Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2022-0452. Online ahead of print.ABSTRACTRenovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertension cause an inflammatory response. This work analyzed the inflammatory and tissue repair profile in renal, hepatic, and cardiac tissues in an animal model of RVH associated with a high-fat diet and caloric restriction. The expressions of RORγ-t, IL-17, T-bet, and TNF-α decreased and IFN-γ increased in the right kidney. In relation to the left kidney, caloric restriction decreased the expression of IFN-γ....
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Thayane Rafaela Feola Pizzo Ana Paula Valverde Lucas Eduardo Orzari Luiz Gustavo Terciotti Robson Damasceno de Lima Fernando Russo Costa do Bomfim Marcelo Augusto Marreto Esquisatto Thiago Ant ônio Moretti de Andrade Maria Esm éria Corezola do Amaral Ca Source Type: research

MiR-122 knockdown regulates vascular smooth muscle cells phenotypic switching through enhanced FOXO3 expression
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2022-0549. Online ahead of print.ABSTRACTVascular smooth muscle cells (VSMCs) phenotypic switching is identified as enhanced dedifferentiation, proliferation, and migration ability of VSMCs, in which microRNAs have been identified as important regulators of the process. The present study is aimed to explore the pathophysiological effect of miR-122 on VSMC phenotypic modulation. Here, the result showed that the decreased miR-122 expression was found in VSMCs subjected to platelet-derived growth factor-BB (PDGF-BB) treatment. Next, we investigated the response of miR-12...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Lan Zhang Qian-Wei Huang Yan-Fen Pu Xiao-Qiang Xiao Bian-Jing Song Xue-Ping Zhang Yong-Sheng Yang Yu-Song Zhang Fu-Han Gong Source Type: research

Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0153. Online ahead of print.ABSTRACTThe purpose of this study was to characterize the role of β1-AR signaling and its cross-talk between cardiac renin-angiotensin system and thyroid-hormone-induced cardiac hypertrophy. T3 was administered at 0.5 mg·kg-1·day-1 for 10 days in β1-KOT3 and WTT3 groups, while control groups received vehicle alone. Echocardiography and myocardial histology was performed; cardiac and serum ANGI/ANGII and ANP and cardiac levels of p-PKA, p-ERK1/2, p-p38-MAPK, p-AKT, p-4EBP1, and ACE were measured. WTT3 showed decreased IVSTd and incr...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Anderson L B da Silveira Fernando A C Seara Danilo Lustrino Andr é S Mecawi Jos é Antunes-Rodrigues Ísis C Kettelhut Patr ícia Chakur-Brum Luis C Reis Emerson L Olivares Source Type: research

Considerations for Choosing an Optimal Animal Model of Cardiovascular Disease
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0206. Online ahead of print.ABSTRACTThe decision to use the optimal animal model to mimic the various types of cardiovascular disease is a critical one for a basic scientist. Clinical cardiovascular disease can be complex and presents itself as atherosclerosis, hypertension, ischemia/reperfusion injury, myocardial infarcts, and cardiomyopathies, amongst others. This may be further complicated by the simultaneous presence of two or more cardiovascular lesions (for example, atherosclerosis and hypertension) and co-morbidities (i.e. diabetes, infectious disease, obe...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Mihir Parikh Grant N Pierce Source Type: research

The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0199. Online ahead of print.ABSTRACTNon-nutritive sweeteners are popular food additives owing to their low caloric density and powerful sweetness relative to natural sugars. Their lack of metabolism contributes to evidence proclaiming their safety, yet several studies contravene this demonstrating that sweeteners activate sweet taste G protein-coupled receptors (GPCRs) and elicit deleterious metabolic functions through unknown mechanisms. We hypothesize that activation of GPCRs, particularly orphan receptors due to their abundance in metabolically active tissues,...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Madeline E Power Nicholas R Fernandez O P Oni Aditaya Kalia J L Rourke Source Type: research

Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0226. Online ahead of print.ABSTRACTAngiotensin (Ang II ) is formed by the action of angiotensin converting enzyme (ACE) in the renin- angiotensin system. This hormone is known to induce cardiac hypertrophy and heart failure and its actions are mediated by the interaction of both pro- and anti- hypertrophic Ang II receptors ( AT1R and AT2R). Ang II is also metabolized by ACE 2 to Ang 1-7, which elicits the activation of Mas receptors ( MasR) for inducing antihypertrophic actions. Since heart failure under different pathophysiological situations is preceded by ada...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Sukhwinder K Bhullar Naranjan S Dhalla Source Type: research

RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway
In conclusion, RAD54B exerts a direct protective effect against DNA damage through enhancing homologous recombination repair in endothelial senescence, resulting in inhibition of the downstream CHK1/p53/p21 pathway, suggesting that RAD54B may be a potential therapeutic target for vascular aging-associated diseases.PMID:37748205 | DOI:10.1139/cjpp-2023-0192 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Yanqi Mai Tong Lin Lili Zhang Wanqi Yang Sitong Liu Minghui Wang Peiqing Liu Zhuoming Li Wenwei Luo Source Type: research

Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Diabetic Complications
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0223. Online ahead of print.ABSTRACTCardiovascular (CVD) complications have remained a major cause of death among patients with diabetes. Hence the need for effective therapeutics against diabetes-induced CVD complications. Since its discovery, proprotein convertase subtilisin/kexin type 9 (PCSK9) has been reported to be involved in the pathology of various cardiovascular diseases, with studies showing a positive association between plasma levels of PCSK9, hyperglycemia, and dyslipidemia. PCSK9 regulates lipid homeostasis by interacting with low-density lipoprote...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Omonzejie E Imaralu Chandrakala Aluganti Narasimhulu Pawan K Singal Dinender Kumar Singla Source Type: research