Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix

In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reactionand support its use as a potential biomaterial for mitigating fibrosis after MI. Delaying the progression of cardiac tissueremodeling may widen the therapeutic window for management of scarring after MI.PMID:37527924 | DOI:10.30802/AALAS-CM-22-000097
Source: Comparative Medicine - Category: Zoology Authors: Source Type: research