A 12-Month-Old Healthy Girl with a New Oral Ulcer and Chronic Diaper Rash
A 12-month-old healthy girl presented with a chronic diaper rash. Physical examination demonstrated crusting of the scalp, erythematous papules with surrounding petechiae on the lower abdomen, and an intraoral palatal ulcer. Further imaging demonstrated bone involvement. Histopathologic examination of involved skin and the intraoral ulcer demonstrated epithelioid histiocytes with “coffee bean-shaped” nuclei, staining positive for CD1a and langerin by immunohistochemistry, consistent with Langerhans cell histiocytosis (LCH). LCH is a disease entity of unknown etiology characterized by histiocytic proliferation t...
Source: Dermatopathology - November 15, 2017 Category: Pathology Source Type: research

A 71-Year-Old Female with Myocardial Infarction and Long-Standing Ulcers on the Thigh
Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis. We review the existing literature on the subject...
Source: Dermatopathology - November 15, 2017 Category: Pathology Source Type: research

A 65-Year-Old Male with Primary Central Nervous System Diffuse Large B-Cell Lymphoma on Nivolumab with Oral Mucositis and Targetoid Plaques
Conclusion: As PD-1 inhibitors become more widely used in the treatment of advanced malignancies, the early recognition and treatment of rare dermatologic toxicities remain of great importance.Dermatopathology 2017;4:13-17 (Source: Dermatopathology)
Source: Dermatopathology - November 15, 2017 Category: Pathology Source Type: research

A 25-Year-Old Male with Orogenital Ulcers, Rash, and Difficulty Swallowing
A 25-year-old otherwise healthy male presented with new-onset odynophagia, rash, and orogenital ulcers. Despite treatment with antibiotics for presumed bacterial pharyngitis, the patient remained symptomatic, with abnormal vital signs and laboratory values. Upon dermatology consultation and histopathologic correlation, he was diagnosed with Beh çet disease. Behçet disease is a rare rheumatologic condition that presents with recurrent oral ulcers and varying degrees of ophthalmic, neurologic, cardiac, and vascular disease. Given its protean nature, the treatment of Behçet disease is tailored to the pati...
Source: Dermatopathology - November 7, 2017 Category: Pathology Source Type: research

A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis
Syringolymphoid hyperplasia (SLH) is an extremely rare histopathological entity with fewer than 40 cases reported in the literature. SLH have been seen as both benign lesions and in association with T-cell lymphoproliferative lesions. A 20-year-old male presented with a solitary, infiltrated plaque on the left cheek initially diagnosed as a sebaceous carcinoma at an external institution. A repeat biopsy demonstrated prominent follicular mucinosis (FM), squamous metaplasia of the eccrine coils, and a moderately dense perieccrine lymphocytic infiltrate mimicking eccrine carcinoma. The lesion was subsequently diagnosed as SLH...
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Bednar Tumor: An Uncommon Entity
We report a rare case of Bednar tumor in a 40-year-old female patient. The diagnosis of Bednar tumor must be considered while reporting pigmented subcutaneous spindle cell lesions.Dermatopathology 2016;3:36-38 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review
Conclusion: Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.Dermatopathology 2016;3:39-43 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Lrig1 Expression in Human Sebaceous Gland Tumors
Conclusion:Lrig1 is a known tumor suppressor gene and is usually considered to be an indicator of poorly aggressive tumors. In human sebaceous tumors, the stronger Lrig1 staining in sebaceous carcinoma compared to other sebaceous tumors might be a feature of an advanced stage in tumorigenesis and a bad prognosis. In our study, 100% of sebaceous carcinomas revealed Lrig1 overexpression. We propose that Lrig1 may be used as a possible new marker of poorly differentiated sebaceous carcinoma.Dermatopathology 2016;3:44-54 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

A 65-Year-Old Female from Connecticut with Orf Infection
We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her sheep. The clinical and histopathologic features, important to arrive at the correct diagnosis of this uncommon yet important infection, are described. We also discuss the benign nature of this condition and emphasize that treatment is not required.Dermatopathology 2016;3:55-60 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema
Conclusion. These results show that the injection of hyaluronidase is capable of degrading exogenous HA in mouse skin and endogenous HA in human skin in vivo and may be a therapeutic option for skin diseases characterized by abnormal accumulation of HA.Dermatopathology 2016;3:61-67 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin
Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis.Dermatopathology 2016;3:68-78 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation
Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin.Dermatopathology 2016;3:79-82 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

A Case of Adrenergic Urticaria Associated with Vitiligo
Adrenergic urticaria is a rare form of urticaria, induced by a stress-induced concomitant release of epinephrine and norepinephrine. Here we describe the case of a 60-year-old female patient presenting with disseminated erythematous papules surrounded by a white halo and vitiligo lesions on the hands, arms, and feet. Histological examination of one of the erythematous papules showed a dermal inflammatory infiltrate composed of lymphocytes and eosinophils of perivascular and interstitial localization. After 2 weeks of treatment with antihistamines, the lesions disappeared completely.Dermatopathology 2016;3:83-86 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components
Hybrid benign peripheral nerve sheath tumors are rare tumors exhibiting areas of more than one neural neoplasm such as schwannoma/neurofibroma, neurofibroma/perineurioma, or schwannoma/perineurioma. These tumors usually arise in the skin of the extremities and trunk, and less commonly affect extracutaneous sites. Here we report two cases of these tumors exhibiting hybrid features of schwannoma/perineurioma and schwannoma/neurofibroma located in the scalp and the ankle, respectively.Dermatopathology 2017;4:1-6 (Source: Dermatopathology)
Source: Dermatopathology - October 25, 2017 Category: Pathology Source Type: research

A Case of Adrenergic Urticaria Associated with Vitiligo
Adrenergic urticaria is a rare form of urticaria, induced by a stress-induced concomitant release of epinephrine and norepinephrine. Here we describe the case of a 60-year-old female patient presenting with disseminated erythematous papules surrounded by a white halo and vitiligo lesions on the hands, arms, and feet. Histological examination of one of the erythematous papules showed a dermal inflammatory infiltrate composed of lymphocytes and eosinophils of perivascular and interstitial localization. After 2 weeks of treatment with antihistamines, the lesions disappeared completely.Dermatopathology 2016;3:83-86 (Source: Dermatopathology)
Source: Dermatopathology - December 14, 2016 Category: Pathology Source Type: research

Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation
Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin.Dermatopathology 2016;3:79-82 (Source: Dermatopathology)
Source: Dermatopathology - November 11, 2016 Category: Pathology Source Type: research

T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin
Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis.Dermatopathology 2016;3:68-78 (Source: Dermatopathology)
Source: Dermatopathology - October 20, 2016 Category: Pathology Source Type: research

Injected Hyaluronidase Reduces the Volume of Exogenous Hyaluronate Fillers in Mice and Results in Clinical Improvement in a Patient with Pretibial Myxedema
Conclusion. These results show that the injection of hyaluronidase is capable of degrading exogenous HA in mouse skin and endogenous HA in human skin in vivo and may be a therapeutic option for skin diseases characterized by abnormal accumulation of HA.Dermatopathology 2016;3:61-67 (Source: Dermatopathology)
Source: Dermatopathology - July 6, 2016 Category: Pathology Source Type: research

A 65-Year-Old Female from Connecticut with Orf Infection
We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her sheep. The clinical and histopathologic features, important to arrive at the correct diagnosis of this uncommon yet important infection, are described. We also discuss the benign nature of this condition and emphasize that treatment is not required.Dermatopathology 2016;3:55-60 (Source: Dermatopathology)
Source: Dermatopathology - June 21, 2016 Category: Pathology Source Type: research

Lrig1 Expression in Human Sebaceous Gland Tumors
Conclusion: Lrig1 is a known tumor suppressor gene and is usually considered to be an indicator of poorly aggressive tumors. In human sebaceous tumors, the stronger Lrig1 staining in sebaceous carcinoma compared to other sebaceous tumors might be a feature of an advanced stage in tumorigenesis and a bad prognosis. In our study, 100% of sebaceous carcinomas revealed Lrig1 overexpression. We propose that Lrig1 may be used as a possible new marker of poorly differentiated sebaceous carcinoma.Dermatopathology 2016;3:44-54 (Source: Dermatopathology)
Source: Dermatopathology - May 31, 2016 Category: Pathology Source Type: research

Paraneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review
Conclusion: Paraneoplastic dermatoses could be the initial presentations of systemic lymphoma. Knowledge about their association with anaplastic large-cell lymphoma may help with timely diagnosis. In a patient with unexplained dermatosis associated with B symptoms who is unresponsive to topic treatment, an investigation for systemic lymphoma workup is warranted.Dermatopathology 2016;3:39-43 (Source: Dermatopathology)
Source: Dermatopathology - April 29, 2016 Category: Pathology Source Type: research

Bednar Tumor: An Uncommon Entity
We report a rare case of Bednar tumor in a 40-year-old female patient. The diagnosis of Bednar tumor must be considered while reporting pigmented subcutaneous spindle cell lesions.Dermatopathology 2016;3:36-38 (Source: Dermatopathology)
Source: Dermatopathology - April 19, 2016 Category: Pathology Source Type: research

A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis
Syringolymphoid hyperplasia (SLH) is an extremely rare histopathological entity with fewer than 40 cases reported in the literature. SLH have been seen as both benign lesions and in association with T-cell lymphoproliferative lesions. A 20-year-old male presented with a solitary, infiltrated plaque on the left cheek initially diagnosed as a sebaceous carcinoma at an external institution. A repeat biopsy demonstrated prominent follicular mucinosis (FM), squamous metaplasia of the eccrine coils, and a moderately dense perieccrine lymphocytic infiltrate mimicking eccrine carcinoma. The lesion was subsequently diagnosed as SLH...
Source: Dermatopathology - April 14, 2016 Category: Pathology Source Type: research

Slowly Growing Nodule on the Trunk: Cutaneous Granular Cell Tumor
Granular cell tumor (GCT) is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. The tumor mostly presents with a symptomatic slowly growing solitary nodule and overlying normal skin; therefore, it is not always considered in the differential diagnosis. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a GCT at the histopathological examination. The neoplastic cells had centrally located nuclei and granular eosinophilic cytoplasm and stained positively for S100, neuron...
Source: Dermatopathology - April 12, 2016 Category: Pathology Source Type: research

Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.Dermatopathology 2016;3:13-22 (Source: Dermatopathology)
Source: Dermatopathology - March 21, 2016 Category: Pathology Source Type: research

Pagetoid Reticulosis: Report of Two Cases and Review of the Literature
In this report, we present two cases of pagetoid reticulosis, compare its microscopic features to those of ‘classical' mycosis fungoides, and provide a brief review of the pertinent literature.Dermatopathology 2016;3:8-12 (Source: Dermatopathology)
Source: Dermatopathology - March 3, 2016 Category: Pathology Source Type: research

Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report
We present one case of OMM that was initially diagnosed as a racial pigmentation elsewhere 2 years earlier. Clinical examination showed multiple macules and nodules located on the hard and soft palate, gingiva and superior alveolar mucosa. These lesions were painless and presented a color variation going from dark blue to black. Histological analysis showed sheets and nests of atypical melanocytes displaying a range of shapes such as plasmacytoid, epithelioid, and round cells, located in the superficial corium extending to the deep tissues. A few tumor cells contained variable amounts of melanin. There was no invasion of b...
Source: Dermatopathology - February 25, 2016 Category: Pathology Source Type: research

Psammomatous Melanotic Schwannoma: A Challenging Histological Diagnosis
Psammomatous melanotic schwannoma (PMS) is a rare pigmented tumor that can be part of the Carney complex. Here, we describe the case of a 35-year-old female patient presenting an isolated subcutaneous PMS. Histopathological analysis could not formally exclude the malignant nature of the tumor. The challenging histological diagnosis and consequently the management of the patient are described.Dermatopathology 2015;2:67-70 (Source: Dermatopathology)
Source: Dermatopathology - December 15, 2015 Category: Pathology Source Type: research

The Dilemma of Coexisting Nevoid Hyperkeratosis of the Nipple and Areola in Mycosis Fungoides: A Report of Three Cases
In this report, we present 3 patients with hyperkeratotic lesions of the nipple and areola associated with MF but showing different histopathological features. We also review similar cases in the literature and discuss possibilities concerning this association. Two of our cases represent the association between MF and NHNA without histopathological features of MF on the nipple-areola complex. The other case represents hyperkeratosis of the nipple and areola with specific histological and immunohistochemical features of MF. Hence, we would like to hypothesize that MF may involve the nipple and areola and have an appearance ...
Source: Dermatopathology - November 17, 2015 Category: Pathology Source Type: research

Benign Fibrous Histiocytomas of the Oral Mucosa: Report on Three Cases and Review of the Literature
This article presents 3 additional cases of BFH of the oral mucosa, with a review of previously published cases. Although a malignant variant of BFH also exists, the present review focuses only on benign lesions. The clinical presentation, diagnosis, histopathological and immunohistochemical features of BFH are discussed. According to the present analysis, the majority of oral mucosal BFH have occurred in middle-aged and elderly patients, with a slight female predilection. Within the oral cavity, BHF may occur at any mucosal site, including the lips, tongue, buccal mucosa, mandibular and maxillary gingiva as well as the pa...
Source: Dermatopathology - April 28, 2015 Category: Pathology Source Type: research

Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update
Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general acceptance and routine application requires robust validation. Here, we summarize the most well-established and commonly used biomarkers along with an array of newer ones reported in the past several decades that either demonstrate or hold high clinical promise in the field of cutaneous pathology. We also highlight recent applications of novel IHC markers in melanoma diagnosis including genetic mutation statu...
Source: Dermatopathology - April 7, 2015 Category: Pathology Source Type: research

Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses
Conclusions: Nevus-associated melanoma was most commonly located on the extremities and the trunk, whereas de novo melanoma was most commonly located in the head and neck and the acral region. Furthermore, nevus-associated melanoma was similar to de novo melanoma in terms of prognosis and other disease characteristics.Dermatopathology 2015;2:46-51 (Source: Dermatopathology)
Source: Dermatopathology - April 1, 2015 Category: Pathology Source Type: research

Nevus-Associated versus de novo Melanoma: Do They Have Different Characteristics and Prognoses?
Conclusions: Nevus-associated melanoma was most commonly located on the extremities and the trunk, whereas de novo melanoma was most commonly located in the head and neck and the acral region. Furthermore, nevus-associated melanoma was similar to de novo melanoma in terms of prognosis and other disease characteristics.Dermatopathology 2015;2:46-51 (Source: Dermatopathology)
Source: Dermatopathology - March 31, 2015 Category: Pathology Source Type: research

Porokeratoma: A Possible Association with Human Papillomavirus Infection
Porokeratoma is a rare, relatively newly described and still unclear entity. Here, we describe the case of a 52-year-old male patient who presented with four well-defined, verrucous and hyperkeratotic lesions. Microscopically, one of the lesions showed acanthopapillomatosis overlying compact orthokeratosis. Prominent broad and confluent cornoid lamellae were present, with no granular layer and some dyskeratotic keratinocytes. PCR sequencing and in situ hybridization revealed the presence of human papillomavirus (HPV) type 16 in the lesion. The association of porokeratoma and HPV infection has not previously been reported.D...
Source: Dermatopathology - March 31, 2015 Category: Pathology Source Type: research

Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
Cutaneous myopericytoma is a rarely reported mesenchymal neoplasm with a benign biologic behavior. It is seen more commonly in males and typically occurs in adults on the distal extremities. To the best of our knowledge, there are only 13 reports describing 45 cases of cutaneous myopericytoma in the literature. The 3 cases in this report expand the clinical presentation and reinforce the histopathologic features of cutaneous myopericytoma. While the clinical presentation in 2 cases (located on the scalp and heel) was in keeping with that reported previously of a slow-growing painless firm nodule, the third case, located on...
Source: Dermatopathology - February 11, 2015 Category: Pathology Source Type: research

Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis): A Case Report and Review of the Literature
Conclusion: Wong-type DM is a clinicopathologic DM-PRP hybrid that can also exhibit porokeratosis-like features best described as columnar dyskeratosis. Recognizing these types of lesions in DM is warranted in order to make an accurate assessment of their prognostic significance.Dermatopathology 2015;2:1-8 (Source: Dermatopathology)
Source: Dermatopathology - January 26, 2015 Category: Pathology Source Type: research

Modulation of MCP-1, TGF-β1, and α-SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study
Vitamin B complex can modulate the inflammatory response and activate wound healing. However, the action mechanisms involved in this process are still unclear. The aim of this study was to evaluate the effects of vitamin B complex on the modulation of monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-β1, and α-smooth muscle actin (α-SMA) in granulation tissue growth. Cutaneous ulcers on Wistar rats were topically treated with vitamin B complex. MCP-1, TGF-β1, and α-SMA expressions were evaluated 24, 72, and 168 h after the treatment. Inflammatory cells were counted and colla...
Source: Dermatopathology - November 27, 2014 Category: Pathology Source Type: research

Cellular Neurothekeoma in a Female with Guillain-Barré Syndrome: A Case Report and Review of the Literature
We present a case of cellular neurothekeoma in a patient with a history of Guillain-Barré syndrome as well as a review of the literature. Our case report is unique in that no prior association has been found in the literature between cellular neurothekeoma and Guillain-Barré syndrome.Dermatopathology 2014;1:91-97 (Source: Dermatopathology)
Source: Dermatopathology - November 20, 2014 Category: Pathology Source Type: research

Cervicofacial Botryomycosis: Is Atopic Dermatitis a Predisposing Factor
Conclusions: We highlight the well-defined histologic features and recall an almost forgotten disease. We review common predisposing conditions and present evidence that atopic dermatitis might be an additional predisposing factor.Dermatopathology 2014;1:81-85 (Source: Dermatopathology)
Source: Dermatopathology - November 10, 2014 Category: Pathology Source Type: research

Perineural Invasion in the Absence of Malignancy: Report of Two Cases and Review of the Literature
In this report, we describe 2 cases of perineural infiltration by benign-appearing epithelial cells in the skin. One case concerns a tumor-free reexcision specimen of a basal cell carcinoma and the other one an ulceration at the outer ear, consistent with acanthoma fissuratum, without a history of a previous excision. This finding was interpreted as a reactive process with dislocation of epithelium from the overlying epidermis into the perineural space.Dermatopathology 2014;1:86-90 (Source: Dermatopathology)
Source: Dermatopathology - November 8, 2014 Category: Pathology Source Type: research

Cervicofacial Botryomycosis: Is Atopic Dermatitis a Predisposing Factor?
Conclusions: We highlight the well-defined histologic features and recall an almost forgotten disease. We review common predisposing conditions and present evidence that atopic dermatitis might be an additional predisposing factor.Dermatopathology 2014;1:81-85 (Source: Dermatopathology)
Source: Dermatopathology - November 8, 2014 Category: Pathology Source Type: research

Necrotizing Infundibular Crystalline Folliculitis: A Case Report of an Exceptional Lesion of Unknown Etiology
Necrotizing infundibular crystalline folliculitis is a rare follicular lesion of which the etiology is not well understood. Here we describe the case of a 71-year-old male patient presenting with multiple hyperkeratotic lesions localized on the forehead. Histopathological analysis of one of the lesions revealed a follicular invagination containing cellular debris and keratin lamellae containing filamentous mucinous material and numerous crystals birefringent in polarized light microscopy.Dermatopathology 2014;1:3-6 (Source: Dermatopathology)
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Cutaneous Angioneurofibroma: A New Histopathological Variant of Neurofibroma
Cutaneous neurofibromas are benign dermal tumors composed of spindle cells in a myxoid stroma containing numerous blood vessels. Here we describe 6 cases of solitary cutaneous neurofibroma showing unusually higher density of blood vessels in the stroma when compared to that of classical neurofibromas. We propose this lesion to be a new histopathological variant of neurofibroma and name it angioneurofibroma.Dermatopathology 2014;1:7-10 (Source: Dermatopathology)
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients
In conclusion, vitiligo is rather a systemic than a local skin disease; the findings from an enormous amount of RNA sequencing data support the previous findings about vitiligo and should be further analyzed.Dermatopathology 2014;1:11-23 (Source: Dermatopathology)
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Trauma-Induced Cutaneous Focal Mucinosis of the Mammary Areola: An Unusual Presentation
We report 2 male patients with trauma-induced CFM arising at the mammary areola, which is an unusual site for CFM. Both male patients presented with a solitary nodular lesion of up to 2 cm in diameter at the right areola. Histology was characterized by circumscribed abundant dermal mucin deposits in a polylobulated pattern without an increased number of fibroblasts or capillaries and with absence of an inflammatory infiltrate. Alcian blue stain at pH 2.5 highlighted the mucin deposits. Immunohistochemistry showed partial expression of FXIIIa by 30% of the stromal cells, but no reactivity for CD34, smooth muscle actin, desm...
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

A Case of a Cellular Neurothekeoma Presenting with Headaches and Review of the Literature
A 12-year-old female presented with a 1-year history of a slow-growing lesion on the frontal scalp. The patient reported intermittent headaches increasing in frequency localized under the lesion. Physical exam revealed a firm, fixed, 5-mm orange-pink papule on the right frontal scalp. Excisional biopsy was performed using a 6-mm punch biopsy, after which the patient reported a cessation of headaches. Histopathology showed a diffuse proliferation of spindled and epithelioid cells within the superficial and deep reticular dermis demonstrating a nested as well as fascicular growth pattern. There was also focal myxoid dermal c...
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Coexpression of SOX10/CD271 (p75NTR) and β-Galactosidase in Large to Giant Congenital Melanocytic Nevi of Pediatric Patients
Conclusions: Oncogene-induced senescence might prevent malignant transformation through activation of the mitogen-activated protein kinase pathway. SOX10 is necessary for the viability of human CMN cell cultures and may be responsible for clinical changes during aging.Dermatopathology 2014;1:35-46 (Source: Dermatopathology)
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Nodular Mucinosis of the Breast in a Male: Reassessment of Diagnostic Criteria and Proposal for Its Classification as a Soft Tissue Tumor in the Myofibroblastoma and Spindle Cell Lipoma Spectrum
We present a case of NMB occurring in the nipple of a 46-year-old man and analyze the clinicopathological features of the other cases of NMB reported in the English literature, concluding that two of them most likely correspond to trauma-induced cutaneous focal mucinosis of the mammary areola. Finally, we review diagnostic criteria for NMB and elaborate an ontogenetic hypothesis based on both its morphological resemblance to myofibroblastoma and its immunohistochemical profile.Dermatopathology 2014;1:47-54 (Source: Dermatopathology)
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research

Adolescent Onset of Localized Papillomatosis, Lymphedema, and Multiple Beta-Papillomavirus Infection: Epidermal Nevus, Segmental Lymphedema Praecox, or Verrucosis A Case Report and Case Series of Epidermal Nevi
Herein, we report the case of a 12-year-old female who noted the recent onset of an oval, circumscribed, 10-cm papillomatous plaque affecting the thigh and vulva that showed histologic signs of lymphedema without evidence of secondary lymphedema. The sequencing of genes associated with a delayed onset of lymphedema or epidermal nevi (EN) - GATA2 and GJC2, and HRAS and KRAS, respectively - showed wild-type alleles. Polymerase chain reaction for human papillomavirus (HPV) DNA demonstrated infections with 15 HPV genotypes. Evidence of productive HPV infection, HPV capsid expression, and cytopathic changes was detected. At the...
Source: Dermatopathology - November 7, 2014 Category: Pathology Source Type: research