Lichenoid Keratosis-Like Melanoma: A Clinically and Histopathologically Challenging Lesion
Regressive melanoma with lichenoid tissue reaction may be clinically and histopathologically challenging. A 73-year-old male visited our clinic for a general skin checkup. We noticed a red papule on the right side of his back. On dermatoscopy, scattered grayish dots were observed. The differential diagnosis included lichenoid keratosis and melanoma. Histopathological examination of the excised lesion showed a regressive melanoma with a histopathological pattern of lichenoid keratosis.Dermatopathology 2019;6:294 –296 (Source: Dermatopathology)
Source: Dermatopathology - August 6, 2020 Category: Pathology Source Type: research
Alcohol-Associated Immunoglobulin A Vasculitis: A Case Report and Review of the Literature
We present a case of a man with IgA vasculitis associated with alcohol use and review the literature on alcohol-associated vasculitis. Although rarely reported, alcohol-associated IgA vasculitis is an important entity to consider for appropriate diagnosis and management of such patients.Dermatopathology 2019;6:288 –293 (Source: Dermatopathology)
Source: Dermatopathology - June 2, 2020 Category: Pathology Source Type: research
Morphological Analysis of Dermatoporosis by in vivo Reflectance Confocal Microscopy and Ultrasonography
Conclusion: US and in vivo RCM are useful tools for the diagnosis of dermatoporosis. Dermal-epidermal atrophy, reduction of dermal papillae/area, and the thickness of dermal elastosis seem to be the major histometric parameters which characterize dermatoporosis.Dermatopathology 2019;6:279 –287 (Source: Dermatopathology)
Source: Dermatopathology - March 17, 2020 Category: Pathology Source Type: research
Cutaneous Mucormycosis Resulting from Hematogenous Dissemination of < b > < i > Rhizomucor pusillus < /i > < /b > in an Immunocompromised Patient
Rhizomucor pusillus is an opportunistic fungus that causes infections (mucormycosis) in patients with a predisposing disease, such as diabetes mellitus and immunodeficiency. Classic manifestations are sinus, pulmonary, and skin infections. Skin lesions consist of tender, erythematous, indurated, and necrotic plaques. The diagnosis is made by identification of the organisms by histopathological analysis of the lesion, showing nonseptate fungal hyphae in the dermis and invasion of the vessel walls, or by means of cultures. Amphotericin B and surgery are the treatments of choice.Dermatopathology 2019;6:275 –278 (Source: Dermatopathology)
Source: Dermatopathology - March 10, 2020 Category: Pathology Source Type: research
Perineural and Vascular Invasion in an Endocrine Mucin-Producing Sweat Gland Carcinoma of the Ear with Associated Mucinous Carcinoma
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a low-grade, indolent tumor found almost exclusively on the eyelids that may histologically mimic metastatic breast carcinoma. To our knowledge, we present the first case of EMPSGC located on the external ear, and the first case with histologic evidence of vascular and perineural invasion. Due to the aggressive potential of this lesion, wide local excision and adjuvant radiation therapy were performed to help reduce the risk of recurrence.Dermatopathology 2019;6:271 –274 (Source: Dermatopathology)
Source: Dermatopathology - February 27, 2020 Category: Pathology Source Type: research
A Case of Fever and Erythema Nodosum-Like Lesions Leading to a New Diagnosis of Gamma-Delta T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
A 69-year-old Vietnamese female presented with fever and new-onset tender subcutaneous nodules on her trunk and lower extremities initially thought to be clinically consistent with erythema nodosum. A biopsy showed an atypical, predominantly lobular lymphocytic panniculitis with admixed neutrophils, karyorrhectic debris, and histiocytes with subcutaneous fat necrosis. Immunohistochemistry was consistent with gamma-delta T-cell lymphoma. The patient was initiated on a chemotherapy regimen of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP) with partial remission, and is currently undergoing eval...
Source: Dermatopathology - February 18, 2020 Category: Pathology Source Type: research
Successful Treatment of Scalp Myxedema with Injected Hyaluronidase: A Case Report
Localized myxedema is an uncommon complication of Graves ’ disease. It is characterized by the accumulation of glycosaminoglycans, particularly hyaluronate. Here we describe the case of a 51-year-old female patient suffering from Graves’ disease, who has presented for years a thickening of the scalp, consistent with myxedema, and successfully treated with repeated injections of hyaluronidase.Dermatopathology 2019;6:260 –265 (Source: Dermatopathology)
Source: Dermatopathology - February 7, 2020 Category: Pathology Source Type: research
A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies
We report the case of a 73-year-old woman with a history of non-small cell lung cancer treated with nivolumab 10 months prior to presentation who developed painful nodules, bullae, and a scaly rash on her extremities. Four months after discontinuation of nivolumab, she noted an acute eruption of painful nodules on her extremities, followed by pink papules and tense bullae on her palms and soles. Biopsies were performed of three lesions in sites of varying morphologies. These findings were felt to be consistent with a nivolumab-induced lichenoid reaction. She was initially treated with intralesional steroid injections, topi...
Source: Dermatopathology - January 31, 2020 Category: Pathology Source Type: research
