Interpretation and clinical significance of multiple-flows exhaled nitric oxide in severe asthma framework
Conclusions: J’awNO was differently expressed among the SA endotypes and showed a better accuracy than FeNO in predicting a good response to biologic treatment, supporting its potential use in clinical practice. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Luzzi, S., Alderighi, L., Pianigiani, T., Perea, B., Messina, M., Meocci, M., Bergantini, L., D'Alessandro, M., Bargagli, E., Cameli, P. Tags: Airway pharmacology and treatment Source Type: research
Effects of hormonal fluctuations during the menstrual cycle on asthma
Introduction: The effect of the menstrual cycle due to hormonal fluctuations on asthma is little known compared to the effect of allergens, irritants, respiratory infections and many other factors.Study Objectives: To identify anamnestic, clinical, hormonal, and functional elements related to the menstrual cycle that may influence asthma control.Materials and methods: descriptive prospective study on 95 non-menopausal asthmatic patients, aged 16 to 50 years. They provided spirometries and assays of progesterone and estradiol during the phases: follicular between the 3rd and 5th day of the cycle, luteal between the 19th and...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Aissani, S., Haouichat, H., Zitouni, A. Tags: Airway pharmacology and treatment Source Type: research
Serum inhaled corticosteroid levels in patients with severe asthma.
There are no robust methods of assessing compliance to inhaled corticosteroid (ICS) therapy. Medication possession ratio calculated based on dispensed prescriptions is often used but does not account for whether the medication was taken, and if so correctly. We explored the feasibility of measuring serum ICS levels in patients with severe asthma on biologics.Patients with severe asthma approved for mepolizumab were invited. Patients were instructed to withhold their ICS on the morning of the first visit for spirometry, but to continue their prescribed ICS for the remainder of the study. Serum was taken approximately four h...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Pang, Y. L., Ali, M., Fowler, S. J., Keevil, B., Mckeever, T., Sayers, I., Shaw, D. E. Tags: Airway pharmacology and treatment Source Type: research
Therapeutic drug monitoring of inhaled drugs in hair of patients with asthma: a proof-of-concept study
Conclusions: These results confirm the feasibility of measuring budesonide and formoterol in the hair and suggest a relationship between drug exposure and hair concentrations. This may be of interest in difficult-to-treat severe asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Salvator, H., Delyle, S., Roquencourt, C., Lambinet, F., Bardin, E., Devillier, P., Grassin Delyle, S. Tags: Airway pharmacology and treatment Source Type: research
Induced sputum is a simple examination in relation to the diagnosis of eosinophilic asthma.
Conclusion: Examining inflammatory cells in induced sputum has a high diagnostic yield and is a safe and easily performed procedure in patients suffering from severe asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Pedersen, L. M., Andersen, H. H., Smidt-Hansen, T., Schmid, J. M. Tags: Airway pharmacology and treatment Source Type: research
Screening for obstructive sleep apnea in patients with Down Syndrome
Conclusions: PASHOS test showed discrete but better diagnostic accuracy than the usual OSA screening test. The results evidence the need to validate specific OSA screening tools for population with DS. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Fortuna Gutierrez, A., Podzamczer Valls, I., Mayos Perez, M., Clos Batet, S., Videla Toro, L., Carmona-Iragui, M., Barroeta Espar, I., Arranz Martinez, J. J., Benejam Paul, B., Lleo Bisa, A., Fortea Ormaechea, J., Gimenez Badia, S. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
The usefulness of observed apnea item in obstructive sleep apnea diagnosis: results from the 2019-2020 Korean National Health and Nutrition Examination Survey
Conclusions: The observed apnea item within the STOP-Bang questionnaire is useful for screening and diagnosing OSA in South Korea. Furthermore, it was confirmed that the prevalence of various comorbidities, such as hypertension, diabetes, and cardiovascular disease, increased in the group with observed apnea. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Gu, K.-M., KO, E. B., Jung, H. I., Park, S. Y., Baek, M. S., Kim, W. Y., Choi, J.-C., Shin, J.-W., Kim, J.-Y., Jung, J.-W. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Evaluation of a modified Epworth Sleepiness Scale to reliably assess excessive daytime sleepiness in low-income countries: results from the Benin Society and Sleep study (BeSAS)
Conclusion: Although the mES is not a perfect score, it appears more relevant in the Benin population than the original Epworth scale but needs further validation/improvement in other low-income countries. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Wachinou, A. P., Fiogbe, A., Totah, T., Agodokpessi, G., Heinzer, R. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Simplified questionnaire for detecting patients with severe OSA
Conclusions: The simplified questionnaire could be a useful tool for detecting severe OSA patients who need immediately treatment in community in a Chinese population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Huang, C., Feng, Y., Wang, L., Xiang, X., Steier, J., Luo, Y. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Risk factors for OSA in a population of Italian telecommunication workers
Conclusion: Obesity emerged as the main risk factor for prolonged oxygen desaturation. The noxious effect of smoking habits on T90 was larger in women than men. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Verlato, G., Insalaco, G., Marchetti, P., Vesentini, R., Romeo, L. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Kleine-Levin and post covid 19 syndromes, a possible relationship?
Kleine–Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia, behavioural or cognitive disturbances, compulsive eating behaviour, and hypersexuality. An underlying hypothalamic pathology is suggested by the critical role of this structure in regulating sleep, appetite, and sexual behaviours; however, no consistent hypothalamic abnormalities have been identified. Viral and autoimmune causative factors have been suggested, on the basis of the frequent report of flu-like symptoms at onset, and the most frequent precipitating factor (70%). MAL, 58 years old, diagnosed with Covid 19 in ...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Maranhao, A., Saad, C. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Comparison of Objective and Subjective Sleep Assessment in a Post-Covid Population as Assessed by WatchPAT.
With the emergence of the SARS-CoV-2 pandemic & Post-COVID syndrome, sleep disturbance & insomnia are among the major symptoms reported. The Pittsburgh Sleep Quality Index(PSQI)is a validated, self-reported questionnaire to assess sleep quality. The PSQI has been utilised in qualitative studies examining sleep disturbance Post-COVID-19, but has not been compared to objective sleep assessment in this population.Participants were recruited from a Post-COVID Clinic. Sleep disturbance, sleepiness & fatigue were assessed using the PSQI, Epworth Sleepiness Score, Chalder Fatigue Score & Berlin Score. Those with e...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Campbell, C. D., Sulaiman, I. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Considering obstructive sleep apnoea syndrome as a differential diagnosis in Long COVID patients
ConclusionOSAS should be actively investigated as a differential diagnosis in Long COVID patients when other features are present to ensure appropriate management. Further research is needed to determine if this is due to causation or correlation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: McEwan, K., Salman, R., Tarrant, R., Halpin, S., Sivan, M. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Sickle cell disease phenotypes and obstructive sleep apnea; are they related?
Conclusion: The risk of having OSA and the severity of OSA is higher in Benin phenotype when compared to the Arab-Indian phenotype which indicate the presence of potential OSA risk factors other than the SCD itself. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Alsaleh, S., Alshehri, N., Alsiddiqi, S., Rayis, M., Eltahir, S., Alzaid, M., Alotaibi, W. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Eat, breathe, sleep with Osteogenesis Imperfecta
Although Osteogenesis Imperfecta (OI) affects the connective tissue causing brittle bones with consequent skeletal deformities, it is important to go beyond bones, as OI might also affect other important functions. We have implemented a multidisciplinary study to assess lung function, breathing pattern, sleep quality and nutritional status in 27 adults OI type III and IV patients (median age: 34.6 years; 19 women; 14 type III). According to nocturnal oxygen desaturation, two groups were identified: 13 patients with (OI_OSA, incidence: 48.2%) and 14 without (no_OSA) obstructive sleep apnea. The former was characterized by h...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: LoMauro, A., Landoni, V., Fraschini, P., Molteni, F., Aliverti, A., Bertoli, S., De Amicis, R. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
