Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos
Comp Med. 2023 Aug 3. doi: 10.30802/AALAS-CM-22-000123. Online ahead of print.ABSTRACTRisperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goalof the current study was to examine the effects of risperidone in zebrafish embryos (Danio rerio) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.PMID:37536933 | DOI:10.30802/AALA...
Source: Comparative Medicine - August 3, 2023 Category: Zoology Authors: Hirla Costa Silva Fukushima Ricardo Lacava Bailone Ricardo Carneiro Borra Source Type: research
Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos
Comp Med. 2023 Aug 3. doi: 10.30802/AALAS-CM-22-000123. Online ahead of print.ABSTRACTRisperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goalof the current study was to examine the effects of risperidone in zebrafish embryos (Danio rerio) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.PMID:37536933 | DOI:10.30802/AALA...
Source: Comparative Medicine - August 3, 2023 Category: Zoology Authors: Hirla Costa Silva Fukushima Ricardo Lacava Bailone Ricardo Carneiro Borra Source Type: research
Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix
In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reactionand support its use as a potential biomaterial for mitigating fibrosis after M...
Source: Comparative Medicine - August 1, 2023 Category: Zoology Authors: Reshma S Nair Praveen K Soghan Sachin J Shenoy Mukund A Prabhu Vikas Kumar Surya Ramachandran Thapasimuthu V Anilkumar Source Type: research
Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix
In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reactionand support its use as a potential biomaterial for mitigating fibrosis after M...
Source: Comparative Medicine - August 1, 2023 Category: Zoology Authors: Reshma S Nair Praveen K Soghan Sachin J Shenoy Mukund A Prabhu Vikas Kumar Surya Ramachandran Thapasimuthu V Anilkumar Source Type: research
Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix
In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reactionand support its use as a potential biomaterial for mitigating fibrosis after M...
Source: Comparative Medicine - August 1, 2023 Category: Zoology Authors: Reshma S Nair Praveen K Soghan Sachin J Shenoy Mukund A Prabhu Vikas Kumar Surya Ramachandran Thapasimuthu V Anilkumar Source Type: research
