type: research

Doctor diagnosed asthma and wheeze among Chinese pre-school children in relation to indoor and outdoor air pollution and urbanization
In conclusion, traffic related air pollution (TRAP), dampness or mould and ETS at home can be risk factors for asthma and wheeze among pre-school children in China. Breastfeeding can be protective for asthma. Urbanization was associated with less wheeze but more doctor diagnosed asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Norback, D., Lu, C., Wang, J., Zhang, Y., Li, B., Zhao, Z., Huang, C., Zhang, X., Qian, H., Sun, Y., Sundell, J., Deng, Q. Tags: Occupational and Environmental Health Source Type: research