Sign of Leser-Tr élat and Cutaneous T-Cell Lymphoma: A Rare Association

Sign of Leser-Tr élat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have be en considered controversial and some authors assert the absence of a causal link. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer. Here, we describe a new case associated with a cutaneous T-cell lymphoma and a partial response to extracorporeal photop heresis.Dermatopathology 2018;5:69 –73
Source: Dermatopathology - Category: Pathology Source Type: research