Imaging-Guided Transcatheter Aortic Valve Replacement and Percutaneous Coronary Intervention in Decompensated Severe Aortic Stenosis with Acute Renal Impairment
AbstractAn 82-year-old woman with severe aortic valve stenosis (AS) and a significant proximal right coronary artery (RCA) stenosis presented with decompensated heart failure and acute kidney injury. She was treated with intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) and trans-oesophageal echocardiography (TOE)-guided transcatheter aortic valve replacement (TAVR). (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 28, 2021 Category: Cardiology Source Type: research
Role of Pocket Ultrasound in Assessing Intravascular Volume to Guide Management in Heart Failure Patients with Renal Impairment
ConclusionUltrasound-guided management of patients admitted with acute HF exacerbation and renal impairment may be beneficial in preserving kidney function. US provides a simple easily accessible tool to guide the management of patients with HF. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 26, 2021 Category: Cardiology Source Type: research
Phenotypic Differences of Glu89Gln Genotype in ATTR Amyloidosis From Endemic Loci: Update From THAOS
ConclusionsThe majority of patients with ATTRv Glu89Gln amyloidosis in THAOS are from Bulgaria or Italy. There were notable phenotypic differences, with the cardiac phenotype more common in Bulgaria and the neurologic phenotype more common in Italy. Over one-third of patients had a mixed phenotype, suggesting a potential role of multiple genetic and/or environmental factors and the need for comprehensive assessment of all patients.Trial RegistrationClinicalTrials.gov: NCT00628745. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 19, 2021 Category: Cardiology Source Type: research
Contemporary ICD Use in Patients with Heart Failure
AbstractDespite constant breakthroughs in heart failure (HF) therapy, the population of HF patients resume to grow and is linked to increased mortality and morbidity. Ventricular arrhythmias (VA) are one of the leading causes of mortality in HF subjects. Implantable cardioverter-defibrillators (ICDs) are currently the gold standard in treatment, preventing arrhythmic sudden cardiac death (SCD) episodes. However, the death rates related to HF remain elevated, as not all HF subjects benefit equally. Cardiac resynchronization therapy (CRT) has emerged as a novel approach for HF patients. These devices have been thoroughly inv...
Source: Cardiology and Therapy - June 15, 2021 Category: Cardiology Source Type: research
Effectiveness and Effect on Renal Parameters of Amlodipine vs. Other Dihydropyridine Calcium Channel Blockers in Patients with Essential Hypertension: Retrospective Observational Study Based on Real-World Evidence from Electronic Medical Records
ConclusionAmlodipine and other CCBs demonstrated good efficacy and similar effects on renal parameters from baseline to end of study. Amlodipine also showed higher potency by demonstrating greater BP reduction at a lower dose. Thus, amlodipine can remain a preferred choice among CCBs, even with the advent of the newer CCBs. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 11, 2021 Category: Cardiology Source Type: research
Multidisciplinary Approaches for Transthyretin Amyloidosis
AbstractAmyloidosis caused by systemic deposition of transthyretin (TTR) is called ATTR amyloidosis and mainly includes hereditary ATTR (ATTRv) amyloidosis and wild-type ATTR (ATTRwt) amyloidosis. Until recently, ATTRv amyloidosis had been considered a disease in the field of neurology because neuropathic symptoms predominated in patients described in early reports, whereas advances in diagnostic techniques and increased recognition of this disease revealed the presence of patients with cardiomyopathy as a predominant feature. In contrast, ATTRwt amyloidosis has been considered a disease in the field of cardiology. However...
Source: Cardiology and Therapy - June 4, 2021 Category: Cardiology Source Type: research
Expert Consensus on Sizing and Positioning of SAPIEN 3/Ultra in Bicuspid Aortic Valves
AbstractSevere aortic stenosis patients with bicuspid anatomy have been excluded from the major transcatheter aortic valve replacement (TAVI) randomized clinical trials. As a result, there is no official recommendation on bicuspid TAVI. A panel of bicuspid experts was created to fill this gap. In this consensus statement, an algorithm is proposed to guide the choice of surgery or TAVI within this complex patient population, depending on aortic dilatation, age, surgical risk score, and anatomy. A step-by-step guide for sizing and positioning of the SAPIEN 3/Ultra TAVI bioprostheses is presented. Annular sizing remains the p...
Source: Cardiology and Therapy - June 3, 2021 Category: Cardiology Source Type: research
Variations in Awareness of Association Between Adverse Pregnancy Outcomes and Cardiovascular Risk by Specialty
ConclusionAwareness of the association between APO and future maternal CVD risk varies by specialty. A significant percentage of the physicians who responded to the survey did not routinely ask about APOs when assessing CVD risk and failed to identify PTB as a risk factor for APOs. Education on this topic and targeted efforts to improve screening for APOs are needed within all specialties to help reduce CVD morbidity and mortality. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 27, 2021 Category: Cardiology Source Type: research
Ablation Therapy as Management of Typical Atrial Flutter in the Early Period After Cardiac Surgery
ConclusionsIn this small cohort, early postoperative ablation of typical flutter was associated with a favorable short- and long-term safety and efficacy profile and can be considered part of heart rhythm management options in this setting. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 24, 2021 Category: Cardiology Source Type: research
Contemporary Strategies to Manage High Blood Pressure in Patients with Coexistent Resistant Hypertension and Heart Failure With Reduced Ejection Fraction
AbstractResistant hypertension (RH) represents an advanced subtype of hypertension that is complex to diagnose and treat. Compared with general hypertension, RH increases the risk patients will develop more advanced cardiovascular complications, including heart failure with reduced ejection fraction (HFrEF). As expected, the prevalence of RH has increased since the introduction of lower blood pressure targets included in the recent 2017 American blood pressure guidelines. The array of pharmacotherapies available to treat both hypertension and HFrEF has also expanded within the past decade. However, the efficacy of these cu...
Source: Cardiology and Therapy - May 17, 2021 Category: Cardiology Source Type: research
Trimetazidine and Bisoprolol to Treat Angina in Symptomatic Patients: Post Hoc Analysis From the CHOICE-2 Study
ConclusionThe TMZ –bisoprolol combination is a rapidly effective treatment for reducing the frequency of angina attacks and the use of short-acting nitrates in patients with stable angina in a real-world clinical setting. The benefits of this combination therapy was observed as early as 2 weeks after treatment init iation and the treatment was well tolerated.Trial RegistrationISRCTN identifier: ISRCTN65209863 (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 17, 2021 Category: Cardiology Source Type: research
Impact of Delayed Diagnosis and Misdiagnosis for Patients with Transthyretin Amyloid Cardiomyopathy (ATTR-CM): A Targeted Literature Review
ConclusionATTR-CM patients commonly experience diagnostic delay and misdiagnosis. Efforts are required to provide timely diagnosis so that patients can benefit from earlier access to new disease-modifying therapies. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 20, 2021 Category: Cardiology Source Type: research
Effectiveness of Telmisartan on Blood Pressure Control in Hypertensive Patients in India: A Real-World Retrospective Study from Electronic Medical Records
ConclusionTelmisartan may be a good candidate for blood pressure control in Indian patients with essential hypertension and comorbidities. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 8, 2021 Category: Cardiology Source Type: research
Distal Transradial Access for Coronary Angiography and Interventions in Everyday Practice: Data From the TRIANGLE Registry (TwitteR Initiated registry for coronary ANgiography in Germany via distaL radial accEss)
ConclusionCoronary angiography and interventions via the distal transradial access in the area of the anatomical snuffbox can be performed with a high rate of success and safety. This data suggests a reduced rate of radial artery occlusion compared to previously reported data after cannulation via the standard forearm radial artery puncture site. Randomized studies are needed to further investigate these results.Trial RegistrationThis study was registered in the German registry for clinical trials: DRKS00017110, retrospectively on 07.May 2019 (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 5, 2021 Category: Cardiology Source Type: research
Supplementary Therapeutic Possibilities to Alleviate Myocardial Damage Due to Microvascular Dysfunction in Coronavirus Disease 2019 (COVID-19)
AbstractMyocardial damage with a consequent rise in cardio-specific troponin level is a frequent phenomenon in severe cases of coronavirus disease 2019 (COVID-19). Its causes are capillary endothelial cell dysfunction, associated carditis, low oxygenization, and increased sympathetic tone, which all worsen myocardial stiffness and microvascular dysfunction (MD). They lead to severe myocardial dysfunction, arrhythmia, acute congestive heart failure, and a significant rise in death cases. During COVID-19, no specific cardiological treatment is started. As adjuvant therapy, anxiolytics in COVID-19 are widely used, but not in ...
Source: Cardiology and Therapy - April 2, 2021 Category: Cardiology Source Type: research
