Multi-focal dysplasia is associated with high recurrence rates after successful ablation of dysplastic Barrett's esophagus
Barrett's esophagus (BE) might recur after complete eradication of intestinal metaplasia (CEIM). We investigated factors associated with recurrence of BE after successful Radiofrequency ablation (RFA). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 28, 2023 Category: Gastroenterology Authors: Boris Sapoznikov, George Fisch, Steven Shamah, Nadav Shinhar, Fabiana Benjaminov, Zohar Levi, Noam Peleg Tags: Alimentary Tract Source Type: research
Giant gastric ulcer caused by cytomegalovirus in immunocompetent adult
A 29-year-old man presented with a persistent fever, diarrhea, and loss of appetite lasting for a week. There was no history of prior illness, surgery, or blood transfusion. Physical examination revealed tenderness in the left lower abdomen. Blood tests showed mild liver damage, while a CT scan revealed thickening of the gastric (Fig. 1A) and colon walls, mild splenomegaly, and a small amount of ascites effusion. Upper and lower gastrointestinal endoscopies revealed ulcers in the gastric cardia (Fig. 1B), upper body (Fig. 1C), gastric antrum (Fig. 1D), ileocecal valve, rectum (Fig. 1E), and erosions in the duodenum, ...
Source: Digestive and Liver Disease - July 28, 2023 Category: Gastroenterology Authors: Shinya Matsumura, Moe Murao, Tomohiro Ueda, Kentaro Suzuki Tags: Image of the Month Source Type: research
Comparison of the severity of metabolic, liver and cardiovascular damage in NAFLD patients attending the hepatology clinic over the last three decades
NAFLD prevalence is increasing worldwide. Aim: to assess whether severity of hepatic, metabolic and cardiovascular (CV) disease changed over time. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 26, 2023 Category: Gastroenterology Authors: Rosa Lombardi, Lucia Colavolpe, Francesca Alletto, Annalisa Cespiati, Erika Fatta, Cristina Bertelli, Felice Cinque, Giuseppina Pisano, Edoardo Pulixi, Paolo Francione, Gabriele Maffi, Federica Iuculano, Paola Dongiovanni, Larry Burdick, Daniela Bignamini Tags: Liver, Pancreas and Biliary Tract Source Type: research
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(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 24, 2023 Category: Gastroenterology Source Type: research
Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis
Tripartite motif containing proteins 23(TRIM23) is identified as an E3 ubiquitin ligase involved in signal transduction, but its role in liver fibrosis remains unknown. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 24, 2023 Category: Gastroenterology Authors: Jie Chen, Rui Zhang, Feng Li, Shengli Lin, Jian Wang Tags: Liver, Pancreas and Biliary Tract Source Type: research
A prospective study on the differential association of sarcopenia and frailty with health outcomes in cirrhotic patients
To investigate the joint impact of sarcopenia and frailty on mortality and the development of decompensation in cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 21, 2023 Category: Gastroenterology Authors: Jia Luo, Dawei Yang, Zhengyu Xu, Dai Zhang, Min Li, Yuanyuan Kong, Xiaoming Wang, Xiaojuan Ou, Yu Wang, Xinyan Zhao, Shan Shan, Zhenghan Yang, Jidong Jia Tags: Liver, Pancreas and Biliary Tract Source Type: research
Disease course of ulcerative proctitis in children: A population-based study on behalf of the SIGENP IBD Group
The natural history of ulcerative proctitis (UP) has been poorly investigated in children. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 21, 2023 Category: Gastroenterology Authors: Massimo Martinelli, Flora Fedele, Claudio Romano, Marina Aloi, Paolo Lionetti, Patrizia Alvisi, Serena Arrigo, Luca Bosa, Matteo Bramuzzo, Giulia D'Arcangelo, Valeria Dipasquale, Enrico Felici, Maurizio Fuoti, Simona Gatti, Francesco Graziano, Maria Teres Tags: Alimentary Tract Source Type: research
Pancreatic metastasis from small bowel neuroendocrine tumor
A 60-year-old man, with a past medical history of obesity and diabetes, was admitted for obstructive jaundice. Preoperative CT-scan showed a 3 cm pancreatic head mass causing Wirsung and bile duct dilatation. Endoscopic ultrasonography found a 3 cm pancreatic mass; a biliary stent was placed and a biopsy was performed. Cytology found a moderately differentiated endocrine tumor. 68Ga-DOTATOC PET showed intense fixation of the pancreatic tumor, of multiple lymph nodes on the ileocolic pedicle and of a small tumor localized on the distal ileum (Fig. 1). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 21, 2023 Category: Gastroenterology Authors: Pietro Addeo, Antonin Fattori, Alessio Imperiale, Philippe Bachellier Tags: Image of the Month Source Type: research
Aggressive fibromatosis misdiagnosed as jejunal diverticulum inflammation
A 49-year-old woman incidentally presented with a 10-day abdominal pain and found a palpable mass in the left abdomen. Endoscopy revealed a diverticulum near the flexural ligament with a blood clot (Fig. 1A and B). Enhanced CT of the abdomen showed a thick-walled pouch-like soft tissue mass (size 4.9 cm × 4.4 cm × 5.8 cm) with inhomogeneous enhancement at the duodenal and jejunal migrations, and a linear enhancement shadow in the center (Fig. 1C and D). CT volume rendering (VR) technique revealed the location and contour of the lesion (Fig. 1E and Video 1). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 20, 2023 Category: Gastroenterology Authors: Bo Duan, Yingli Wang, Qingyu Ji Tags: Image of the Month Source Type: research
Switching from VEDOlizumab intravenous to subcutaneous formulation in ulcerative colitis patients in clinical remission: The SVEDO Study, an IG-IBD study
The administration of biological drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 19, 2023 Category: Gastroenterology Authors: Davide Giuseppe Ribaldone, Laura Parisio, Angela Variola, Fabrizio Bossa, Fabiana Castiglione, Manuela Marzo, Nicole Piazza, Annalisa Aratari, Edoardo Vincenzo Savarino, Giorgia Bodini, Mauro Mastronardi, Federica Micheli, Silvia Mazzuoli, Marta Ascolani, Tags: Alimentary Tract Source Type: research
The hidden dangers of chronic pancreatitis in pregnancy: Evidence from a large-scale population study
Chronic pancreatitis is a debilitating condition that can affect women of childbearing age, and its impact on maternal and perinatal outcomes is poorly understood. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 18, 2023 Category: Gastroenterology Authors: Chengu Niu, Jing Zhang, Kaiwen Zhu, Hongli Liu, Patrick I Okolo Tags: Liver, Pancreas and Biliary Tract Source Type: research
Exploring the optimal therapeutic management of stage ypIA pancreatic ductal adenocarcinoma patients in the era of primary chemotherapy
Data on the proper post-surgical chemotherapy (PSC) in pancreatic ductal adenocarcinoma (PDAC) patients already treated with neoadjuvant therapy (NAT) are lacking, especially for stage ypIA. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 15, 2023 Category: Gastroenterology Authors: Marina Macchini, Giulio Belfiori, Stefano Crippa, Giulia Orsi, Giulia Gasparini, Domenico Tamburrino, Stefano Partelli, Marco Schiavo Lena, Diego Palumbo, Francesco De Cobelli, Massimo Falconi, Michele Reni Tags: Oncology Source Type: research
Long-term Outcome of Autoimmune Hepatitis: Consecutive Patient Cohort and Data on the Second Twenty Years
Mortality rates for autoimmune hepatitis (AIH) vary. Data are lacking beyond 20 years follow-up. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Laura Harrison, Barbara Hoeroldt, Harpreet Dhaliwal, Elaine Wadland, Asha Dube, Dermot Gleeson Tags: Liver, Pancreas and Biliary Tract Source Type: research
Histological healing as a predictor of sustained clinical remission in paediatric ulcerative colitis
The study aimed to assess the longitudinal impact of endoscopic healing (EH) and histological healing (HH) in a cohort of paediatric patients affected by ulcerative colitis (UC). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Luca Scarallo, Lorenzo Fioretti, Monica Paci, Sara Naldini, Sara Renzo, Jacopo Barp, Anna Gissi, Monica Di Paola, Vincenzo Villanacci, Paolo Lionetti Tags: Alimentary Tract Source Type: research
Identification of gastric signet ring cell carcinoma based on endoscopic images using few-shot learning
Deep learning (DL) models perform poorly when there are limited gastric signet ring cell carcinoma (SRCC) samples. Few-shot learning (FSL) can address the small sample problem. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Minyue Yin, Rufa Zhang, Jiaxi Lin, Shiqi Zhu, Lu Liu, Xiaolin Liu, Jianying Lu, Chunfang Xu, Jinzhou Zhu Tags: Digestive Endoscopy Source Type: research
