Switching from VEDOlizumab intravenous to subcutaneous formulation in ulcerative colitis patients in clinical remission: The SVEDO Study, an IG-IBD study
The administration of biological drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 19, 2023 Category: Gastroenterology Authors: Davide Giuseppe Ribaldone, Laura Parisio, Angela Variola, Fabrizio Bossa, Fabiana Castiglione, Manuela Marzo, Nicole Piazza, Annalisa Aratari, Edoardo Vincenzo Savarino, Giorgia Bodini, Mauro Mastronardi, Federica Micheli, Silvia Mazzuoli, Marta Ascolani, Tags: Alimentary Tract Source Type: research

The hidden dangers of chronic pancreatitis in pregnancy: Evidence from a large-scale population study
Chronic pancreatitis is a debilitating condition that can affect women of childbearing age, and its impact on maternal and perinatal outcomes is poorly understood. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 18, 2023 Category: Gastroenterology Authors: Chengu Niu, Jing Zhang, Kaiwen Zhu, Hongli Liu, Patrick I Okolo Tags: Liver, Pancreas and Biliary Tract Source Type: research

Exploring the optimal therapeutic management of stage ypIA pancreatic ductal adenocarcinoma patients in the era of primary chemotherapy
Data on the proper post-surgical chemotherapy (PSC) in pancreatic ductal adenocarcinoma (PDAC) patients already treated with neoadjuvant therapy (NAT) are lacking, especially for stage ypIA. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 15, 2023 Category: Gastroenterology Authors: Marina Macchini, Giulio Belfiori, Stefano Crippa, Giulia Orsi, Giulia Gasparini, Domenico Tamburrino, Stefano Partelli, Marco Schiavo Lena, Diego Palumbo, Francesco De Cobelli, Massimo Falconi, Michele Reni Tags: Oncology Source Type: research

Long-term Outcome of Autoimmune Hepatitis: Consecutive Patient Cohort and Data on the Second Twenty Years
Mortality rates for autoimmune hepatitis (AIH) vary. Data are lacking beyond 20 years follow-up. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Laura Harrison, Barbara Hoeroldt, Harpreet Dhaliwal, Elaine Wadland, Asha Dube, Dermot Gleeson Tags: Liver, Pancreas and Biliary Tract Source Type: research

Histological healing as a predictor of sustained clinical remission in paediatric ulcerative colitis
The study aimed to assess the longitudinal impact of endoscopic healing (EH) and histological healing (HH) in a cohort of paediatric patients affected by ulcerative colitis (UC). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Luca Scarallo, Lorenzo Fioretti, Monica Paci, Sara Naldini, Sara Renzo, Jacopo Barp, Anna Gissi, Monica Di Paola, Vincenzo Villanacci, Paolo Lionetti Tags: Alimentary Tract Source Type: research

Identification of gastric signet ring cell carcinoma based on endoscopic images using few-shot learning
Deep learning (DL) models perform poorly when there are limited gastric signet ring cell carcinoma (SRCC) samples. Few-shot learning (FSL) can address the small sample problem. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Minyue Yin, Rufa Zhang, Jiaxi Lin, Shiqi Zhu, Lu Liu, Xiaolin Liu, Jianying Lu, Chunfang Xu, Jinzhou Zhu Tags: Digestive Endoscopy Source Type: research

Cap Polyposis
An 18-year-old man presented with sensation of anal mass and repeated episodes of rectal bleeding for 6 months, which he initially attributed to hemorrhoids. The patient had no history of chronic constipation or other medical history. Physical examination was unremarkable, apart from a palpable mass on digital rectal examination. All laboratory investigations were negative including H. pylori. On colonoscopy, multiple rough and uneven protuberances, with an erythematous surface and a yellow-white coating, can be observed from the upper edge of the anal canal up to 8  cm above it (Fig. 1). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Xu Wang, Yi Ding, Hua Li, Wei-Feng Huang Tags: Image of the Month Source Type: research

Tracking incidentally discovered pancreatic cysts smaller than 30  mm: Natural course and predictors of malignancy
The aim of this study was to assess the natural course and  predictors of malignancy in incidentally detected small pancreatic cysts (PCs). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 14, 2023 Category: Gastroenterology Authors: Hyo Suk Kim, Young Hoon Choi, Ik Hyun Jo, Chang Nyol Paik, In Seok Lee, Jae Hyuck Chang Tags: Liver, Pancreas and Biliary Tract Source Type: research

Reply to comment on: "Association between use of low-dose aspirin and detection of colorectal polyps and cancer in a screening setting"
We thank Professor Shih-Wei Lai for his interest in our manuscript. As stated by Professor Lai, our study was a cross-sectional study, where we evaluated the association between use of aspirin and detection of colorectal cancer and its precursor lesions in individuals who attended the screening [1,2]. We agree that, given the design of the study, no causal relationship between exposure and outcome could be determined. In fact, our conclusions do not imply causality and only point out the association between the exposure and the outcome. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 11, 2023 Category: Gastroenterology Authors: Sara Nafisi, Edoardo Botteri Tags: Correspondence Source Type: research

OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession
Gastric cancer (GC) is one of the most common malignancies worldwide. Ovarian tumor protein superfamily serves a crucial role in tumor growth progression, among them, ovarian tumor domain-containing 7B (OTUD7B) as a deubiquitinase (DUB) is frequently found in various cancers, but the role of OTUD7B in GC is poorly understood. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 8, 2023 Category: Gastroenterology Authors: Zijun Guo, Lin Guo Tags: Oncology Source Type: research

Author's reply: “Mean platelet volume may not be an indicator for prognosis in patients with alcohol use disorder”
We thank Profs. C. Beyan and E. Beyan for their interest [1] in our recently published article, entitled “Mean platelet volume and mortality in patients with alcohol use disorder” [2]. Research in analyzing the clinical meaning of altered platelet volume (MPV) has increased recently, in parallel with the relentless increasing research about platelets’ physiology, especially in relation with infla mmation and/or acute organic stress [3]. In this sense, many authors have found that altered platelet size may be related to inflammation, severity and/or adverse outcome in several clinical conditions, as compiled by Kornil...
Source: Digestive and Liver Disease - July 8, 2023 Category: Gastroenterology Authors: C. Mart ín-González, I. Ribot-Hernández, E. González-Reimers Tags: Correspondence Source Type: research

Mismatch repair deficiency, a future biomarker to guide adjuvant chemotherapy in localized small bowel adenocarcinoma?
We thank Vanoli et  al. for the study “Mismatch repair deficiency as prognostic factor for stage III small bowel adenocarcinoma: a multicentric international study” [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 7, 2023 Category: Gastroenterology Authors: Anthony Turpin Tags: Commentary Source Type: research

Comment on “Effect of vessels that encapsulate tumor clusters (VETC) and different stages of hepatocellular carcinoma after hepatectomy”
Wang et  al. [1] recently conducted a study investigating the impact of vessels that encapsulate tumor clusters (VETC) on the prognosis of hepatocellular carcinoma (HCC) patients at different stages following hepatectomy. Their research provides valuable insights into the prognostic implications of VETC in HCC and enhances our understanding of disease management. The authors comprehensively analyzed the association between VETC and various clinicopathological factors, disease recurrence, and overall survival rates in a cohort of HCC patients who underwent hepatectomy. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 6, 2023 Category: Gastroenterology Authors: Gang Zhao, Xiaobao Shi, Lingyun Zhang, Hongyuan Liang Tags: Correspondence Source Type: research

Efficacy and safety of proactive drug monitoring in inflammatory bowel disease treated with anti-TNF agents: A systematic review and meta-analysis
A systematic review and a meta-analysis of the literature was conducted to assess efficacy and safety of proactive therapeutic drug monitoring (TDM) versus conventional management during maintenance treatment with anti-tumour necrosis factor (anti-TNF α) in patients with inflammatory bowel disease (IBD). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 6, 2023 Category: Gastroenterology Authors: Noem í Manceñido Marcos, Blanca Novella Arribas, Gustavo Mora Navarro, Francisco Rodríguez Salvanés, Pilar Loeches Belinchón, Javier P. Gisbert Tags: Meta-Analysis Source Type: research

Addition of trastuzumab to perioperative chemotherapy in HER2-positive gastroesophageal adenocarcinoma patients: A multicenter retrospective observational AGEO study
Approximately 10 –20% of patients with gastroesophageal adenocarcinoma (GE-ADK) have HER2-positive tumors. The addition of trastuzumab to chemotherapy improves OS in patients with advanced disease. We investigated the effect of perioperative trastuzumab on survival outcomes. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - July 6, 2023 Category: Gastroenterology Authors: Anne-Esther Frydman, Antoine Drouillard, Emilie Soularue, Olivier Dubreuil, Aziz Zaanan, Anthony Turpin, David Tougeron, Sol ène Doat, Jean-Baptiste Bachet Tags: Oncology Source Type: research