A 65-Year-Old Female from Connecticut with Orf Infection
We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her sheep. The clinical and histopathologic features, important to arrive at the correct diagnosis of this uncommon yet important infection, are described. We also discuss the benign nature of this condition and emphasize that treatment is not required.Dermatopathology 2016;3:55-60 (Source: Dermatopathology)
Source: Dermatopathology - June 21, 2016 Category: Pathology Source Type: research
Lrig1 Expression in Human Sebaceous Gland Tumors
Conclusion: Lrig1 is a known tumor suppressor gene and is usually considered to be an indicator of poorly aggressive tumors. In human sebaceous tumors, the stronger Lrig1 staining in sebaceous carcinoma compared to other sebaceous tumors might be a feature of an advanced stage in tumorigenesis and a bad prognosis. In our study, 100% of sebaceous carcinomas revealed Lrig1 overexpression. We propose that Lrig1 may be used as a possible new marker of poorly differentiated sebaceous carcinoma.Dermatopathology 2016;3:44-54 (Source: Dermatopathology)
Source: Dermatopathology - May 31, 2016 Category: Pathology Source Type: research
Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review
Conclusion: Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.Dermatopathology 2016;3:39-43 (Source: Dermatopathology)
Source: Dermatopathology - April 29, 2016 Category: Pathology Source Type: research
Bednar Tumor: An Uncommon Entity
We report a rare case of Bednar tumor in a 40-year-old female patient. The diagnosis of Bednar tumor must be considered while reporting pigmented subcutaneous spindle cell lesions.Dermatopathology 2016;3:36-38 (Source: Dermatopathology)
Source: Dermatopathology - April 19, 2016 Category: Pathology Source Type: research
A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis
Syringolymphoid hyperplasia (SLH) is an extremely rare histopathological entity with fewer than 40 cases reported in the literature. SLH have been seen as both benign lesions and in association with T-cell lymphoproliferative lesions. A 20-year-old male presented with a solitary, infiltrated plaque on the left cheek initially diagnosed as a sebaceous carcinoma at an external institution. A repeat biopsy demonstrated prominent follicular mucinosis (FM), squamous metaplasia of the eccrine coils, and a moderately dense perieccrine lymphocytic infiltrate mimicking eccrine carcinoma. The lesion was subsequently diagnosed as SLH...
Source: Dermatopathology - April 14, 2016 Category: Pathology Source Type: research
Slowly Growing Nodule on the Trunk: Cutaneous Granular Cell Tumor
Granular cell tumor (GCT) is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. The tumor mostly presents with a symptomatic slowly growing solitary nodule and overlying normal skin; therefore, it is not always considered in the differential diagnosis. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a GCT at the histopathological examination. The neoplastic cells had centrally located nuclei and granular eosinophilic cytoplasm and stained positively for S100, neuron-spec...
Source: Dermatopathology - April 12, 2016 Category: Pathology Source Type: research
Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.Dermatopathology 2016;3:13-22 (Source: Dermatopathology)
Source: Dermatopathology - March 21, 2016 Category: Pathology Source Type: research
Pagetoid Reticulosis: Report of Two Cases and Review of the Literature
In this report, we present two cases of pagetoid reticulosis, compare its microscopic features to those of ‘classical' mycosis fungoides, and provide a brief review of the pertinent literature.Dermatopathology 2016;3:8-12 (Source: Dermatopathology)
Source: Dermatopathology - March 3, 2016 Category: Pathology Source Type: research
Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report
We present one case of OMM that was initially diagnosed as a racial pigmentation elsewhere 2 years earlier. Clinical examination showed multiple macules and nodules located on the hard and soft palate, gingiva and superior alveolar mucosa. These lesions were painless and presented a color variation going from dark blue to black. Histological analysis showed sheets and nests of atypical melanocytes displaying a range of shapes such as plasmacytoid, epithelioid, and round cells, located in the superficial corium extending to the deep tissues. A few tumor cells contained variable amounts of melanin. There was no invasion of b...
Source: Dermatopathology - February 25, 2016 Category: Pathology Source Type: research
Psammomatous Melanotic Schwannoma: A Challenging Histological Diagnosis
Psammomatous melanotic schwannoma (PMS) is a rare pigmented tumor that can be part of the Carney complex. Here, we describe the case of a 35-year-old female patient presenting an isolated subcutaneous PMS. Histopathological analysis could not formally exclude the malignant nature of the tumor. The challenging histological diagnosis and consequently the management of the patient are described.Dermatopathology 2015;2:67-70 (Source: Dermatopathology)
Source: Dermatopathology - December 14, 2015 Category: Pathology Source Type: research
The Dilemma of Coexisting Nevoid Hyperkeratosis of the Nipple and Areola in Mycosis Fungoides: A Report of Three Cases
In this report, we present 3 patients with hyperkeratotic lesions of the nipple and areola associated with MF but showing different histopathological features. We also review similar cases in the literature and discuss possibilities concerning this association. Two of our cases represent the association between MF and NHNA without histopathological features of MF on the nipple-areola complex. The other case represents hyperkeratosis of the nipple and areola with specific histological and immunohistochemical features of MF. Hence, we would like to hypothesize that MF may involve the nipple and areola and have an appearance ...
Source: Dermatopathology - November 17, 2015 Category: Pathology Source Type: research
Benign Fibrous Histiocytomas of the Oral Mucosa: Report on Three Cases and Review of the Literature
This article presents 3 additional cases of BFH of the oral mucosa, with a review of previously published cases. Although a malignant variant of BFH also exists, the present review focuses only on benign lesions. The clinical presentation, diagnosis, histopathological and immunohistochemical features of BFH are discussed. According to the present analysis, the majority of oral mucosal BFH have occurred in middle-aged and elderly patients, with a slight female predilection. Within the oral cavity, BHF may occur at any mucosal site, including the lips, tongue, buccal mucosa, mandibular and maxillary gingiva as well as the pa...
Source: Dermatopathology - April 28, 2015 Category: Pathology Source Type: research
Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update
Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general acceptance and routine application requires robust validation. Here, we summarize the most well-established and commonly used biomarkers along with an array of newer ones reported in the past several decades that either demonstrate or hold high clinical promise in the field of cutaneous pathology. We also highlight recent applications of novel IHC markers in melanoma diagnosis including genetic mutation statu...
Source: Dermatopathology - April 7, 2015 Category: Pathology Source Type: research
Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses
Conclusions: Nevus-associated melanoma was most commonly located on the extremities and the trunk, whereas de novo melanoma was most commonly located in the head and neck and the acral region. Furthermore, nevus-associated melanoma was similar to de novo melanoma in terms of prognosis and other disease characteristics.Dermatopathology 2015;2:46-51 (Source: Dermatopathology)
Source: Dermatopathology - April 1, 2015 Category: Pathology Source Type: research
Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses?
Conclusions: Nevus-associated melanoma was most commonly located on the extremities and the trunk, whereas de novo melanoma was most commonly located in the head and neck and the acral region. Furthermore, nevus-associated melanoma was similar to de novo melanoma in terms of prognosis and other disease characteristics.Dermatopathology 2015;2:46-51 (Source: Dermatopathology)
Source: Dermatopathology - March 31, 2015 Category: Pathology Source Type: research
