Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature
AbstractCardiogenic shock (CS) is associated with hemodynamic compromise and end-organ hypoperfusion due to a primary cardiac etiology. In addition to vasoactive medications, percutaneous mechanical circulatory support (MCS) devices offer the ability to support the hemodynamics and prevent acute organ failure. Despite the wide array of available MCS devices for CS, there are limited data on the complications from these devices. In this review, we seek to summarize the complications of MCS devices in the contemporary era. Using a systems-based approach, this review covers domains of hematological, neurological, vascular, in...
Source: Cardiology and Therapy - October 22, 2019 Category: Cardiology Source Type: research
A Review of Antithrombotic Treatment in Critical Limb Ischemia After Endovascular Intervention
AbstractEndovascular intervention is often used to treat critical limb ischemia (CLI). Post-intervention treatment with antiplatelet and/or anticoagulant therapy has reduced morbidity and mortality due to cardiovascular complications. The purpose of this review is to shed light on the various pharmacologic treatment protocols for treating CLI following endovascular procedures. We reviewed the literature comparing outcomes after antithrombotic treatment for patients with CLI. We characterized antithrombotic therapies into three categories: (1) mono-antiplatelet therapy (MAPT) vs. dual antiplatelet therapy (DAPT), (2) MAPT v...
Source: Cardiology and Therapy - October 18, 2019 Category: Cardiology Source Type: research
Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study
ConclusionsElectrocardiographic detection of LVH improved by adding BMI and SA to a model with conventional electrocardiographic criteria. This approach would require little extra effort and application in clinical practice is feasible. However, results should first be replicated in high-risk populations. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 15, 2019 Category: Cardiology Source Type: research
Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials
ConclusionIn this meta-analysis including seven randomized trials, the use of losartan was associated with a significantly smaller change in aortic root diameter in patients with Marfan syndrome. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 12, 2019 Category: Cardiology Source Type: research
A Review of the Role of Bradykinin and Nitric Oxide in the Cardioprotective Action of Angiotensin-Converting Enzyme Inhibitors: Focus on Perindopril
AbstractThe functional integrity of the endothelium is essential for vascular health. In addition to maintaining a delicate balance between vasodilation and vasoconstriction, the endothelium has numerous other complex roles involved in the maintenance of vascular homeostasis. Chronic exposure to cardiovascular risk factors and oxidative stress results in an imbalance in these functions, creating an environment that favors reduced vasodilation and a proinflammatory and prothrombic state. The involvement of endothelial dysfunction in all stages of the cardiovascular continuum makes it an important target for treatment. One o...
Source: Cardiology and Therapy - September 30, 2019 Category: Cardiology Source Type: research
Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review
AbstractInfective endocarditis (IE) continues to be associated with high morbidity and mortality, even when treated with optimal antibiotic regimens. The selection of treatment depends on the causative pathogen, its antibiotic susceptibility profile, local and systemic complications and the presence of prosthetic materials or devices. Standard therapy typically involves 4–6 weeks of intravenous (IV) bactericidal therapy. However, there are instances in which IV antibiotic administration may be challenging due to cost, complications of IV access, adverse side-effects of the medication or concerns for misuse of the IV l...
Source: Cardiology and Therapy - September 17, 2019 Category: Cardiology Source Type: research
Cardiovascular Risk Factors and Secondary Events Among Acute and Chronic Stable Myocardial Infarction Patients: Findings from a Managed Care Database
ConclusionsGreater understanding of differences in the CVD risk profiles and the transition from acute to chronic stable phase may help identify high-risk patients and inform clinical risk stratification and long-term disease management in MI patients.FundingMerck& Co., Inc., Kenilworth, NJ, USA. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 19, 2019 Category: Cardiology Source Type: research
Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice
ConclusionsTreatment with metoprolol/ivabradine FDC significantly improved angina symptoms and adherence, with an excellent tolerability profile, in stable angina patient subgroups relevant to real-life clinical practice, regardless of age, CAD duration, CCS class, comorbidities, previous MI, or history of revascularization.Trial registrationISRCTN51906157.FundingThis study was sponsored by Servier Deutschland GmbH. Editorial assistance and the Rapid Service Fee were funded by Servier, France.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 12, 2019 Category: Cardiology Source Type: research
Estimating the Prevalence of Transthyretin Amyloid Cardiomyopathy in a Large In-Hospital Database in Japan
ConclusionThis retrospective study provides an estimate of the number of patients diagnosed with ATTR-CM in a large in-hospital database in Japan over a period of 9 years. Improving awareness of disease prevalence may improve diagnosis and treatment.FundingPfizer. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 1, 2019 Category: Cardiology Source Type: research
Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF
ConclusionsStudy drug satisfaction did not predict rate of study drug discontinuation. No significant difference was observed between satisfaction with warfarin and rivaroxaban, as expected given the double-blind trial design. Although these results are negative, the importance of PRO data will only increase, and these analyses may inform future studies that explore the relationship between drug-satisfaction PROs, adherence, and clinical outcomes.ClinicalTrials.govNCT00403767.FundingThe ROCKET AF trial was funded by Johnson& Johnson and Bayer. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 1, 2019 Category: Cardiology Source Type: research
New American and European Hypertension Guidelines, Reconciling the Differences
AbstractIn November 2017, the American College of Cardiology and the American Heart Association released hypertension guidelines for the first time, replacing the Joint National Committee periodical reports, appearing from 1977 to 2003. In parallel, the European Society of Cardiology and the European Society of Hypertension updated their own recommendations with a new document released in August 2018. While both documents contain similar recommendations concerning several aspects of detection, prevention, and management of hypertension, they differ in some sensitive characteristics, which specifically affect diagnostic and...
Source: Cardiology and Therapy - July 29, 2019 Category: Cardiology Source Type: research
Acute and Long-Term Outcomes of Patients with Impaired Left Ventricular Systolic Function Undergoing Rotational Atherectomy: A Single-Center Observational Retrospective Study
ConclusionsCompared to patients with preserved LVEF, those with severely reduced LVEF have worse acute outcomes after RA, whereas a moderate reduction of LVEF poses no additional acute hazard after RA. Up to 5 years, the extent of left ventricular dysfunction was associated with a stepwise increase in mortality. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 26, 2019 Category: Cardiology Source Type: research
Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample
ConclusionsThe incidence of arrhythmia and shock in patients with TTC does not correlate with the extent of myocardium involvement. The presence of LBBB in such cases can help recognize at-risk populations, and with timely intervention, life-threatening complications can be avoided. Despite limitations of the dataset and inability to establish causality, prospective studies with longer follow-up are warranted. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 16, 2019 Category: Cardiology Source Type: research
TRimetazidine as an Agent to affeCt clopidogrEl Response: The TRACER Study
ConclusionHigher platelet reactivity was seen in patients on TMZ, suggesting that TMZ attenuated the PD effects of clopidogrel in this study of a predominantly South Asian diabetic subpopulation. Alternative therapies should be considered and further research is warranted.Trial RegistrationClinicalTrials.gov number, NCT03603249. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 9, 2019 Category: Cardiology Source Type: research
Insulin Resistance is Associated with Longitudinal Changes of Cardiac Repolarization Heterogeneity in Apparently Healthy Subjects
ConclusionInsulin resistance may be involved in the longitudinal increase of ventricular repolarization heterogeneity in apparently healthy subjects. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 3, 2019 Category: Cardiology Source Type: research
