The Role of Ivabradine in Managing Symptomatic Patients with Chronic Coronary Syndromes: A Clinically Oriented Approach
We present two clinical cases of patients with symptomatic CCS in whom HR control with ivabradine was fundamental for symptom control and improvement in left ventricular (LV) function. An earlier combination of ivabradine p lus β-blockers would have provided more rapid symptom control and improved LV function in the first case. In the second case, the primary mechanism responsible for angina was most likely a coronary vasomotor abnormality, in which the use of β-blockers aggravated the discomfort. The combination of a dihydropyridine CCB plus ivabradine was highly influential in symptom control. Due to its effects beyond...
Source: Cardiology and Therapy - December 3, 2021 Category: Cardiology Source Type: research
The Effect of Dapagliflozin on Platelet Function Testing Profiles in Diabetic Patients: The EDGE Pilot Study
ConclusionsSignificantly diminished platelet reactivity was observed on dapagliflozin as compared to without dapagliflozin. This dedicated pharmacodynamic study could be potentially informative and applicable for Trinidadian stable CAD patients with T2DM on DAPT. Further studies are required to confirm these exploratory findings.Clinical Trial RegistrationEDGE ClinicalTrials.gov number NCT04400760. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 13, 2021 Category: Cardiology Source Type: research
Performance Evaluation of the Quantitative Point-of-Care LumiraDx d-Dimer Test
ConclusionsThe quantitative LumiraDxd-Dimer Test is easy to use and can accurately measured-dimer levels in a range of blood sample types, including fingerstick samples, which could improve assessment of VTE cases in community and hospital near-patient settings. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 7, 2021 Category: Cardiology Source Type: research
Real-world Evidence for Adherence and Persistence with Atorvastatin Therapy
AbstractAtorvastatin, which has been approved by regulatory agencies for primary- and secondary-prevention patients with dyslipidemia, has historically been the most commonly prescribed statin and is now widely available in generic formulations. Despite widespread statin usage, many patients fail to attain recommended (LDL-C) targets. While several factors impact the successful treatment of dyslipidemia, suboptimal patient adherence is a major limiting factor to medication effectiveness. In this narrative review we sought to investigate patient adherence and persistence with atorvastatin in a real-world setting and to iden...
Source: Cardiology and Therapy - September 29, 2021 Category: Cardiology Source Type: research
Effect of Amlodipine in Stroke and Myocardial infarction: A Systematic Review and Meta-analysis
ConclusionIn the pooled analysis of data from 12 randomised controlled trials and one double-blinded cohort study measuring the effect of CCBs, we found that the CCB amlodipine reduced the risk of stroke and MI in hypertensive patients. Superior results for amlodipine were found in ten of the 13 studies included in this meta-analysis. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 4, 2021 Category: Cardiology Source Type: research
Temporal Trends and Outcomes of Elective Thoracic Aortic Repair and Acute Aortic Syndromes in Bicuspid Aortic Valves: Insights from a National Database
ConclusionData from a national database showed no change in the number of hospitalizations for BAV-related aortopathy, with relatively lower incidence of AAS. Compared with TAV, elective aortic repair for BAV is associated with lower mortality, while BAV-related AAS is associated with higher in-hospital complications. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 24, 2021 Category: Cardiology Source Type: research
Chloride in Heart Failure Syndrome: Its Pathophysiologic Role and Therapeutic Implication
AbstractUntil recently, most studies of heart failure (HF) focused on body fluid dynamics through control of the sodium and water balance in the body. Chloride has remained largely ignored in the medical literature, and in clinical practice, chloride is generally considered as an afterthought to the better-known electrolytes of sodium and potassium. In recent years, however, the important role of chloride in the distribution of body fluid has emerged in the field of HF pathophysiology. Investigation of HF pathophysiology according to the dynamics of serum chloride is rational considering that chloride is an established key...
Source: Cardiology and Therapy - August 14, 2021 Category: Cardiology Source Type: research
Hospitalization for Myocardial Infarction with Ticagrelor or Clopidogrel in Patients with Acute Coronary Syndrome: An On-Treatment Comparative Effectiveness Analysis
ConclusionsIn this real-world on-treatment analysis, hospitalization for MI was significantly lower with ticagrelor compared to clopidogrel, with similar rates of hospitalization for major bleeding. Study findings underscore the importance of being on the appropriate guideline-recommended therapy and support the use of ticagrelor over clopidogrel. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 13, 2021 Category: Cardiology Source Type: research
Correction to: Preoperative, Multidisciplinary Clinical Optimization of Patients with Severely Depressed Left Ventricular Ejection Fraction Who Are Undergoing Coronary Artery Bypass Grafting
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 22, 2021 Category: Cardiology Source Type: research
Gender Disparities in Cardiology-Related COVID-19 Publications
ConclusionsFemale authorship has continued to lag male authorship for the duration of the ongoing COVID-19 pandemic. The pandemic may have impeded progress in reducing gender disparities in academic cardiology publications. The low proportions of first and senior female authors may reflect the impact of the pandemic on women in cardiology in leadership domains. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 15, 2021 Category: Cardiology Source Type: research
Aprocitentan, A Dual Endothelin Receptor Antagonist Under Development for the Treatment of Resistant Hypertension
In conclusion, aprocitentan ameliorates the effects of ET-1 and could potentially reduce BP and provide broader cardiovascular protection in patients with resistant hypertension. Available data support the hypothesis that this new agent could expand our antihypertensive arsenal in resistant hypert ension, making aprocitentan an attractive candidate for further large-scale trials. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 12, 2021 Category: Cardiology Source Type: research
Cardiac Complications in Pregnancy: A Systematic Review and Meta-Analysis of Diagnostic Accuracy of BNP and N-Terminal Pro-BNP
ConclusionOur results suggest that both BNP and NT-proBNP levels can be used as diagnostic tools among pregnant and newly-delivered women to diagnose cardiac complications, including heart failure and pre-eclampsia. While BNP showed a relatively better diagnostic accuracy compared to NT-proBNP, it must be noted that the number of studies evaluating NT-proBNP included in this meta-analysis was low and the studies were inconsistent in terms of cutoff value. Further studies are required to confirm the prospective use of BNP and NT-pro BNP in assessing common symptoms that indicate cardiac complications during labor. Moreover,...
Source: Cardiology and Therapy - July 2, 2021 Category: Cardiology Source Type: research
Cardiovascular Involvement in COVID-19: What Sequelae Should We Expect?
AbstractSeveral forms of cardiovascular involvement have been described in patients with Coronavirus disease 19 (COVID-19): myocardial injury, acute coronary syndrome, acute heart failure, myocarditis, pericardial diseases, arrhythmias, takotsubo syndrome, and arterial and venous atherothrombotic and thromboembolic events. Data on long-term outcome of these patients are still sparse, and the type and real incidence of cardiovascular sequelae are poorly known. It is plausible that myocardial injury may be the initiator of an inflammatory cascade, edema, and subsequent fibrosis, but also a consequence of systemic inflammatio...
Source: Cardiology and Therapy - June 30, 2021 Category: Cardiology Source Type: research
Ischemic Stroke and Sleep: The Linking Genetic Factors
AbstractThis review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38 –46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of n eurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to ...
Source: Cardiology and Therapy - June 30, 2021 Category: Cardiology Source Type: research
Thrombosis Prevention and Anticoagulation Management in the Pediatric Patient with Congenital Heart Disease
AbstractThrombosis is one of the most frequent complications affecting children with congenital heart disease (CHD). Palliative and reparative cardiac surgeries are some of the main players contributing to the thrombosis risk in this patient population. Additional risk factors related to the CHD itself (e.g., cardiac dysfunction, arrhythmias, and polycythemia in cyanotic cardiac disorders) can contribute to thrombogenicity alone or combined with other factors. Thrombotic complications have been recognized as a significant cause of morbidity and mortality in this patient population. Here, we provide an overview of the patho...
Source: Cardiology and Therapy - June 29, 2021 Category: Cardiology Source Type: research
