Fibroblast growth factor 10 reverses cigarette smoke- and elastase-induced emphysema and pulmonary hypertension in mice

Conclusion
In a therapeutic approach, FGF10 overexpression successfully restored lung alveolar and vascular structure in mice with established cigarette smoke- and elastase-induced emphysema and PH. FGF10 treatment triggered an initial increase in the number of alveolar type 2 cells that gradually returned to the basal level when the FGF10-mediated repair process progressed. Therefore, the application of recombinant FGF10 or stimulation of the downstream signalling cascade might represent a novel therapeutic strategy in the future.

Source: European Respiratory Journal - November 9, 2023 Category: Respiratory Medicine Authors: Hadzic, S., Wu, C.-Y., Gredic, M., Pak, O., Loku, E., Kraut, S., Kojonazarov, B., Wilhelm, J., Brosien, M., Bednorz, M., Seimetz, M., Günther, A., Kosanovic, D., Sommer, N., Warburton, D., Li, X., Grimminger, F., Ghofrani, H. A., Schermuly, R. T., Tags: COPD and smoking, Lung biology and experimental studies Original Articles: Basic mechanisms of lung disease Source Type: research