Application of Single-Cell Genomics in Cardiovascular Research
AbstractCardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied in atherosclerosis, myocardial infarction, cardiac ischemia –reperfusion injury, arrhythmia, hypertrophy cardiomyopathy, and heart failure, which are extremely helpful in elucidating the underlying mechanisms of CVDs from physiological and pathological perspectives at DNA, RNA, protein, post-transcriptional, post-translational, and metabolite levels. In th is review, we would lik...
Source: Cardiology and Therapy - January 23, 2023 Category: Cardiology Source Type: research
The Use of Midodrine as an Adjunctive Therapy to Liberate Patients from Intravenous Vasopressors: A Systematic Review and Meta-analysis of Randomized Controlled Studies
ConclusionsAmong patients with vasopressor-dependent shock, midodrine was not associated with early liberation of vasopressor support or shorter ICU or hospital length of stay. Adding midodrine increased the risk of bradycardia. Further large RCTs are needed to better evaluate the efficacy and safety of midodrine in liberating patients from IV vasopressors. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 21, 2023 Category: Cardiology Source Type: research
Guideline LDL-C Threshold Achievement in Acute Myocardial Infarction Patients: A Real-World Evidence Study Demonstrating the Impact of Treatment Intensification with PCSK9i
ConclusionsIntensification with PCSK9i in AMI patients results in a greater proportion of patients achieving below the recommended LDL-C threshold versus statins and or ezetimibe alone. Increased focus on achieving below the LDL-C thresholds with additional LLT as required may benefit patient cardiovascular outcomes. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 19, 2023 Category: Cardiology Source Type: research
Communicating Cardiac Pathology and Procedures: Patient and Medical Perspective
This article, co-authored by a family member of a patient with atrial fibrillation and a cardiothoracic surgeon, discusses the challenges of communicating cardiac diagnoses and treatment options from both the patient and clinician perspective. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 16, 2023 Category: Cardiology Source Type: research
Detection and Diagnosis of Cardiac Amyloidosis in Egypt
AbstractCardiac amyloidosis is a life-threatening disease that occurs when amyloid proteins, most commonly immunoglobulin light chain or transthyretin, mutate or become unstable, misfold, deposit as amyloid fibrils, and accumulate in the myocardium. Early diagnosis of cardiac amyloidosis is hindered by insufficient awareness, specifically regarding clinical red flags and diagnostic pathways. Cardiac amyloidosis diagnosis comprises two important phases, clinical suspicion (phase one) followed by definitive diagnosis (phase two). Each phase is associated with specific clinical techniques. For example, clinical features, elec...
Source: Cardiology and Therapy - January 7, 2023 Category: Cardiology Source Type: research
Colchicine in the Management of Acute Coronary Syndrome: A Meta-analysis
ConclusionsThese data suggest colchicine, in addition to guideline-directed medical therapy following acute coronary syndrome reduces MACE, cerebrovascular accidents, and rates of urgent revascularization at 2 years of follow-up. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 6, 2023 Category: Cardiology Source Type: research
Emerging PET Tracers in Cardiac Molecular Imaging
Abstract18F-fluorodeoxyglucose (FDG) and18F-sodium fluoride (NaF) represent emerging PET tracers used to assess atherosclerosis-related inflammation and molecular calcification, respectively. By localizing to sites with high glucose utilization, FDG has been used to assess myocardial viability for decades, and its role in evaluating cardiac sarcoidosis has come to represent a major application. In addition to determining late-stage changes such as loss of perfusion or viability, by targeting mechanisms present in atherosclerosis, PET-based techniques have the ability to characterize atherogenesis in the early stages to gui...
Source: Cardiology and Therapy - January 3, 2023 Category: Cardiology Source Type: research
Anticoagulation During Pregnancy with a Mechanical Pulmonary Valve: Patient and Medical Perspective
This article discusses the challenges of supporting a successful pregnancy in a woman with multiple prosthetic heart valves and a complicated cardiac history, from both the patient and provider perspective. The patient is a 29-year-old female with truncus arteriosus type I with initial neonatal VSD closure and right ventricular to pulmonary artery conduit. At the age of 13, she subsequently required truncal and pulmonary valve replacements with mechanical prostheses. Standardizing an approach to anticoagulation in pregnancy in women with prosthetic heart valves is not always possible. Her story demonstrates the importance ...
Source: Cardiology and Therapy - December 29, 2022 Category: Cardiology Source Type: research
Comparative Outcomes of TAVR in Mixed Aortic Valve Disease and Aortic Stenosis: A Meta-analysis
ConclusionsPatients with MAVD have similar or improved survival 1 Â year after TAVR compared to those with AS. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 25, 2022 Category: Cardiology Source Type: research
Targeted Temperature Management in Cardiac Arrest: An Updated Narrative Review
AbstractThe established benefits of cooling along with development of sophisticated methods to safely and precisely induce, maintain, monitor, and reverse hypothermia have led to the development of targeted temperature management (TTM). Early trials in human subjects showed that hypothermia conferred better neurological outcomes when compared to normothermia among survivors of cardiac arrest, leading to guidelines recommending targeted hypothermia in this patient population. Multiple studies have sought to explore and compare the benefit of hypothermia in various subgroups of patients, such as survivors of out-of-hospital ...
Source: Cardiology and Therapy - December 17, 2022 Category: Cardiology Source Type: research
One-Year Healthcare Utilization and Expenditures Among Patients with Clinically Significant Mitral Regurgitation in Taiwan
ConclusionThese findings are inconsistent with what has been shown in the USA, which warrants further investigation. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 15, 2022 Category: Cardiology Source Type: research
Hyperkalemia: Prevalence, Predictors and Emerging Treatments
AbstractIt is well established that an elevated potassium level (hyperkalemia) is associated with a risk of adverse events including morbidity, mortality and healthcare system cost. Hyperkalemia is commonly encountered in many chronic conditions including kidney disease, diabetes and heart failure. Furthermore, hyperkalemia may result from the use of renin-angiotensin-aldosterone system inhibitors (RAASi), which are disease-modifying treatments for these conditions. Therefore, balancing the benefits of optimizing treatment with RAASi while mitigating hyperkalemia is crucial to ensure patients are optimally treated. In this...
Source: Cardiology and Therapy - December 12, 2022 Category: Cardiology Source Type: research
Pulmonary Thromboembolism Developed During Hospitalization: A Nationwide Retrospective Observational Study Using Claims Data
ConclusionIt is important to conduct a proper risk assessment on admission as well as to implement proper prophylactic procedures to prevent the development of PE during hospitalization. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 8, 2022 Category: Cardiology Source Type: research
Leadless Cardiac Pacing: New Horizons
AbstractSince the introduction of transvenous cardiac pacing leads, pacemaker system design has remained similar for several decades. Progressive miniaturisation of electronic circuitry and batteries has enabled a smaller, single pacing unit comprising the intracardiac electrodes, generator and computer. This review explores the development of leadless pacing, the clinical trials comparing leadless to transvenous pacing in addition to the future developments of multi-chamber leadless pacing. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 22, 2022 Category: Cardiology Source Type: research
Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis
ConclusionMelatonin supplementation may be useful in reducing cardiac injury and inflammatory biomarkers in CABG candidates. Future studies should investigate the clinical significance of these findings. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 9, 2022 Category: Cardiology Source Type: research
