An Ulcerated Reddish Nodule of the Chest: When You See, Think …

A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. A further histopathologic examination showed the presence of pigment in a few areas of the neoplasm. On immunohistochemical study, neoplastic cells were negative for wide-spectrum cytokeratin and diffusely positive for S-100, MART-1, and HMB-45 proteins. Our final diagnosis was nodular malignant melanoma (MM) with balloon epithelioid cells, a “bizarre” presentation of MM in vertical growth phase, mimicking metastatic and primary neoplasms of different lineage derivations.Dermatopathology 2018;5:117 –120
Source: Dermatopathology - Category: Pathology Source Type: research

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Non-melanoma skin cancers (NMSC), including cutaneous basal and squamous cell carcinomas (cBCC and cSCC), are the most frequent malignancies worldwide, with substantial associated morbidity and cost. A better understanding of the molecular changes (such as genomic and energy metabolic alterations) involved in skin cancer progression from precancerous lesions to localized tumors and then to metastasis will aid in early detection, development of biomarkers and future targeted treatment strategies.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
Abstract Merkel cell carcinoma (MCC) is a highly aggressive non-melanoma skin cancer of the elderly which is associated with the Merkel cell polyomavirus (MCPyV). MCC reveals a trilinear differentiation characterized by neuroendocrine, epithelial and pre/pro B-cell lymphocytic gene expression disguising the cellular origin of MCC. Here we investigated the expression of the neuroendocrine key regulators RE1 silencing transcription factor (REST), neurogenic differentiation 1 (NeuroD1) and the Achaete-scute homolog 1 (ASCL1) in MCC. All MCCs were devoid of REST and were positive for NeuroD1 expression. Only one MCC t...
Source: Neoplasia - Category: Cancer & Oncology Authors: Tags: Neoplasia Source Type: research
To the Editor: It is well-known that systemic autoimmune diseases confer an increased risk for cancer.1 In recent years, studies have described an increased risk for epithelial malignancies in patients with systemic sclerosis —most commonly lung carcinoma.2-4 There are no current studies in the literature evaluating the prevalence of epithelial skin cancers in patients with the localized form of scleroderma, morphea. Using the Slicer Dicer feature of the electronic medical record system EPIC, we retrospectively collect ed anonymous, aggregate-level data on patients ≥18 years of age seen at Johns Hopkins Hospi...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC. PMID: 30251802 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. He had a history of nonmelanoma skin cancers, a stage IB malignant melanoma of a lower extremity and Gleason 4 + 3 prostate cancer treated with brachytherapy, external beam irradiation, and bicalutamide. A shave biopsy was performed and histologic examination revealed infiltrative single-unit atypical cells and small ducts in a superficially transected sclerotic dermis suggestive of a poorly differentiated adenocarcinoma. No epidermal connection was identified. Immunohistochemica...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Publication date: July 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1865, Issue 7 Author(s): Ewa Krzywinska, Marek Dominick Zorawski, Agnieszka Taracha, Grzegorz Kotarba, Agnieszka Kikulska, Michal Mlacki, Katarzyna Kwiatkowska, Tomasz Wilanowski The mammalian Grainyhead-like 3 (GRHL3) transcription factor is essential for epithelial development and plays a protective role against squamous cell carcinoma of the skin and of the oral cavity. A single nucleotide polymorphism (SNP) in GRHL3, rs141193530 (p.P455A), is associated with non-melanoma skin cancer in human patients. Moreover, it ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Abstract The mammalian Grainyhead-like 3 (GRHL3) transcription factor is essential for epithelial development and plays a protective role against squamous cell carcinoma of the skin and of the oral cavity. A single nucleotide polymorphism (SNP) in GRHL3, rs141193530 (p.P455A), is associated with non-melanoma skin cancer in human patients. Moreover, it is known that this SNP, as well as another variant, rs41268753 (p.T454M), are associated with nonsyndromic cleft palate and that rs41268753 negatively affects GRHL3 transcriptional activity. These SNPs are located in adjacent codons of the GRHL3 gene, and the occurre...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research
Abstract Background Post-transplant non-melanoma skin cancers (NMSC) are the most common malignancies in kidney transplant recipients. Objectives To analyse risk factors associated with the occurrence of basal cell carcinomas (BBC) and squamous cell carcinomas (SCC) in kidney transplant recipients. Materials and methods Statistical analysis was performed on 376 kidney transplant recipients screened for NMSC in 2002-2009 and followed until 2013. Results NMSC dev...
Source: European Journal of Dermatology - Category: Dermatology Source Type: research
High Mobility Group A2 (Hmga2) functions as an oncogene overexpressed in a variety of human malignant neoplasms, induced in epithelial-mesenchymal transition, and in association with squamous skin carcinoma stemness. However, little is known about the expression of Hmga2 in cutaneous epithelium and its role during skin non-melanoma tumor development. Here, we find that Hmga2 is expressed as membrane protein out of bulge region in normal skin tissue by immunofluorescence staining, as membrane/cytoplasm/nuclear protein in papilloma tissue, and as nuclear protein in the skin squamous carcinoma tissue.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis & Cancer Genetics Source Type: research
Abstract In Brazil, without considering the non-melanoma skin tumors, bladder cancer in men is the eighth most common, and the urothelial carcinoma or transitional cell carcinoma is the most common among these. Cutaneous metastases from urothelial neoplasms appear as single or multiple erythematous, infiltrated nodules or plaques, and like other cases of distant disease, it is indicative of poor prognosis. The invasive urothelial carcinoma is recognized for its ability to present divergent differentiation and morphological variants. The sarcomatoid urothelial carcinoma is a rare cancer that consists of two different compon...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
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