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Effects of Extended-Release Buprenorphine on Mouse Models of Influenza
In this study, BALB/c and DBA/2 mice were inoculated with influenza virus, and treatment groups received either no analgesics or 2 doses of extended-release buprenorphine 72 h apart. Clinical signs, mortality, and influenza-specific antibody responses were comparable in mice that did or did not receive buprenorphine. We therefore conclude that extended-release buprenorphine can be used to alleviate incidental pain during studies of influenza infection without altering the course of infection or the immune response.PMID:38110195 | DOI:10.30802/AALAS-CM-23-000049 (Source: Comparative Medicine)
Source: Comparative Medicine - December 18, 2023 Category: Zoology Authors: Marie E Brake Brynnan P Russ Shane Gansebom Sarah C Genzer Cassandra Tansey Ian A York Source Type: research

Antibiotic Treatment of Corynebacterium bovis -associated Clinical Disease in NSG Mice
Comp Med. 2023 Dec 16. doi: 10.30802/AALAS-CM-23-000039. Online ahead of print.ABSTRACTDepending on the strain of immunodeficient mice, Corynebacterium bovis infection can be asymptomatic or cause transient or prolonged skin disease. C. bovis infection of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice results in clinical skin disease that progresses in severity. Amoxicillin metaphylaxic and prophylaxic therapy prevents transmission and infection of mice after exposure to C. bovis and inhibits the growth of C. bovis isolates at therapeutic doses that are clinically achievable in mice. Amoxicillin is not efficacious for treatme...
Source: Comparative Medicine - December 16, 2023 Category: Zoology Authors: Elena M Pires Umarani Pugazhenthi Michael K Fink Lauren M Habenicht Derek L Fong Jori K Leszczynski Michael J Schurr Christopher A Manuel Source Type: research

Polyomavirus-associated Disseminated T-cell Lymphoma in a Colony of Zebra Finches ( Taeniopygia guttata )
Comp Med. 2023 Oct 29;73(5):383-390. doi: 10.30802/AALAS-CM-23-000011.ABSTRACTFour zebra finches in a closed research colony presented with variable clinical signs, including masses, skin lesions, shivering, and/or ruffled feathers. These birds were not responsive to treatment efforts; 3 died and one was euthanized. All 4 were submitted for necropsy to determine the cause of the clinical signs. Gross necropsy and histopathologic findings from all birds resulted in a diagnosis of round cell neoplasia in multiple organs, including the skin, liver, kidney, and reproductive tract, with intranuclear inclusion bodies in the neop...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Katherine A Shuster Tzushan S Yang Kate T Snyder Nicole Creanza Patrick K Mitchell Laura B Goodman Jennifer K Grenier Nicholas M Tataryn Lauren E Himmel Katherine N Gibson-Corley Source Type: research

Unique Presentations of Burkholderia gladioli Infections in Several Strains of Immunocompromised Mice
Comp Med. 2023 Oct 29;73(5):391-397.ABSTRACTFour strains of experimentally naïve mice (NOD. Cg-Prkdc scid Il2rg tm1Wjl /SzJ [NSG], NOD. Cg- Rag1 tm1Mom Il2rg tm1Wjl /SzJ [NRG], B6.129S(Cg)-Stat1 tm1Dlv/J [STAT1 -/-], and B6.129S7- Ifngr1 tm1Agt/J[IFNγR -/-] housed in a barrier facility developed unusual and seemingly unrelated clinical signs. Young NSG/NRG mice (n = 49, mean age = 4 ± 0.4 mo) exhibited nonspecific clinical signs of moderate-to-severe lethargy, hunched posture, decreased body condition, and pallor. In contrast to the NSG/NRG mice, the STAT1-/- and IFNγ R-/- mice (n = 5) developed large subcutaneous absc...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Andrea J Osborne Sarah E Clark Matthew Lanza Hannah M Atkins Tiffany Whitcomb Penny Devlin Source Type: research

Development of a Corneal and Eye Protection Strategy in Domestic Swine
This study presents an effective method to provide corneal and eye protection in the domestic swine for at least 50 d. Furthermore, protection of the eye and face is achieved through the innovative use of a modified ophthalmologic face shield. The findings from this study will advance large animal research in these fields, enabling innovation in surgery and tissue engineering in areas of both craniofacial and ophthalmologic research.PMID:38087405 | PMC:PMC10702166 | DOI:10.30802/AALAS-CM-22-000063 (Source: Comparative Medicine)
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Marissa A Suchyta Christopher K Gow Josephine M Lawrence Samir Mardini Source Type: research

Cold Agglutinin Disease in a Rhesus Macaque ( Macaca mulatta )
In this report, we describe a case of CAD in a previously healthy and experimentally naïve adult Indian rhesus macaque that was housed indoors and presented with blood in the urine. After our observations of hemoglobinuria and anemia led us to suspect CAD, we demonstrated that the macaque's blood agglutinated at reduced temperatures. We also noticed that the provision of cold foraging treats triggered episodes of hemoglobinuria. Further investigation revealed that serum from the macaque agglutinated RBCs in vitro with high thermal amplitude (at or below 30 °C) and had an antibody titer of 8 to 32. The serum contained aut...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Cris Kamperschroer Karrie Tartaro Laurie Goodchild Chelsea Menke Ashley Artrip Harshan Pisharath Source Type: research

Isolation and Characterization of a Novel Alpha-Hemolytic Streptococcus spp. from the Oral Cavity and Blood of Septicemic Periparturient Immunodeficient Mice
Comp Med. 2023 Oct 29;73(5):346-356. doi: 10.30802/AALAS-CM-23-000020.ABSTRACTMISTRG is an immunodeficient mouse strain that expresses multiple human cytokines that support hematopoietic stem cell maintenance and myelopoiesis. While establishing a breeding colony of MISTRG mice in a dedicated barrier room, 6 cases of death or disease occurred in pregnant or postpartum mice. Clinically, this manifested as hunched posture, dyspnea, and 1 case of emaciation with ataxia. Pathologic analysis of 7 mice revealed multisystemic necrosuppurative inflammation variably affecting the uterus and placenta, joints, meninges, inner and mid...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Amy Funk Qidong Jia Laura Janke Ashley Crawford Amy Iverson Jason Rosch Joseph Emmons Chandra Savage Heather Glasgow Randall Hayden Elisa Margolis Harshan Pisharath Source Type: research

Validation of PAMFix, A Novel Platelet Stabilization Product, for Use on Flow Cytometric Analysis of Pigtailed Macaque ( Macaca nemestrina ) Blood
In this study, we tested the efficacy of PAMFix on whole blood from pigtailed macaques to determine the short- and long-term effects of PAMFix on platelet P-selectin expression as analyzed by flow cytometry.PMID:38087408 | PMC:PMC10702162 | DOI:10.30802/AALAS-CM-23-000032 (Source: Comparative Medicine)
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Claire E Lyons Aileen J Feng Kelly A Metcalf Pate Source Type: research

Evaluation of Selected Markers in Kidneys of Cynomolgus Monkey ( Macaca fascicularis ) with Induced Diabetes during Renal Ischemia-reperfusion Injury
Comp Med. 2023 Oct 29;73(5):357-372. doi: 10.30802/AALAS-CM-22-000127.ABSTRACTWe previously reported that induced type 1 diabetes mellitus (DM) increases the susceptibility of acute kidney injury in- duced by ischemia-reperfusion injury (IRI) in cynomolgus monkeys. In this follow-up study, we compared the expression of selected markers in the renal tissues of monkeys subjected to bilateral renal IRI with and without diabetes. All tissues were obtained from the original study. Renal biopsies were obtained before and 24 and 48 h after ischemia and were examined for expression of KI-67 (tubular proliferation), Na+ /K+ ATPase ...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Tae M Kim Kyo W Lee Hong D Kim Sung O Hong Hye J Cho Je H Yang Sung J Kim Jae B Park Source Type: research

Assessment of Oral Albendazole and Fumagillin in the Treatment of Pseudoloma neurophilia in Adult Zebrafish
Comp Med. 2023 Oct 29;73(5):335-345. doi: 10.30802/AALAS-CM-23-000035.ABSTRACTPseudoloma neurophilia ( Pn ), the causative agent of the most commonly reported disease of zebrafish, is a microsporidian parasite that confounds research by inducing behavioral and physiologic changes in zebrafish. Although a treatment for P. neurophilia has not been documented in zebrafish, albendazole (ALB) and fumagillin (FUM) have been used to treat microsporidian infections of other fish species. To investigate the efficacy of oral ALB and FUM in the treatment of Pn, we performed a pilot study that demonstrated the safety and palatability ...
Source: Comparative Medicine - December 13, 2023 Category: Zoology Authors: Elizabeth S Lavin Rodman G Getchell Erin K Daugherity Michael L Kent Adam D Frosolone Renata Ivanek Source Type: research

Comparison of Cardiovascular Pathology in Animal Models of SARS-CoV-2 Infection: Recommendations Regarding Standardization of Research Methods
Comp Med. 2023 Oct 29;73(5):407.NO ABSTRACTPMID:38087411 (Source: Comparative Medicine)
Source: Comparative Medicine - December 13, 2023 Category: Zoology Source Type: research