Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Effects of Mouse Kidney Parvovirus on Pharmacokinetics of Chemotherapeutics and the Adenine Model of Chronic Kidney Disease
Comp Med. 2023 Mar 27. doi: 10.30802/AALAS-CM-22-000084. Online ahead of print.ABSTRACTMouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the effects of MKPV infection on the pharmacokinetics of 2 renally excreted chemotherapeutic agents, methotrexate and lenalidomide, we measured drug concentrations in the blood and urine of MKPV-infected or uninfected immunodeficient NOD.Cg-PrkdcscidIl2rgtm1Wjl/S...
Source: Comparative Medicine - March 27, 2023 Category: Zoology Authors: Amanda C Ritter Rodolfo J Ricart Arbona Robert S Livingston S ébastien Monette Neil S Lipman Source Type: research

Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets ( < em > Callithrix jacchus < /em > )
Comp Med. 2023 Mar 21. doi: 10.30802/AALAS-CM-22-000075. Online ahead of print.ABSTRACTThe common marmoset (Callithrix jacchus), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and ...
Source: Comparative Medicine - March 21, 2023 Category: Zoology Authors: Sarah J Powers Natalie Castell Rachel Vistein Anthony N Kalloo Jessica M Izzi Kathleen L Gabrielson Source Type: research

Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets ( < em > Callithrix jacchus < /em > )
Comp Med. 2023 Mar 21. doi: 10.30802/AALAS-CM-22-000075. Online ahead of print.ABSTRACTThe common marmoset (Callithrix jacchus), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and ...
Source: Comparative Medicine - March 21, 2023 Category: Zoology Authors: Sarah J Powers Natalie Castell Rachel Vistein Anthony N Kalloo Jessica M Izzi Kathleen L Gabrielson Source Type: research

Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets ( < em > Callithrix jacchus < /em > )
Comp Med. 2023 Mar 21. doi: 10.30802/AALAS-CM-22-000075. Online ahead of print.ABSTRACTThe common marmoset (Callithrix jacchus), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and ...
Source: Comparative Medicine - March 21, 2023 Category: Zoology Authors: Sarah J Powers Natalie Castell Rachel Vistein Anthony N Kalloo Jessica M Izzi Kathleen L Gabrielson Source Type: research

Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets ( < em > Callithrix jacchus < /em > )
Comp Med. 2023 Mar 21. doi: 10.30802/AALAS-CM-22-000075. Online ahead of print.ABSTRACTThe common marmoset (Callithrix jacchus), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and ...
Source: Comparative Medicine - March 21, 2023 Category: Zoology Authors: Sarah J Powers Natalie Castell Rachel Vistein Anthony N Kalloo Jessica M Izzi Kathleen L Gabrielson Source Type: research

Bacterial Cholecystitis and Cholangiohepatitis in Common Marmosets ( < em > Callithrix jacchus < /em > )
Comp Med. 2023 Mar 21. doi: 10.30802/AALAS-CM-22-000075. Online ahead of print.ABSTRACTThe common marmoset (Callithrix jacchus), a New World NHP, has emerged as important animal model in multiple areas of translational biomedical research. The quality of translational research in marmosets depends on early diagnosis, treatment, and prevention of their spontaneous diseases. Here, we characterize an outbreak of infectious cholangiohepatitis that affected 7 adult common marmosets in a single building over a 10-mo period. Marmosets presented for acute onset of lethargy, dull mentation, weight loss, dehydration, hyporexia, and ...
Source: Comparative Medicine - March 21, 2023 Category: Zoology Authors: Sarah J Powers Natalie Castell Rachel Vistein Anthony N Kalloo Jessica M Izzi Kathleen L Gabrielson Source Type: research