Melanoma Diagnosis: The Importance of Histopathological Report

Dermatopathology 2018;5:41 –43
Source: Dermatopathology - Category: Pathology Source Type: research

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Condition:   Malignant Melanoma Interventions:   Drug: Tilsotolimod;   Drug: Saline (0.9% sodium chloride) Sponsors:   A.J.M. van den Eertwegh;   Idera Pharmaceuticals, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
TUESDAY, Oct. 15, 2019 -- From 1995 to 2014, there was a 51.1 percent increase in the incidence of pediatric, adolescent, and young adult head and neck melanoma in North America, according to a study published online Oct. 3 in JAMA...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 13 October 2019Source: Seminars in Cancer BiologyAuthor(s): Vikram Shaw, Suyash Srivastava, Sanjay K. SrivastavaAbstractThe recent development of high throughput compound screening has allowed drug repurposing to emerge as an effective avenue for discovering novel treatments for cancer. FDA-approved antipsychotic drugs fluspirilene, penfluridol, and pimozide are clinically used for the treatment of psychotic disorders, primarily schizophrenia. These compounds, belong to diphenylbutylpiperidine class of antipsychotic drugs, are the potent inhibitors of dopamine D2 receptor and calcium chan...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In this study, 218 dysregulated genes and 104 dysregulated miRNAs in response to UV were screened by analyzing sequencing datasets. Among them, 29 up-regulated miRNAs and 28 down-regulated miRNAs were involved in the melanoma pathway. As the only differential gene in the melanoma pathway, GADD45B severely affects the prognosis of melanoma patients. MiR-300 is the only differentially expressed miRNA that regulates GADD45B. In addition, compared to normal melanocytes, miR-300 was significantly down-regulated in melanoma cells (log FC = −1.63) and exosomes (log FC = −1.34). Among the transcription factors predicte...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
A scanning electrochemical microscope can detect a cancer biomarker in skin cells collected with sticky tape, no scalpel needed
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Getting a second opinion from a pathologist specially trained in skin lesions -- a dermatopathologist -- yields the most accurate results, the new study found.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Abstract An accurate profiling of the genomic landscape is mandatory to establish the best clinical and therapeutic approach for patients with solid malignancies. Moreover, tumor cells constantly adapt to external pressures-i.e., systemic treatment-with the selection and expansion of resistant subclones and the emergence of heterogeneous overlapping genomic alterations of resistance. The current standard for molecular characterization in cancer is the performance of a tissue tumor biopsy at the time of diagnosis and, when possible, a re-biopsy at the time of progression. However, tissue biopsy is not always feasib...
Source: Cell Research - Category: Cytology Authors: Tags: Recent Results Cancer Res Source Type: research
A skin cancer protection program in Australia led to marked changes in sun-related behaviors that correspond to a reduction in the incidence of melanoma over the same period, suggest survey results.Medscape Medical News
Source: Medscape Med Students Headlines - Category: Universities & Medical Training Tags: Hematology-Oncology News Source Type: news
Condition:   Melanoma Interventions:   Biological: PVSRIPO;   Drug: Nivolumab Sponsors:   Darell D. Bigner, MD, PhD;   Duke University;   Istari Oncology, Inc.;   Bristol-Myers Squibb Not yet recruiting
Source: - Category: Research Source Type: clinical trials
A new Yale-developed immunotherapy system has been shown to reduce or eliminate melanoma and triple-negative breast and pancreatic tumors in mice.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
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