Idarucizumab for Emergency Reversal of the Anticoagulant Effects of Dabigatran: Final Results of a Japanese Postmarketing Surveillance Study
ConclusionsThe final analysis from the PMS study confirms previous findings suggesting that idarucizumab can safely and effectively reverse the anticoagulant effects of dabigatran in Japanese patients in clinical practice. The results support the continued use of idarucizumab in Japan.Trial RegistrationThis study is registered with ClinicalTrials.gov (NCT02946931).Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 17, 2023 Category: Cardiology Source Type: research
Real-World Insights into Evolocumab Use in Patients with Hyperlipidemia Across Five Countries: Analysis from the ZERBINI Study
ConclusionThese findings provide real-world evidence that evolocumab use is in accordance with its international guideline-recommended place in dyslipidemia therapy, as well as confirmation of its effectiveness and safety in a heterogeneous population. Evolocumab can address a healthcare gap in the management of dyslipidemia by increasing the proportion of patients achieving LDL-C goals recommended to lower cardiovascular risk.Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 7, 2023 Category: Cardiology Source Type: research
Evaluation of Incidence and Risk Factors of Sudden Cardiac Death in Patients with Chronic Coronary Syndrome Attending Physical Training
ConclusionsTaking ACEI/ARBs and BBs proved to be a protective factor, emphasizing the use of optimal medical therapy. Assessment of cardiac risk factors and control of comorbidities also proved to be important. The occurrence of SCD was connected to irregular physical activity, probably relating to the adverse effects of ad hoc exercising. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 6, 2023 Category: Cardiology Source Type: research
Antiplatelet Treatment Patterns and Outcomes for Secondary Stroke Prevention in the United Kingdom
ConclusionsIn the United Kingdom, 13.9% of patients hospitalized for stroke might not have any antiplatelet treatment to prevent secondary stroke; among the treated, clopidogrel, aspirin, and DAPT were commonly used. These study findings suggest that improved anti-thrombotic therapies for long-term SSP treatment are needed, which may lead to higher treatment and persistence rates and, therefore, improved outcomes in this population. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 4, 2023 Category: Cardiology Source Type: research
Correction to: Epidemiological Study Regarding the Incidence of Venous Thromboembolism in Patients After Cancer Remission
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 27, 2023 Category: Cardiology Source Type: research
Contemporary Use of Coronary Physiology in Cardiology
AbstractCoronary angiography has a limited ability to predict the functional significance of intermediate coronary lesions. Hence, physiological assessment of coronary lesions, via fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR), has been introduced to determine their functional significance. An accumulating body of evidence has consolidated the role of physiology-guided revascularization, particularly among patients with stable ischemic heart disease. The use of FFR or iFR to guide decision-making in patients with stable ischemic heart disease and intermediate coronary lesions received a class I recom...
Source: Cardiology and Therapy - September 5, 2023 Category: Cardiology Source Type: research
Summary and Comparison of the 2022 ACC/AHA/HFSA and 2021 ESC Heart Failure Guidelines
AbstractThe guidelines released by the American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA) in 2022 and those released in 2021 by the European Society of Cardiology (ESC) play a crucial role in offering evidence-based recommendations for the diagnosis and management of heart failure (HF). This comprehensive review aims to provide an overview of these guidelines, incorporating insights from relevant clinical trials. While there is considerable alignment between the two sets of guidelines, certain notable differences arise due to variations in publication timelines, which ...
Source: Cardiology and Therapy - August 31, 2023 Category: Cardiology Source Type: research
Utility of Follow-Up Echocardiograms in Uncomplicated Surgical Secundum Atrial Septal Defect Closures: Preliminary Analysis
ConclusionIn patients who underwent an uncomplicated ASD2 closure, there were no significant abnormalities noted on follow-up TTEs. The need for repeat lifetime TTEs and their frequency, in this uncomplicated population, should be reassessed if larger studies with longer follow-up confirm these initial findings. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 7, 2023 Category: Cardiology Source Type: research
Atrial Arrhythmias in Adults with Fontan Palliation
AbstractSingle ventricle physiology is a rare form of congenital heart disease and was, historically, a uniformly lethal condition. However, the atriopulmonary Fontan operation, and its successive iterations, the lateral tunnel and extracardiac conduit Fontan, became the fundamental approach to treating single ventricle heart disease. Over time, dysrhythmias are some of the most common complications with Fontan physiology, compounding morbidity and mortality. Atrial arrhythmias are prevalent in the Fontan population and occur in about 15 –60% of patients with Fontan palliation, increasingly with age. Diagnosing atrial ar...
Source: Cardiology and Therapy - July 26, 2023 Category: Cardiology Source Type: research
Correction to: Anticoagulant Treatment Adherence and Persistence in German Patients with Atrial Fibrillation
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 18, 2023 Category: Cardiology Source Type: research
Complications of SARS-CoV-2 Infection During Cardiac Rehabilitation: A Case Series
ConclusionAlmost all patients developed complications which, however, did not evolve towards more severe expressions of the disease. These data suggest that even in this new phase of the pandemic, vaccination may exert a potential role to reduce the risk of progression towards more severe disease of SARS-CoV-2 infection in vulnerable patients with cardiovascular comorbidities. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 15, 2023 Category: Cardiology Source Type: research
Correction to: Colchicine in the Management of Acute Coronary Syndrome: A Meta-analysis
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 6, 2023 Category: Cardiology Source Type: research
Practical Recommendations for the Use of Angiotensin Receptor-Neprilysin Inhibitors (ARNI) in Heart Failure: Insights from Indian Cardiologists
AbstractHeart failure is a significant public health concern characterized by notable rates of morbidity and mortality. Despite the presence of guideline-directed medical therapy (GDMT), its utilization remains inadequate. This practical recommendation paper focuses on the utilization of angiotensin receptor –neprilysin inhibitor (ARNI) as a pivotal treatment for heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF), and heart failure with improved ejection fraction (HFimpEF). The recommendations presented in this paper have been developed by a gr oup of cardiologist...
Source: Cardiology and Therapy - June 29, 2023 Category: Cardiology Source Type: research
Endovascular Revascularization and Outcomes of Critical Limb-Threatening Ischemia in Trinidad and Tobago: The EVENT Pilot Study —Challenges in a Limited-Resource, Caribbean Setting
ConclusionsThis study may prove clinically informative and applicable for an EVR-1st management strategy for high-risk patients with CLTI in a limited-resource, Caribbean setting.Trial registration number: NCT05547022 (retrospectively registered). (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 17, 2023 Category: Cardiology Source Type: research
Correlation of RETINAL Artery Diameter with Coronary Artery Disease: The RETINA CAD Pilot Study —Are the Eyes the Windows to the Heart?
ConclusionA significantly negative correlation was observed between retinal artery diameter and SYNTAX score. This study alludes to the practical use of optical coherence tomography –angiography (OCT–A) as a noninvasive diagnostic modality for patients with cardiovascular disease (CVD). Further large-scale, multicentric studies are required to confirm these exploratory findings.Trial registration numberNCT04233619. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 15, 2023 Category: Cardiology Source Type: research
