Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study
ConclusionsThe results of this interim analysis suggest that idarucizumab is safe and effective for the reversal of dabigatran in Japanese patients in a real-world setting, and support the continued use of idarucizumab.Trial RegistrationClinicalTrials.gov identifier, NCT02946931. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 8, 2020 Category: Cardiology Source Type: research
Cardiology and Therapy: A Summary of 2019 and Key Areas of Emerging Research in 2020
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 5, 2020 Category: Cardiology Source Type: research
Emergency Department Visits and Subsequent Hospital Admission Trends for Patients with Chest Pain and a History of Coronary Artery Disease
ConclusionED visits and subsequent inpatient admissions resulting from CAD decreased from 2006 to 2013. Patients with CP had a substantially higher number of ED visits, with a significant decline in inpatient admissions. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 1, 2020 Category: Cardiology Source Type: research
Update on Transcatheter Aortic Valve Replacement
AbstractTranscatheter aortic valve replacement (TAVR) is a minimally invasive approach to treat symptomatic severe aortic stenosis. The patient populations that have been shown to benefit from this procedure continue to grow with time. Techniques and technology in TAVR persistently advance with a continued trend toward improved outcomes for patients. In this review, we highlight the advances in vascular access, TAVR valve design, progress in reducing procedural complications, and emerging evidence in the field. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 27, 2020 Category: Cardiology Source Type: research
What Lessons Have We Learned and What Remains to be Clarified for PCSK9 Inhibitors? A Review of FOURIER and ODYSSEY Outcomes Trials
AbstractFor more than half a century, low-density lipoprotein cholesterol (LDL-C) has been recognized as a major risk factor for incident atherosclerotic cardiovascular disease. The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003, which prevents LDL-C receptor recycling, identified a new target for drug intervention. Re cently, two large-scale randomized clinical outcomes trials involving fully human anti-PCSK9 monoclonal antibodies tested the hypothesis that targeting this pathway would reduce cardiovascular events. Both the FOURIER (Further cardiovascular OUtcomes Research with PCSK9 Inhibiti...
Source: Cardiology and Therapy - February 4, 2020 Category: Cardiology Source Type: research
Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
ConclusionsIn subjects with uncontrolled BP on existing antihypertensive therapy, switching to perindopril arginine 10 mg/indapamide 2.5 mg was associated with statistically significant decreases in BP and higher rates of target BP achievement in all BMI groups, including more than 70% of overweight and obese patients.Trial RegistrationISRCTN ID, ISRCTN14315146 (retrospectively registered 18/11/2019). (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 31, 2020 Category: Cardiology Source Type: research
The Beneficial Effects of Cardiac Rehabilitation
AbstractCardiac rehabilitation (CR) is a combined range of measures aimed at providing patients with cardiovascular disease with the optimum psychological and physical conditions so that they themselves can prevent their disease from progressing or potentially reversing its course. The following measures are the three main parts of CR: exercise training, lifestyle modification, and psychological intervention. The course of cardiac rehabilitation generally takes 3 –4 weeks. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 28, 2020 Category: Cardiology Source Type: research
Relationship between Invasive and Echocardiographic Transvalvular Gradients after Transcatheter Aortic Valve Replacement
ConclusionsBalloon-expandable valves were associated with lower invasive measurements versus post-TAVR Doppler gradients, while results were inconclusive regarding self-expanding valves. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 21, 2020 Category: Cardiology Source Type: research
Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland
ConclusionsSurvey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 19, 2020 Category: Cardiology Source Type: research
Facing the Challenge of Lowering Blood Pressure and Cholesterol in the Same Patient: Report of a Symposium at the European Society of Hypertension
AbstractA symposium held at the 29th European Meeting on Hypertension and Cardiovascular Protection in Milan, Italy, discussed the potential impact and long-term benefits of early active management of cardiovascular disease (CVD) risk in patients with hypertension, and potential barriers to this strategy. Hypertension often aggregates with other cardiovascular risk factors, exponentially increasing morbidity and mortality. While effective therapies to treat hypertension exist, a substantial number of patients still experience major cardiovascular events. Two major issues account for these disappointing results: interventio...
Source: Cardiology and Therapy - January 12, 2020 Category: Cardiology Source Type: research
Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives
ConclusionsPulmonary vein isolation is the treatment of choice for symptomatic patients with paroxysmal and persistent drug-refractory AF. The reconnection of previously isolated pulmonary veins remains the major cause of AF recurrence. Novel ablation tools, such as balloon technologies or alternative energy sources, might help to overcome this limitation. Patients with non-paroxysmal AF and with AF recurrence might benefit from alternative ablation strategies. However, further studies are warranted to further improve our knowledge of the underlying mechanisms of AF and to obtain long-term clinical outcomes on new ablation...
Source: Cardiology and Therapy - January 1, 2020 Category: Cardiology Source Type: research
Mitraclip Plus Medical Therapy Versus Medical Therapy Alone for Functional Mitral Regurgitation: A Meta-Analysis
ConclusionsMitraClip plus medical therapy improves overall mortality and reduces HF re-hospitalization rates compared to medical therapy alone in patients with FMR. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 8, 2019 Category: Cardiology Source Type: research
Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study
ConclusionsThe findings suggested that small or modest doses of methadone could exert dose-dependent effects on cardiac repolarization in cancer patients.Trial RegistrationUMIN Clinical Trials Registry, UMIN000034519. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 19, 2019 Category: Cardiology Source Type: research
Comparative Outcomes of Transapical Versus Transfemoral Access for Transcatheter Aortic Valve Replacement in Diabetics
ConclusionsThis observational analysis showed no difference in-hospital mortality between TF-TAVR and TA-TAVR among diabetic patients. Studies exploring the optimal access for TAVR among diabetics are recommended. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 10, 2019 Category: Cardiology Source Type: research
Comparison of Cardiac Repolarization After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement: A Longitudinal Study
ConclusionsQTD and QTcD immediately decreased after TAVI as compared to SAVR. Our findings indicate that TAVI more rapidly improved dispersion of spatial repolarization than SAVR. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 5, 2019 Category: Cardiology Source Type: research
