An Ulcerated Reddish Nodule of the Chest: When You See, Think …
A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. A further histopathologic examination showed the presence of ...
Source: Dermatopathology - September 19, 2018 Category: Pathology Source Type: research
Hyaline Cell-Rich Apocrine Mixed Tumor with Cytologic Atypia
Hyaline cell-rich apocrine mixed tumor is relatively rare, and it often possesses atypical cells. Despite the presence of atypical cells, other histopathological features such as well circumscription, smooth border, predominance of bland cells, and no mitotic figures lead to classify these tumors as benign. In addition, no recurrence or metastasis has been reported even when cytologic atypia is identified. Here we report a case of hyaline cell-rich apocrine mixed tumor with cytologic atypia, which did not recur for 14 months after excision.Dermatopathology 2018;5:108 –112 (Source: Dermatopathology)
Source: Dermatopathology - September 17, 2018 Category: Pathology Source Type: research
Melanocytic Lesions of the Nail Unit
This article will first describe the histology of the nail unit, followed by a brief summary of clinical and histopathological features as well as differential diagnosis of melanocytic lesions of the nail unit.Dermatopathology 2018;5:98 –107 (Source: Dermatopathology)
Source: Dermatopathology - July 24, 2018 Category: Pathology Source Type: research
Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Differentiation
Shadow cells are characterized by an eosinophilic cytoplasm and a ghost-like nuclear contour; the cell shape is preserved, in spite of nuclear disappearance. Shadow cell nests (SCNs) are frequently observed in pilomatricoma (PMX), where the transitional cells immediately adjacent to SCNs often have a crescent-shaped nucleus showing fragmentation similar to that of apoptotic bodies. They show nuclear accumulation of beta-catenin and DNA double strand breaks (as revealed by in situ 3 ′-tailing reaction or immunohistochemistry for single-stranded DNA [ssDNA]), while they are negative for cleaved caspase-3 or cleaved lamin A...
Source: Dermatopathology - July 19, 2018 Category: Pathology Source Type: research
Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know
Cutaneous cysts have been classified by dermatopathologists in many different ways. Here, we propose a novel classification of cutaneous adnexal cysts according to their origin in the folliculosebaceous unit and the sweat glands. By examining the lining of the cystic structure, its origin can be easily identified. Epidermal cysts have an epithelial wall containing a granular layer with lamellar keratinization, indicating an infundibular origin. Tricholemmal cysts have an undulating epithelial wall with no granular layer and a compact keratinization, showing an isthmic origin. In steatocystoma, dermoid cyst, and folliculose...
Source: Dermatopathology - June 7, 2018 Category: Pathology Source Type: research
Nail Unit Glomus Tumor with Myxoid and Symplastic Change Presenting with Longitudinal Erythronychia
Glomus tumors are soft tissue neoplasms, which are most frequently encountered in the nail unit and generally straightforward to diagnose by histopathology. The typical clinical presentation is that of a circular violaceous or erythematous lesion within the nail bed. However, there are rare variants of glomus tumors which may pose diagnostic challenges because of the presence of unusual histologic features. Herein we report such a glomus tumor that demonstrates the rare combination of both myxoid and symplastic change. The clinical presentation of longitudinal erythronychia, as seen with this case, can occur with glomus tu...
Source: Dermatopathology - June 1, 2018 Category: Pathology Source Type: research
An Unusual Case of Facial Steatocystoma Multiplex: A Clinicopathologic and Dermoscopic Report
Conclusion: Herein, we report a rare variant of steatocystoma multiplex limited to the face and scalp subjected to dermatoscopy and characteristic histological correlation. To the best of our knowledge and following a literature search, dermoscopic features of this condition have not been reported thus far.Dermatopathology 2018;5:58 –63 (Source: Dermatopathology)
Source: Dermatopathology - May 29, 2018 Category: Pathology Source Type: research
An Unusual Morphological Presentation of Cutaneous Squamous Cell Carcinoma Mimicking Microcystic Adnexal Carcinoma: A Diagnostic Pitfall
Cutaneous squamous cell carcinoma (SCC) exhibiting microcystic adnexal carcinoma-like differentiation is an extremely rare tumor that shows both squamous and ductal differentiation. This tumor is often misdiagnosed clinically and histologically and is confused with other malignant and benign cutaneous neoplasms. It usually occurs in middle-aged to older adults. Here, we report a case of SCC with microcystic adnexal carcinoma-like differentiation on the left chin of a 71-year-old male. The histopathological examination revealed a nodular tumor infiltrating the dermis, subcutaneous fat, and striated muscle tissue, consisting...
Source: Dermatopathology - May 29, 2018 Category: Pathology Source Type: research
Sign of Leser-Tr élat and Cutaneous T-Cell Lymphoma: A Rare Association
Sign of Leser-Tr élat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have be en considered controversial and some authors assert the absence of a causal link. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer. Here, we describe a new case associated with a cutaneous T-cell lymphoma and a partial response to extracorporeal photop heresis.Der...
Source: Dermatopathology - May 29, 2018 Category: Pathology Source Type: research
The “Dysplastic Nevus” Conundrum: A Look Back, a Peek Forward
Dermatopathology 2018;5:53 –57 (Source: Dermatopathology)
Source: Dermatopathology - April 20, 2018 Category: Pathology Source Type: research
A 30-Year-Old Man with HIV, Fever, and a Rash
Patients who present with papular rashes have a wide differential diagnosis particularly in the setting of immune compromise. A 30-year-old male diagnosed with HIV since 2009, never on antiretroviral therapy, with a nadir CD4 count of 333 cells/mm3 and a current viral load of 44,300 copies/mL, presented with a diffuse monomorphic papular eruption that began on his trunk and extremities and subsequently spread to the penis and scrotum, sparing the distal acral sites. A thorough infectious workup revealed a positive rapid plasma reagin (RPR) and varicella IgM and IgG antibodies. Interestingly, the patient had been diagnosed ...
Source: Dermatopathology - March 23, 2018 Category: Pathology Source Type: research
A 92-Year-Old Male with Eosinophilic Asthma Presenting with Recurrent Palpable Purpuric Plaques
We report a case of biopsy-confirmed Churg-Strauss syndrome in a 92-year-old male with a history of eosinophilic asthma and peripheral eosinophilia who was later diagnosed with Churg-Strauss syndrome.Dermatopathology 2018;5:44-48 (Source: Dermatopathology)
Source: Dermatopathology - March 15, 2018 Category: Pathology Source Type: research
Melanoma Diagnosis: The Importance of Histopathological Report
Dermatopathology 2018;5:41 –43 (Source: Dermatopathology)
Source: Dermatopathology - March 13, 2018 Category: Pathology Source Type: research
Gangrenous Chickenpox with Atypical Clinical and Histopathological Findings
Dermatopathology 2018;5:38 –40 (Source: Dermatopathology)
Source: Dermatopathology - February 21, 2018 Category: Pathology Source Type: research
Lymphocytic Lobular Panniculitis: A Diagnostic Challenge
Dermatopathology 2018;5:30 –33 (Source: Dermatopathology)
Source: Dermatopathology - February 15, 2018 Category: Pathology Source Type: research
