HOTAIR: A potential therapeutic target in the treatment of hepatocellular carcinoma?
In this study, the authors revealed that HOTAIR was overexpressed in hepatocellular carcinoma (HCC) tumor tissues than the non-tumor tissues. They further showed that high HOTAIR expression exhibited close correlation with HCC progression and high expression of HOTAIR was associated with a poorer prognosis of HCC. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 6, 2023 Category: Gastroenterology Authors: Li-Jun Zhou, Jun-Ying Tan, Fu-Qian Zhang Tags: Correspondence Source Type: research
Association of changes in body mass index and waist circumference with cardiovascular risk in non-alcoholic fatty liver disease: A nationwide study
We investigated whether changes in body mass index (BMI) and waist circumference (WC) are associated with cardiovascular risk in patients with NAFLD using a nationwide dataset. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 5, 2023 Category: Gastroenterology Authors: Se Young Jang, Hwa Jung Kim, Jun Young Chang Source Type: research
Clinical efficacy and nocebo effect following non-medical biosimilar switch in patients with inflammatory bowel disease: A prospective observational study
We aimed to evaluate clinical efficacy, biomarker activity, therapeutic drug monitoring (TDM), adverse events (AEs), and nocebo effect in inflammatory bowel disease (IBD) patients who underwent non-medical biosimilar switching. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 5, 2023 Category: Gastroenterology Authors: Panu Wetwittayakhlang, Khaled Karkout, Arti Wongcha-um, Paraskevi Tselekouni, Reem Al-Jabri, Waqqas Afif, Gary Wild, Alain Bitton, Talat Bessissow, Peter L. Lakatos Tags: Alimentary Tract Source Type: research
Stopping nucleos(t)ide analogues treatment in non-cirrhotic HBeAg-negative patients: Yes, we can!
Third generation nucleos(t)ide analogues (NA): Entecavir (ETV), Tenofovir Disoproxil (TDF) and Tenofovir Alafenamide (TAF) efficiently block viral replication and, on long-term, may halt the progression of liver disease reducing the occurrence of hepatocellular carcinoma and hepatic decompensation, prolonging patient's survival. While NA therapy can be stopped in HBeAg-positive patients with HBeAg seroconversion and>1 year consolidation therapy, long-term NA treatment has been recommended for HBeAg-negative chronic hepatitis B (CHB) patients until HBsAg clearance [1,2]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 5, 2023 Category: Gastroenterology Authors: Alessandro Loglio, Mauro Vigan ò Tags: Commentary Source Type: research
Where does capsule endoscopy fit in the diagnostic algorithm of small bowel intussusception?
The investigation of small bowel (SB) intussusception is variable, reflecting the lack of existing standards. The aim of this study was to understand the role of small bowel capsule endoscopy (SBCE) to investigate this pathology. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 1, 2023 Category: Gastroenterology Authors: Stefania Chetcuti Zammit, Aman Yadav, Deirdre McNamara, Alejandro Bojorquez, Cristina Carretero-Rib ón, Martin Keuchel, Peter Baltes, Reuma Margalit-Yehuda, Uri Kopylov, Reena Sidhu, Clelia Marmo, Maria Elena Riccioni, Xavier Dray, Romain Leenhardt, Eman Tags: Digestive Endoscopy Source Type: research
