Higher scores in the Clinical Frailty Scale are associated with covert and overt hepatic encephalopathy in patients with cirrhosis
Frailty increases the vulnerability to internal and external stressors and may therefore be an indicator of a higher frequency of cirrhosis complications. We aimed to investigate the association of the Clinical Frailty Scale (CFS) with covert (CHE) and overt HE (OHE) development in patients with cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 16, 2023 Category: Gastroenterology Authors: Eva Maria Schleicher, Leonard Kaps, J örn M. Schattenberg, Peter Robert Galle, Marcus-Alexander Wörns, Simon Johannes Gairing, Christian Labenz Tags: Liver, Pancreas and Biliary Tract Source Type: research
Relationship between educational attainment and non-alcoholic fatty liver disease: A two-sample Mendelian randomization study
Observational studies have identified an inverse association between education and non-alcoholic fatty liver disease (NAFLD). However, it is not possible to establish causality for this relationship. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 15, 2023 Category: Gastroenterology Authors: Zhewen Ren, Anke Wesselius, Coen D.A. Stehouwer, Martijn C.G.J. Brouwers Tags: Liver, Pancreas and Biliary Tract Source Type: research
Apelin and the gut microbiome: Potential interaction in human MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with increasing numbers worldwide. Adipokines like apelin (APLN) can act as key players in the complex pathophysiology of MASLD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 11, 2023 Category: Gastroenterology Authors: Maria Effenberger, Christoph Grander, Bela Hausmann, Barbara Enrich, Petra Pjevac, Heinz Zoller, Herbert Tilg Tags: Alimentary Tract Source Type: research
Colorectal cancer recurrence and its impact on survival after curative surgery: An analysis based on multistate models
To investigate the usefulness of multistate models (MSM) for determining colorectal cancer (CRC) recurrence rate, to analyse the effect of different factors on tumour recurrence and death, and to assess the impact of recurrence for CRC prognosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 11, 2023 Category: Gastroenterology Authors: Vanesa Balboa-Barreiro, Sonia P értega-Díaz, Teresa García-Rodríguez, Cristina González-Martín, Remedios Pardeiro-Pértega, Loreto Yáñez-González-Dopeso, Teresa Seoane-Pillado Tags: Oncology Source Type: research
Transition care in patients with IBD: The pediatric and the adult gastroenterologist's perspective. Results from a national survey
Transition is a crucial process in the care of IBD patients, although it remains largely heterogeneous. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 9, 2023 Category: Gastroenterology Authors: Fabiana Castiglione, Luca Scarallo, Olga Maria Nardone, Marina Aloi, Patrizia Alvisi, Alessandro Armuzzi, Serena Arrigo, Giorgia Bodini, Emma Calabrese, Linda Ceccarelli, Walter Fries, Antonio Marseglia, Massimo Martinelli, Monica Milla, Ambrogio Orlando, Tags: Alimentary Tract Source Type: research
Which is more appropriate for the evaluation of HCC, RECIST or mRECIST criteria?
We have read with great interest the recent article conducted by Dr Haghnejad and colleagues [1], published in Digestive and Liver Disease. This retrospective multicentre study enrolled all consecutive hepatocellular carcinoma (HCC) patients treated with atezolizumab plus bevacizumab after failing one or more multikinase inhibitors (MKIs) treatments (such as sorafenib). Finally, they included 50 patients in this analysis. With a median follow-up of 18.21 months, they found the objective response rate was 14 %, and the disease control rate was 56 %. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Yong Xie, Tianshi Lyu, Jian Wang, Yinghua Zou Tags: Correspondence Source Type: research
Immunoglobulin A vasculitis involving the duodenum and jejunum
A 66-year-old woman with a history of hypertension and coronary atherosclerotic heart disease presented with acute onset of paroxysmal epigastric pain for 3 days. She was taking oral aspirin and felodipine. She denied a history of vomiting and diarrhea. Physical examination showed tenderness in the upper abdomen. Laboratory findings revealed mild leucocytosis. Fecal occult blood test was positive. Urine microscopy was normal. Chest computed tomography (CT) and electrocardiography showed no significant abnormalities. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Dong-Ge Han, Xu Liu, Wei Liu Tags: Image of the Month Source Type: research
Risk factors for unsuccessful colorectal endoscopic submucosal dissection: A systematic review and meta-analysis
Despite its growing popularity, endoscopic submucosal dissection (ESD) for colorectal neoplasms is still technically challenging. The factors contributing to the failure of ESD are not yet comprehensively elucidated. Therefore, this systematic review was conducted to explore the potential risk factors associated with unsuccessful colorectal ESD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Feng Gu, Wei Jiang, Jingyi Zhu, Lei Ma, Boyuan He, Huihong Zhai Tags: Meta-Analysis Source Type: research
Multiple colorectal adenomas syndrome: The role of MUTYH mutation and the polyps ’ number in clinical management and colorectal cancer risk
Multiple colorectal adenomas (MCRAs) can result from APC (AFAP) or biallelic MUTYH (MAP) mutations, but most patients are wild type and referred to as non-APC/MUTYH polyposis (NAMP). We aim to examine the risk of colorectal cancer (CRC) and the role of endoscopy in managing patients with MCRAs, with a specific focus on clinical features and genotype. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Silvia Negro, Quoc Riccardo Bao, Marco Scarpa, Federico Scognamiglio, Salvatore Pucciarelli, Andrea Remo, Marco Agostini, Edoardo D'Angelo, Isabella Mammi, Francesca Schiavi, Silvia Rossi, Fabiana Zingone, Francesco Ferrara, Alberto Fantin, Chiara Cristof Tags: Oncology Source Type: research
Advancement of artificial intelligence systems for surveillance endoscopy of Barrett's esophagus
Barrett's esophagus (BE) is a precursor disease for esophageal adenocarcinoma. Timely detection and treatment has significant influence on patient outcomes. Over the last years, several artificial intelligence (AI) systems have emerged to assist the endoscopist. The primary focus of research has been computer aided detection (CADe). Several groups have succeeded in developing competitive models for neoplasia detection. Additionally, computer aided diagnosis (CADx) models have been developed for subsequent lesion characterization and assistance in clinical decision making. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: M.R. Jong, A.J. de Groof Tags: Special Article Source Type: research
Immunomodulator combination versus mono therapy: Does combination therapy have an impact on infliximab therapy?
We read with interest the original article by Poula Sousa et al. [1]. Sousa and colleagues aimed at clarifying the benefits of combination treatment on the maintenance phase of infliximab in CD patients, in comparison with infliximab monotherapy. They brought up very important questions regarding the role of thiopurines in the therapeutic algorithm. In this analysis of the 2-year prospective DIRECT study, the authors investigated the correlation between faecal calprotectin (FC), C-reactive protein (CRP), serum drug levels, and the development of anti-TNF antibodies in adult IBD patients receiving anti-TNF-α treatment. (...
Source: Digestive and Liver Disease - December 8, 2023 Category: Gastroenterology Authors: Ilhami Yuksel, Yavuz Cagir, Ali Atay Tags: Correspondence Source Type: research
Histological healing induced by tofacitinib in ulcerative colitis: A multicentre study
While the efficacy of tofacitinib to induce and maintain clinical and endoscopic remission is well established in ulcerative colitis (UC), little is known about its efficacy to induce histological remission. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Sophie Vieujean, David Laharie, Anthony Buisson, Xavier Roblin, Mathurin Fumery, Stephane Nancey, Pauline Wils, Romain Altwegg, Laurence Seidel, B énédicte Caron, Laurent Peyrin-Biroulet Tags: Alimentary Tract Source Type: research
Author's Reply: “Bacterial infections predispose to the development of portal vein thrombosis in patients with decompensated cirrhosis”
We read with great interest the letter, by Zanetto and colleagues [1], which has validated and expanded upon our recent results [2] concerning the association between bacterial infections and portal vein thrombosis (PVT) development in cirrhotic patients. They enrolled 128 patients, followed-up for up to one year. As reported, 14% developed PVT, and, as in our study, bacterial infections were more common in patients who developed PVT (56% vs 24%, p = 0.005), and were an independent risk factor for PVT occurrence in two models of multivariate analysis (Model 1: HR 2.99, p = 0.02; Model 2: HR 3.60, p = 0.007). (Source...
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Andrea Dalbeni, Filippo Cattazzo, Leonardo De Marco, Michele Bevilacqua, Mirko Zoncap è, Rosa Lombardi, Roberta Stupia, Anna Mantovani, David Sacerdoti Tags: Correspondence Source Type: research
A new histopathological phenomenon: Pancreatic islet cell loss in the elderly population
We observed the phenomenon of pancreatic islet cell loss (ICL) in our previous histopathological study. Multiple studies have reported that a decrease in β-cells is correlated with diabetes or chronic pancreatitis. Few studies have reported ICL in a healthy population. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Rujia Li, Ting Yang, Mingshou Zhang, Ke Ren, Jun Li, Iwao Sato, Shuang-Qin Yi Tags: Liver, Pancreas and Biliary Tract Source Type: research
A specific phenotype of pouchitis was associated with worst prognosis in patients with ulcerative colitis according to Chicago classification
The impact of different pouch phenotypes on long-term functional outcomes and quality of life (QoL) remains unclear. Our aim is to investigate the association between endoscopic pouchitis phenotypes and patients' long-term prognosis by assessing pouch function and QoL. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2023 Category: Gastroenterology Authors: Zhongyuan Wang, Jiansheng Wang, Zirui Yang, Song Li, Chao Ding, Jianfeng Gong Tags: Alimentary Tract Source Type: research
