Gastric adenocarcinoma of fundic gland type
A 61-year-old woman presented with a 2-week history of abdominal distension. She had no documented medical history. Abdominal examination was unremarkable. Upper gastrointestinal endoscopy showed a reddish erosive lesion of 15 × 12 mm on the greater curvature of the upper gastric body (Fig. 1A), which was well-defined by magnifying endoscopy with narrow-band imaging model (Fig. 1B, C). Biopsy was subsequently taken. Well differentiated columnar cells with moderate nuclear atypia were confirmed by microscopic examin ation. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 29, 2024 Category: Gastroenterology Authors: Ding Zhang, Wei Liu, Zu-Jiang Yu Tags: Image of the Month Source Type: research
Factors associated with corticosteroid use in Crohn's disease and ulcerative colitis patients in Israel: A multicenter cross-sectional study
The objective was to contribute to the development of strategies minimizing corticosteroid dependence and improving patient outcomes, given the adverse effects associated with prolonged corticosteroid use. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 29, 2024 Category: Gastroenterology Authors: Revital Barkan, Leonid Shpoker, Rasha Abboud, Smadar Nafrin, Tal Ilsar, lani Ofri, Ayala Blau, Rachel Gingold-Belfer, Henit Yanai, Iris Dotan, Jacob E Ollech Tags: Alimentary Tract Source Type: research
Overexpression of NDRG1 leads to poor prognosis in hepatocellular carcinoma through mediating immune infiltration and EMT
NDRG1, the first member of the NDRG family, is a multifunctional protein associated with carcinogenesis. Its function in human cancer is currently poorly understood. The aim of this study was to explore the importance of NDRG1 in tumor immune cell infiltration and epithelial –mesenchymal transition (EMT) in hepatocellular carcinoma. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 29, 2024 Category: Gastroenterology Authors: Xiao Wang, Ran Sun, Na Che, Danfang Zhang, Yanlei Li, Nan Zhao Tags: Oncology Source Type: research
Artificial intelligence for liver diseases: The urgency of collaboration
We have read with interest the paper by Balsano et al [1]. about opportunities and barriers of Artificial Intelligence in hepatology and liver surgery apllications. While this review contributes to the existing knowledge, we would like to raise some concerns that warrant further consideration. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 29, 2024 Category: Gastroenterology Authors: Manuela Cesaretti, Alessandro Izzo, Orestes Mavrothalassitis, Roberta Anna Pellegrino Tags: Correspondence Source Type: research
Assessing disease severity in inflammatory bowel disease - Can we reliably encompass the full burden of illness?
We had the opportunity to read the original article entitled “Validation of disease severity index for predicting complicated Crohn's disease: A comparison study with Lémann index” by Qiu et al. [1]. We congratulate the authors on their efforts to further validate the disease severity index (DSI) for inflammatory bowel disease (IBD) [2] and compare it w ith existing indices measuring bowel damage in Crohn's disease (CD). However, we would like to acknowledge several points, as listed below, to further extend this work and reiterate the value of this holistic IBD index. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 29, 2024 Category: Gastroenterology Authors: Akhilesh Swaminathan, Andrew S. Day, Richard B. Gearry Tags: Correspondence Source Type: research
Infliximab is an effective option in patients with ulcerative colitis previously exposed to full subcutaneous anti-TNF agent: Results from a real-world multicenter study
Data on infliximab efficacy in bio-exposed patients with ulcerative colitis (UC) are limited. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 27, 2024 Category: Gastroenterology Authors: M. Hup é, A. Streichenberger, P. Wils, N. Arab, M. Serrero, A. Amiot, A. Bozon, L. Vuitton, M. Fumery, R. Altwegg, M. Nachury, X. Hébuterne, C. Yzet, D. Coban, M. Dodel, M. Bazoge, B. Pereira, A. Buisson Tags: Alimentary Tract Source Type: research
Do glucagon-like peptide-1 based therapies alter the risk of late-onset inflammatory bowel disease?
The use of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) widely used to treat type 2 diabetes, has accelerated worldwide after it was approved for treating obesity by the U.S. Food and Drug Administration in 2021 and the European Medicines Agency in 2022. The use of semaglutide is likely to accelerate further in the future after a recent trial reported that semaglutide lowers the risk of adverse cardiovascular events by 20% in patients with overweight or obesity and previous cardiovascular disease but without diabetes [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 27, 2024 Category: Gastroenterology Authors: Heidi S øgaard Christensen, Diana Vincens Andersen, Tine Jess, Kristine Højgaard Allin Tags: Correspondence Source Type: research
ABCA8: A potential therapeutic target in the treatment of colorectal cancer?
None (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 27, 2024 Category: Gastroenterology Authors: Dian-Bo Dong, Hong-Jin Shao Tags: Correspondence Source Type: research
Single or continuous multiple intravenous re-induction in Crohn's disease patients who lost response to ustekinumab: Evidence from real-world data
Re-induction optimization of ustekinumab is effective in Crohn's disease (CD) patients who experienced a loss of response (LOR) to ustekinumab. However, whether continuous multiple intravenous optimization is better than single dose re-induction remains unknown. We aimed to compare effectiveness of two strategies in CD patients with LOR to ustekinumab. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 27, 2024 Category: Gastroenterology Authors: Jian Tang, Qing Li, Zhaopeng Huang, Lishuo Shi, Qin Guo, Miao Li, Xiang Gao, Kang Chao Tags: Alimentary Tract Source Type: research
Hepatofugal portal flow is highly predictive of acute-on-chronic liver failure: A new hemodynamic patho-physiological hypothesis
Acute-on-chronic liver failure (ACLF) is a severe complication of advanced liver disease. A significant number of ACLF patients have not clear precipitating factors. The aim of the study was to investigate the role of alterations in porto-hepatic hemodynamics, especially non-forward portal flow (NFPF), in ACLF and liver-related mortality. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 27, 2024 Category: Gastroenterology Authors: Bevilacqua Michele, De Marco Leonardo, Stupia Roberta, Cattazzo Filippo, Zoncap é Mirko, Paon Veronica, Ieluzzi Donatella, Dalbeni Andrea, Sacerdoti David Tags: Liver, Pancreas and Biliary Tract Source Type: research
Full Title Page /Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 25, 2024 Category: Gastroenterology Source Type: research
Mismatch repair deficiency in multifocal gastric epithelial neoplasia and non-dysplastic glands: Harbinger of Lynch syndrome in an autoimmune gastritis patient
A 66-year-old woman, with a first-degree family history of gastric cancer (GC), a personal history of endometrial intraepithelial neoplasia, and a recent diagnosis of GC, associated with a previously undiagnosed autoimmune gastritis (AIG), was referred to our Clinic. AIG diagnosis was made according the internationally-recognised Sydney-Houston criteria (i.e., atrophy of the corpus/fundus mucosa which spares the antrum in the absence of active Helicobacter pylori infection). Parietal cell antibodies were positive. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 22, 2024 Category: Gastroenterology Authors: Alessandro Vanoli, Marco Vincenzo Lenti, Fabio Sirchia, Antonio Di Sabatino Tags: Image of the Month Source Type: research
An artificial intelligence system for chronic atrophic gastritis diagnosis and risk stratification under white light endoscopy
The diagnosis and stratification of gastric atrophy (GA) predict patients ’ gastric cancer progression risk and determine endoscopy surveillance interval. We aimed to construct an artificial intelligence (AI) system for GA endoscopic identification and risk stratification based on the Kimura-Takemoto classification. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 20, 2024 Category: Gastroenterology Authors: Xiao Tao, Yijie Zhu, Zehua Dong, Li Huang, Renduo Shang, Hongliu Du, Junxiao Wang, Xiaoquan Zeng, Wen Wang, Jiamin Wang, Yanxia Li, Yunchao Deng, Lianlian Wu, Honggang Yu Tags: Alimentary Tract Source Type: research
Triplet chemotherapy plus cetuximab as first-line treatment in extended RAS wild-type metastatic colorectal cancer patients
Triplet chemotherapy plus cetuximab showed promising results in phase II trials in unsystematically selected RAS population. We evaluated FOLFIRINOX+cetuximab efficacy as first-line treatment in extended RAS wild-type metastatic colorectal cancer (mCRC) patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 16, 2024 Category: Gastroenterology Authors: Emmanuelle Samalin, Thibault Mazard, Eric Assenat, Magali Rouyer, Christelle de la Fouchardi ère, Rosine Guimbaud, Denis Smith, Fabienne Portales, Marc Ychou, Antoine Adenis, Catherine Fiess, Evelyne Lopez-Crapez, Simon Thezenas Tags: Oncology Source Type: research
Prevalence and features of chronic nonbacterial osteomyelitis in a cohort of children with inflammatory bowel diseases
The incidence and prevalence of inflammatory bowel diseases (IBD) are increasing worldwide in childhood and adolescence, even in countries where such conditions were previously infrequent [1,2]. As systemic disease, it is well known that IBD may involve several extraintestinal organs and systems [3], and almost half of the patients will eventually develop an extraintestinal manifestation (EIM) during lifetime [4], with non-negligible impact on the quality of life. Such consideration gains even more relevance when dealing with children and adolescents, because of their expected long lives ahead. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 16, 2024 Category: Gastroenterology Authors: Luca Scarallo, Daniela Knafelz, Serena Arrigo, Enrico Felici, Paolo Lionetti, Edoardo Marrani, Gabriele Simonini, Patrizia Alvisi, Matteo Bramuzzo, Claudio Romano, SIGENP IBD Working Group Tags: Correspondence Source Type: research
