Outcomes with Orbital and Rotational Atherectomy for Inpatient Percutaneous Coronary Intervention
ConclusionRA remains the predominant atherectomy modality for inpatient PCI in the United States (93%). There was no change in the trend of use for either modality over the years 2016 and 2017. OA was noted to have a lower incidence of in-hospital death, but a higher risk of coronary perforation and a higher cost of index hospitalization for the overall unmatched cohorts. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 12, 2021 Category: Cardiology Source Type: research
Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review
AbstractPurpose of ReviewChronic venous insufficiency is found to some extent in a large proportion of the world ’s population, especially in the elderly and obese. Despite its prevalence, little research has been pursued into this pathology when compared to similarly common conditions. Pain is often the presenting symptom of chronic venous insufficiency and has significant deleterious effects on quality of life. This manuscript will describe the development of pain in chronic venous insufficiency, and will also review both traditional methods of pain management and novel advances in both medical and surgical therapy for...
Source: Cardiology and Therapy - March 11, 2021 Category: Cardiology Source Type: research
Wilderness Cardiology: A Case of Envenomation-Associated Cardiotoxicity Following a Rattlesnake Bite
We present the case of a 62-year-old male with shortness of breath, right lower extremity edema, and elevated cardiac troponin 6 days after a Northern Pacific rattlesnake bite. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 23, 2021 Category: Cardiology Source Type: research
Disease Management and Outcomes in Patients Hospitalized for Acute Heart Failure in Japan
ConclusionsContemporary treatment for AHF hospitalization in Japan comprises a long duration of IV therapy followed by extended use of oral medications and in-hospital cardiac rehabilitation prior to discharge. Patients requiring intensified therapies had much longer LOS and higher in-hospital mortality. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 20, 2021 Category: Cardiology Source Type: research
Correlation Between the 6-Min Walk Test and Exercise Tolerance Test in Cardiac Rehabilitation After Coronary Artery Bypass Grafting: A Cross-sectional Study
ConclusionsThe results from this study suggest that the 6MWT is a valid tool for assessing functional capacity for prescribing exercise in a group of postoperative CABG participants admitted to CR units. This finding is helpful for healthcare professionals and for patients, as the test is easy to administer and also well tolerated by patients.Trial Registration NumberPHT-9923. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 13, 2021 Category: Cardiology Source Type: research
Coronary Artery Bypass: Review of Surgical Techniques and Impact on Long-Term Revascularization Outcomes
AbstractCoronary revascularization for multivessel disease remains a common and costly source of hospitalizations in the United States. Surgical techniques influence outcomes for coronary bypass and also affect the need for percutaneous coronary intervention in the future. As more radial access has been used for coronary angiography, consideration for use of the radial artery as a surgical conduit remains unclear. Saphenous vein grafts are commonly used for coronary bypass, however long-term patency remains suboptimal, and is also associated with a higher risk of adverse events with percutaneous coronary intervention. Thus...
Source: Cardiology and Therapy - January 30, 2021 Category: Cardiology Source Type: research
Exercise as Potential Therapeutic Target to Modulate Alzheimer ’s Disease Pathology in APOE ε4 Carriers: A Systematic Review
AbstractAlzheimer ’s disease (AD) is a progressive neurodegenerative disease for which no effective treatment exists at present. Previous research has found that exercise reduces the risk of AD. Since the apolipoprotein E (APOE) ε4 allele increases the risk of AD and is associated with faster disease progression t han the other isoforms, we aimed to highlight the impact of exercise on AD pathology in APOE ε4 carriers. This review focuses on the effect of exercise on cognitive function, dementia risk, amyloid-β (Aβ) metabolism, lipid metabolism, neuroinflammation, neurotrophic factors and vascularization in APOE ε4 c...
Source: Cardiology and Therapy - January 5, 2021 Category: Cardiology Source Type: research
Preoperative, Multidisciplinary Clinical Optimization of Patients with Severely Depressed Left Ventricular Ejection Fraction Who Are Undergoing Coronary Artery Bypass Grafting
AbstractCoronary artery bypass grafting (CABG) remains a routine operation despite major advancements in angioplastic procedures. Around 200,000 CABG procedures are performed annually in the U.S. Patients who are not candidates for angioplasty intervention often have advanced coronary disease and comorbidities that raise the risk of heart failure with decreased ejection fraction to around 25%. Over the years, significant developments in various preoperative interventions have occurred; in this paper, we suggest a multidisciplinary preoperative algorithm that can be included in a regularly scheduled multidisciplinary care p...
Source: Cardiology and Therapy - December 23, 2020 Category: Cardiology Source Type: research
Estimating the Gender Distribution of Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis
ConclusionsStudies conducted to date suggest ATTRwt disproportionally affects males. The proportion of males was significantly impacted by the age at diagnosis and method diagnosis, which may suggest important gender-based differences in the clinical manifestation and diagnostic challenges of ATTRwt in females that warrant future research. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 14, 2020 Category: Cardiology Source Type: research
The Effect of Empagliflozin on Platelet Function Profiles in Patients with Stable Coronary Artery Disease in Trinidad: The EFFECT Pilot Study
ConclusionsSignificantly attenuated platelet reactivity was observed on empagliflozin as compared to without empagliflozin. This dedicated pharmacodynamic study could be clinically pertinent for Trinidadian patients with stable CAD and T2DM on DAPT. Further studies are required to confirm these exploratory findings. (Funded by the University of the West Indies, St. Augustine; EFFECT).Clinical Trial RegistrationClinicalTrials.gov number NCT04342819. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 11, 2020 Category: Cardiology Source Type: research
Impact of Coronary Stent Architecture on Clinical Outcomes: Do Minor Changes in Stent Architecture Really Matter?
ConclusionsModifications in coronary stent architecture which enhance the radial strength and radiopacity without gross changes in strut thickness and design do not seem to impact clinical outcomes.Clinical Trial RegistrationClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 4, 2020 Category: Cardiology Source Type: research
Point-of-Care Testing for D-Dimer in the Diagnosis of Venous Thromboembolism in Primary Care: A Narrative Review
AbstractVenous thromboembolism (VTE) is regarded as a significant cause of mortality and disability, affecting 1 –2 per 1000 people annually, presenting with a relatively wide range of symptoms, which can pose a diagnostic challenge. Historically, people in whom VTE is suspected will have been taken to hospital for diagnosis and treatment; however, a high proportion of patients are found not to have VTE. Con cerns have been expressed about potential delays in treatment, with the risk of additional morbidity and disability, and death. Diagnostic strategies are typically based on the use of a clinical prediction rule to de...
Source: Cardiology and Therapy - December 2, 2020 Category: Cardiology Source Type: research
Safety and Effectiveness of Hydroxychloroquine and Azithromycin Combination Therapy for Treatment of Hospitalized Patients with COVID-19: A Propensity-Matched Study
ConclusionIn this propensity-matched study, there was no difference in in-hospital mortality, life-threatening arrhythmias, or incidence of PEA arrest between the HCQ-AZM and untreated control groups. QTc intervals were longer in patients receiving HCQ-AZM, but only one patient developed drug-related ventricular tachycardia. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 14, 2020 Category: Cardiology Source Type: research
Efficacy and Safety of Ivabradine Once-Daily Prolonged-Release versus Twice-Daily Immediate-Release Formulation in Patients with Stable Chronic Heart Failure with Systolic Dysfunction: A Randomized, Double-Blind, Phase 3 Non-Inferiority (PROFICIENT) Study
ConclusionIvabradine PR was found to be non-inferior to ivabradine IR in the management of patients with stable CHF, with a comparable safety profile. Once-daily ivabradine PR effectively maintained the HR in patients shifted from the ivabradine IR twice-daily regimen, and thus may aid in improving treatment compliance.Trial RegistrationCTRI/2018/04/013464 (Trial Registered Prospectively on 24/04/2018) (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 30, 2020 Category: Cardiology Source Type: research
Expansion of TAVR into Low-Risk Patients and Who to Consider for SAVR
AbstractTranscatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis (AS) over the last decade. The results of the Placement of Aortic Transcatheter Valves (PARTNER) 3 and Evolut Low Risk trials demonstrated the safety and efficacy of TAVR in low-surgical-risk patients and led to the approval of TAVR for use across the risk spectrum. Heart teams around the world will now be faced with evaluating a deluge of younger, healthier patients with severe AS. Prior to the PARTNER 3 and Evolut Low Risk studies, this heterogenous patient population would have undergone surgical aortic valve...
Source: Cardiology and Therapy - August 31, 2020 Category: Cardiology Source Type: research
