Author's Reply: “Bacterial infections predispose to the development of portal vein thrombosis in patients with decompensated cirrhosis”
We read with great interest the letter, by Zanetto and colleagues [1], which has validated and expanded upon our recent results [2] concerning the association between bacterial infections and portal vein thrombosis (PVT) development in cirrhotic patients. They enrolled 128 patients, followed-up for up to one year. As reported, 14% developed PVT, and, as in our study, bacterial infections were more common in patients who developed PVT (56% vs 24%, p = 0.005), and were an independent risk factor for PVT occurrence in two models of multivariate analysis (Model 1: HR 2.99, p = 0.02; Model 2: HR 3.60, p = 0.007). (Source...
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Andrea Dalbeni, Filippo Cattazzo, Leonardo De Marco, Michele Bevilacqua, Mirko Zoncap è, Rosa Lombardi, Roberta Stupia, Anna Mantovani, David Sacerdoti Tags: Correspondence Source Type: research
A new histopathological phenomenon: Pancreatic islet cell loss in the elderly population
We observed the phenomenon of pancreatic islet cell loss (ICL) in our previous histopathological study. Multiple studies have reported that a decrease in β-cells is correlated with diabetes or chronic pancreatitis. Few studies have reported ICL in a healthy population. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Rujia Li, Ting Yang, Mingshou Zhang, Ke Ren, Jun Li, Iwao Sato, Shuang-Qin Yi Tags: Liver, Pancreas and Biliary Tract Source Type: research
A specific phenotype of pouchitis was associated with worst prognosis in patients with ulcerative colitis according to Chicago classification
The impact of different pouch phenotypes on long-term functional outcomes and quality of life (QoL) remains unclear. Our aim is to investigate the association between endoscopic pouchitis phenotypes and patients' long-term prognosis by assessing pouch function and QoL. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Zhongyuan Wang, Jiansheng Wang, Zirui Yang, Song Li, Chao Ding, Jianfeng Gong Tags: Alimentary Tract Source Type: research
Extremely rare presentation of primary jejunal monophasic synovial sarcoma
A 70-year-old female was admitted with lower abdominal pain lasting one month. The CA-125 was 356 U/mL (reference: (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 6, 2023 Category: Gastroenterology Authors: Kai-Fei Zhao, Chao-Bang Xie, Zi-Jian Tang, Qiong Huang Tags: Image of the Month Source Type: research
Inflammatory mesenteric fat detected by Intestinal ultrasound is correlated with poor long-term clinical outcomes in patients with Crohn's disease
Data on the correlation between inflammatory mesenteric fat (i-fat), detected by intestinal ultrasound (IUS), and the prognosis of Crohn's disease (CD) remains limited. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 6, 2023 Category: Gastroenterology Authors: Wenjie Cheng, Zicheng Huang, Si Qin, Zhuohua Liang, Xiang Gao, GuangJian Liu, Qin Guo Tags: Alimentary Tract Source Type: research
Can artificial intelligence replace endoscopists when assessing mucosal healing in ulcerative colitis? A systematic review and diagnostic test accuracy meta-analysis
Mucosal healing (MH) in inflammatory bowel diseases (IBD) is an important landmark for clinical decision making. Artificial intelligence systems (AI) that automatically deliver the grade of endoscopic inflammation may solve moderate interobserver agreement and the need of central reading in clinical trials. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 5, 2023 Category: Gastroenterology Authors: Alessandro Rimondi, Klaus Gottlieb, Edward J. Despott, Marietta Iacucci, Alberto Murino, Gian Eugenio Tontini Tags: Meta-Analysis Source Type: research
Multidisciplinary treatment of hepatocellular carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part II – Non-surgical treatments
Worldwide, hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. The remarkable improvements in treating HCC achieved in the last years have increased the complexity of its management. Following the need to have updated guidelines on the multidisciplinary treatment management of HCC, the Italian Scientific Societies involved in the management of this cancer have promoted the drafting of a new dedicated document. This document was drawn up according to the GRADE methodology needed to produce guidelines based on evidence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 4, 2023 Category: Gastroenterology Authors: Giuseppe Cabibbo, Bruno Daniele, Mauro Borzio, Andrea Casadei-Gardini, Umberto Cillo, Agostino Colli, Massimiliano Conforti, Vincenzo Dadduzio, Francesco Dionisi, Fabio Farinati, Ivan Gardini, Edoardo Giovanni Giannini, Rita Golfieri, Maria Guido, Andrea Tags: Guidelines Source Type: research
Intractable diarrhea in infancy and molecular analysis: We are beyond the tip of the iceberg
Intractable diarrhea (ID) could be defined as a syndrome of severe chronic diarrhea associated with malnutrition not easily resolved by conventional management. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 2, 2023 Category: Gastroenterology Authors: A. Diamanti, C.M. Trovato, P. Gandullia, A. Lezo, M.I. Spagnuolo, G. Bolasco, T. Capriati, L. Lacitignola, L. Norsa, P. Francalanci, A. Novelli, on behalf of Nutrition Sigenp group Tags: Alimentary Tract Source Type: research
Short and long-term outcomes of surgery for inflammatory (uncomplicated) ileocecal Crohn's disease: Multicentric retrospective analysis of 211 patients
Surgical management for patients with inflammatory ileocecal Crohn's disease (CD) could be a reasonable alternative to second-line medical treatment. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 2, 2023 Category: Gastroenterology Authors: Nicolas Avellaneda, Annalisa Maroli, Anders Tottrup, Christianne Buskens, Paulo Gustavo Kotze, Gianluca Pellino, Anders Dige, Anne-Mette Haase, Anouck Haanappel, Lorenzo Giorgi, Michelle Carvello, Beatriz Yuki Maruyama, Peter Christensen, Antonino Spinell Tags: Alimentary Tract Source Type: research
Author's Reply: “A retrospective analysis of treatment patterns, drug discontinuation and healthcare costs in Crohn's disease patients treated with biologics”
We thank and appreciate Dr. Masood and Dr. Khalid's interest in our work and the relevance they gave to our study [1,2]. Most of the comments regard the fact that our analysis was not addressing and considering clinical outcomes and complications which are extremely important for the management of Irritable Bowel Disease (IBD) patients. The answer lies in the definition of the current analysis. The design was that of an observational retrospective analysis based on data derived from Italian administrative databases, extracted from a subsample of Italian Local Health Units (LHUs). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 2, 2023 Category: Gastroenterology Authors: Luca Degli Esposti Tags: Correspondence Source Type: research
Liver metastasis of small cell neuroendocrine prostate carcinoma
A 67-year-old man, with a past medical history of prostate adenocarcinoma 3 years ago, was admitted for abdominal distention. Endocrine therapy was initiated since then. Seven months ago, abdominal MRI revealed hepatic mass (Fig. 1a). Next, percutane-ous liver biopsy was performed. Histopathological analysis showed small-cell neuroendocrine prostate carcinoma (SCNPC). Immunohistochemical analysis showed CD56 (+++), CgA (++), Syn (+++) (Fig. 1b and Fig. 2). After discussion, serplulimab 300 mg plus etoposide 150 mg plus carboplatin 500 mg every 3 weeks was initiated. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 2, 2023 Category: Gastroenterology Authors: Yong Xie, Tianshi Lyu, Jian Wang, Yinghua Zou Tags: Image of the Month Source Type: research
Exploring the link: Porto-sinusoidal vascular disorder and inflammatory bowel disease – A comprehensive narrative review
Porto-sinusoidal vascular disorder (PSVD) encompasses a group of vascular disorders characterized by lesions involving the portal venules and sinusoids, independent of the presence of portal hypertension (PH), and for which liver biopsy is essential for diagnosis. PSVD has been shown to be common in patients with immune-mediated diseases, including inflammatory bowel disease (IBD). The association between PSVD and the use of thiopurines and thioguanine in patients with IBD has been well established. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 2, 2023 Category: Gastroenterology Authors: Nicola Pugliese, Lucia Giuli, Elisabetta Mastrorocco, Francesco Santopaolo, Giacomo Marcozzi, Cristina Bezzio, Arianna Dal Buono, Roberto Gabbiadini, Antonio Gasbarrini, Francesca Romana Ponziani, Alessandro Armuzzi, Alessio Aghemo Tags: Review Article Source Type: research
Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 1, 2023 Category: Gastroenterology Source Type: research
Abdominal ultrasound in the characterization of branch-duct intraductal papillary mucinous neoplasms: A new tool for surveillance of low-risk patients?
Magnetic resonance imaging (MRI) is regarded as gold-standard for intraductal papillary mucinous neoplasms (IPMNs) follow-up. Given the low risk of transformation and the increasing population under surveillance, there is growing interest in identifying optimal follow-up strategies. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 1, 2023 Category: Gastroenterology Authors: Marco Ferronato, Chiara Elide Lizzio, Dante Berardinelli, Desy Marini, Eleonora Elia, Lorenzo Andreetto, Alice Trentini, Maria Chiara Potenza, Carla Serra, Elena Mazzotta, Claudio Ricci, Riccardo Casadei, Marina Migliori Tags: Oncology Source Type: research
Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part I – Surgical treatments
Worldwide, hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. The remarkable improvements in treating HCC achieved in the last years have increased the complexity of HCC management. Following the need to have updated guidelines on the multidisciplinary treatment management of HCC, the Italian Scientific Societies involved in the management of this cancer have promoted the drafting of a new dedicated document. This document was drawn up according to the GRADE methodology needed to produce guidelines based on evidence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 28, 2023 Category: Gastroenterology Authors: Giuseppe Cabibbo, Bruno Daniele, Mauro Borzio, Andrea Casadei-Gardini, Umberto Cillo, Agostino Colli, Massimiliano Conforti, Vincenzo Dadduzio, Francesco Dionisi, Fabio Farinati, Ivan Gardini, Edoardo Giovanni Giannini, Rita Golfieri, Maria Guido, Andrea Tags: Guidelines Source Type: research
