Leadless Cardiac Pacing: New Horizons
AbstractSince the introduction of transvenous cardiac pacing leads, pacemaker system design has remained similar for several decades. Progressive miniaturisation of electronic circuitry and batteries has enabled a smaller, single pacing unit comprising the intracardiac electrodes, generator and computer. This review explores the development of leadless pacing, the clinical trials comparing leadless to transvenous pacing in addition to the future developments of multi-chamber leadless pacing. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 22, 2022 Category: Cardiology Source Type: research
Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis
ConclusionMelatonin supplementation may be useful in reducing cardiac injury and inflammatory biomarkers in CABG candidates. Future studies should investigate the clinical significance of these findings. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 9, 2022 Category: Cardiology Source Type: research
Phenotyping and Hemodynamic Assessment in Cardiogenic Shock: From Physiology to Clinical Application
AbstractThere is growing interest in invasive hemodynamic assessment in cardiogenic shock, primarily due to the widespread adoption of mechanical circulatory support (MCS). Invasive hemodynamic assessment is central to two aspects of cardiogenic shock management: (1) the phenotyping of cardiogenic shock, and (2) the assessment of response to therapy. Phenotyping of cardiogenic shock serves to guide timely therapeutic intervention, and the assessment of hemodynamic response to therapy directs the escalation or de-escalation of therapy, including MCS. This review aims to discuss these two aspects of hemodynamic assessment in...
Source: Cardiology and Therapy - November 5, 2022 Category: Cardiology Source Type: research
Epidemiological Study Regarding the Incidence of Venous Thromboembolism in Patients After Cancer Remission
ConclusionRisk of developing VTE decreased to the same level as that in patients without cancer 2 years after cancer remission. Although the guidelines do not specify the duration of anticoagulant prophylaxis for new onset or recurrent VTE after cancer remission and the appropriate duration of such prophylaxis may vary depending on VTE risk factors, determining the period of high risk of VTE f or each patient and preventing VTE is considered important. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 1, 2022 Category: Cardiology Source Type: research
Epidemiology and Treatment Patterns of Venous Thromboembolism: an Observational Study of Nationwide Time-Series Trends in Japan
ConclusionWhile the gradual increase in VTE outpatient treatment appears to be in line with guideline recommendations, PE outpatient treatment could be further facilitated. The large proportion of patients diagnosed with VTE during hospitalization for other conditions suggests the importance of further utilizing in-hospital manuals for thrombosis prevention. The presence or absence of cancer did not appear to affect the basic treatment strategy of anticoagulation for VTE. Future studies are expected to better define the characteristics of patients who can be safely and effectively treated in an outpatient setting, and to e...
Source: Cardiology and Therapy - November 1, 2022 Category: Cardiology Source Type: research
Contemporary Therapies and Future Directions in the Management of Hypertrophic Cardiomyopathy
AbstractHypertrophic cardiomyopathy (HCM) is a genetic disorder caused by pathogenic variants in sarcomeric genes, leading to left ventricular hypertrophy and complex phenotypic heterogeneity. While HCM is the most common inherited cardiomyopathy, pharmacological treatment options have previously been limited and were predominantly directed towards symptom control owing to left ventricular outflow obstruction. These therapies, including beta blockers, calcium channel blockers, and disopyramide, have not been shown to affect the natural history of the disease, which is of particular concern for younger patients who have an ...
Source: Cardiology and Therapy - October 15, 2022 Category: Cardiology Source Type: research
Long-Term Association between Intensive Medical Treatment and the Incidence of Cardiovascular Outcomes in Patients with Dyslipidemia: an Observational Study
ConclusionsA reduced hazard of AMI was observed in patients who complete a greater number of medical appointments and receive multidisciplinary treatment on a regular basis. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 12, 2022 Category: Cardiology Source Type: research
The Barriers to Rapid Reperfusion in Acute ST-Elevation Myocardial Infarction
ConclusionWe found several targets for system improvements in order to mitigate reperfusion delays along the entire chain of care, regardless of reperfusion modality chosen. More patients should receive prehospital thrombolysis. The most important measures will be training to ensure a more efficient on-site workflow, improved protocols and infrastructure facilitating the communication between first responders and in-hospital clinicians, and education emphasizing prehospital transport times.Clinical Trials IdentifierNCT04614805. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 6, 2022 Category: Cardiology Source Type: research
Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study
ConclusionAlso in a countryside area, the aortic pulse wave velocity is higher in subjects with hypertension, hyperlipidemia, diabetes and obesity, and significantly increases with age. Furthermore, with advancing age, aortic pulse wave velocity is higher in women than men.Trial RegistrationClinicalTrials.gov identifier, NCT02282748. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 24, 2022 Category: Cardiology Source Type: research
Comparison of Two Different Rota-Flush Solutions in Patients Undergoing Rotational Atherectomy: A Randomized, Controlled, Triple-Blind Trial
ConclusionsThe findings suggest that although continuous intracoronary infusion of heparin rota-flush solution does not increase the incidence of slow flow/no-reflow, traditional rota-flush solution without RotaGlide prevents coronary spasm more effectively compared to the heparin rota-flush without significant impact on severe hypotension. These results do not support a strategy of routine use of heparin rota-flush solution in patients receiving RA procedures. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 21, 2022 Category: Cardiology Source Type: research
Utility of Follow-Up Echocardiograms in Uncomplicated PDA Device Closures Performed During Infancy
ConclusionIn patients who underwent an uncomplicated PDA closure during infancy, TTE parameters either stayed stable or improved over time. These findings need to be corroborated in larger studies with longer follow-up. If verified, the long-term TTE guidelines may need to be simplified for this patient population. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 8, 2022 Category: Cardiology Source Type: research
The Egyptian Association of Vascular Biology and Atherosclerosis (EAVA) Perspectives on the Usage of Inclisiran
ConclusionThe Egyptian Association for Vascular Biology and Atherosclerosis (EAVA) analyzed the data necessary for obtaining clear indications for the usage of inclisiran. We propose the addition of inclisiran to statins with or without ezetimibe for patients with documented atherosclerotic cardiovascular disease (ASCVD) or similar risk, familial hypercholesterolemia (FH) with another major risk factor, and very high and high risk diabetes mellitus, who did not reach LDL-c goals and/or with true statin intolerance. Inclisiran is also recommended as upfront therapy, with triple combination, in extreme risk subjects such as ...
Source: Cardiology and Therapy - September 2, 2022 Category: Cardiology Source Type: research
Therapeutic Usefulness of a Novel Calcium Channel Blocker Azelnidipine in the Treatment of Hypertension: A Narrative Review
AbstractThe prevalence of hypertension and comorbidities such as metabolic syndrome, diabetes mellitus, and chronic kidney disease in India is alarmingly high. Amlodipine, an older-generation calcium channel blocker (CCB), is currently the gold standard for hypertension management in India. However, it has several disadvantages, including reflex tachycardia and pedal edema. Therefore, an effective antihypertensive agent that does not cause these adverse effects and provides end-organ protection is required for the holistic management of hypertension in the country. Azelnidipine is a new-generation CCB that has recently bee...
Source: Cardiology and Therapy - August 13, 2022 Category: Cardiology Source Type: research
Renal Denervation for Resistant Hypertension: A Concise Update on Treatment Options and the Latest Clinical Evidence
AbstractEvidence from recent sham-controlled trials supports the use of endovascular renal denervation (RDN) to lower blood pressure in general as well as in treatment-resistant hypertension. According to recent studies, the effects of RDN are long lasting. Newer technologies using multipolar radiofrequency catheters and an additional ablation of the renal side branches as well as ultrasound with improved circumferential tissue penetration have made these advances possible. This has initiated a change of the perspective on RDN in clinical guidelines and has thereby set a cornerstone for a broader clinical application of RD...
Source: Cardiology and Therapy - August 9, 2022 Category: Cardiology Source Type: research
Evolving Presentation of Cardiogenic Shock: A Review of the Medical Literature and Current Practices
AbstractCardiogenic shock (CS) remains a leading cause of morbidity and mortality among patients with cardiovascular disease. In the past, acute myocardial infarction was the leading cause of CS. However, in recent years, other etiologies, such as decompensated chronic heart failure, arrhythmia, valvular disease, and post-cardiotomy, each with distinct hemodynamic profiles, have risen in prevalence. The number of treatment options, particularly with regard to device-mediated therapy has also increased. In this review, we sought to survey the medical literature and provide an update on current practices. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 7, 2022 Category: Cardiology Source Type: research
