Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos

Comp Med. 2023 Aug 3. doi: 10.30802/AALAS-CM-22-000123. Online ahead of print.ABSTRACTRisperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goalof the current study was to examine the effects of risperidone in zebrafish embryos (Danio rerio) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.PMID:37536933 | DOI:10.30802/AALAS-CM-22-000123
Source: Comparative Medicine - Category: Zoology Authors: Source Type: research