Carprofen Attenuates Postoperative Mechanical and Thermal Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice
Comp Med. 2024 Mar 29. doi: 10.30802/AALAS-CM-23-000058. Online ahead of print.ABSTRACTImmunodeficient NSG mice are reported to be less responsive to buprenorphine analgesia. Here, we used NSG mice to compare the efficacy of the commonly used dose of carprofen (5 mg/kg) with 5 and 10 times that dose (25 and 50 mg/kg) for attenuating postoperative mechanical and thermal hypersensitivity following an incisional pain model. Male and female NSG mice (n = 45) were randomly assigned to one of 4 groups and received daily subcutaneous injections for 3 d: saline (5 mL/kg), 5 mg/kg carprofen (Carp5), 25 mg/kg carprofen (Carp25), and...
Source: Comparative Medicine - March 29, 2024 Category: Zoology Authors: Eden D Alamaw Kerriann M Casey Krystal Tien Benjamin D Franco Gregory Gorman Renee M Cotton Claude Nagamine Katechan Jampachaisri Patrick Sharp Cholawat Pacharinsak Monika K Huss Source Type: research
Consistency in Reporting of Loss of Righting Reflex for Assessment of General Anesthesia in Rats and Mice: A Systematic Review
Comp Med. 2024 Feb 1;74(1):12-18. doi: 10.30802/AALAS-CM-23-000063.ABSTRACTGeneral anesthesia induces a reversible loss of consciousness (LOC), a state that is characterized by the inability to feel pain. Identifying LOC in animals poses unique challenges, because the method most commonly used in humans, responding to questions, cannot be used in animals. For over a century, loss of righting reflex (LORR) has been used to assess LOC in animals. This is the only animal method that correlates directly with LOC in humans and has become the standard proxy measure used in research. However, the reporting of how LORR is assessed...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Michael Z Teng Dexter Merenick Anisha Jessel Heather Ganshorn Daniel S J Pang Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote ( < em > Canis latrans < /em > )
Comp Med. 2024 Feb 1;74(1):3-11. doi: 10.30802/AALAS-CM-23-000044.ABSTRACTL-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and m...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Sara M Freeman J Leon Catrow James Eric Cox Alexandra Turano McKenna A Rich Hillary P Ihrig Naveena Poudyal Cheng-Wei Tom Chang Eric M Gese Julie K Young Aaron L Olsen Source Type: research
Consistency in Reporting of Loss of Righting Reflex for Assessment of General Anesthesia in Rats and Mice: A Systematic Review
Comp Med. 2024 Feb 1;74(1):12-18. doi: 10.30802/AALAS-CM-23-000063.ABSTRACTGeneral anesthesia induces a reversible loss of consciousness (LOC), a state that is characterized by the inability to feel pain. Identifying LOC in animals poses unique challenges, because the method most commonly used in humans, responding to questions, cannot be used in animals. For over a century, loss of righting reflex (LORR) has been used to assess LOC in animals. This is the only animal method that correlates directly with LOC in humans and has become the standard proxy measure used in research. However, the reporting of how LORR is assessed...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Michael Z Teng Dexter Merenick Anisha Jessel Heather Ganshorn Daniel S J Pang Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote ( < em > Canis latrans < /em > )
Comp Med. 2024 Feb 1;74(1):3-11. doi: 10.30802/AALAS-CM-23-000044.ABSTRACTL-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and m...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Sara M Freeman J Leon Catrow James Eric Cox Alexandra Turano McKenna A Rich Hillary P Ihrig Naveena Poudyal Cheng-Wei Tom Chang Eric M Gese Julie K Young Aaron L Olsen Source Type: research
Consistency in Reporting of Loss of Righting Reflex for Assessment of General Anesthesia in Rats and Mice: A Systematic Review
Comp Med. 2024 Feb 1;74(1):12-18. doi: 10.30802/AALAS-CM-23-000063.ABSTRACTGeneral anesthesia induces a reversible loss of consciousness (LOC), a state that is characterized by the inability to feel pain. Identifying LOC in animals poses unique challenges, because the method most commonly used in humans, responding to questions, cannot be used in animals. For over a century, loss of righting reflex (LORR) has been used to assess LOC in animals. This is the only animal method that correlates directly with LOC in humans and has become the standard proxy measure used in research. However, the reporting of how LORR is assessed...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Michael Z Teng Dexter Merenick Anisha Jessel Heather Ganshorn Daniel S J Pang Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote ( < em > Canis latrans < /em > )
Comp Med. 2024 Feb 1;74(1):3-11. doi: 10.30802/AALAS-CM-23-000044.ABSTRACTL-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and m...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Sara M Freeman J Leon Catrow James Eric Cox Alexandra Turano McKenna A Rich Hillary P Ihrig Naveena Poudyal Cheng-Wei Tom Chang Eric M Gese Julie K Young Aaron L Olsen Source Type: research
Consistency in Reporting of Loss of Righting Reflex for Assessment of General Anesthesia in Rats and Mice: A Systematic Review
Comp Med. 2024 Feb 1;74(1):12-18. doi: 10.30802/AALAS-CM-23-000063.ABSTRACTGeneral anesthesia induces a reversible loss of consciousness (LOC), a state that is characterized by the inability to feel pain. Identifying LOC in animals poses unique challenges, because the method most commonly used in humans, responding to questions, cannot be used in animals. For over a century, loss of righting reflex (LORR) has been used to assess LOC in animals. This is the only animal method that correlates directly with LOC in humans and has become the standard proxy measure used in research. However, the reporting of how LORR is assessed...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Michael Z Teng Dexter Merenick Anisha Jessel Heather Ganshorn Daniel S J Pang Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote ( < em > Canis latrans < /em > )
Comp Med. 2024 Feb 1;74(1):3-11. doi: 10.30802/AALAS-CM-23-000044.ABSTRACTL-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and m...
Source: Comparative Medicine - March 27, 2024 Category: Zoology Authors: Sara M Freeman J Leon Catrow James Eric Cox Alexandra Turano McKenna A Rich Hillary P Ihrig Naveena Poudyal Cheng-Wei Tom Chang Eric M Gese Julie K Young Aaron L Olsen Source Type: research
Comparison of Two Different Alfaxalone Concentrations Combined with Midazolam to Anesthetize Cynomolgus Macaques ( < em > Macaca fascicularis < /em > ) for Plethysmography
Comp Med. 2024 Mar 21. doi: 10.30802/AALAS-CM-23-000069. Online ahead of print.ABSTRACTPlethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques. An obstacle to the use of AM is the volume required to anesthetize via intramuscular injection. A more concentrated formulation of alfaxalone w...
Source: Comparative Medicine - March 21, 2024 Category: Zoology Authors: Robert J Edwards Jeanean M Ghering Ondraya M Frick Kirby S Pasloske Kacee H Santos Summer M Astleford Charles E White Brianna M Marion Source Type: research
Comparison of Two Different Alfaxalone Concentrations Combined with Midazolam to Anesthetize Cynomolgus Macaques ( < em > Macaca fascicularis < /em > ) for Plethysmography
Comp Med. 2024 Mar 21. doi: 10.30802/AALAS-CM-23-000069. Online ahead of print.ABSTRACTPlethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques. An obstacle to the use of AM is the volume required to anesthetize via intramuscular injection. A more concentrated formulation of alfaxalone w...
Source: Comparative Medicine - March 21, 2024 Category: Zoology Authors: Robert J Edwards Jeanean M Ghering Ondraya M Frick Kirby S Pasloske Kacee H Santos Summer M Astleford Charles E White Brianna M Marion Source Type: research
