Comparison of Two Different Alfaxalone Concentrations Combined with Midazolam to Anesthetize Cynomolgus Macaques ( < em > Macaca fascicularis < /em > ) for Plethysmography
Comp Med. 2024 Mar 21. doi: 10.30802/AALAS-CM-23-000069. Online ahead of print.ABSTRACTPlethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques. An obstacle to the use of AM is the volume required to anesthetize via intramuscular injection. A more concentrated formulation of alfaxalone w...
Source: Comparative Medicine - March 21, 2024 Category: Zoology Authors: Robert J Edwards Jeanean M Ghering Ondraya M Frick Kirby S Pasloske Kacee H Santos Summer M Astleford Charles E White Brianna M Marion Source Type: research
Comparison of Two Different Alfaxalone Concentrations Combined with Midazolam to Anesthetize Cynomolgus Macaques ( < em > Macaca fascicularis < /em > ) for Plethysmography
Comp Med. 2024 Mar 21. doi: 10.30802/AALAS-CM-23-000069. Online ahead of print.ABSTRACTPlethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques. An obstacle to the use of AM is the volume required to anesthetize via intramuscular injection. A more concentrated formulation of alfaxalone w...
Source: Comparative Medicine - March 21, 2024 Category: Zoology Authors: Robert J Edwards Jeanean M Ghering Ondraya M Frick Kirby S Pasloske Kacee H Santos Summer M Astleford Charles E White Brianna M Marion Source Type: research
Methods for Decreasing Preweaning Mortality in a Fragile Mouse Model of Hypomorphic Collagen VII Deficiency
In this study, standard husbandry practices were enhanced by the addition of a softened diet, a nutritionally fortified dietary supplement, soft bedding, gentle handling techniques, decreased handling, lengthened weaning age, and dam productivity tracking. This alternative care plan was shown to increase the survival of a fragile recessive dystrophic epidermolysis bullosa mouse model, and some aspects could be used in developing a care plan for other fragile mouse strains.PMID:38508685 | DOI:10.30802/AALAS-CM-23-000087 (Source: Comparative Medicine)
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Chloe L Strege William C Miller Cindy Eide Jennifer Hubbard Jakub Tolar Source Type: research
Perioperative Evaluation of Arterial and Venous Whole Blood in the Lamb ( < em > Ovis aries < /em > ) Fontan Model
Comp Med. 2024 Mar 20. doi: 10.30802/AALAS-CM-24-000008. Online ahead of print.ABSTRACTWhole blood analysis can evaluate numerous parameters, including pH, pCO₂, pO₂, HCO₃-, base excess, glucose, electrolytes, lactate, blood urea nitrogen, creatinine, bilirubin, and hemoglobin. This valuable tool enables clinicians to make more informed decisions about patient care. However, the current body of literature describing perioperative whole blood analysis in Dorset sheep (Ovis aries) is small, so clinicians lack adequate information to guide their decision-making when evaluating test results. We evaluated arterial and ven...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: William E Schwartzman Jingru Che Mark A Naguib Jack Palillo Michael Jimenez Mackenzie E Turner Andrew R Yates Carmen Arsuaga-Zorrilla Christopher Breuer John Kelly Source Type: research
Abnormal Feather Phenotype Associated with a Fatal Stress Response and Unusual Tolerance to Human Contact in the Zebra Finch ( < em > Taeniopygia castanotis < /em > )
In this report, we describe a set of partially overlapping traits shared by 3 birds in 2 broods from the same nest box that included atypical morphologic, developmental, and behavioral characteristics. The most obvious feature of this novel phenotype was feathers exhibiting a clumped appearance, which was accompanied by slow growth, delayed expression of adult plumage traits, and tameness, which we define as a lack of escape response upon handling without behavioral indicators of stress such as rapid breathing. Surprisingly, these birds also displayed a fatal response to nonhuman stressors. In one brood, a male expressed a...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Lucas R West Lainy B Day Source Type: research
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice
Comp Med. 2024 Mar 20. doi: 10.30802/AALAS-CM-23-000065. Online ahead of print.ABSTRACTDisturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclear. In pairs of human twins discordant for IBD, the healthy twin has a higher risk of developing IBD and a gut microbiota that is more similar to that of IBD patients as compared with healthy individuals. Furthermore, appropriate medical treatment may mitigate these disturbances. To study the correlation...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Lina A Knudsen Zachariassen Line Sf Mikael L Strube Jesper F Havelund Bartosz Pilecki Anders B Nexoe Frederik T Moller Signe B S ørensen Niels Marcussen Nils J F ærgeman Andre Franke Corinna Bang Uffe Holmskov Axel K Hansen Vibeke Andersen Source Type: research
Methods for Decreasing Preweaning Mortality in a Fragile Mouse Model of Hypomorphic Collagen VII Deficiency
In this study, standard husbandry practices were enhanced by the addition of a softened diet, a nutritionally fortified dietary supplement, soft bedding, gentle handling techniques, decreased handling, lengthened weaning age, and dam productivity tracking. This alternative care plan was shown to increase the survival of a fragile recessive dystrophic epidermolysis bullosa mouse model, and some aspects could be used in developing a care plan for other fragile mouse strains.PMID:38508685 | DOI:10.30802/AALAS-CM-23-000087 (Source: Comparative Medicine)
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Chloe L Strege William C Miller Cindy Eide Jennifer Hubbard Jakub Tolar Source Type: research
Perioperative Evaluation of Arterial and Venous Whole Blood in the Lamb ( < em > Ovis aries < /em > ) Fontan Model
Comp Med. 2024 Mar 20. doi: 10.30802/AALAS-CM-24-000008. Online ahead of print.ABSTRACTWhole blood analysis can evaluate numerous parameters, including pH, pCO₂, pO₂, HCO₃-, base excess, glucose, electrolytes, lactate, blood urea nitrogen, creatinine, bilirubin, and hemoglobin. This valuable tool enables clinicians to make more informed decisions about patient care. However, the current body of literature describing perioperative whole blood analysis in Dorset sheep (Ovis aries) is small, so clinicians lack adequate information to guide their decision-making when evaluating test results. We evaluated arterial and ven...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: William E Schwartzman Jingru Che Mark A Naguib Jack Palillo Michael Jimenez Mackenzie E Turner Andrew R Yates Carmen Arsuaga-Zorrilla Christopher Breuer John Kelly Source Type: research
Abnormal Feather Phenotype Associated with a Fatal Stress Response and Unusual Tolerance to Human Contact in the Zebra Finch ( < em > Taeniopygia castanotis < /em > )
In this report, we describe a set of partially overlapping traits shared by 3 birds in 2 broods from the same nest box that included atypical morphologic, developmental, and behavioral characteristics. The most obvious feature of this novel phenotype was feathers exhibiting a clumped appearance, which was accompanied by slow growth, delayed expression of adult plumage traits, and tameness, which we define as a lack of escape response upon handling without behavioral indicators of stress such as rapid breathing. Surprisingly, these birds also displayed a fatal response to nonhuman stressors. In one brood, a male expressed a...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Lucas R West Lainy B Day Source Type: research
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice
Comp Med. 2024 Mar 20. doi: 10.30802/AALAS-CM-23-000065. Online ahead of print.ABSTRACTDisturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclear. In pairs of human twins discordant for IBD, the healthy twin has a higher risk of developing IBD and a gut microbiota that is more similar to that of IBD patients as compared with healthy individuals. Furthermore, appropriate medical treatment may mitigate these disturbances. To study the correlation...
Source: Comparative Medicine - March 20, 2024 Category: Zoology Authors: Lina A Knudsen Zachariassen Line Sf Mikael L Strube Jesper F Havelund Bartosz Pilecki Anders B Nexoe Frederik T Moller Signe B S ørensen Niels Marcussen Nils J F ærgeman Andre Franke Corinna Bang Uffe Holmskov Axel K Hansen Vibeke Andersen Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
The Use of Rabbits Used to Propagate Human Lice for Research
Comp Med. 2024 Mar 7. doi: 10.30802/AALAS-CM-23-000073. Online ahead of print.ABSTRACTThe globally important human diseases of trench fever, epidemic typhus, and relapsing fever are vectored by the human louse Pediculus humanus humanus. Although these conditions are epidemically quiescent at present, they persist in socially dysfunctional situations of war, deprivation, and crowding. The taxonomically closely related head louse, Pediculus humanus capitis, does not respect economic or social status and is quite common in most countries. The 2 types of lice are now recognized as conspecific ecotypes of a single species. Whil...
Source: Comparative Medicine - March 7, 2024 Category: Zoology Authors: Steven H Weisbroth Source Type: research
