Prevalence of celiac disease in systemic lupus erythematosus, sjogren syndrome and systemic sclerosis: A systematic review and meta-analysis
Celiac disease (CeD) is an immune-mediated disorder affecting the small bowel, associated with genetic factors and increasing global prevalence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 6, 2024 Category: Gastroenterology Authors: Renato Beas, Euler Altamirano-Farfan, Diego Izquierdo-Veraza, Dalton A. Norwood, Adrian Riva-Moscoso, Ambar Godoy, Eleazar E. Montalvan-Sanchez, Mirian Ramirez, Daniel A. Guifarro, Emily Kitchin, Monika Fischer, Satya Kurada Tags: Meta-Analysis Source Type: research
Association between remnant cholesterol and metabolic dysfunction-associated steatotic liver disease in the elderly
This study aimed to investigate the relationship between RC and MASLD in the elderly Chinese population. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 5, 2024 Category: Gastroenterology Authors: Yanqi Lan, Zhinan Guo, Junsheng Dai, Kailin Chen, Youlan Chen Tags: Liver, Pancreas and Biliary Tract Source Type: research
The long intergenic non-coding RNA LINC01140 modulates gastric cancer phenotypes and cancer cell lines aggressiveness
Long-intergenic non-protein coding gene 01140 (LINC01140) a long non-coding RNA is highly expressed in various cancers. However, its biological functions in gastric cancer progression is still unknown. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 31, 2024 Category: Gastroenterology Authors: Juhi Singh, Gopeshwar Narayan, Vinod Kumar Dixit Tags: Oncology Source Type: research
Author's reply: The importance of professional training to foster the implementation of Artificial Intelligence in the clinical setting of liver diseases
I have carefully read the letter entitled “Artificial intelligence for liver diseases: The urgency of collaboration” by Cesaretti and colleagues [1], which comments on our review on the advantages and pitfalls of the application of Artificial Intelligence (AI) in the study, management and treatment of liver diseases [2]. Indeed, the com mentary points out questions and interesting insights that require further discussion. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 30, 2024 Category: Gastroenterology Authors: Clara Balsano Tags: Correspondence Source Type: research
Combination of Model for End-Stage Liver Disease (MELD) and Sarcopenia predicts mortality after transjugular intrahepatic portosystemic shunt (TIPS)
TIPS is the most effective treatment for portal hypertension. Patient selection remains important to achieving optimal post-TIPS outcomes. The study evaluates 1-year mortality factors in cirrhotic patients receiving TIPS.Methods: 87 cirrhotic patients received a TIPS between 2015 - 2021. Predictors of 1-year and overall mortality were assessed by estimating cumulative incidence functions and Grey's test to adjust for liver transplantation as a risk competing with mortality. Variables with p (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 29, 2024 Category: Gastroenterology Authors: Maria Gabriela Delgado, Nando Mertineit, Jaime Bosch, Iris Baumgartner, Annalisa Berzigotti Tags: Liver, Pancreas and Biliary Tract Source Type: research
Resmetirom for the treatment of nonalcoholic steatohepatitis: Evaluating the robustness of available evidence
Non-alcoholic steatohepatitis (NASH), recently renamed metabolic dysfunction-associated steatohepatitis (MASH) [1] is still an orphan condition, with no pharmacological therapy yet approved for use in clinical practice. Nonetheless, the clinical trial landscape in the field is rapidly changing with several molecules currently being studied in Phase 3 clinical programs. In particular, thyroid hormone beta receptor (TRB) agonists have received considerable attention as they reduce de novo lipogenesis, promote fatty acid oxidation, modulate mitophagy and mitochondrial biogenesis as well as cholesterol metabolism and potential...
Source: Digestive and Liver Disease - March 29, 2024 Category: Gastroenterology Authors: Stefano Ciardullo, Alessandro Mantovani Tags: Correspondence Source Type: research
Reticulated platelets are increased and hyper-activated in patients with cirrhosis, especially those with poor outcome
Reticulated platelets (RePLT) are emergency circulating platelets released to contrast peripheral platelet destruction. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 28, 2024 Category: Gastroenterology Authors: Alberto Zanetto, Serena Toffanin, Elena Campello, Claudia Maria Radu, Sabrina Gavasso, Patrizia Burra, Francesco Paolo Russo, Marco Senzolo, Paolo Simioni Tags: Liver, Pancreas and Biliary Tract Source Type: research
Portal hypertension is associated with poorer outcome and clinical liver decompensation in patients with HCC treated with Atezolizumab-Bevacizumab
Portal hypertension (PHT) often complicates hepatocellular carcinoma (HCC) treatment and prognosis. We aimed to assess PHT's impact on AtezoBev outcomes and identify predictors of acute variceal bleeding (AVB) and clinical ascites occurrence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 27, 2024 Category: Gastroenterology Authors: Philippe Sultanik, Claudia Campani, Edouard Larrey, Bertille Campion, Manon Evain, Charles Roux, Lorraine Blaise, Mathilde Wagner, Marika Rudler, Jean Charles Nault, Dominique Thabut, Manon Allaire Tags: Oncology Source Type: research
“Per ELISA”: Time to adopt anti-transglutaminase/deamidated gliadin peptide diagnostic combination in coeliac disease of adults?
Anti-endomysial antibodies (EMA) and anti-tissue transglutaminases (a-tTg) play a pivotal role in coeliac disease (CD) diagnosis. Deamidated anti-gliadin peptides (DGP) were added to the CD diagnostic workup. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 26, 2024 Category: Gastroenterology Authors: Antonio Rispo, Giulio Calabrese, Benedetta Toro, Oriana Olmo, Simona Ricciolino, Nicola Mattia Cantisani, Lara Limansky, Miriam Giaquinto, Rossella Caso, Nicola Imperatore Tags: Alimentary Tract Source Type: research
Ustekinumab-induced leukocytoclastic vasculitis in a young male with Crohn's disease
Ustekinumab-induced Leukocytoclastic Vasculitis in a Young Male with Crohn's disease (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 24, 2024 Category: Gastroenterology Authors: Xiao-Peng Zhang, Huan Wang, Liang-ru Zhu Tags: Image of the Month Source Type: research
Author's reply: AI in medicine, bridging the chasm between potential and capability
We thank Dr. Koga and colleagues for commenting on our recent publication [1]. Their commentary delves into the promises and challenges associated with artificial intelligence (AI) in medical image interpretation, further enriching and refining the implications of our research [2]. By underscoring the critical significance of selecting the appropriate machine learning architecture, their analysis presents a clear roadmap for integrating AI into future medical practices. Despite the relative focus on the field of medical imaging, their commentary offers an opportunity for us to revisit the gap between the potential and the ...
Source: Digestive and Liver Disease - March 24, 2024 Category: Gastroenterology Authors: Yiwen Zhang, Lili Xu, Hongwei Ji Tags: Correspondence Source Type: research
The 1st EoETALY Consensus on the Diagnosis and Management of Eosinophilic Esophagitis –Current Treatment and Monitoring
The present document constitutes Part 2 of the EoETALY Consensus Statements guideline on the diagnosis and management of eosinophilic esophagitis (EoE) developed by experts in the field of EoE across Italy (i.e., EoETALY Consensus Group). Part 1 was published as a different document, and included three chapters discussing 1) definition, epidemiology, and pathogenesis; 2) clinical presentation and natural history and 3) diagnosis of EoE. The present work provides guidelines on the management of EoE in two final chapters: 4) treatment and 5) monitoring and follow-up, and also includes considerations on knowledge gaps and a p...
Source: Digestive and Liver Disease - March 24, 2024 Category: Gastroenterology Authors: Nicola de Bortoli, Pierfrancesco Visaggi, Roberto Penagini, Bruno Annibale, Federica Baiano Svizzero, Giovanni Barbara, Ottavia Bartolo, Edda Battaglia, Antonio Di Sabatino, Paola De Angelis, Ludovico Docimo, Marzio Frazzoni, Manuele Furnari, Andrea Iori, Tags: Guidelines Source Type: research
“The crackers challenge”: A reassuring low-dose gluten challenge in adults on gluten-free diet without proper diagnosis of coeliac disease
Gluten-free diet (GFD) is the one therapy in coeliac disease (CeD). Unfortunately, some patients adopt GFD before the diagnostic work-up. The guidelines suggest a 14-day gluten intake> 3 gr to get CeD diagnosis, although many subjects refuse this approach. Other evidence showed that the intake of 50 mg/day of gluten for 3 months could be useful for CeD diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 23, 2024 Category: Gastroenterology Authors: Antonio Rispo, Alessia Dalila Guarino, Monica Siniscalchi, Nicola Imperatore, Antonella Santonicola, Simona Ricciolino, Roberto de Sire, Benedetta Toro, Nicola Mattia Cantisani, Carolina Ciacci Tags: Alimentary Tract Source Type: research
Full Title Page /Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 22, 2024 Category: Gastroenterology Source Type: research
Diagnosis and management of anemia in pediatric inflammatory bowel diseases: Clinical practice guidelines on behalf of the SIGENP IBD Working group
Anemia is one of the most frequent extra-intestinal manifestations of inflammatory bowel disease. Insidious onset, variability of symptoms and lack of standardized screening practices may increase the risk of underestimating its burden in children with IBD. Despite its relevance and peculiarity in everyday clinical practice, this topic is only dealt with in a few documents specifically for the pediatric field. The aim of the current guidelines is therefore to provide pediatric gastroenterologists with a practical update to support the clinical and therapeutic management of children with IBD and anemia. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 18, 2024 Category: Gastroenterology Authors: Massimo Martinelli, Maria Teresa Fioretti, Marina Aloi, Patrizia Alvisi, Serena Arrigo, Claudia Banzato, Matteo Bramuzzo, Angelo Campanozzi, Fortunata Civitelli, Daniela Knafelz, Paolo Lionetti, Antonio Marseglia, Francesca Musto, Lorenzo Norsa, Giuseppe Tags: Guidelines Source Type: research
