Lichenoid Keratosis-Like Melanoma: A Clinically and Histopathologically Challenging Lesion
Regressive melanoma with lichenoid tissue reaction may be clinically and histopathologically challenging. A 73-year-old male visited our clinic for a general skin checkup. We noticed a red papule on the right side of his back. On dermatoscopy, scattered grayish dots were observed. The differential diagnosis included lichenoid keratosis and melanoma. Histopathological examination of the excised lesion showed a regressive melanoma with a histopathological pattern of lichenoid keratosis.Dermatopathology 2019;6:294 –296 (Source: Dermatopathology)
Source: Dermatopathology - August 6, 2020 Category: Pathology Source Type: research

Alcohol-Associated Immunoglobulin A Vasculitis: A Case Report and Review of the Literature
We present a case of a man with IgA vasculitis associated with alcohol use and review the literature on alcohol-associated vasculitis. Although rarely reported, alcohol-associated IgA vasculitis is an important entity to consider for appropriate diagnosis and management of such patients.Dermatopathology 2019;6:288 –293 (Source: Dermatopathology)
Source: Dermatopathology - June 2, 2020 Category: Pathology Source Type: research

Morphological Analysis of Dermatoporosis by in vivo Reflectance Confocal Microscopy and Ultrasonography
Conclusion: US and in vivo RCM are useful tools for the diagnosis of dermatoporosis. Dermal-epidermal atrophy, reduction of dermal papillae/area, and the thickness of dermal elastosis seem to be the major histometric parameters which characterize dermatoporosis.Dermatopathology 2019;6:279 –287 (Source: Dermatopathology)
Source: Dermatopathology - March 17, 2020 Category: Pathology Source Type: research

Cutaneous Mucormycosis Resulting from Hematogenous Dissemination of < b > < i > Rhizomucor pusillus < /i > < /b > in an Immunocompromised Patient
Rhizomucor pusillus is an opportunistic fungus that causes infections (mucormycosis) in patients with a predisposing disease, such as diabetes mellitus and immunodeficiency. Classic manifestations are sinus, pulmonary, and skin infections. Skin lesions consist of tender, erythematous, indurated, and necrotic plaques. The diagnosis is made by identification of the organisms by histopathological analysis of the lesion, showing nonseptate fungal hyphae in the dermis and invasion of the vessel walls, or by means of cultures. Amphotericin B and surgery are the treatments of choice.Dermatopathology 2019;6:275 –278 (Source: Dermatopathology)
Source: Dermatopathology - March 10, 2020 Category: Pathology Source Type: research

Perineural and Vascular Invasion in an Endocrine Mucin-Producing Sweat Gland Carcinoma of the Ear with Associated Mucinous Carcinoma
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a low-grade, indolent tumor found almost exclusively on the eyelids that may histologically mimic metastatic breast carcinoma. To our knowledge, we present the first case of EMPSGC located on the external ear, and the first case with histologic evidence of vascular and perineural invasion. Due to the aggressive potential of this lesion, wide local excision and adjuvant radiation therapy were performed to help reduce the risk of recurrence.Dermatopathology 2019;6:271 –274 (Source: Dermatopathology)
Source: Dermatopathology - February 27, 2020 Category: Pathology Source Type: research

A Case of Fever and Erythema Nodosum-Like Lesions Leading to a New Diagnosis of Gamma-Delta T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
A 69-year-old Vietnamese female presented with fever and new-onset tender subcutaneous nodules on her trunk and lower extremities initially thought to be clinically consistent with erythema nodosum. A biopsy showed an atypical, predominantly lobular lymphocytic panniculitis with admixed neutrophils, karyorrhectic debris, and histiocytes with subcutaneous fat necrosis. Immunohistochemistry was consistent with gamma-delta T-cell lymphoma. The patient was initiated on a chemotherapy regimen of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP) with partial remission, and is currently undergoing eval...
Source: Dermatopathology - February 18, 2020 Category: Pathology Source Type: research

Successful Treatment of Scalp Myxedema with Injected Hyaluronidase: A Case Report
Localized myxedema is an uncommon complication of Graves ’ disease. It is characterized by the accumulation of glycosaminoglycans, particularly hyaluronate. Here we describe the case of a 51-year-old female patient suffering from Graves’ disease, who has presented for years a thickening of the scalp, consistent with myxedema, and successfully treated with repeated injections of hyaluronidase.Dermatopathology 2019;6:260 –265 (Source: Dermatopathology)
Source: Dermatopathology - February 7, 2020 Category: Pathology Source Type: research

A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies
We report the case of a 73-year-old woman with a history of non-small cell lung cancer treated with nivolumab 10 months prior to presentation who developed painful nodules, bullae, and a scaly rash on her extremities. Four months after discontinuation of nivolumab, she noted an acute eruption of painful nodules on her extremities, followed by pink papules and tense bullae on her palms and soles. Biopsies were performed of three lesions in sites of varying morphologies. These findings were felt to be consistent with a nivolumab-induced lichenoid reaction. She was initially treated with intralesional steroid injections, topi...
Source: Dermatopathology - January 31, 2020 Category: Pathology Source Type: research

A 67-Year-Old Male with Diffuse Purpuric Vesicles and Bullae
Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis that most commonly affects the postcapillary venules in the skin. It classically presents with purpuric macules that progress to palpable purpura on the bilateral shins 7 –10 days after an inciting medication or infection, or in the setting of connective tissue disease, malignancy, or inflammatory bowel disease. Up to 50% of cases have no identifiable cause. Lesions on the buttocks, abdomen, upper extremities, and face are uncommon, as are bullae and ulcers. We pre sent a rare case of bullous LCV manifesting as grouped vesicles on the face and body mimick...
Source: Dermatopathology - January 24, 2020 Category: Pathology Source Type: research

A 23-Year-Old Man with Hyper-IgM Syndrome Presenting with Asymptomatic Violaceous Facial Plaques
Tumid lupus is a rare subtype of chronic cutaneous lupus that is characterized by urticaria-like photosensitive plaques. Unlike discoid lupus, it has minimal to no surface change and resolves without scarring. On pathological examination, it may be distinguished from other types of lupus by abundant interstitial mucin deposits. Herein, we describe a case of tumid lupus in a 23-year-old Kuwaiti male with hyper-IgM syndrome. To our best knowledge, this is the first report of tumid lupus in a patient with a primary immunodeficiency.Dermatopathology 2019;6:246 –250 (Source: Dermatopathology)
Source: Dermatopathology - January 22, 2020 Category: Pathology Source Type: research

A 78-Year-Old Female with a Diffuse Pruritic Rash and Palmoplantar Desquamation
We report a case of mycosis fungoides imitating clinical and histopathological features of erythema annulare centrifugum.Dermatopathology 2019;6:241 –245 (Source: Dermatopathology)
Source: Dermatopathology - January 22, 2020 Category: Pathology Source Type: research

Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity
In this study, 45 patients were assessed using the marginal TA severity scoring system, and their biopsies (both longitudinal and transverse sections) were systematically assessed by three dermatopathologists, the aim being to correlate histopathological findings with clinical staging. Intraclass correlation coefficients were used to determine the level of agreement between the assessors. We found poor agreement of the identification and grading of perifollicular and interfollicular fibrosis (0.55 [0.23 –0.75] and 0.01 [2.20–0.41], respectively), and no correlation could be drawn with the clinical severity scor...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Primary Cutaneous Anaplastic Large-Cell Lymphoma
A 35-year-old male presented with a 6-month history of asymptomatic, generalised, self-healing lesions. On clinical examination, there were diffuse, ulcerated, necrotic papules and nodules with lymphoedema of the face. Histology sections confirmed atypical lymphoid-type cells which appeared round-to-oval with irregular nuclei (horseshoe-shaped). Immunohistochemistry stains were positive for CD30, CD3, and epithelial membrane antigen. The features were in keeping with an anaplastic large-cell lymphoma, T cell type. This transformed into a systemic variant of the disease after the patient had completed chemotherapy.Dermatopa...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

< b > < i > Emergomyces africanus < /i > < /b > : The Mimicking Fungus
A 31-year-old HIV-seropositive woman from Durban, KwaZulu-Natal, South Africa, presented with a 3-month history of widespread umbilicated and ulcerated skin papules, plaques, and nodules. The skin lesions were biopsied and sent for histology and fungal culture; the cultured isolate was referred for molecular identification. Histology, fungal culture, and molecular testing confirmed that the dimorphic fungal pathogenEmergomyces africanus had caused a disseminated mycosis.Dermatopathology 2019;6:157 –162 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Dowling-Degos Disease Presenting Primarily with Comedones and Atrophic Scarring
We present a patient with histologically confirmed DDD whose predominant clinical finding was of comedones and scarring, with less prominent pigmentation, thus expanding the clinical spectrum of DDD.Dermatopathology 2019;6:153 –156 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Report of 2 Novel Presentations of Subcutaneous Fat Necrosis of the Newborn
Subcutaneous fat necrosis of the newborn (SCFNN) is a rare form of panniculitis classically affecting healthy full-term infants. There are a number of predisposing factors including perinatal asphyxia. The condition generally has a benign course with spontaneous resolution, but monitoring for metabolic complications, in particular the potentially life-threatening complication of hypercalcaemia, is critical. The authors report 2 cases of preterm infants with perinatal asphyxia with atypical presentations of SCFNN: the first with bony involvement resembling Langerhans cell histiocytosis and with follicular pseudocarcinomatou...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Epstein-Barr Virus-Associated Smooth Muscle Tumour: A Case Series with a Significant Proportion of Tumours Showing Proclivity for Cutaneous Soft Tissues
Conclusion: A significant proportion of EBV-SMTs may present in the cutaneous soft tissues. This neoplasm should, therefore, be included in the histopathological differential diagnosis of any cutaneous or superficial subcutaneous spindle cell tumour, especially in patients with a history of underlying immune suppression. Accurate diagnosis thereof and its distinction from other spindle cell neoplasms is important in view of management implications and the potential for multicentricity in some patients.Dermatopathology 2019;6:133 –146 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Keratolytic Winter Erythema: An Update
Keratolytic winter erythema (KWE) is a rare autosomal dominant keratoderma affecting primarily the palms and soles, manifesting with recurrent waves of erythema followed by epidermal peeling. The condition is so named in view of its anecdotal worsening during the winter months. It is highly penetrant but shows considerable individual clinical variability, waning and reappearing throughout the life course. Histologically, early established lesions of KWE manifest with degenerative changes involving the Malpighian layer, with associated absence of the stratum granulosum. The damaged zone undergoes parakeratotic transformatio...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

An Update on Adverse Cutaneous Drug Reactions in HIV/AIDS
Background: The global mortality from HIV and the cutaneous burden of infective, inflammatory and malignant diseases in the setting of AIDS have significantly declined following the advent of highly active antiretroviral therapy. Regrettably, there has been a contemporaneous escalation in the incidence of adverse cutaneous drug reactions (ACDR), with studies attesting that HIV-positive individuals are a hundred times more susceptible to drug reactions than the general population, and advanced immunodeficiency portending an even greater risk. Several variables are accountable for this amplified risk in HIV.Summary: Adverse ...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Peri-Umbilical Lymphangioma Circumscriptum Associated with Intra-Abdominal Lymphatic Malformations
A 12-year-old African female presented with a 6-year history of relatively asymptomatic umbilical lesions. On clinical examination, the lesions were papillomatous, violaceous nodules and translucent papules with a serosanguineous discharge. The lesions emanated from the umbilicus and extended peri-umbilically. Histopathology confirmed a lymphangioma and MRI and CT imaging revealed multiple intra-abdominal lymphatic malformations. The patient was referred to plastic surgery for further management. Due to the extent of involvement, surgical resection was an option but currently the therapeutic approach is sclerotherapy with ...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Carcinoid Syndrome-Induced Scleroderma-Like Disease
We report a case of scleroderma occurring in a 72-year-old female with metastatic neuroendocrine carcinoma and associated pericardial fibrosis. The use of an alternative nomenclature such as “scleroderma-like” or “sclerodermoid” disease is proposed in order to emphasise its distinction from true idiopathic scleroderma, despite the histopathological similarities on skin biopsy.Dermatopathology 2019;6:99 –104 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Lupus Masquerading as a Drug Reaction in HIV Infection
An HIV-positive female on antiretroviral therapy (ART) presented with an annular eruption diagnosed as a drug reaction based on histology of a lichenoid dermatitis. She responded to oral steroid therapy and discontinuation, but progressed to develop features in keeping with cutaneous lupus. Although the antinuclear factor remained negative, her low serum complement levels, histology, and clinical features pointed to a diagnosis of subacute lupus in the setting of HIV infection. She responded well to antimalarial therapy and recommenced ART.Dermatopathology 2019;6:85 –90 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Malignant Chondroid Syringoma: A Report of Two Cases with a Sarcomatous Mesenchymal Component
Malignant chondroid syringoma (MCS; malignant mixed tumour) is a rare neoplasm typically arising on the extremities and trunk. We are report 2 unique cases of MCS, one occurring on the scalp of a 78-year-old man and the other on the trunk of a 72-year-old woman. Both tumours harboured malignant epithelial and malignant mesenchymal components. The latter was represented by liposarcoma in the first case. The malignant components of the second tumour comprised spindle cell squamous cell carcinoma (SCC) and osteosarcoma. Origin from a pre-existing benign chondroid syringoma was clearly evident in both neoplasms. The presence o...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

South African Tick Bite Fever: An Overview
The rickettsiae are a diverse group of vector-borne zoonotic bacterial pathogens. The two common spotted fever diseases in existence in southern Africa are boutonneuse fever-like tick bite fever (TBF), caused byRickettsia conorii, and African TBF, caused byR. africae. This review addresses demographic, epidemiological, clinical, diagnostic, therapeutic, and preventive aspects of TBF in the southern African context, including a discussion of the dermatopathological findings and potential diagnostic pitfalls.Dermatopathology 2019;6:70 –76 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Emergomycosis ( < b > < i > Emergomyces africanus < /i > < /b > ) in Advanced HIV Disease
In 2013, a novel thermally dimorphic fungal pathogen was described to cause disseminated disease among persons living with advanced HIV/AIDS in South Africa. Although the organism was initially described as anEmmonsia-like fungus, it is now known to belong to a new genus of thermally dimorphic fungi and was recently namedEmergomyces africanus. There is considerable clinical and histopathological overlap between emergomycosis and histoplasmosis. This review addresses taxonomic, clinical, diagnostic, and therapeutic aspects ofEs. africanus disease, a condition which has, to date, only been reported from southern Africa.Derma...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

β-Catenin Expression and Activation in Conjunctival Melanoma
Conclusions: In conjunctival melanoma, nuclear localization and activation of β-catenin appear to be limited, suggesting that inhibition of ARF6, responsible for β-catenin activation, in subsets of skin melanoma may not represent a treatment option for this tumor. In vitro, Wnt3a or Wnt5a did not induce nuclear β-catenin localization.Dermatopathology 2019;6:50 –62 (Source: Dermatopathology)
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

Induction of Hyalurosome by Topical Hyaluronate Fragments: Results in Superficial Filling of the Skin Complementary to Hyaluronate Filler Injections
Hyaluronate (HA) plays a major role in the process of skin aging. The main use of HA has been for hydration and dermal fillers. Another approach, based on the discovery of the signaling effects of topically applied hyaluronate fragments (HAF), has subsequently been developed. It has been thoroughly demonstrated that topical applications of HAF of a very specific size induce HA filling of the epidermis and the upper dermis. These effects are particularly visible in dermatoporotic patients. Moreover, the combination of HA-based filler injections with topical applications of HAFs/retinoids showed an optimization of the effect...
Source: Dermatopathology - June 26, 2019 Category: Pathology Source Type: research

A Case of Compound Nevus with Intradermal Pseudoglandular Features: A Rare Variant and Possible Pitfall
We report a case of benign compound melanocytic nevus, with a dermal component showing an epithelioid proliferation arranged in small nests with central lumen-like structures mimicking glands. Immunohistochemical staining was necessary to determine the exact nature of the proliferation, since the tubular differentiation can be seen in benign and malignant epithelial neoplasms and has to be clearly identified to avoid misdiagnosis.Dermatopathology 2019;6:41 –44 (Source: Dermatopathology)
Source: Dermatopathology - June 17, 2019 Category: Pathology Source Type: research

Diagnostic Value of Histological Analysis of Punch Biopsies in Suspected Cutaneous Buruli Ulcer: A Study on 32 Cases of Confirmed Buruli Ulcer in Cameroon
Conclusion: Punch biopsies help in establishing the correct diagnosis of BU and also in the differential diagnosis of chronic ulcers. The main histological feature for BU is diffuse coagulative necrosis of subcutaneous tissue, with acid-fast bacilli detected by ZN stain.Dermatopathology 2019;6:28 –36 (Source: Dermatopathology)
Source: Dermatopathology - May 7, 2019 Category: Pathology Source Type: research

Congenital Self-Healing Langerhans Cell Histiocytosis: A Rare Presentation of Blueberry Muffin Baby “Spectrum”
A case of congenital self-healing Langerhans cell histiocytosis (CSHLCH), also known as Hashimoto-Pritzker disease, is reported. The newborn presented as blueberry muffin baby at birth, showing numerous non-blanching blue-purplish and dark-red papular, nodular lesions without documented infections and systemic involvement. Histopathological and immunohistochemical findings were suggestive for Langerhans cell histiocytosis. During the first 12 weeks of life, the cutaneous lesions progressively and spontaneously regressed with some atrophic scars. One-year follow-up is negative for relapse of cutaneous lesions or systemic in...
Source: Dermatopathology - May 7, 2019 Category: Pathology Source Type: research

Epidermolytic Acanthoma Mimicking Condyloma: A Case Report
Epidermolytic acanthoma is a rare benign tumor that appears as a solitary papule or, rarely, multiple small papules on the trunk and extremities, or on genitalia. They are generally asymptomatic, although they can be pruritic. The clinical presentation is often misleading, and the lesions are often misdiagnosed histologically and frequently confused with condyloma acuminatum. Here, we report a case of an epidermolytic acanthoma on the penis of a 57-year-old male, whose final diagnosis was made after several years.Dermatopathology 2019;6:23 –27 (Source: Dermatopathology)
Source: Dermatopathology - May 7, 2019 Category: Pathology Source Type: research

Atypical Cellular Blue Nevus of the Foot: A Case Report
Blue nevus is a congenital and acquired melanocytic proliferation that includes different histological types. The atypical cellular type has been rarely described and it classically has a benign course. However, because of its intermediate features between common blue nevus and malignant blue nevus, long-term clinical follow-up is required. Here we report the case of a 28-year-old woman who presented with an atypical cellular blue nevus on the right foot.Dermatopathology 2019;6:20 –22 (Source: Dermatopathology)
Source: Dermatopathology - March 7, 2019 Category: Pathology Source Type: research

T-Cadherin Expression in Actinic Keratosis Transforming to Invasive Squamous Cell Carcinoma
Conclusions: T-cadherin-negative iSCC arises from AK showing partial or extensive regional loss of T-cadherin in the basal layer of the epidermis. We speculate that T-cadherin loss in individual AK lesions could indicate potential transformation of AK into aggressive iSCC.Dermatopathology 2019;6:12 –19 (Source: Dermatopathology)
Source: Dermatopathology - January 13, 2019 Category: Pathology Source Type: research

Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines
Discussion: We suggest that Notch1-dependent keratinocytic malfunction causes the development of SL. Consequently, hyperpigmentation would be a result and not the primary cause of the pathogenesis. Confirmation of these findings might have clinical implications as hitherto treatment has mainly focused on melanocytes and pigmentation and not on the proliferation/differentiation balance of keratinocytes.Dermatopathology 2019;6:1 –11 (Source: Dermatopathology)
Source: Dermatopathology - January 3, 2019 Category: Pathology Source Type: research

Neoplastic Leg Ulcers
Dermatopathology 2018;5:113 –116 (Source: Dermatopathology)
Source: Dermatopathology - September 19, 2018 Category: Pathology Source Type: research

An Ulcerated Reddish Nodule of the Chest: When You See, Think …
A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. A further histopathologic examination showed the presence of ...
Source: Dermatopathology - September 19, 2018 Category: Pathology Source Type: research

Hyaline Cell-Rich Apocrine Mixed Tumor with Cytologic Atypia
Hyaline cell-rich apocrine mixed tumor is relatively rare, and it often possesses atypical cells. Despite the presence of atypical cells, other histopathological features such as well circumscription, smooth border, predominance of bland cells, and no mitotic figures lead to classify these tumors as benign. In addition, no recurrence or metastasis has been reported even when cytologic atypia is identified. Here we report a case of hyaline cell-rich apocrine mixed tumor with cytologic atypia, which did not recur for 14 months after excision.Dermatopathology 2018;5:108 –112 (Source: Dermatopathology)
Source: Dermatopathology - September 17, 2018 Category: Pathology Source Type: research

Melanocytic Lesions of the Nail Unit
This article will first describe the histology of the nail unit, followed by a brief summary of clinical and histopathological features as well as differential diagnosis of melanocytic lesions of the nail unit.Dermatopathology 2018;5:98 –107 (Source: Dermatopathology)
Source: Dermatopathology - July 24, 2018 Category: Pathology Source Type: research

Shadow Cell Differentiation: A Comparative Analysis of Modes of Cell Death with Apoptosis and Epidermal/Trichilemmal Differentiation
Shadow cells are characterized by an eosinophilic cytoplasm and a ghost-like nuclear contour; the cell shape is preserved, in spite of nuclear disappearance. Shadow cell nests (SCNs) are frequently observed in pilomatricoma (PMX), where the transitional cells immediately adjacent to SCNs often have a crescent-shaped nucleus showing fragmentation similar to that of apoptotic bodies. They show nuclear accumulation of beta-catenin and DNA double strand breaks (as revealed by in situ 3 ′-tailing reaction or immunohistochemistry for single-stranded DNA [ssDNA]), while they are negative for cleaved caspase-3 or cleaved lam...
Source: Dermatopathology - July 19, 2018 Category: Pathology Source Type: research

Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know
Cutaneous cysts have been classified by dermatopathologists in many different ways. Here, we propose a novel classification of cutaneous adnexal cysts according to their origin in the folliculosebaceous unit and the sweat glands. By examining the lining of the cystic structure, its origin can be easily identified. Epidermal cysts have an epithelial wall containing a granular layer with lamellar keratinization, indicating an infundibular origin. Tricholemmal cysts have an undulating epithelial wall with no granular layer and a compact keratinization, showing an isthmic origin. In steatocystoma, dermoid cyst, and folliculose...
Source: Dermatopathology - June 7, 2018 Category: Pathology Source Type: research

Nail Unit Glomus Tumor with Myxoid and Symplastic Change Presenting with Longitudinal Erythronychia
Glomus tumors are soft tissue neoplasms, which are most frequently encountered in the nail unit and generally straightforward to diagnose by histopathology. The typical clinical presentation is that of a circular violaceous or erythematous lesion within the nail bed. However, there are rare variants of glomus tumors which may pose diagnostic challenges because of the presence of unusual histologic features. Herein we report such a glomus tumor that demonstrates the rare combination of both myxoid and symplastic change. The clinical presentation of longitudinal erythronychia, as seen with this case, can occur with glomus tu...
Source: Dermatopathology - June 1, 2018 Category: Pathology Source Type: research

An Unusual Case of Facial Steatocystoma Multiplex: A Clinicopathologic and Dermoscopic Report
Conclusion: Herein, we report a rare variant of steatocystoma multiplex limited to the face and scalp subjected to dermatoscopy and characteristic histological correlation. To the best of our knowledge and following a literature search, dermoscopic features of this condition have not been reported thus far.Dermatopathology 2018;5:58 –63 (Source: Dermatopathology)
Source: Dermatopathology - May 30, 2018 Category: Pathology Source Type: research

An Unusual Morphological Presentation of Cutaneous Squamous Cell Carcinoma Mimicking Microcystic Adnexal Carcinoma: A Diagnostic Pitfall
Cutaneous squamous cell carcinoma (SCC) exhibiting microcystic adnexal carcinoma-like differentiation is an extremely rare tumor that shows both squamous and ductal differentiation. This tumor is often misdiagnosed clinically and histologically and is confused with other malignant and benign cutaneous neoplasms. It usually occurs in middle-aged to older adults. Here, we report a case of SCC with microcystic adnexal carcinoma-like differentiation on the left chin of a 71-year-old male. The histopathological examination revealed a nodular tumor infiltrating the dermis, subcutaneous fat, and striated muscle tissue, consisting...
Source: Dermatopathology - May 30, 2018 Category: Pathology Source Type: research

Sign of Leser-Tr élat and Cutaneous T-Cell Lymphoma: A Rare Association
Sign of Leser-Tr élat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have be en considered controversial and some authors assert the absence of a causal link. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer. Here, we describe a new case associated with a cutaneous T-cell lymphoma and a partial response to extracorporeal photop...
Source: Dermatopathology - May 30, 2018 Category: Pathology Source Type: research

The “Dysplastic Nevus” Conundrum: A Look Back, a Peek Forward
Dermatopathology 2018;5:53 –57 (Source: Dermatopathology)
Source: Dermatopathology - April 20, 2018 Category: Pathology Source Type: research

A 30-Year-Old Man with HIV, Fever, and a Rash
Patients who present with papular rashes have a wide differential diagnosis particularly in the setting of immune compromise. A 30-year-old male diagnosed with HIV since 2009, never on antiretroviral therapy, with a nadir CD4 count of 333 cells/mm3 and a current viral load of 44,300 copies/mL, presented with a diffuse monomorphic papular eruption that began on his trunk and extremities and subsequently spread to the penis and scrotum, sparing the distal acral sites. A thorough infectious workup revealed a positive rapid plasma reagin (RPR) and varicella IgM and IgG antibodies. Interestingly, the patient had been diagnosed ...
Source: Dermatopathology - March 23, 2018 Category: Pathology Source Type: research

A 92-Year-Old Male with Eosinophilic Asthma Presenting with Recurrent Palpable Purpuric Plaques
We report a case of biopsy-confirmed Churg-Strauss syndrome in a 92-year-old male with a history of eosinophilic asthma and peripheral eosinophilia who was later diagnosed with Churg-Strauss syndrome.Dermatopathology 2018;5:44-48 (Source: Dermatopathology)
Source: Dermatopathology - March 15, 2018 Category: Pathology Source Type: research

Melanoma Diagnosis: The Importance of Histopathological Report
Dermatopathology 2018;5:41 –43 (Source: Dermatopathology)
Source: Dermatopathology - March 13, 2018 Category: Pathology Source Type: research

Gangrenous Chickenpox with Atypical Clinical and Histopathological Findings
Dermatopathology 2018;5:38 –40 (Source: Dermatopathology)
Source: Dermatopathology - February 21, 2018 Category: Pathology Source Type: research

Lymphocytic Lobular Panniculitis: A Diagnostic Challenge
Dermatopathology 2018;5:30 –33 (Source: Dermatopathology)
Source: Dermatopathology - February 15, 2018 Category: Pathology Source Type: research