Real-World Risk of Recurrent Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients with LDL-C Above Guideline-Recommended Threshold: A Retrospective Observational Study
ConclusionThis real-world study confirms that statin-treated high-risk patients with ASCVD and above-threshold LDL-C levels have substantial incidence of recurrent CV events. These findings reinforce the opportunity for lipid-lowering therapy intensification in high-risk patients to levels below guideline-recommended threshold in order to reduce CV risk. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 29, 2024 Category: Cardiology Source Type: research
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results
ConclusionsA good relationship between relevant echo and cMRI parameters was shown. Improvements in RV structure and function with macitentan treatment was observed by echo, consistent with results observed by cMRI in the primary analysis of the REPAIR study. Echo is a valuable complementary method to cMRI, with the potential to non-invasively monitor treatment response at follow-up.Trial registration numberREPAIR NCT02310672.Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 28, 2024 Category: Cardiology Source Type: research
The Utility of Screening Fetal Echocardiograms Following Normal Level II Ultrasounds in Fetuses with Maternal Congenital Heart Disease
ConclusionsCritical CHD was not missed with a normal LII-US in this at risk population. F-echo also missed the majority of CHD when a LII-US was read as normal. A cost –benefit analysis of screening F-echo in fetuses with maternal CHD should be conducted if a normal LII-US has been performed. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 23, 2024 Category: Cardiology Source Type: research
Add-on Sacubitril/Valsartan Therapy Induces Left Ventricular Remodeling in Non-responders to Cardiac Resynchronization Therapy to a Similar Extent as in Heart Failure Patients Without Resynchronization
ConclusionSV therapy induced similar improvements in echocardiographic parameters and in NT-proBNP levels in CRT-NR patients and in patients with HFrEF without resynchronization. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 12, 2024 Category: Cardiology Source Type: research
Can Artificial Intelligence Improve the Readability of Patient Education Materials on Aortic Stenosis? A Pilot Study
ConclusionAI dialogue platforms can enhance the readability of PEMs for patients with AS but may not fully meet recommended reading skill levels, highlighting potential tools to help strengthen cardiac health literacy in the future. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 9, 2024 Category: Cardiology Source Type: research
Clinical and Genotype Characteristics and Symptom Migration in Patients With Mixed Phenotype Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey
ConclusionsThese THAOS data represent the largest analysis of a real-world mixed phenotype ATTR amyloidosis population to date and suggest that a mixed phenotype may be more prevalent than previously thought. Patients may also migrate from a primarily neurologic or cardiologic presentation to a mixed phenotype over time. These data reinforce the need for multidisciplinary evaluation at initial assessment and follow-up of all patients with ATTR amyloidosis.Trial RegistrationClinicalTrials.gov: NCT00628745. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 20, 2023 Category: Cardiology Source Type: research
Automatic Quantification of Local Plaque Thickness Differences as Assessed by Serial Coronary Computed Tomography Angiography Using Scan-Quality-Based Vessel-Specific Thresholds
ConclusionThis study demonstrates the feasibility of developing vessel-specific, quality-based thresholds for visualizing local plaque thickness differences evaluated by serial CCTA. These thresholds have the potential to facilitate the early detection of atherosclerosis progression. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 7, 2023 Category: Cardiology Source Type: research
Dual-Pathway Inhibition with Rivaroxaban and Low-Dose Aspirin Does Not Alter Immune Cell Responsiveness and Distribution in Patients with Coronary Artery Disease
ConclusionThree months of DPI does not result in any meaningful change in immune cell responsiveness and distribution in patients with CAD or PAD.Trial RegistrationClinicalTrials.gov ID: NCT05210725 (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 6, 2023 Category: Cardiology Source Type: research
Impact of Access Site on Periprocedural Bleeding and Cerebral and Coronary Events in High-Bleeding-Risk Percutaneous Coronary Intervention: Findings from the RIVA-PCI Trial
ConclusionsIn HBR patients with AF undergoing PCI for acute or chronic coronary syndrome, the use of TRA might be associated with a decrease in in-hospital bleeding, while not increasing the risk of embolic or ischemic events compared to femoral access. Further studies are required to confirm these preliminary findings. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 6, 2023 Category: Cardiology Source Type: research
Application of Hydrogels in Cardiac Regeneration
AbstractMyocardial infarction (MI) is a leading cause of death globally. Due to limited cardiac regeneration, infarcted myocardial tissue is gradually replaced by cardiac fibrosis, causing cardiac dysfunction, arrhythmia, aneurysm, free wall rupture, and sudden cardiac death. Thus, the development of effective methods to promote cardiac regeneration is extremely important for MI treatment. In recent years, hydrogels have shown promise in various methods for cardiac regeneration. Hydrogels can be divided into natural and synthetic types. Different hydrogels have different features and can be cross-linked in various ways. Hy...
Source: Cardiology and Therapy - November 18, 2023 Category: Cardiology Source Type: research
Cardiovascular Compatibility of Proton Pump Inhibitors: Practice Recommendations
AbstractThis manuscript aims to critically evaluate the current evidence regarding adverse cardiovascular effects associated with proton pump inhibitors (PPIs) in patients with coronary artery disease (CAD). It also provides guidance for the selection of the most appropriate PPI within the context of cardiovascular polypharmacy and emphasizes the importance of establishing consensus among clinicians on the need to prescribe PPIs with limited cytochrome P450 (CYP450) enzyme inhibition to reduce the risk of drug interactions. PPIs are among the most widely used drugs for the treatment of gastroesophageal reflux disease (GERD...
Source: Cardiology and Therapy - November 10, 2023 Category: Cardiology Source Type: research
Podcast on Self-administered Intranasal Etripamil for Symptomatic Paroxysmal Supraventricular Tachycardia: The RAPID Trial
AbstractParoxysmal supraventricular tachycardia (PSVT) is commonly seen in clinical practice and represents a significant burden to the healthcare system and to patients. First-line treatments include calcium channel blockers (CCB), although they are intravenous and require medical supervision. Etripamil is an investigational self-administered intranasal L-type CCB for unsupervised treatment of PSVT. In this podcast, we discuss the RAPID trial (NCT03464019), which was a phase 3 study that evaluated the safety and efficacy of etripamil in terminating PSVT episodes using a repeat-dosing regimen. RAPID was a multicenter, rand...
Source: Cardiology and Therapy - November 10, 2023 Category: Cardiology Source Type: research
Left Atrial Appendage Closure: A Narrative Review
AbstractAtrial fibrillation (AF) is the most common cardiac arrhythmia and the cause of thromboembolic events in elderly patients worldwide. AF is associated with a significantly increased risk of morbidity and mortality due to cardiac emboli, primarily from left atrial appendage (LAA) thrombus. Oral anticoagulation therapy is the standard treatm ent to effectively reduce the risk of thromboembolic events in patients with AF. However, anticoagulation treatment increases bleeding risk. LAA closure (LAAC) has recently been introduced as a feasible mechanical preventive intervention for thromboembolic events while minimi...
Source: Cardiology and Therapy - November 8, 2023 Category: Cardiology Source Type: research
Comparative Effectiveness of Various Radiofrequency Ablation Catheters in the Ablation of Typical Atrial Flutter
ConclusionsThe typical atrial flutter radiofrequency ablation procedure had a high success rate, which was not influenced by the type of ablation catheter. Contact force ablation catheter and HPSD are associated with shorter total lesion time. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 20, 2023 Category: Cardiology Source Type: research
Idarucizumab for Emergency Reversal of the Anticoagulant Effects of Dabigatran: Final Results of a Japanese Postmarketing Surveillance Study
ConclusionsThe final analysis from the PMS study confirms previous findings suggesting that idarucizumab can safely and effectively reverse the anticoagulant effects of dabigatran in Japanese patients in clinical practice. The results support the continued use of idarucizumab in Japan.Trial RegistrationThis study is registered with ClinicalTrials.gov (NCT02946931).Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 17, 2023 Category: Cardiology Source Type: research
