Ethnic and Gender Disparities in the Uptake of Transcatheter Aortic Valve Replacement in the United States
ConclusionsIn this observational study, we demonstrated that there is evidence of ethnic and gender differences in the overall uptake and adjusted mortality of TAVRs in the United States. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 24, 2019 Category: Cardiology Source Type: research
The Association between Transcatheter Aortic Valve Replacement (TAVR) Approach and New-Onset Bundle Branch Blocks
ConclusionsRelative to transfemoral TAVR, patients undergoing transapical TAVR are at increased risk for new-onset bundle branch block, peri-procedural myocardial infarction, rehospitalization, TAV-in-TAV deployment, and all-cause mortality at 1 year. Interventional cardiologists and cardiothoracic surgeons alike should take these findings into consideration when choosing which approach is most suitable for patients undergoing TAVR for severe aortic stenosis. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 22, 2019 Category: Cardiology Source Type: research
Adverse Outcomes Associated with Pre-Existing and New-Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study
ConclusionsNew-onset AF during ACS was associated with a significantly increased risk of adverse outcomes, especially in the elderly patients. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 16, 2019 Category: Cardiology Source Type: research
Development and Psychometric Evaluation of Coronary Artery Disease Treatment Adherence Scale
ConclusionsThe Coronary Artery Disease Treatment Adherence Scale is a valid and reliable tool and can be used in different healthcare settings for the assessment of treatment adherence among patients ’ with coronary artery disease.Trial RegistrationTehran University of Medical Sciences, identifier, 35456. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 9, 2019 Category: Cardiology Source Type: research
Effects of Evolocumab on the ApoA1 Remnant Ratio: A Pooled Analysis of Phase 3 Studies
ConclusionsThis post hoc analysis suggests that evolocumab increases the apoA1 remnant ratio.FundingAmgen Inc.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 8, 2019 Category: Cardiology Source Type: research
Left Ventricular Diastolic Dysfunction and Transcatheter Aortic Valve Replacement Outcomes: A Review
AbstractAortic stenosis (AS) is the most common valvular disease that can lead to increased afterload, left ventricular (LV) remodeling, and myocardial fibrosis. We reviewed the literature addressing the impact of transcatheter aortic valve replacement (TAVR) on LV remodeling and patients ’ outcomes by elimination of AS-related high afterload. TAVR reduces afterload and improves LV remodeling recovery. However, myocardial fibrosis may not completely reverse after the TAVR. The LV diastolic dysfunction (LVDD) induced by AS is an independent predictor of post-TAVR mortality, and mort ality increases with severity of LVDD. ...
Source: Cardiology and Therapy - March 6, 2019 Category: Cardiology Source Type: research
Identifying Outcome Measures for Coronary Artery Disease Value-Based Contracting Using the Delphi Method
ConclusionsOur study results verify the utility of a widely used clinical CAD outcome measure, myocardial infarction events, for the purpose of pharmaceutical value-based contracting. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 1, 2019 Category: Cardiology Source Type: research
Icosapent Ethyl Effects on Fatty Acid Profiles in Statin-Treated Patients With High Triglycerides: The Randomized, Placebo-controlled ANCHOR Study
ConclusionsIcosapent ethyl 4 g/day significantly increased EPA and produced other potentially beneficial shifts in fatty acids in plasma and RBCs versus placebo.Trial RegistrationClinicalTrials.gov Identifier, NCT01047501FundingAmarin Pharma Inc.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 20, 2019 Category: Cardiology Source Type: research
Effectiveness of Long-acting Trimetazidine in Different Clinical Situations in Patients with Stable Angina Pectoris: Findings from ODA Trial
ConclusionsTMZ 80 mg od, in association with other antianginal therapy, effectively reduced angina attacks and SAN consumption and improved physical activity and adherence to antianginal therapy both in patients initiating TMZ treatment and those switching from a bid or tid formulation.Trial RegistrationISRCTN registry Identifier, ISRCTN97780949.FundingServier.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 18, 2019 Category: Cardiology Source Type: research
Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study
ConclusionsIdentification of an early characteristic recoil signal occurring on the MA TDI right after the e ’ velocity seems to be useful in the characterization of LVDD. Additional prospective studies are now needed to validate its utility as an additional criterion to be used in LVDD. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 16, 2019 Category: Cardiology Source Type: research
Plasma LDL-Cholesterol Level at Admission is Independently Associated with Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
ConclusionThis study demonstrates that besides the more established predictors of infarct size, elevated LDL-c is associated with augmented infarct size in patients with STEMI treated with pPCI. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 13, 2019 Category: Cardiology Source Type: research
Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study
ConclusionsIn Japan, physicians who attempt stroke prevention in patients with atrial fibrillation choose appropriate anticoagulant treatment, taking into consideration the individual patient backgrounds as well as the features of each antithrombotic agent.Trial RegistrationClinicalTrials.gov Identifier, NCT01491178 and University Hospital Medical Information Network (UMIN) Clinical Trial Registry Identifier, UMIN000009644.FundingNippon Boehringer Ingelheim Co., Ltd.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 11, 2019 Category: Cardiology Source Type: research
Growth Differentiation Factor-15 Levels at Admission Provide Incremental Prognostic Information on All-Cause Long-term Mortality in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention
ConclusionGDF-15 levels at admission in STEMI patients are independently associated with 10-year all-cause mortality rates and could improve risk stratification on top of clinical variables and other cardiac biomarkers. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 30, 2019 Category: Cardiology Source Type: research
Cardiology and Therapy: A Summary of 2018 and Key Areas of Emerging Research in 2019
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 25, 2019 Category: Cardiology Source Type: research
Treatment of Orthostatic Hypotension Due to Autonomic Dysfunction (Neurogenic Orthostatic Hypotension) in a Patient with Cardiovascular Disease and Parkinson's Disease
ConclusionDroxidopa is approved by the US Food and Drug Administration to treat symptomatic nOH and is not contraindicated in patients with cardiovascular conditions. In this case, treatment with droxidopa improved the patient ’s orthostatic tolerance and, importantly, did not change the patient’s rate-controlled AF or his symptoms of class IV heart failure. Because symptoms associated with nOH can be detrimental to patient safety and mobility, it is critical to screen for and treat patients with nOH, even when there are cardiovascular comorbidities.FundingEditorial support and article processing charges were funded by...
Source: Cardiology and Therapy - January 9, 2019 Category: Cardiology Source Type: research
