A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis
Syringolymphoid hyperplasia (SLH) is an extremely rare histopathological entity with fewer than 40 cases reported in the literature. SLH have been seen as both benign lesions and in association with T-cell lymphoproliferative lesions. A 20-year-old male presented with a solitary, infiltrated plaque on the left cheek initially diagnosed as a sebaceous carcinoma at an external institution. A repeat biopsy demonstrated prominent follicular mucinosis (FM), squamous metaplasia of the eccrine coils, and a moderately dense perieccrine lymphocytic infiltrate mimicking eccrine carcinoma. The lesion was subsequently diagnosed as SLH...
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Bednar Tumor: An Uncommon Entity
We report a rare case of Bednar tumor in a 40-year-old female patient. The diagnosis of Bednar tumor must be considered while reporting pigmented subcutaneous spindle cell lesions.Dermatopathology 2016;3:36-38 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review
Conclusion: Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.Dermatopathology 2016;3:39-43 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Lrig1 Expression in Human Sebaceous Gland Tumors
Conclusion:Lrig1 is a known tumor suppressor gene and is usually considered to be an indicator of poorly aggressive tumors. In human sebaceous tumors, the stronger Lrig1 staining in sebaceous carcinoma compared to other sebaceous tumors might be a feature of an advanced stage in tumorigenesis and a bad prognosis. In our study, 100% of sebaceous carcinomas revealed Lrig1 overexpression. We propose that Lrig1 may be used as a possible new marker of poorly differentiated sebaceous carcinoma.Dermatopathology 2016;3:44-54 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
A 65-Year-Old Female from Connecticut with Orf Infection
We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her sheep. The clinical and histopathologic features, important to arrive at the correct diagnosis of this uncommon yet important infection, are described. We also discuss the benign nature of this condition and emphasize that treatment is not required.Dermatopathology 2016;3:55-60 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema
Conclusion. These results show that the injection of hyaluronidase is capable of degrading exogenous HA in mouse skin and endogenous HA in human skin in vivo and may be a therapeutic option for skin diseases characterized by abnormal accumulation of HA.Dermatopathology 2016;3:61-67 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin
Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis.Dermatopathology 2016;3:68-78 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation
Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin.Dermatopathology 2016;3:79-82 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
A Case of Adrenergic Urticaria Associated with Vitiligo
Adrenergic urticaria is a rare form of urticaria, induced by a stress-induced concomitant release of epinephrine and norepinephrine. Here we describe the case of a 60-year-old female patient presenting with disseminated erythematous papules surrounded by a white halo and vitiligo lesions on the hands, arms, and feet. Histological examination of one of the erythematous papules showed a dermal inflammatory infiltrate composed of lymphocytes and eosinophils of perivascular and interstitial localization. After 2 weeks of treatment with antihistamines, the lesions disappeared completely.Dermatopathology 2016;3:83-86 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components
Hybrid benign peripheral nerve sheath tumors are rare tumors exhibiting areas of more than one neural neoplasm such as schwannoma/neurofibroma, neurofibroma/perineurioma, or schwannoma/perineurioma. These tumors usually arise in the skin of the extremities and trunk, and less commonly affect extracutaneous sites. Here we report two cases of these tumors exhibiting hybrid features of schwannoma/perineurioma and schwannoma/neurofibroma located in the scalp and the ankle, respectively.Dermatopathology 2017;4:1-6 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research
A Case of Adrenergic Urticaria Associated with Vitiligo
Adrenergic urticaria is a rare form of urticaria, induced by a stress-induced concomitant release of epinephrine and norepinephrine. Here we describe the case of a 60-year-old female patient presenting with disseminated erythematous papules surrounded by a white halo and vitiligo lesions on the hands, arms, and feet. Histological examination of one of the erythematous papules showed a dermal inflammatory infiltrate composed of lymphocytes and eosinophils of perivascular and interstitial localization. After 2 weeks of treatment with antihistamines, the lesions disappeared completely.Dermatopathology 2016;3:83-86 (Source: Dermatopathology)
Source: Dermatopathology - December 14, 2016 Category: Pathology Source Type: research
Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation
Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin.Dermatopathology 2016;3:79-82 (Source: Dermatopathology)
Source: Dermatopathology - November 11, 2016 Category: Pathology Source Type: research
T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin
Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis.Dermatopathology 2016;3:68-78 (Source: Dermatopathology)
Source: Dermatopathology - October 20, 2016 Category: Pathology Source Type: research
Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema
Conclusion. These results show that the injection of hyaluronidase is capable of degrading exogenous HA in mouse skin and endogenous HA in human skin in vivo and may be a therapeutic option for skin diseases characterized by abnormal accumulation of HA.Dermatopathology 2016;3:61-67 (Source: Dermatopathology)
Source: Dermatopathology - July 6, 2016 Category: Pathology Source Type: research
