Carcinoid Syndrome-Induced Scleroderma-Like Disease
We report a case of scleroderma occurring in a 72-year-old female with metastatic neuroendocrine carcinoma and associated pericardial fibrosis. The use of an alternative nomenclature such as “scleroderma-like” or “sclerodermoid” disease is proposed in order to emphasise its distinction from true idiopathic scleroderma, despite the histopathological similarities on skin biopsy.Dermatopathology 2019;6:99 –104 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
Lupus Masquerading as a Drug Reaction in HIV Infection
An HIV-positive female on antiretroviral therapy (ART) presented with an annular eruption diagnosed as a drug reaction based on histology of a lichenoid dermatitis. She responded to oral steroid therapy and discontinuation, but progressed to develop features in keeping with cutaneous lupus. Although the antinuclear factor remained negative, her low serum complement levels, histology, and clinical features pointed to a diagnosis of subacute lupus in the setting of HIV infection. She responded well to antimalarial therapy and recommenced ART.Dermatopathology 2019;6:85 –90 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component
Malignant chondroid syringoma (MCS; malignant mixed tumour) is a rare neoplasm typically arising on the extremities and trunk. We are report 2 unique cases of MCS, one occurring on the scalp of a 78-year-old man and the other on the trunk of a 72-year-old woman. Both tumours harboured malignant epithelial and malignant mesenchymal components. The latter was represented by liposarcoma in the first case. The malignant components of the second tumour comprised spindle cell squamous cell carcinoma (SCC) and osteosarcoma. Origin from a pre-existing benign chondroid syringoma was clearly evident in both neoplasms. The presence o...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
South African Tick Bite Fever: An Overview
The rickettsiae are a diverse group of vector-borne zoonotic bacterial pathogens. The two common spotted fever diseases in existence in southern Africa are boutonneuse fever-like tick bite fever (TBF), caused byRickettsia conorii, and African TBF, caused byR. africae. This review addresses demographic, epidemiological, clinical, diagnostic, therapeutic, and preventive aspects of TBF in the southern African context, including a discussion of the dermatopathological findings and potential diagnostic pitfalls.Dermatopathology 2019;6:70 –76 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
Emergomycosis ( < b > < i > Emergomyces africanus < /i > < /b > ) in Advanced HIV Disease
In 2013, a novel thermally dimorphic fungal pathogen was described to cause disseminated disease among persons living with advanced HIV/AIDS in South Africa. Although the organism was initially described as anEmmonsia-like fungus, it is now known to belong to a new genus of thermally dimorphic fungi and was recently namedEmergomyces africanus. There is considerable clinical and histopathological overlap between emergomycosis and histoplasmosis. This review addresses taxonomic, clinical, diagnostic, and therapeutic aspects ofEs. africanus disease, a condition which has, to date, only been reported from southern Africa.Derma...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
β-Catenin Expression and Activation in Conjunctival Melanoma
Conclusions: In conjunctival melanoma, nuclear localization and activation of β-catenin appear to be limited, suggesting that inhibition of ARF6, responsible for β-catenin activation, in subsets of skin melanoma may not represent a treatment option for this tumor. In vitro, Wnt3a or Wnt5a did not induce nuclear β-catenin localization.Dermatopathology 2019;6:50 –62 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
Induction of Hyalurosome by Topical Hyaluronate Fragments: Results in Superficial Filling of the Skin Complementary to Hyaluronate Filler Injections
Hyaluronate (HA) plays a major role in the process of skin aging. The main use of HA has been for hydration and dermal fillers. Another approach, based on the discovery of the signaling effects of topically applied hyaluronate fragments (HAF), has subsequently been developed. It has been thoroughly demonstrated that topical applications of HAF of a very specific size induce HA filling of the epidermis and the upper dermis. These effects are particularly visible in dermatoporotic patients. Moreover, the combination of HA-based filler injections with topical applications of HAFs/retinoids showed an optimization of the effect...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research
A Case of Compound Nevus with Intradermal Pseudoglandular Features: A Rare Variant and Possible Pitfall
We report a case of benign compound melanocytic nevus, with a dermal component showing an epithelioid proliferation arranged in small nests with central lumen-like structures mimicking glands. Immunohistochemical staining was necessary to determine the exact nature of the proliferation, since the tubular differentiation can be seen in benign and malignant epithelial neoplasms and has to be clearly identified to avoid misdiagnosis.Dermatopathology 2019;6:41 –44 (Source: Dermatopathology)
Source: Dermatopathology - June 17, 2019 Category: Pathology Source Type: research
Diagnostic Value of Histological Analysis of Punch Biopsies in Suspected Cutaneous Buruli Ulcer: A Study on 32 Cases of Confirmed Buruli Ulcer in Cameroon
Conclusion: Punch biopsies help in establishing the correct diagnosis of BU and also in the differential diagnosis of chronic ulcers. The main histological feature for BU is diffuse coagulative necrosis of subcutaneous tissue, with acid-fast bacilli detected by ZN stain.Dermatopathology 2019;6:28 –36 (Source: Dermatopathology)
Source: Dermatopathology - May 7, 2019 Category: Pathology Source Type: research
Congenital Self-Healing Langerhans Cell Histiocytosis: A Rare Presentation of Blueberry Muffin Baby “Spectrum”
A case of congenital self-healing Langerhans cell histiocytosis (CSHLCH), also known as Hashimoto-Pritzker disease, is reported. The newborn presented as blueberry muffin baby at birth, showing numerous non-blanching blue-purplish and dark-red papular, nodular lesions without documented infections and systemic involvement. Histopathological and immunohistochemical findings were suggestive for Langerhans cell histiocytosis. During the first 12 weeks of life, the cutaneous lesions progressively and spontaneously regressed with some atrophic scars. One-year follow-up is negative for relapse of cutaneous lesions or systemic in...
Source: Dermatopathology - May 7, 2019 Category: Pathology Source Type: research
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report
Epidermolytic acanthoma is a rare benign tumor that appears as a solitary papule or, rarely, multiple small papules on the trunk and extremities, or on genitalia. They are generally asymptomatic, although they can be pruritic. The clinical presentation is often misleading, and the lesions are often misdiagnosed histologically and frequently confused with condyloma acuminatum. Here, we report a case of an epidermolytic acanthoma on the penis of a 57-year-old male, whose final diagnosis was made after several years.Dermatopathology 2019;6:23 –27 (Source: Dermatopathology)
Source: Dermatopathology - May 6, 2019 Category: Pathology Source Type: research
Atypical Cellular Blue Nevus of the Foot: A Case Report
Blue nevus is a congenital and acquired melanocytic proliferation that includes different histological types. The atypical cellular type has been rarely described and it classically has a benign course. However, because of its intermediate features between common blue nevus and malignant blue nevus, long-term clinical follow-up is required. Here we report the case of a 28-year-old woman who presented with an atypical cellular blue nevus on the right foot.Dermatopathology 2019;6:20 –22 (Source: Dermatopathology)
Source: Dermatopathology - March 7, 2019 Category: Pathology Source Type: research
T-Cadherin Expression in Actinic Keratosis Transforming to Invasive Squamous Cell Carcinoma
Conclusions: T-cadherin-negative iSCC arises from AK showing partial or extensive regional loss of T-cadherin in the basal layer of the epidermis. We speculate that T-cadherin loss in individual AK lesions could indicate potential transformation of AK into aggressive iSCC.Dermatopathology 2019;6:12 –19 (Source: Dermatopathology)
Source: Dermatopathology - January 13, 2019 Category: Pathology Source Type: research
Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines
Discussion: We suggest that Notch1-dependent keratinocytic malfunction causes the development of SL. Consequently, hyperpigmentation would be a result and not the primary cause of the pathogenesis. Confirmation of these findings might have clinical implications as hitherto treatment has mainly focused on melanocytes and pigmentation and not on the proliferation/differentiation balance of keratinocytes.Dermatopathology 2019;6:1 –11 (Source: Dermatopathology)
Source: Dermatopathology - January 3, 2019 Category: Pathology Source Type: research
Neoplastic Leg Ulcers
Dermatopathology 2018;5:113 –116 (Source: Dermatopathology)
Source: Dermatopathology - September 19, 2018 Category: Pathology Source Type: research
